Lisa A Ridnour
Affiliation: National Institutes of Health
Ridnour L, Cheng R, Weiss J, Kaur S, Soto Pantoja D, Basudhar D, et al
. NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay. Cancer Res. 2015;75:2788-99 pubmed publisher
..Together, these results suggest that post-IR NOS inhibition improves radiation tumor response via Th1 immune polarization within the tumor microenvironment. ..
Somasundaram V, Basudhar D, Bharadwaj G, No J, Ridnour L, Cheng R, et al
. Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction and Metabolism. Antioxid Redox Signal. 2018;: pubmed publisher
..Understanding the source of NO and its spacio-temporal profile within the tumor microenvironment could help improve efficacy of cancer immunotherapies by improving tumor infiltration of immune cells for better tumor clearance. ..
Glynn S, Prueitt R, Ridnour L, Boersma B, Dorsey T, Wink D, et al
. COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer. BMC Cancer. 2010;10:626 pubmed publisher
..The findings suggest that COX-2-specific inhibitors and inhibitors of the Akt pathway may act synergistically as anticancer drugs in the ER-negative and HER2-positive breast cancer subtype. ..
Ridnour L, Isenberg J, Espey M, Thomas D, Roberts D, Wink D. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc Natl Acad Sci U S A. 2005;102:13147-52 pubmed
..Limiting TSP1 expression by positive feedback through the ERK mitogen-activated protein kinase pathway may facilitate switching to a proangiogenic state at low doses of NO. ..
Ridnour L, Windhausen A, Isenberg J, Yeung N, Thomas D, Vitek M, et al
. Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2007;104:16898-903 pubmed