Genomes and Genes
John I Risinger
Affiliation: National Institutes of Health
- Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signalingJohn I Risinger
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, USA
Cancer Res 65:5031-7. 2005..These data classify histologically similar endometrioid endometrial cancers into two distinct groupings with implications affecting therapy and prevention...
- Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cellsJulie A Hong
Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1201, USA
Cancer Res 65:7763-74. 2005....
- Evolutionary diversification of SPANX-N sperm protein gene structure and expressionNatalay Kouprina
Laboratory of Molecular Pharmacology, National Cancer Institute NCI, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 2:e359. 2007..SPANX proteins thus provide unique targets to investigate their roles in the function of spermatozoa, selected malignancies, and for SPANX-N, in other tissues as well...
- Gene expression analysis of tumor infiltrating lymphocyte markers in endometrial cancers indicates no significant increases in those cases with microsatellite instabilityJohn I Risinger
Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Cancer Biomark 2:61-8. 2006..These data indicate that significant differences in TIL derived transcripts do not occur between endometrioid endometrial cancers with and without microsatellite instability...
- Normal viability of Kai1/Cd82 deficient miceJohn I Risinger
Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, Michigan Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
Mol Carcinog 53:610-24. 2014..This suggests that Kai/Cd82 has an unappreciated role in the early establishment of proliferation and division when challenged with a new environment that might play a role in adaptability to new metastatic sites...
- Characterization of an antibody that can detect the Kai1/CD82 murine metastasis suppressorMary C Custer
Laboratory of Biosystems and Cancer, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Prostate 66:567-77. 2006..The human homolog, KAI1, is an activation antigen of T-cells and is a metastasis suppressor for prostate and other cancers. Little is known about the mouse protein because of the lack of antibody reagents...
- Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic responseOlga Aprelikova
Laboratory of Tumor and Stem Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 69:616-24. 2009....
- Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patientsBih Rong Wei
Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
PLoS ONE 4:e7670. 2009..Improved means for early detection and reliable patient monitoring are needed to increase survival...
- The role of miR-31 and its target gene SATB2 in cancer-associated fibroblastsOlga Aprelikova
Laboratory of Tumor and Stem Cell Biology, National Cancer Institute, Bethesda, MD, USA
Cell Cycle 9:4387-98. 2010..These findings provide new insights into tumor-stroma interaction and document that miR-31 and its target gene SATB2, are involved in regulation of tumor cell motility...
- Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancerJohn I Risinger
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 63:6-11. 2003..These data provide the basis for investigation of previously unrecognized novel pathways involved in the development of endometrial cancers...
- Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer: a Gynecologic Oncology Group StudyJohn H Farley
Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20832, USA
Cancer 116:355-61. 2010..The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival...
- Promoter hypermethylation as an epigenetic component in Type I and Type II endometrial cancersJohn I Risinger
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 983:208-12. 2003..These data tend to support the hypothesis that type I and type II endometrial cancers will exhibit distinct patterns of gene silencing based on promoter hypermethylation events...
- Cell proliferation and apoptosis in human uterine leiomyomas and myometriaDarlene Dixon
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
Virchows Arch 441:53-62. 2002..We conclude that increased cell proliferation is the most significant contributor to growth and that the proliferative state is autonomous for each tumor in a given patient and is independent of tumor size...
- Racial disparities in recurrence among patients with early-stage endometrial cancer: is recurrence increased in black patients who receive estrogen replacement therapy?G Larry Maxwell
Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Cancer 113:1431-7. 2008..The objective of the current investigation was to determine whether there is a racial disparity in outcome between black patients and white patients with early-stage endometrial cancer treated similarly in a clinical trial setting...
- The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle proteinNatalay Kouprina
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, MD 20892, USA
Hum Mol Genet 14:2155-65. 2005..This finding suggests that MCPH is the consequence of an impairment in mitotic spindle regulation in cortical progenitors due to mutations in ASPM...
- Testing guidelines for hereditary non-polyposis colorectal cancerAsad Umar
Division of Cancer Prevention and Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Cancer 4:153-8. 2004
- Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genesSergei Vatolin
Laboratory of Immunopathology, National Institutes of Allergy and Infectious Disease, NIH, Bethesda, Maryland, USA
Cancer Res 65:7751-62. 2005..We suggest that BORIS is likely tethering epigenetic machinery to a novel class of CTCF/BORIS 11ZF target sequences that mediate induction of cancer-testis genes...
- The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominidsNatalay Kouprina
Laboratory of Biosystems and Cancer, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:3077-82. 2004..Thus, evolution of the SPANX family appears to have involved positive selection that affected not only the protein sequence but also the synonymous sites in the coding sequence...
- Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomasJay E Allard
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and the United States Military Cancer Institute, Walter Reed Army Medical Center, Washington, DC, USA
Gynecol Oncol 107:52-7. 2007..Since FOLR1 overexpression is a frequent event in some types of endometrial carcinoma, we examined the relationship between FOLR1 overexpression and clinical and pathologic features to determine its prognostic relevance...
- Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinomaLouis A Dainty
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and the United States Military Cancer Institute, Walter Reed Army Medical Center, Washington, DC 20307, USA
Gynecol Oncol 105:563-70. 2007..The purpose of this study was to examine the expression of FOLR1 in uterine cancers and to identify changes in gene expression that are associated with overexpression of FOLR1...
- Prediction of lymph node metastasis in patients with endometrioid endometrial cancer using expression microarrayMichael A Bidus
Walter Reed Army Medical Center and the United States Military Cancer Institute, Washington, DC 20307, USA
Clin Cancer Res 12:83-8. 2006..To characterize the gene expression profiles of endometrioid endometrial cancers associated with lymph node metastasis in an effort to identify genes associated with metastatic spread...
- Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancerG Larry Maxwell
Division of Gynecologic Oncology Walter Reed Army Medical Center, Washington, DC 20307, USA
Clin Cancer Res 11:4056-66. 2005..An understanding of the molecular heterogeneity of various histologic types of endometrial cancer has the potential to lead to better individualization of treatment in the future...
- Racial disparities research: it's not just black and whiteG Larry Maxwell
Gynecol Oncol 101:194-7. 2006
- Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristicsSara A Carney
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Lab Invest 82:719-28. 2002..Answers to these questions will undoubtedly lead to the development of more effective treatment and intervention regimens for clinical cases of uterine leiomyoma...