Brendan A Rich

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint An investigation of prepulse inhibition in pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Unit on Affective Psychophysiology, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Bipolar Disord 7:198-203. 2005
  2. ncbi request reprint The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Biol Psychiatry 58:532-9. 2005
  3. ncbi request reprint Using affect-modulated startle to study phenotypes of pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 7:536-45. 2005
  4. pmc Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation
    Brendan A Rich
    National Institute of Mental Health, National Institutes of Health, Building 15K, Room 204, MSC2670, Bethesda, MD 20892 2670, USA
    Dev Psychopathol 20:529-46. 2008
  5. pmc Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892 2670, MD, USA
    J Child Psychol Psychiatry 49:88-96. 2008
  6. ncbi request reprint Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Section on Development and Affective Neuroscience, NIMH Mood and Anxiety Program, Bethesda, MD 20892, USA
    Am J Psychiatry 164:309-17. 2007
  7. ncbi request reprint Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
    Bipolar Disord 9:810-9. 2007
  8. pmc Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder
    Melissa A Brotman
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 167:61-9. 2010
  9. ncbi request reprint Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder
    Melissa A Brotman
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 165:385-9. 2008
  10. pmc Neural activation during encoding of emotional faces in pediatric bipolar disorder
    Daniel P Dickstein
    Division of Intramural Research Program, National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, Bethesda, MD 20892 2670, USA
    Bipolar Disord 9:679-92. 2007

Detail Information

Publications21

  1. ncbi request reprint An investigation of prepulse inhibition in pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Unit on Affective Psychophysiology, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Bipolar Disord 7:198-203. 2005
    ..Sensorimotor gating deficits may contribute to the emotional and behavioral dysregulation characteristic of pediatric BPD. The current study investigated possible PPI deficits in children with BPD...
  2. ncbi request reprint The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Biol Psychiatry 58:532-9. 2005
    ..We tested the hypothesis that frustration adversely impacts attention and behavior in children with bipolar disorder (BPD)...
  3. ncbi request reprint Using affect-modulated startle to study phenotypes of pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 7:536-45. 2005
    ..The current study used affect-modulated startle to examine potential differences in reactivity to emotional stimuli (reward and punishment) in narrow and broad phenotype PBD and controls...
  4. pmc Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation
    Brendan A Rich
    National Institute of Mental Health, National Institutes of Health, Building 15K, Room 204, MSC2670, Bethesda, MD 20892 2670, USA
    Dev Psychopathol 20:529-46. 2008
    ..These deficits are associated with psychosocial impairments. Understanding the neural circuitry associated with face-labeling deficits has the potential to clarify the pathophysiology of these disorders...
  5. pmc Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892 2670, MD, USA
    J Child Psychol Psychiatry 49:88-96. 2008
    ....
  6. ncbi request reprint Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Section on Development and Affective Neuroscience, NIMH Mood and Anxiety Program, Bethesda, MD 20892, USA
    Am J Psychiatry 164:309-17. 2007
    ..e., a history of at least one manic or hypomanic episode with euphoric mood) as well as those with no diagnosis (i.e., healthy comparison children)...
  7. ncbi request reprint Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
    Bipolar Disord 9:810-9. 2007
    ..The present study was undertaken to determine if neuronal responses differed between BD and control subjects on a simple motor response flexibility task...
  8. pmc Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder
    Melissa A Brotman
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 167:61-9. 2010
    ..The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths...
  9. ncbi request reprint Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder
    Melissa A Brotman
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 165:385-9. 2008
    ....
  10. pmc Neural activation during encoding of emotional faces in pediatric bipolar disorder
    Daniel P Dickstein
    Division of Intramural Research Program, National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, Bethesda, MD 20892 2670, USA
    Bipolar Disord 9:679-92. 2007
    ..To begin to address these limitations, the current study tests the hypothesis that pediatric BD (PBD) subjects exhibit altered neural activation during encoding of emotional faces compared to typically developing controls...
  11. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  12. ncbi request reprint Cognitive flexibility in phenotypes of pediatric bipolar disorder
    Daniel P Dickstein
    National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670 Building 15K Room 204, Bethesda MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 46:341-55. 2007
    ..6 +/- 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression)...
  13. ncbi request reprint Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder
    Ellen Leibenluft
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Health and Human Services, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 164:52-60. 2007
    ..They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder (ADHD) versus those with bipolar disorder without ADHD...
  14. ncbi request reprint Specificity of facial expression labeling deficits in childhood psychopathology
    Amanda E Guyer
    Mood and Anxiety Program MAP, National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
    J Child Psychol Psychiatry 48:863-71. 2007
    ..We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation...
  15. ncbi request reprint Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disorders
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:819-21. 2007
    ..Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness...
  16. pmc Risk for bipolar disorder is associated with face-processing deficits across emotions
    Melissa A Brotman
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 47:1455-61. 2008
    ..It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest...
  17. pmc Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Proc Natl Acad Sci U S A 103:8900-5. 2006
    ..Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability...
  18. ncbi request reprint Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:991-7. 2006
    ..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
  19. ncbi request reprint Comorbid anxiety in phenotypes of pediatric bipolar disorder
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1255, USA
    J Child Adolesc Psychopharmacol 15:534-48. 2005
    ..Adult BPD studies suggest comorbid anxiety disorders are common and impact treatment outcome. We explored the association of comorbid anxiety with two phenotypes of pediatric BPD...
  20. ncbi request reprint Pediatric bipolar disorder
    Ellen Leibenluft
    Section on Bipolar Spectrum Disorders, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda MD, USA
    Annu Rev Clin Psychol 4:163-87. 2008
    ..Throughout the review, we pay particular attention to youths with severe chronic irritability, hyperarousal, and hyperreactivity, who reflect the population in whom the diagnosis of BD is most debated...
  21. pmc Perception of facial emotion in adults with bipolar or unipolar depression and controls
    Kathryn L Schaefer
    Department of Counseling and Personnel Services, University of Maryland, College Park, MD, USA
    J Psychiatr Res 44:1229-35. 2010
    ..Groups were compared in terms of sensitivity and accuracy in identifying emotions. Our preliminary findings suggest that subjects with bipolar depression may have emotional processing abnormalities relative to controls...

Research Grants1

  1. Neural Mechanisms of Pediatric Bipolar Disorder: The Impact of Comorbid Anxiety
    Brendan Rich; Fiscal Year: 2008
    ..This information can then aid in the development of behavioral and neural markers to be used to identify children at-risk for PBD, thus greatly improving the quality of life of children with PBD and their families. ..