Lisa A Ridnour

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The biphasic nature of nitric oxide responses in tumor biology
    Lisa A Ridnour
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1329-37. 2006
  2. pmc Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation
    Lisa A Ridnour
    Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44081. 2012
  3. pmc Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence
    Donna M Wilcock
    University of Kentucky Sanders Brown Center on Aging, Department of Physiology, Lexington, KY 40536, USA
    J Neuroinflammation 8:115. 2011
  4. ncbi request reprint Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process
    Lisa A Ridnour
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Boulevard, Room 411, St Louis, MO 63108, USA
    Free Radic Biol Med 38:1361-71. 2005
  5. pmc Molecular mechanisms for discrete nitric oxide levels in cancer
    Lisa A Ridnour
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    Nitric Oxide 19:73-6. 2008
  6. pmc Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways
    Lisa A Ridnour
    Radiation Biology Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:16898-903. 2007
  7. pmc Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1
    Lisa A Ridnour
    Radiation Biology Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13147-52. 2005
  8. ncbi request reprint The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1363-71. 2006
  9. pmc Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression
    Julie L Heinecke
    Radiation Biology Branch, Tumor and Metastasis Biology Section, Pediatric Oncology Branch, and Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 111:6323-8. 2014
  10. pmc Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
    Jeff S Isenberg
    Laboratory of Pathology and Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13141-6. 2005

Detail Information

Publications48

  1. ncbi request reprint The biphasic nature of nitric oxide responses in tumor biology
    Lisa A Ridnour
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1329-37. 2006
    ..This article discusses the biphasic nature of NO in cancer biology and the implications of NO-driven redox flux for modulation of tumor-stimulated angiogenesis, growth, and metastasis...
  2. pmc Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation
    Lisa A Ridnour
    Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44081. 2012
    ..In summary, our findings suggest that tumors with high TIMP-1 and NOS2 behave more aggressively by mechanisms that favor Akt pathway activation...
  3. pmc Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence
    Donna M Wilcock
    University of Kentucky Sanders Brown Center on Aging, Department of Physiology, Lexington, KY 40536, USA
    J Neuroinflammation 8:115. 2011
    ..Also, vasogenic edema was reported in phase 2 of a passive immunization clinical trial. In order to overcome these vascular adverse effects it is critical that we understand the mechanism(s) by which they occur...
  4. ncbi request reprint Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process
    Lisa A Ridnour
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Boulevard, Room 411, St Louis, MO 63108, USA
    Free Radic Biol Med 38:1361-71. 2005
    ....
  5. pmc Molecular mechanisms for discrete nitric oxide levels in cancer
    Lisa A Ridnour
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    Nitric Oxide 19:73-6. 2008
    ..The quantification of redox events at the cellular level has revealed potential mechanisms that may either limit or potentiate tumor growth, and helped define the positive and negative function of nitric oxide in cancer...
  6. pmc Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways
    Lisa A Ridnour
    Radiation Biology Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:16898-903. 2007
    ....
  7. pmc Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1
    Lisa A Ridnour
    Radiation Biology Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13147-52. 2005
    ..Limiting TSP1 expression by positive feedback through the ERK mitogen-activated protein kinase pathway may facilitate switching to a proangiogenic state at low doses of NO...
  8. ncbi request reprint The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1363-71. 2006
    ..In this review, we discuss the biochemistry of such reactions in the context of their pharmacologic and biologic implications...
  9. pmc Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression
    Julie L Heinecke
    Radiation Biology Branch, Tumor and Metastasis Biology Section, Pediatric Oncology Branch, and Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 111:6323-8. 2014
    ..In summary, these results link elevated NOS2 to signals from the tumor microenvironment that arise with cancer progression and show that NO production regulates chemoresistance and metastasis of breast cancer cells. ..
  10. pmc Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
    Jeff S Isenberg
    Laboratory of Pathology and Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13141-6. 2005
    ..These results demonstrate a potent antagonism between TSP1 and proangiogenic signaling downstream of NO. Further elucidation of this inhibitory signaling pathway may identify new molecular targets to regulate pathological angiogenesis...
  11. ncbi request reprint Superoxide fluxes limit nitric oxide-induced signaling
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 281:25984-93. 2006
    ..We conclude that the reaction of O2- with NO is an important regulatory mechanism, which modulates signaling pathways by limiting steady-state levels of NO and preventing H2O2 formation from O2-...
  12. ncbi request reprint CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1
    Jeff S Isenberg
    Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:26069-80. 2006
    ..Therefore, ligation of either CD36 or CD47 is sufficient to inhibit NO-stimulated vascular cell responses and cGMP signaling, but only CD47 is necessary for this activity of thrombospondin-1 at physiological concentrations...
  13. pmc Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients
    Sharon A Glynn
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 120:3843-54. 2010
    ..Last, pathway analysis linked the tumor NOS2 gene signature to c-Myc activation. Thus, NOS2 is associated with a basal-like transcription pattern and poor survival of ER-negative patients...
  14. ncbi request reprint The chemical dynamics of NO and reactive nitrogen oxides: a practical guide
    Daniele Mancardi
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Curr Mol Med 4:723-40. 2004
    ..From this discussion, a picture can be formed concerning the possible chemical dynamics, which can be plausible in different biological mechanisms...
  15. pmc Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Am J Pathol 173:1100-12. 2008
    ..Therefore, thrombospondin-1/CD47 antagonists may have selective radioprotective activity for normal tissues...
  16. pmc Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy
    Jonathan M Weiss
    Cancer and Inflammation Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 207:2455-67. 2010
    ..Our data demonstrate the mechanistic basis for IL-2/α-CD40-mediated control of metastases and suggest that the context-dependent application of NO donors may hold promise for prevention of metastatic disease...
  17. pmc The emergence of nitroxyl (HNO) as a pharmacological agent
    Christopher H Switzer
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B35, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1787:835-40. 2009
    ..This also gives insight into the potential molecular motifs that may be reactive towards HNO and opens up a novel field of pharmacological development...
  18. ncbi request reprint Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients
    Jeff S Isenberg
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 40:1028-33. 2006
    ..The findings suggest that subnanomolar NO gradients are sufficient to mobilize endothelial cell migration into hypoxic tissue during neovascularization events, such as in wound healing and cancer...
  19. ncbi request reprint Discriminating formation of HNO from other reactive nitrogen oxide species
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 40:1056-66. 2006
    ..These data indicate that free HNO can be biosynthesized and thus may function as an endogenous signaling agent that is regulated by GSH content...
  20. doi request reprint Comparing the chemical biology of NO and HNO
    Wilmarie Flores-Santana
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Pharm Res 32:1139-53. 2009
    ..In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions...
  21. pmc COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer
    Sharon A Glynn
    Laboratory of Human Carcinogenesis, Center for Cancer Research CCR, National Cancer Institute NCI, NIH, Bethesda, Maryland MD, USA
    BMC Cancer 10:626. 2010
    ..Here, we studied the association of COX-2 with breast cancer survival and how this association is influenced by tumor estrogen and HER2 receptor status and Akt pathway activation...
  22. pmc Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling
    Justin B Maxhimer
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Sci Transl Med 1:3ra7. 2009
    ..Thus, inhibiting CD47 signaling maintains the viability of normal tissues following irradiation while increasing the radiosensitivity of tumors...
  23. doi request reprint Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer
    Christopher H Switzer
    Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 72:2394-404. 2012
    ..Together, our findings suggest that dithiolethiones show potential clinical use for estrogen negative breast cancer as a chemotherapeutic or adjuvant therapy...
  24. pmc Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer
    Christopher H Switzer
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 32:644-51. 2011
    ..We examine here the various functions of NO and PP2A in breast cancer and propose a novel mechanism by which activation of PP2A antagonizes NO signaling that promotes ER(-) breast cancer...
  25. pmc Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells
    Gema Martin-Manso
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:7090-9. 2008
    ..Thus, TSP1 may play an important role in antitumor immunity by enhancing recruitment and activation of M1 TAMs, which provides an additional selective pressure for loss of TSP1 and TSP2 expression during tumor progression...
  26. pmc CD47 deficiency confers cell and tissue radioprotection by activation of autophagy
    David R Soto-Pantoja
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Autophagy 8:1628-42. 2012
    ..This study indicates that CD47 deficiency confers cell survival through the activation of autophagic flux and identifies CD47 blockade as a pharmacological route to modulate autophagy for protecting tissue from radiation injury...
  27. pmc Blockade of CD47 increases survival of mice exposed to lethal total body irradiation
    David R Soto-Pantoja
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Sci Rep 3:1038. 2013
    ..Thus, CD47 is a new target for radiomitigation that prevents both hematopoietic and gastrointestinal radiation syndromes...
  28. pmc Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1
    Lisa A Ridnour
    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Neurochem 123:736-49. 2012
    ..TIMP-1 increased in the APPSwDI/NOS2(-/-) mice with decreased MMP activity and increased amyloid burden, thereby supporting roles for NO in the regulation of MMP/TIMP balance and plaque clearance...
  29. ncbi request reprint Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis
    David D Roberts
    Laboratory of Pathology and Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 13:795-8. 2007
    ..We discuss the implications of the balance between these pathways for applying thrombospondin-1 mimetics and redox modifiers as cancer therapeutics...
  30. pmc Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Neoplasia 10:886-96. 2008
    ..These data indicate that TSP1 primarily regulates long-term vascular responses in tumors, in part, because the tumor vasculature has a limited capacity to acutely respond to vasoactive agents...
  31. doi request reprint Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity
    Lisa A Ridnour
    Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Cancer Res 19:1340-6. 2013
    ....
  32. ncbi request reprint Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:11600-4. 2006
    ....
  33. pmc Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells
    Terry W Moody
    National Cancer Institute, Office of the Director, Center for Cancer Research, Bethesda, MD 20892 1500, USA
    Lung Cancer 68:154-60. 2010
    ..Because S-valproate and S-diclofenac inhibit the growth of NSCLC cells and reduce PGE(2) levels, they may prove beneficial in the chemoprevention and/or therapy of NSCLC...
  34. pmc Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease
    Jane J Sohn
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44156. 2012
    ..In vitro experiments tested the ability of macrophages to induce senescence in primary cells. Inflammation modulating microRNAs were identified in senescence colon tissue for further investigation...
  35. pmc Nitric oxide and redox mechanisms in the immune response
    David A Wink
    Radiation Biology Branch, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    J Leukoc Biol 89:873-91. 2011
    ..In this review, we discuss the chemistry of NO and ROS in the context of antipathogen activity and immune regulation and also discuss similarities and differences between murine and human production of these intermediates...
  36. ncbi request reprint The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
    Lisa A Ridnour
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Biol Chem 385:1-10. 2004
    ....
  37. pmc Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton
    Yifeng Jia
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stress Chaperones 15:165-81. 2010
    ..Thiolutin treatment specifically ablates Hsp27 interaction with nestin and collapses nestin filaments. These results provide new mechanistic insights into regulation of cell adhesion and cytoskeletal dynamics by Hsp27...
  38. pmc S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer
    Christopher H Switzer
    Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Mol Cancer Res 10:1203-15. 2012
    ..These results indicate that the inhibition of NOS2 activity or NO signaling networks may have beneficial effects in treating basal-like breast cancer patients...
  39. pmc Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:8894-9. 2004
    ..The findings show that concentration and duration of NO exposure are critical determinants in the regulation of tumor-related proteins...
  40. pmc The reemergence of nitric oxide and cancer
    David A Wink
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nitric Oxide 19:65-7. 2008
  41. ncbi request reprint Nitric oxide in wound-healing
    Jeff S Isenberg
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Microsurgery 25:442-51. 2005
    ..Current research suggests that nitric oxide and several nitric oxide donors can exert biologic effects, although the particular net responses of cells contributing to wound repair are context-dependent...
  42. pmc A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide
    Sharon A Glynn
    Laboratory of Human Carcinogenesis, Center for Cancer Research, Office of Preventive Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Clin Cancer Res 15:4165-73. 2009
    ..We hypothesized that this single-nucleotide polymorphism affects breast cancer survival of patients receiving chemotherapy...
  43. ncbi request reprint Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats
    Kyle E Brown
    Gastroenterology Section, John Cochran VAMC, St Louis, MO, USA
    Liver Int 23:232-42. 2003
    ..The aim of this study was to determine the effects of dietary fat of varying PUFA content on iron-induced oxidative stress and fibrosis...
  44. ncbi request reprint Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal
    Lisa A Ridnour
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City 52242, USA
    Antioxid Redox Signal 6:501-12. 2004
    ..These results suggest that the tumor suppressive effect of MnSOD overexpression is in part mediated by an antioxidant imbalance resulting in the reduced capacity to metabolize increased levels of intracellular peroxides...
  45. pmc Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state?
    Kyle E Brown
    Iowa City Veterans Administration Medical Center, Iowa City, IA, USA
    Free Radic Biol Med 42:228-35. 2007
    ..This is the first demonstration of increased telomerase activity associated with thiol alterations in vivo. Enhanced telomerase activity may be an important factor contributing to the resistance of rodent liver to iron-induced damage...
  46. ncbi request reprint Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 48:8220-8. 2005
    ..These data suggest that primary amine NONOates may be useful as HNO donors in complement to the existing series of secondary amine NONOates, which are well-characterized NO donors...
  47. pmc Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin
    Shujia Dai
    Barnett Institute, Northeastern University, Boston, Massachusetts 02115, USA
    J Proteome Res 7:4384-95. 2008
    ....
  48. ncbi request reprint Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 127:722-31. 2005
    ..The mechanism of product autoxidation is also considered...