Christina L Roark

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint gammadelta T-cell receptors: functional correlations
    REBECCA L O'BRIEN
    Integrated Deaprtment of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Rev 215:77-88. 2007
  2. pmc Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:5576-83. 2007
  3. pmc gammadelta T cells: an important source of IL-17
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Curr Opin Immunol 20:353-7. 2008
  4. ncbi request reprint Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness
    Niyun Jin
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:2671-9. 2005
  5. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
  6. pmc Protective role of gammadelta T cells in spontaneous ocular inflammation
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, Colorado 80206, USA
    Invest Ophthalmol Vis Sci 50:3266-74. 2009
  7. pmc Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 182:2002-10. 2009
  8. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
  9. pmc Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness
    Laura Cook
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:309-19. 2008
  10. ncbi request reprint Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 177:4436-43. 2006

Detail Information

Publications21

  1. ncbi request reprint gammadelta T-cell receptors: functional correlations
    REBECCA L O'BRIEN
    Integrated Deaprtment of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Rev 215:77-88. 2007
    ..The use of recombinant soluble versions of gammadeltaTCRs appears to be a promising approach to finding new ligands, and recent results using this method are reviewed...
  2. pmc Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:5576-83. 2007
    ..A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that Vgamma4/Vdelta4(+) gammadelta T cells exacerbate CIA through their production of IL-17...
  3. pmc gammadelta T cells: an important source of IL-17
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Curr Opin Immunol 20:353-7. 2008
    ..Interestingly, some gammadelta T cells produce IL-17 in response to IL-23 alone, even in naïve animals, suggesting they are already differentiated and may develop differently than CD4(+) alphabeta Th17 cells...
  4. ncbi request reprint Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness
    Niyun Jin
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:2671-9. 2005
    ..We conclude that AHR-suppressive Vgamma4(+) gammadelta T cells require induction. They are induced by allergen stimulation, but AHR suppression by these cells does not require their restimulation with the same allergen...
  5. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
    ..These data are the first to demonstrate an important role for Th17-polarized CD4(+) T lymphocytes in the immune response directed against S. rectivirgula in this murine model of hypersensitivity pneumonitis and pulmonary fibrosis...
  6. pmc Protective role of gammadelta T cells in spontaneous ocular inflammation
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, Colorado 80206, USA
    Invest Ophthalmol Vis Sci 50:3266-74. 2009
    ..That certain mice lacking gammadelta T cells often spontaneously develop keratitis, characterized by a progressive and destructive inflammation of the cornea is reported here...
  7. pmc Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 182:2002-10. 2009
    ..We conclude that both the development and the cytokine potential of the AHR-enhancing gammadelta T cells differs critically from that of Th2 cells and NKT cells, despite similar influences of these cell populations on AHR...
  8. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
    ..Thus, airway allergen challenge differentially affects two distinct subsets of gammadelta T cells with nonoverlapping functional potentials, and the outcome is IgE suppression...
  9. pmc Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness
    Laura Cook
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:309-19. 2008
    ..Our findings suggest that CD8+ DCs in the lymphoid tissues enable an early step in the development of gammadelta T cells through direct cell contact. DC-expressed CD8 might take part in this interaction...
  10. ncbi request reprint Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 177:4436-43. 2006
    ..These findings indicate that chronic inhalation of B. subtilis can result in T cell accumulation in the lung and fibrosis, constituting a new model of immune-mediated pulmonary fibrosis...
  11. pmc Macrophages express multiple ligands for gammadelta TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, United States
    Mol Immunol 45:3253-63. 2008
    ....
  12. pmc Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin
    Jena D French
    National Jewish Health, Integrated Department of Immunology, Denver, CO 80206, USA
    J Immunol 182:1892-900. 2009
    ....
  13. ncbi request reprint Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 179:2961-8. 2007
    ..The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses...
  14. ncbi request reprint Distribution and leukocyte contacts of gammadelta T cells in the lung
    J M Wands
    Departments of Immunology, National Jewish Medical and Research Center, Denver, Colorado, USA
    J Leukoc Biol 78:1086-96. 2005
    ..The continuous interaction of gammadelta T cells with these sentinels likely is related to their protective role...
  15. pmc {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells
    Jena D French
    Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 102:14741-6. 2005
    ..Our results suggest that CD8(+) alphabeta T cells are the most potent inhibitors of gammadelta T cell homeostasis and exert their effect by competing for IL-15...
  16. ncbi request reprint Subset-specific, uniform activation among V gamma 6/V delta 1+ gamma delta T cells elicited by inflammation
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Leukoc Biol 75:68-75. 2004
    ....
  17. ncbi request reprint gammadelta T lymphocytes-selectable cells within the innate system?
    Willi K Born
    Department of Immunology at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    J Clin Immunol 27:133-44. 2007
    ....
  18. pmc IL-17-producing gammadelta T cells
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA
    Eur J Immunol 39:662-6. 2009
    ..Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on...
  19. ncbi request reprint Detection of cell surface ligands for the gamma delta TCR using soluble TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:4167-75. 2004
    ..This study suggests that soluble versions of gammadelta TCRs can be as tools to identify and characterize the natural ligands of gammadelta T cells...
  20. ncbi request reprint Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen
    Michael T Falta
    University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado 80262, USA
    Arthritis Rheum 52:1885-96. 2005
    ..We undertook this study to better understand the parameters for specific binding of this tetramer...
  21. ncbi request reprint V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3170-8. 2003
    ..These findings establish Vgamma4(+) gammadelta T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR...