Christina L Roark

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint gammadelta T-cell receptors: functional correlations
    REBECCA L O'BRIEN
    Integrated Deaprtment of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Rev 215:77-88. 2007
  2. pmc Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:5576-83. 2007
  3. pmc gammadelta T cells: an important source of IL-17
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Curr Opin Immunol 20:353-7. 2008
  4. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
  5. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
  6. pmc Protective role of gammadelta T cells in spontaneous ocular inflammation
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, Colorado 80206, USA
    Invest Ophthalmol Vis Sci 50:3266-74. 2009
  7. pmc Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 182:2002-10. 2009
  8. pmc Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness
    Laura Cook
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:309-19. 2008
  9. pmc Macrophages express multiple ligands for gammadelta TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, United States
    Mol Immunol 45:3253-63. 2008
  10. ncbi request reprint Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 177:4436-43. 2006

Detail Information

Publications21

  1. ncbi request reprint gammadelta T-cell receptors: functional correlations
    REBECCA L O'BRIEN
    Integrated Deaprtment of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Rev 215:77-88. 2007
    ..The use of recombinant soluble versions of gammadeltaTCRs appears to be a promising approach to finding new ligands, and recent results using this method are reviewed...
  2. pmc Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:5576-83. 2007
    ..A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that Vgamma4/Vdelta4(+) gammadelta T cells exacerbate CIA through their production of IL-17...
  3. pmc gammadelta T cells: an important source of IL-17
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Curr Opin Immunol 20:353-7. 2008
    ..Interestingly, some gammadelta T cells produce IL-17 in response to IL-23 alone, even in naïve animals, suggesting they are already differentiated and may develop differently than CD4(+) alphabeta Th17 cells...
  4. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
    ..These data are the first to demonstrate an important role for Th17-polarized CD4(+) T lymphocytes in the immune response directed against S. rectivirgula in this murine model of hypersensitivity pneumonitis and pulmonary fibrosis...
  5. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
    ..Thus, airway allergen challenge differentially affects two distinct subsets of gammadelta T cells with nonoverlapping functional potentials, and the outcome is IgE suppression...
  6. pmc Protective role of gammadelta T cells in spontaneous ocular inflammation
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, Colorado 80206, USA
    Invest Ophthalmol Vis Sci 50:3266-74. 2009
    ..That certain mice lacking gammadelta T cells often spontaneously develop keratitis, characterized by a progressive and destructive inflammation of the cornea is reported here...
  7. pmc Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 182:2002-10. 2009
    ..We conclude that both the development and the cytokine potential of the AHR-enhancing gammadelta T cells differs critically from that of Th2 cells and NKT cells, despite similar influences of these cell populations on AHR...
  8. pmc Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness
    Laura Cook
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:309-19. 2008
    ..Our findings suggest that CD8+ DCs in the lymphoid tissues enable an early step in the development of gammadelta T cells through direct cell contact. DC-expressed CD8 might take part in this interaction...
  9. pmc Macrophages express multiple ligands for gammadelta TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, United States
    Mol Immunol 45:3253-63. 2008
    ....
  10. ncbi request reprint Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 177:4436-43. 2006
    ..These findings indicate that chronic inhalation of B. subtilis can result in T cell accumulation in the lung and fibrosis, constituting a new model of immune-mediated pulmonary fibrosis...
  11. pmc Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin
    Jena D French
    National Jewish Health, Integrated Department of Immunology, Denver, CO 80206, USA
    J Immunol 182:1892-900. 2009
    ....
  12. ncbi request reprint Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 179:2961-8. 2007
    ..The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses...
  13. ncbi request reprint Distribution and leukocyte contacts of gammadelta T cells in the lung
    J M Wands
    Departments of Immunology, National Jewish Medical and Research Center, Denver, Colorado, USA
    J Leukoc Biol 78:1086-96. 2005
    ..The continuous interaction of gammadelta T cells with these sentinels likely is related to their protective role...
  14. ncbi request reprint gammadelta T lymphocytes-selectable cells within the innate system?
    Willi K Born
    Department of Immunology at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    J Clin Immunol 27:133-44. 2007
    ....
  15. pmc IL-17-producing gammadelta T cells
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA
    Eur J Immunol 39:662-6. 2009
    ..Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on...
  16. ncbi request reprint Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness
    Niyun Jin
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:2671-9. 2005
    ..We conclude that AHR-suppressive Vgamma4(+) gammadelta T cells require induction. They are induced by allergen stimulation, but AHR suppression by these cells does not require their restimulation with the same allergen...
  17. pmc {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells
    Jena D French
    Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 102:14741-6. 2005
    ..Our results suggest that CD8(+) alphabeta T cells are the most potent inhibitors of gammadelta T cell homeostasis and exert their effect by competing for IL-15...
  18. ncbi request reprint Detection of cell surface ligands for the gamma delta TCR using soluble TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:4167-75. 2004
    ..This study suggests that soluble versions of gammadelta TCRs can be as tools to identify and characterize the natural ligands of gammadelta T cells...
  19. ncbi request reprint V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3170-8. 2003
    ..These findings establish Vgamma4(+) gammadelta T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR...
  20. ncbi request reprint Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen
    Michael T Falta
    University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado 80262, USA
    Arthritis Rheum 52:1885-96. 2005
    ..We undertook this study to better understand the parameters for specific binding of this tetramer...
  21. ncbi request reprint Subset-specific, uniform activation among V gamma 6/V delta 1+ gamma delta T cells elicited by inflammation
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Leukoc Biol 75:68-75. 2004
    ....