M R Robinson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Safety and pharmacokinetics of intravitreal 2-methoxyestradiol implants in normal rabbit and pharmacodynamics in a rat model of choroidal neovascularization
    M R Robinson
    National Eye Institute, NIH, 10 Center Dr MSC 1863, Bldg 10 Room 10N112, Bethesda, MD 20892 1863, USA
    Exp Eye Res 74:309-17. 2002
  2. ncbi request reprint Fibrovascular changes misdiagnosed as cytomegalovirus retinitis reactivation in a patient with immune recovery
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    Clin Infect Dis 38:139-41. 2004
  3. ncbi request reprint Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    J Immunother 27:478-9. 2004
  4. ncbi request reprint A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Eye Res 82:479-87. 2006
  5. ncbi request reprint Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease
    M R Robinson
    National Eye Institute NIH, 10 10S229, 110 Center Drive, MSC 1863, Bethesda, MD 20892 1863, USA
    Bone Marrow Transplant 33:1031-5. 2004
  6. ncbi request reprint Burkitt's/Burkitt's-like lymphoma presenting as bacterial sinusitis in two HIV-infected children
    M R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    AIDS Patient Care STDS 15:453-8. 2001
  7. ncbi request reprint Tarsal-conjunctival disease associated with Wegener's granulomatosis
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 110:1770-80. 2003
  8. ncbi request reprint Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis
    S M Whitcup
    The Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1863, USA
    JAMA 282:1633-7. 1999
  9. ncbi request reprint Immune-recovery uveitis in patients with cytomegalovirus retinitis taking highly active antiretroviral therapy
    M R Robinson
    National Institute of Health, Bethesda, Maryland 20892 1863, USA
    Am J Ophthalmol 130:49-56. 2000
  10. ncbi request reprint High-dose intravitreal ganciclovir and foscarnet for cytomegalovirus retinitis
    G Velez
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Ophthalmol 131:396-7. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Safety and pharmacokinetics of intravitreal 2-methoxyestradiol implants in normal rabbit and pharmacodynamics in a rat model of choroidal neovascularization
    M R Robinson
    National Eye Institute, NIH, 10 Center Dr MSC 1863, Bldg 10 Room 10N112, Bethesda, MD 20892 1863, USA
    Exp Eye Res 74:309-17. 2002
    ..Sustained-release 2ME2 intravitreal implants may hold promise in the treatment of recurrent CNV refractory to standard therapy...
  2. ncbi request reprint Fibrovascular changes misdiagnosed as cytomegalovirus retinitis reactivation in a patient with immune recovery
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    Clin Infect Dis 38:139-41. 2004
    ..Fibrovascular membranes can be misdiagnosed as reactivated CMV retinitis, and a proper diagnosis is essential to avoid unnecessary therapy with potentially toxic antiviral medications...
  3. ncbi request reprint Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    J Immunother 27:478-9. 2004
    ..This suggests that CTLA-4 is an important regulatory molecule for maintenance of tolerance to melanosomal antigens and prevention of uveitis...
  4. ncbi request reprint A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Eye Res 82:479-87. 2006
    ..Animal models, retaining the dynamics of blood and lymph flow, may improve the basic understanding of the ocular barriers involved with transscleral drug transport and warrants further investigation...
  5. ncbi request reprint Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease
    M R Robinson
    National Eye Institute NIH, 10 10S229, 110 Center Drive, MSC 1863, Bethesda, MD 20892 1863, USA
    Bone Marrow Transplant 33:1031-5. 2004
    ..Additional studies are required to determine the long-term safety and efficacy of topical corticosteroids for cicatricial conjunctivitis associated with ocular GVHD in the context of a randomized, prospective clinical trial...
  6. ncbi request reprint Burkitt's/Burkitt's-like lymphoma presenting as bacterial sinusitis in two HIV-infected children
    M R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    AIDS Patient Care STDS 15:453-8. 2001
    ..Burkitt's/Burkitt's-like lymphoma in the paranasal sinuses has not been previously described in HIV-infected children...
  7. ncbi request reprint Tarsal-conjunctival disease associated with Wegener's granulomatosis
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 110:1770-80. 2003
    ..To describe the clinical characteristics of tarsal-conjunctival disease in a cohort of patients with Wegener's granulomatosis (WG)...
  8. ncbi request reprint Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis
    S M Whitcup
    The Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1863, USA
    JAMA 282:1633-7. 1999
    ..Persons with cytomegalovirus (CMV) retinitis and acquired immunodeficiency syndrome (AIDS) have required lifelong anti-CMV therapy to prevent the progression of retinal disease and subsequent loss of vision...
  9. ncbi request reprint Immune-recovery uveitis in patients with cytomegalovirus retinitis taking highly active antiretroviral therapy
    M R Robinson
    National Institute of Health, Bethesda, Maryland 20892 1863, USA
    Am J Ophthalmol 130:49-56. 2000
    ..To investigate the clinical features associated with immune recovery in human immunodeficiency virus (HIV)-infected patients with cytomegalovirus retinitis who are taking highly active antiretroviral therapy...
  10. ncbi request reprint High-dose intravitreal ganciclovir and foscarnet for cytomegalovirus retinitis
    G Velez
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Ophthalmol 131:396-7. 2001
    ..To describe the chronic use of high doses of intravitreal ganciclovir, in combination with foscarnet, for the treatment of cytomegalovirus retinitis...
  11. ncbi request reprint Ocular manifestations of HIV infection
    M R Robinson
    National Institutes of Health, National Eye Institute, Bethesda, Maryland 20892 1863, USA
    Curr Opin Ophthalmol 10:431-7. 1999
    ..HAART has dramatically altered the incidence and natural history of many opportunistic infections, and we discuss the impact of HAART on ophthalmic disease...
  12. ncbi request reprint Pharmacokinetics and toxicity of intravitreal chemotherapy for primary intraocular lymphoma
    G Velez
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Arch Ophthalmol 119:1518-24. 2001
    ..To investigate the pharmacokinetics and toxicity of intravitreal chemotherapeutic agents in the rabbit eye for the potential treatment of primary intraocular lymphoma and other intraocular malignancies...
  13. ncbi request reprint Frosted branch angiitis in a child with HIV infection
    H F Fine
    Clinical Research Training Program, National Eye Institute, National Institutes of Health, MSC 1863, 10 Center Drive, 10 10N112, Bethesda, MD 20892 1863, USA
    Am J Ophthalmol 131:394-6. 2001
    ..We describe the first pediatric case of HIV-associated frosted branch angiitis...
  14. ncbi request reprint Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease
    A R Djalilian
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    Am J Ophthalmol 132:782-3. 2001
    ..To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease...
  15. pmc Orbital socket contracture: a complication of inflammatory orbital disease in patients with Wegener's granulomatosis
    C Talar-Williams
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Br J Ophthalmol 89:493-7. 2005
    ..To describe the clinical characteristics of orbital socket contracture in patients with Wegener's granulomatosis (WG)...
  16. ncbi request reprint Intravitreal injection of triamcinolone acetonide for immune recovery uveitis
    Maytinee Sirimaharaj
    Save Sight Institute, Department of Clinical Ophthalmology, University of Sydney, Australia
    Retina 26:578-80. 2006
  17. pmc Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension
    Roberto F Machado
    Vascular Therapeutics Section, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA
    Br J Haematol 130:445-53. 2005
    ....
  18. pmc Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    Peter Attia
    Surgery Branch, National Cancer Institute, National Institutes of Health, CRC, Room 3W 3940, 10 Center Dr, Bethesda, MD 20892 1201, USA
    J Clin Oncol 23:6043-53. 2005
    ..We have now treated 56 patients to evaluate two different dose schedules of anti-CTLA-4 and to explore the relationship between autoimmunity and tumor regression...
  19. ncbi request reprint A pharmacokinetic and safety evaluation of an episcleral cyclosporine implant for potential use in high-risk keratoplasty rejection
    Susan S Lee
    National Eye Institute, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 48:2023-9. 2007
    ..To determine the short and long-term pharmacokinetics and assess the toxicity of a cyclosporine (CsA) episcleral implant for the prevention of high-risk keratoplasty rejection...
  20. ncbi request reprint Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging
    Stephanie H Kim
    Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA
    Invest Ophthalmol Vis Sci 48:808-14. 2007
    ..As an alternative, subconjunctival infusions of drug to the episclera of the back of the eye have been performed, but results in clinical trials for macular diseases showed mixed..
  21. ncbi request reprint The pharmacokinetics of rituximab following an intravitreal injection
    Hyuncheol Kim
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1863, USA
    Exp Eye Res 82:760-6. 2006
    ....
  22. ncbi request reprint CMV retinitis in a patient with good syndrome
    H Nida Sen
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Ocul Immunol Inflamm 13:475-8. 2005
    ..To describe cytomegalovirus (CMV) retinitis in a patient with Good syndrome...
  23. ncbi request reprint Effective transscleral delivery of two retinal anti-angiogenic molecules: carboxyamido-triazole (CAI) and 2-methoxyestradiol (2ME2)
    Lars P J Cruysberg
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Retina 25:1022-31. 2005
    ..To evaluate the human transscleral diffusion and intravitreal delivery of carboxyamido-triazole (CAI) and 2-Methoxyestradiol (2ME2)...
  24. ncbi request reprint New corticosteroid-eluting porous polyethylene implant for the management of lower eyelid retraction: a pilot study
    Daniel C Garibaldi
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ophthal Plast Reconstr Surg 22:424-9. 2006
    ..We designed a pPE corticosteroid-eluting implant and evaluated its characteristics in vitro and in vivo...
  25. ncbi request reprint Safety and pharmacokinetics of a preservative-free triamcinolone acetonide formulation for intravitreal administration
    Hyuncheol Kim
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Retina 26:523-30. 2006
    ..The safety and pharmacokinetics of a triamcinolone acetonide (TA) preservative-free (TA-PF) formulation were investigated after intravitreal administration in rabbits...
  26. ncbi request reprint A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis
    Brian C Gilger
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Invest Ophthalmol Vis Sci 47:2596-605. 2006
    ..To determine the feasibility, safety, and effectiveness of an episcleral or deep scleral lamellar sustained release cyclosporine (CsA) device in a naturally occurring animal model of uveitis...
  27. ncbi request reprint Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging
    Hyuncheol Kim
    Divison of Bioengineering and Physical Sciences, Office of Research Services, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 45:2722-31. 2004
    ..The movement of this drug surrogate was assessed with magnetic resonance imaging (MRI) in the rabbit eye. The results were compared with a similar implant placed in the vitreous cavity through a scleral incision at the equator...
  28. ncbi request reprint Study of ocular transport of drugs released from an intravitreal implant using magnetic resonance imaging
    Hyuncheol Kim
    Division of Bioengineering and Physical Science ORS, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Biomed Eng 33:150-64. 2005
    ..03-cm thick, this resulted in an effective membrane permeability of 2.0 x 10(-6) cm s(-1). Convective movement of Gd-DTPA was shown to have minimal effect on the concentration profiles since the Peclet number was 0.09 for this system...
  29. ncbi request reprint Preclinical evaluation of a novel episcleral cyclosporine implant for ocular graft-versus-host disease
    Hyuncheol Kim
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    Invest Ophthalmol Vis Sci 46:655-62. 2005
    ..To develop a local drug delivery system that provides therapeutic cyclosporine levels to treat lacrimal gland graft-versus-host disease after allogeneic hematopoietic stem cell transplantation...
  30. ncbi request reprint Conjunctival involvement with T-cell prolymphocytic leukemia: report of a case and review of the literature
    Susan S Lee
    National Eye Institute, NIH, Bethesda, Maryland 20892 1863, USA
    Surv Ophthalmol 49:525-36. 2004
    ..Conjunctival involvement with leukemia was consistent with good visual acuity; however, it portended a poor prognosis...
  31. ncbi request reprint Transport barriers in transscleral drug delivery for retinal diseases
    Stephanie H Kim
    Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20892 5766, USA
    Ophthalmic Res 39:244-54. 2007
    ..These barriers must be investigated further to gain a more complete understanding of the transport barriers involved in transscleral drug delivery...
  32. ncbi request reprint Post-surgical scleritis associated with the ganciclovir implant
    Sunil Srivastava
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    Ophthalmic Surg Lasers Imaging 35:254-5. 2004
    ..The inflammation progressed 360 degrees around the pars plana with progressive thinning at the implant sites. Post-surgical necrotizing scleritis is another complication that can occur in patients with ganciclovir implants...
  33. ncbi request reprint Intravitreal injection of triamcinolone for diffuse macular edema
    Hanna Rodriguez-Coleman
    Arch Ophthalmol 122:1085-6; author reply 1086-8. 2004
  34. pmc Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    Mark E Dudley
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA
    Science 298:850-4. 2002
    ..This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases...
  35. pmc Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    Mark E Dudley
    Surgery Branch, National Cancer Institute, NIH, CRC 3 3940, 10 Center Dr MSC 1201, Bethesda MD 20892 1202, USA
    J Clin Oncol 23:2346-57. 2005
    ..We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma...
  36. ncbi request reprint Extensive retinal neovascularization as a late finding in human immunodeficiency virus-infected patients with immune recovery uveitis
    Mary E Wright
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Clin Infect Dis 36:1063-6. 2003
    ..These late complications indicate a need for continued ophthalmologic follow-up of HIV-infected patients who have a history of CMV retinitis, even for individuals who have not required anti-CMV therapy for >4 years...
  37. ncbi request reprint The safety and efficacy of chicken type II collagen on uveitis associated with juvenile rheumatoid arthritis
    Darby J S Thompson
    The EMMES Corporation, Rockville, MD 20850, USA
    Ocul Immunol Inflamm 10:83-91. 2002
    ..To investigate the safety and efficacy of chicken type II collagen in treating uveitis associated with juvenile rheumatoid arthritis (JRA)...
  38. ncbi request reprint Five-year follow-up of a cohort of profoundly immunosuppressed patients discontinuing therapy for cytomegalovirus retinitis
    Peter A Sklar
    The Critical Care Medicine Department, Clinical Center, National Institute of Allergy and Infectious Diseases, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    AIDS 18:567-9. 2004
    ..Survival from the diagnosis of CMVR was universal for up to 95 months, with an observation period averaging more than 6 years. The CD4 cell count continued to rise through the fourth year of follow-up...
  39. ncbi request reprint Novel approaches to ocular drug delivery
    Jennifer L Davis
    North Carolina State University, Clinical Pharmacology Laboratory, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Curr Opin Mol Ther 6:195-205. 2004
    ..This review will discuss the most recent advances in drug delivery systems for the treatment of ocular diseases...
  40. ncbi request reprint Serious ophthalmic pathology compromising vision in HCV/HIV co-infected patients treated with peginterferon alpha-2b and ribavirin
    Claire Farel
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    AIDS 18:1805-9. 2004
    ..To characterize the ocular changes associated with peginterferon alpha 2b (peg-IFN alpha-2b) and ribavirin therapy for chronic hepatitis C infection in HIV co-infected individuals...