Juan Rivera

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The alliance of sphingosine-1-phosphate and its receptors in immunity
    Juan Rivera
    Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:753-63. 2008
  2. pmc Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined
    Sandra E Dillahunt
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:2058-67. 2013
  3. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
  4. pmc Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation
    Damiana Alvarez-Errico
    Laboratory of Molecular Immunogenetics, Department of Health and Human Services, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:5000-8. 2010
  5. ncbi request reprint Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses
    Yumi Yamashita
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:740-3. 2007
  6. ncbi request reprint IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses
    Ana Olivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:2515-25. 2006
  7. pmc Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells
    Shoko Iwaki
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1881, Bethesda, MD 20892 1881, USA
    Cell Signal 20:195-205. 2008
  8. ncbi request reprint The role of Src family kinases in mast cell effector function
    Yasuko Furumoto
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Novartis Found Symp 271:39-47; discussion 47-53, 95-9. 2005
  9. pmc Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase
    Sandra Odom
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 199:1491-502. 2004
  10. ncbi request reprint Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells
    Gregorio Gomez
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    J Immunol 175:7602-10. 2005

Detail Information

Publications69

  1. pmc The alliance of sphingosine-1-phosphate and its receptors in immunity
    Juan Rivera
    Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:753-63. 2008
    ....
  2. pmc Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined
    Sandra E Dillahunt
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:2058-67. 2013
    ....
  3. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
    ..Our findings demonstrate that basophil-expressed Lyn kinase exerts regulatory control on Th2 cell differentiation and function...
  4. pmc Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation
    Damiana Alvarez-Errico
    Laboratory of Molecular Immunogenetics, Department of Health and Human Services, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:5000-8. 2010
    ..These findings demonstrate that Lyn B differs from Lyn A in its association with SHIP-1 and in the regulation of calcium responses. However, complementation of both isoforms is required in mast cell activation...
  5. ncbi request reprint Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses
    Yumi Yamashita
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:740-3. 2007
    ..The findings demonstrate a genetic influence on the extent of a mast cell's response and identify Fyn kinase as a contributory determinant...
  6. ncbi request reprint IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses
    Ana Olivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:2515-25. 2006
    ..Taken together with our previous study, which demonstrated delayed SphK activation in Lyn-deficient BMMC, we propose a cooperative role between Fyn and Lyn kinases in the activation of SphKs, which contributes to mast cell responses...
  7. pmc Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells
    Shoko Iwaki
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1881, Bethesda, MD 20892 1881, USA
    Cell Signal 20:195-205. 2008
    ..The observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated...
  8. ncbi request reprint The role of Src family kinases in mast cell effector function
    Yasuko Furumoto
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Novartis Found Symp 271:39-47; discussion 47-53, 95-9. 2005
    ..Collectively, these studies argue that sustained Lyn kinase activity negatively regulates mast cell responses. This suggests the possible existence of Lyn polymorphisms that may contribute in allergic disease...
  9. pmc Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase
    Sandra Odom
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 199:1491-502. 2004
    ..Thus, lyn-/- mice and mast cells thereof show multiple allergy-associated traits, causing reconsideration of the possible efficacy in therapeutic targeting of Lyn in allergic disease...
  10. ncbi request reprint Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells
    Gregorio Gomez
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    J Immunol 175:7602-10. 2005
    ..These studies reveal a major positive role for Fyn kinase in multiple mast cell inflammatory responses and demonstrate a selective negative regulatory role for certain cytokines...
  11. pmc Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:105-13. 2010
    ....
  12. pmc PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability
    Yasuko Furumoto
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Blood 118:5466-75. 2011
    ..Thus, Pten deletion in the mast cell compartment results in a mast cell proliferative phenotype in mice, demonstrating that dysregulation of PI3K signals is vital to the observed mast cell hyperplasia...
  13. pmc Cutting edge: persistence of increased mast cell numbers in tissues links dermatitis to enhanced airway disease in a mouse model of atopy
    Alon Y Hershko
    Molecular Immunology Section, Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:531-5. 2012
    ..Importantly, our findings also show that exposure to a given allergen can modify the immune response to an unrelated allergen...
  14. pmc Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness
    Martina Kovarova
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Exp Med 203:1161-71. 2006
    ..These findings provide the first evidence of lipid raft dysfunction in SLOS and may explain the observed association of allergy with SLOS...
  15. pmc New insights on mast cell activation via the high affinity receptor for IgE
    Juan Rivera
    Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Adv Immunol 98:85-120. 2008
    ..These recent discoveries open new avenues of investigation with therapeutic potential...
  16. ncbi request reprint Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor
    Yasuko Furumoto
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Res 30:241-53. 2004
    ..In this synopsis, we review the current knowledge on the role of the Src PTKs, Fyn and Lyn, in mast-cell activation and discuss the implications of our findings on allergic disease...
  17. ncbi request reprint Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
    Valentino Parravicini
    Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Nat Immunol 3:741-8. 2002
    ..Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, Fc epsilon RI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases...
  18. ncbi request reprint Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival
    Yasuko Furumoto
    Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:5167-71. 2006
    ..The findings demonstrate that PTEN functions as a key regulator of mast cell homeostasis and FcepsilonRI-responsiveness...
  19. ncbi request reprint A current understanding of Fc epsilon RI-dependent mast cell activation
    Juan Rivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 8:14-20. 2008
    ..Here, we summarize the current knowledge and future challenges and directions...
  20. pmc Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells
    Ryo Suzuki
    National Institutes of Health, Bethesda, MD 20892 1930, USA
    J Leukoc Biol 88:863-75. 2010
    ..This demonstrates that in addition to a role described previously for Orai1 in promoting MC degranulation, nonselective cation channels participate in promoting the exocytotic response...
  21. ncbi request reprint The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis
    Ana Olivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:287-97. 2007
    ..Thus, sphingosine kinases are determinants of mast cell responsiveness, demonstrating a previously unrecognized relationship with anaphylaxis...
  22. ncbi request reprint The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production
    Yasuko Furumoto
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:49177-87. 2004
    ..These findings show that the FcepsilonRIbeta functions to both selectively amplify (degranulation and leukotriene secretion) and dampen (lymphokine) mast cell effector responses...
  23. doi request reprint Molecular editing of cellular responses by the high-affinity receptor for IgE
    Ryo Suzuki
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Science 343:1021-5. 2014
    ..These findings uncover how receptor discrimination of stimulus strength can be interpreted as distinct in vivo outcomes. ..
  24. pmc Interrogation of sphingosine-1-phosphate receptor 2 function in vivo reveals a prominent role in the recovery from IgE and IgG-mediated anaphylaxis with minimal effect on its onset
    Ana Olivera
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskelatal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Lett 150:89-96. 2013
    ..Our findings show that S1PR2 is dispensable for initiating IgE/Ag-mediated connective tissue mast cell degranulation and anaphylaxis, but it is required for normal recovery from anaphylaxis...
  25. pmc Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity
    Genqing Liang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 129:1377-1386.e13. 2012
    ..Basophils have the capacity to present antigen to naive T cells and promote T(H)2 differentiation directly or indirectly through IL-4 production...
  26. pmc Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice
    Ana Olivera
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:1429-40. 2010
    ..This suggests that specific S1PR2 agonists may serve to counteract the vasodilation associated with anaphylactic shock...
  27. pmc Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis
    Alon Y Hershko
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:562-71. 2011
    ..Thus, MC-derived IL-2 contributes to the maintenance of suppression in chronic allergic skin inflammation...
  28. pmc E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling
    Mariona Serra-Pagès
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    J Leukoc Biol 92:1155-65. 2012
    ....
  29. ncbi request reprint Src family kinases and lipid mediators in control of allergic inflammation
    Juan Rivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Immunol Rev 217:255-68. 2007
    ..These studies demonstrate the connection between Src protein tyrosine kinases and lipid second messengers that control mast cell function and allergic responses...
  30. pmc TGF-beta 1 inhibits mast cell Fc epsilon RI expression
    Gregorio Gomez
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:5987-93. 2005
    ..The related cytokines, TGF-beta2 and TGF-beta3, had similar effects. We propose that TGF-beta1 acts as a negative regulator of mast cell function, in part by decreasing FcepsilonRI expression...
  31. pmc Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk
    Toshiyuki Yamashita
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:28584-94. 2008
    ..The findings argue for a novel regulatory mechanism, where dephosphorylation of phospho-Tyr58 is likely to promote the down-regulation of Syk activation and suppression of mast cell responses...
  32. pmc Basophils and the T helper 2 environment can promote the development of lupus nephritis
    Nicolas Charles
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Med 16:701-7. 2010
    ....
  33. pmc Adapters in the organization of mast cell signaling
    Damiana Alvarez-Errico
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 232:195-217. 2009
    ..This organization is essential for normal mast cell responses. Here, we summarize the role of adapter proteins in mast cells focusing on the most recent advances toward understanding how these molecules work upon FcepsilonRI engagement...
  34. ncbi request reprint Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation
    Juan Rivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 27:251-3. 2006
    ..The new findings place this complex at the forefront in discriminating between signals required for cytokine production and those required for mast-cell degranulation and eicosanoid production...
  35. pmc An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease
    Ana Olivera
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 716:123-42. 2011
    ..The dual actions of S1P, promoting the immediate response of mast cells, while controlling the systemic consequences of mast cell activity will be discussed in detail...
  36. ncbi request reprint NTAL/LAB and LAT: a balancing act in mast-cell activation and function
    Juan Rivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 9N228, Bethesda, MD 20892 1820, USA
    Trends Immunol 26:119-22. 2005
  37. pmc The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation
    Shin Ichiroh Saitoh
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 198:831-43. 2003
    ..Deletion of all four distal tyrosines, and in particular, loss of the primary phospholipase C-gamma-binding tyrosine had a significant effect on antigen-induced histamine release...
  38. ncbi request reprint A molecular understanding of mast cell activation and the promise of anti-allergic therapeutics
    Martina Kovarova
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Med Chem 11:2083-91. 2004
    ..While our understanding of IgE-mediated mast cell activation is still at its inception, the modest success in identifying molecules essential to this process affords some confidence for better treatment of allergic disease...
  39. pmc Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity
    Nikhil K Basu
    Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9S 241, Bethesda, MD 20892 1830, USA
    Proc Natl Acad Sci U S A 102:6285-90. 2005
    ..Here, we report a mechanism involving PKC-mediated phosphorylation of UGT such that phosphoserine/threonine regulates substrate specificity in response to chemical exposures, which possibly confers survival benefit...
  40. ncbi request reprint Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?
    Surajit Ganguly
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:32758-64. 2007
    ..Pineal FcepsilonRIalpha and FcepsilonRIgamma may represent a previously unrealized molecular link between the neuroendocrine and immune systems...
  41. ncbi request reprint Molecular adapters in Fc(epsilon)RI signaling and the allergic response
    Juan Rivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Curr Opin Immunol 14:688-93. 2002
    ..An evaluation of the role of these adapters points to complementary but independent steps in early signaling and the possibility that preference for one or another adaptor complex may result in selective mast cell responses...
  42. ncbi request reprint Macromolecular protein signaling complexes and mast cell responses: a view of the organization of IgE-dependent mast cell signaling
    Juan Rivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, National Institute of Health NIH, Bethesda, MD 20892 1820, USA
    Mol Immunol 38:1253-8. 2002
    ..In brief, we review the knowledge on macromolecular signaling complexes used by FcepsilonRI in mast cell activation and provide our view on the regulation of signal generation and its effect on mast cell activation...
  43. pmc The tyrosine kinase network regulating mast cell activation
    Alasdair M Gilfillan
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Immunol Rev 228:149-69. 2009
    ..In this review, we discuss the regulation and role of specific members of this tyrosine kinase network in KIT and Fc epsilon RI-mediated mast cell activation...
  44. ncbi request reprint Sphingolipids and the balancing of immune cell function: lessons from the mast cell
    Ana Olivera
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:1153-8. 2005
    ..Current efforts are unraveling the complex underlying mechanisms regulating the sphingolipid pathway. Pharmacological intervention of these key processes may hold promise for controlling unwanted immune responses...
  45. ncbi request reprint Molecular regulation of mast cell activation
    Juan Rivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 1820, USA
    J Allergy Clin Immunol 117:1214-25; quiz 1226. 2006
    ..The unifying theme is that the regulatory steps mentioned herein are required for promoting effective responses while protecting against unwanted inflammatory responses...
  46. pmc Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy
    Susanne C Diesner
    Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Immunol Lett 141:210-9. 2012
    ..Further, S1P was proposed to play a major role in the induction and promotion of allergic diseases. However, to date only limited information is available on the role of S1P in food allergy...
  47. pmc BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis
    Rahul Roychoudhuri
    Center for Cancer Research, National Cancer Institute, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nature 498:506-10. 2013
    ..These findings identify BACH2 as a key regulator of CD4(+) T-cell differentiation that prevents inflammatory disease by controlling the balance between tolerance and immunity. ..
  48. doi request reprint Genetic background and the dilemma of translating mouse studies to humans
    Juan Rivera
    Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 28:1-4. 2008
    ..However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions...
  49. pmc Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis
    Barbara Dema
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e90424. 2014
    ..The finding argue that the overall levels of IgE autoantibodies, independently or in combination with IgG autoantibodies, may serve as indicators of active disease...
  50. pmc Mast cell and T cell communication; amplification and control of adaptive immunity
    Alon Y Hershko
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Lett 128:98-104. 2010
    ..Here we briefly summarize these advances and discuss some of the major challenges in understanding the communication of MCs and T cells...
  51. pmc Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells
    Claudia Gonzalez-Espinosa
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:1453-65. 2003
    ..These findings demonstrate that perturbation of small numbers of IgE receptors on mast cells favors certain signals that contribute to a lymphokine response that can mediate allergic inflammation...
  52. ncbi request reprint Munc18-2/syntaxin3 complexes are spatially separated from syntaxin3-containing SNARE complexes
    Isabel Pombo
    Unite d Immuno Allergie, Institut Pasteur, Paris, France
    FEBS Lett 550:144-8. 2003
    ..This demonstrates a spatial separation between these two types of complexes and suggests that Munc18-2 acts in a step different from SNARE complex formation and fusion...
  53. pmc Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis
    Puneet S Jolly
    Department of Biochemistry, Virginia Commonwealth University Medical Center, Richmond 23298, USA
    J Exp Med 199:959-70. 2004
    ..Together, our results suggest that activation of SphKs and consequently S1PRs by FcepsilonRI triggering plays a crucial role in mast cell functions and might be involved in the movement of mast cells to sites of inflammation...
  54. ncbi request reprint IL-10 inhibits Fc epsilon RI expression in mouse mast cells
    Sheila R Gillespie
    Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA
    J Immunol 172:3181-8. 2004
    ....
  55. ncbi request reprint Oxidative stress stimulates IL-4 and IL-6 production in mast cells by an APE/Ref-1-dependent pathway
    Barbara Frossi
    Dipartimento di Scienze e Tecnologie Biomediche, Universita Degli Studi di Udine, Udine, Italy
    Eur J Immunol 33:2168-77. 2003
    ..Nonetheless, H(2)O(2) and FcepsilonRI signalings are additive in augmenting IL-4 production. Most importantly, oxidative stress can induce a pro-type 2 inflammatory response from mast cells that is independent of FcepsilonRI stimulation...
  56. ncbi request reprint The ins and outs of IgE-dependent mast-cell exocytosis
    Ulrich Blank
    INSERM E 0225, Bichat Medical School, 16 rue Henri Huchard, BP 416, 75870 Cedex 18, France
    Trends Immunol 25:266-73. 2004
  57. pmc Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase
    Nicole Urtz
    Novartis Institute for Biomedical Research, Brunner Strasse 59, A 1235 Vienna, Austria
    Mol Cell Biol 24:8765-77. 2004
    ..These findings position the activation of SPHK1 as an FcepsilonRI proximal event...
  58. ncbi request reprint SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line
    Ulrich Blank
    Institut Pasteur, Unite d Immuno Allergie, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Mol Immunol 38:1341-5. 2002
    ..Our results suggest a new way of how Rab3 GTPases may intersect with the function of SNAREs thought to be universal mediators of membrane fusion...
  59. ncbi request reprint TGF-beta1 inhibits late-stage mast cell maturation
    Mohit Kashyap
    Department of Biology, Virginia Commonwealth University, Richmond, VA 23284 2012, USA
    Exp Hematol 33:1281-91. 2005
    ..The objective of this study was to determine the effects of transforming growth factor (TGF)-beta1 on mast cell development...
  60. pmc Vav1 is a component of transcriptionally active complexes
    Martin Houlard
    Unité Inserm 363, Oncologie Cellulaire et Moléculaire, Institut Cochin de Genetique Moleculaire, Hopital Cochin, Paris 75014, France
    J Exp Med 195:1115-27. 2002
    ..Thus, we describe a novel nuclear role for Vav1 as a component and facilitator of NFAT and NFkappaB-like transcriptional activity...
  61. ncbi request reprint Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition
    Barbara Frossi
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Udine, Italy
    J Immunol 178:2549-55. 2007
    ..The findings also demonstrate the dominance of the Fyn/p38 MAPK pathway in driving IL-4 production...
  62. pmc The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production
    Diletta Arcidiacono
    Department of Biomedical Sciences, University of Padua, Via G Colombo 3, 35121 Padua, Italy
    Cell Microbiol 10:899-907. 2008
    ..These findings strongly suggest that VCC has a pro-inflammatory activity promoting a Th2-type immune profile...
  63. pmc IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species
    Laura M Sly
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Immunol 181:3850-60. 2008
    ..In support of the essential role that IgE-induced ROS plays in IgE-enhanced BMMC survival, we found the addition of H(2)O(2) to IgE+Ag-stimulated BMMCs leads to IL-3 secretion...
  64. doi request reprint VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways
    Neeraj Tiwari
    INSERM U699, Paris, France
    Blood 111:3665-74. 2008
    ..The findings demonstrate that VAMP-8 segregates secretory lysosomal granule exocytosis in mast cells from cytokine/chemokine molecular trafficking pathways...
  65. ncbi request reprint Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis
    Sophie Martin-Verdeaux
    Unite d Immuno Allergie, Institut Pasteur, Paris, France
    J Cell Sci 116:325-34. 2003
    ..These findings suggest a role for Munc18-2 and the microtubule network in the regulation of secretory granule dynamics in mast cells...
  66. ncbi request reprint The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations
    Marina de Bernard
    Dipartimento di Biologia, Biomediche Sperimentali, Universita di Padova, Via G Colombo 3, Padova, Italy
    Cell Microbiol 7:191-8. 2005
    ..These observations indicate that VacA may act as a pro-inflammatory factor of H. pylori at very early stages of the innate immune response...
  67. ncbi request reprint Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V
    Tong Shi
    St George Hospital, University of New South Wales, Sydney, New South Wales, Australia
    Arthritis Rheum 54:2558-67. 2006
    ..We undertook this study to investigate the possible contribution of the GPIb-IX-V receptor to platelet activation mediated by the anti-beta2GPI antibody-beta2GPI complex...
  68. ncbi request reprint Snake bites and bee stings: the mast cell strikes back
    Juan Rivera
    Nat Med 12:999-1000. 2006
  69. doi request reprint Assays for regulated exocytosis of mast cell granules
    Ulrich Blank
    Bichat Medical School, Paris, France
    Curr Protoc Cell Biol . 2006
    ..Given that animal models for basophil and mast cell activation are being used with increasing frequency, the unit also includes protocols to measure exocytosis of mast cell granule content in vivo...