Research Topics
Genomes and Genes
| S G RheeSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxinsHyun Ae Woo
Laboratory of Cell Signaling and Laboratory of Biophysical Chemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:3125-8. 2005..These results suggest that reduction of Cys-SO2H by Srx is specific to 2-Cys Prx isoforms. For proteins such as Prx VI and GAPDH, sulfinic acid formation might be an irreversible process that causes protein damage...
Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalphaYuyeon Jung
Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul, Korea
J Biol Chem 283:23863-71. 2008..Together, our results indicate that LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state...- Redox signaling: hydrogen peroxide as intracellular messengerS G Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Exp Mol Med 31:53-9. 1999..The goal of this report is to review our current knowledge of ROS-regulated signal transduction and propose future directions... - Regulation of phosphoinositide-specific phospholipase CS G Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 0320, USA
Annu Rev Biochem 70:281-312. 2001.... - Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxinsSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Opin Cell Biol 17:183-9. 2005.... - Cellular regulation by hydrogen peroxideSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 14:S211-5. 2003..Furthermore, the activity of peroxiredoxin enzymes seems to be regulated via protein phosphorylation as in the case of many other intracellular messenger metabolizing enzymes... - Reversible inactivation of the tumor suppressor PTEN by H2O2Seung Rock Lee
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8015, USA
J Biol Chem 277:20336-42. 2002.... - Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modificationSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Antioxid Redox Signal 7:619-26. 2005..Similarily, GPx1 is activated by c-Abl- and Arg-mediated phosphorylation. The tyrosine phosphorylation is critical for ubiquitination-dependent degradation of catalase... - Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signalingSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 38:1543-52. 2005..This reversible overoxidation may represent an adaptation unique to eukaryotic cells that accommodates the intracellular messenger function of H(2)O(2), but experimental validation of such speculation is yet to come... - Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3D Y Jhon
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 268:6654-61. 1993.... - Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediateM S Seo
Laboratory of Cell Signaling and Department of Extramural Affairs, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:20346-54. 2000.... - Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymesD Massenburg
Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 91:11718-22. 1994.... - Cloning and sequence of multiple forms of phospholipase CP G Suh
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892
Cell 54:161-9. 1988..Those of PLC-I and III were short and appeared to be unrelated to these tyrosine kinases. The physiological implications of the multiple species of PLC enzymes are discussed... - Characterization of a mammalian peroxiredoxin that contains one conserved cysteineS W Kang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 273:6303-11. 1998..Thus, the primary cellular function of 1-Cys Prx appears to be to reduce peroxides with the use of electrons provided by an as yet unidentified source; the enzyme therefore represents a new type of peroxidase... - Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiaeH Z Chae
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 268:16815-21. 1993..This result suggests that TSA is a physiologically important antioxidant... - Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activationC S Shi
BCell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:24293-300. 2001..Thus, RGS3 may limit Gbetagamma signaling not only by virtue of its GTPase-activating protein activity for Galpha subunits, but also by directly interfering with the activation of effectors... - Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymesH Z Chae
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 91:7017-21. 1994..We also report that a second family of proteins, defined by the 57-kDa component (AhpF) of alkyl hydroperoxide reductase and by thioredoxin reductase, has expanded to include six additional members... - Purification, molecular cloning, and sequencing of phospholipase C-beta 4C W Lee
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 268:21318-27. 1993..These results suggest that the brain cDNA encodes PLC-beta 4, which is likely a mammalian homolog of PLC-norpA... - Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activationD Y Jin
Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:30952-61. 1997..AOE372 function suggests thioredoxin peroxidase as an immediate regulator of H2O2-mediated activation of NF-kappaB... - Regulation of phospholipase C isozymes: activation of phospholipase C-gamma in the absence of tyrosine-phosphorylationF Sekiya
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 0320, USA
Chem Phys Lipids 98:3-11. 1999..These results reveal an elaborate mechanism of cross-talk and mutual regulation between four effector enzymes that participate in receptor signaling by acting on phospholipids... - PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254H K Kim
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
Cell 65:435-41. 1991..These results provide direct evidence that growth factor receptors activate the function of intracellular protein by tyrosine phosphorylation... - Catalytic properties of inositol trisphosphate kinase: activation by Ca2+ and calmodulinS H Ryu
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892
FASEB J 1:388-93. 1987..Studies with various inositol polyphosphates indicate that the substrate-binding site is quite specific to Ins-1,4,5-P3. Nevertheless, Ins-2,4,5-P3 could be phosphorylated at a velocity approximately 1/20-1/30 that of Ins-1,4,5-P3... - Molecular cloning and expression of a complementary DNA for inositol 1,4,5-trisphosphate 3-kinaseK Y Choi
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Science 248:64-6. 1990..Expression of the cDNA in COS cells resulted in an approximately 150-fold increase in inositol 1,4,5-trisphosphate 3-kinase activity of these cells... - Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidationS G Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Sci STKE 2000:pe1. 2000..Thus, the higher levels of intracellular phosphoproteins observed in cells most likely occur because of the concomitant inhibition of protein phosphatases and activation of protein kinases... - Thioredoxin-dependent peroxide reductase from yeastH Z Chae
Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 269:27670-8. 1994..The Saccharomyces cerevisiae thioredoxin reductase gene was also cloned and sequenced, and the deduced amino sequence was shown to be 51% identical with that of the Escherichia coli enzyme... - Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene productsP G Suh
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
Proc Natl Acad Sci U S A 85:5419-23. 1988..Therefore, this unexpected similarity raises the possibility that the 148-kDa phospholipase C and cytoplasmic tyrosine kinases are modulated by common cellular component(s)... - Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2D Park
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 267:16048-55. 1992..see also accompanying article (Lee, C. H., Park, D., Wu, D., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 16044-16047)... - Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4S B Lee
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 271:25-31. 1996..Splice variants have not previously been detected for delta-type PLC isozymes... - Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liverS R Lee
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 274:4722-34. 1999.... - Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitroJ W Kim
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 265:3940-3. 1990..We propose, therefore, that the phosphorylation of PLC-gamma by EGF receptor kinase alters its interaction with putative inhibitory proteins and leads to its activation... - Inhibition of phospholipase D by amphiphysinsC Lee
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 0320, USA
J Biol Chem 275:18751-8. 2000..Thus, the inhibition of PLD by amphiphysins, synaptojanin, and AP180 might play an important role in synaptic vesicle trafficking... - Different ARF domains are required for the activation of cholera toxin and phospholipase DG F Zhang
Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 270:21-4. 1995..It appears that the amino-terminal region of ARF1 is not critical for its action as a GTP-dependent activator of cholera toxin, whereas it is necessary for activation of the putative effector enzyme, PLD... - Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMPD Park
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892
Mol Cell Biol 12:5816-23. 1992..These results suggest that Nck is a target for a variety of protein kinases that might modulate the postulated role of Nck as an adaptor for the physical and functional coordination of signalling proteins... - Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxinWoojin Jeong
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:14400-7. 2006..The disulfide-S-monoxide is further reduced through the oxidation of three thiol equivalents to complete the catalytic cycle and regenerate Prx-Cys-SH... - The RING-H2-finger protein APC11 as a target of hydrogen peroxideTong Shin Chang
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 37:521-30. 2004..Inhibition of APC11 function by H(2)O(2) thus likely contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress... - Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondriaTong Shin Chang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:41975-84. 2004..Our results suggest that Prx III is a critical regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling... - Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteineTong Shin Chang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:50994-1001. 2004..Finally, depletion of human Srx by RNA interference suggested that Srx is largely responsible for reduction of the Cys-SO2H of Prx in A549 human cells... - Regulation of PDGF signalling and vascular remodelling by peroxiredoxin IIMin Hee Choi
Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
Nature 435:347-53. 2005..These results demonstrate a localized role for endogenous H2O2 in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease... - Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factorsJaeyul Kwon
Laboratories of Cell Signaling and Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8015, USA
Proc Natl Acad Sci U S A 101:16419-24. 2004..Furthermore, together with previous observations, our data indicate that peroxiredoxin likely participates in PIP3 signaling by modulating the local concentration of H2O2... - Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1Benoit Poulin
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8015, USA
Proc Natl Acad Sci U S A 102:4276-81. 2005..Our results thus clarify the molecular mechanism of PLC-gamma1 activation, revealing the specific function of pY783 and the distinct roles of the two SH2 domains in this process... - Cell signaling. H2O2, a necessary evil for cell signalingSue Goo Rhee
Institute of Molecular Life Science and Technology, Ewha Women's University, Seoul 120-750, South Korea
Science 312:1882-3. 2006 - Structural basis of cellular redox regulation by human TRP14Joo Rang Woo
Center for Cellular Switch Protein Structure and Systemic Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Euh eun dong, Yuseong Gu, Daejeon 305 806, Korea
J Biol Chem 279:48120-5. 2004..These structural differences in the active site suggest that TRP14 has evolved to regulate cellular redox signaling by recognizing a distinctive group of substrates that would complement the group of proteins regulated by Trx1... - AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase CIn Hye Lee
Division of Molecular Life Sciences, Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
J Biol Chem 279:26645-53. 2004..The secondary activation of PLC is likely because of the scaffolding activity of AHNAK, which is consistent with the role of 4 CRUs as a molecular linker between PLC-gamma and PKC-alpha... - Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysisDuck Yeon Lee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 0301, USA
Biochemistry 45:15301-9. 2006..The modeling and mutagenesis analyses strongly implicate Asp187 of Prx I as the catalytic residue responsible for ATP hydrolysis in the cysteinesulfinic acid reduction of Prx by hSrx... - Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin functionWoojin Jeong
Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:3142-50. 2004..These results suggest that TRP14 and Trx1 might act on distinct substrate proteins... - Oxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cellsJae-Ryong Kim
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
Arch Biochem Biophys 397:414-23. 2002.... - Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathwaysWoojin Jeong
Laboratory of Cell Signaling, National Heart, Lung and Bllod Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:3151-9. 2004..The complex was detected in HeLa cells treated with H(2)O(2) or TNF-alpha but not in untreated cells, suggesting that LC8 cytoplasmic dynein light chain is a possible substrate of TRP14... - Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylationTong Shin Chang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:25370-6. 2002..These results suggest that Cdc2-mediated phosphorylation and inactivation of Prx I and the resulting intracellular accumulation of H(2)O(2) might be important for progression of the cell cycle... - Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequenceHyun Ae Woo
Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea
J Biol Chem 278:47361-4. 2003..The generation of antibodies specific for sulfonylated peptides should provide insight into protein function similar to that achieved with antibodies to peptides containing phosphoserine or phosphothreonine... - Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acidKap Seok Yang
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:38029-36. 2002..072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2)... - Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formationHyun Ae Woo
Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
Science 300:653-6. 2003..The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated... 
Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complexIn Hye Lee
Department of Life Science, Ewha Womans University, 11 1 Daehyun Dong, Seodaemoon Gu, Seoul 120 750, Korea
J Biol Chem 283:6312-20. 2008..These data indicate that Ahnak potentiates PKC activation through inhibiting the interaction of PKC with PP2A...- Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidantAmy L Mowbray
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
J Biol Chem 283:1622-7. 2008..However, PRX 5 depletion did not. Together, these results suggest that PRX 1 is a novel mechanosensitive antioxidant, playing an important role in shear-dependent regulation of endothelial biology and atherosclerosis... - Measuring H2O2 produced in response to cell surface receptor activationSue Goo Rhee
Nat Chem Biol 3:244-6. 2007 - 1H, 15N, and 13C chemical shift assignments of the human Sulfiredoxin (hSrx)Duck-Yeon Lee
J Biomol NMR 32:339. 2005 - 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implicationsSang Won Kang
Center for Cell Signaling Research and Division of Molecular Life Science, Ewha Womans University, Seoul 120 750, Korea
Trends Mol Med 11:571-8. 2005..Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species... - ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stressWoojin Jeong
Division of Life and Pharmaceutical Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul, Korea
J Biol Chem 283:25557-66. 2008..Our results suggest that ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress... - Annexin A2-S100A10 heterotetramer, a novel substrate of thioredoxinMijung Kwon
Cancer Biology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
J Biol Chem 280:23584-92. 2005..Therefore, we identify AIIt as a substrate of the thioredoxin system and propose a new model for the role of AIIt in the redox-dependent processing of plasminogen and generation of an angiostatin at the cell surface... - Activity assay of mammalian 2-cys peroxiredoxins using yeast thioredoxin reductase systemJu-A Kim
Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Woman's University, Seoul, Korea
Anal Biochem 338:216-23. 2005..5 microM, respectively. This modified assay method is useful for measuring 2-cys Prx activity in cell lysates and can also be adapted for a 96-well plate reader for high-throughput screening of chemical compounds that target 2-cys Prx... - Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130Peter Varnai
Endocrinology and Reproduction Research Branch, NICHD National Institutes of Health, 49 Convent Drive, Bldg 49, Bethesda, MD 20892, USA
J Biol Chem 277:27412-22. 2002.... - Peroxiredoxin II is essential for sustaining life span of erythrocytes in miceTae Hoon Lee
Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
Blood 101:5033-8. 2003..Our results suggest that Prx II-/- mice have hemolytic anemia and that Prx II plays a major role in protecting RBCs from oxidative stress in mice... 
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expressionSatish Devadas
Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
J Exp Med 195:59-70. 2002..Thus, antigen receptor signaling induces generation of discrete species of oxidants that selectively regulate two distinct redox sensitive pathways, a proapoptotic (FasL) and a proliferative pathway (ERK)...- Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alphaSang Won Kang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:2535-43. 2004..Our results also suggest that cytosolic peroxiredoxins are important regulators of TNF signaling pathways... - Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sitesKatsue Suzuki-Inoue
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Biochem J 378:1023-9. 2004..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V... - Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2Hye Sun Park
Center for Cell Signaling Research, Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea
Mol Cell Biol 24:4384-94. 2004..These results suggest that ROS production in growth factor-stimulated cells is mediated by the sequential activation of PI3K, beta Pix, and Rac1, which then binds to Nox1 to stimulate its NADPH oxidase activity... - Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activationFujio Sekiya
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:32181-90. 2004..Finally, concurrent production of phosphatidylinositol 3,4,5-trisphosphate was found to contribute to the activation of phosphorylated PLC-gamma 1... - Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone functionHo Hee Jang
Division of Applied Life Sciences, Gyeonsang National University, Chinju, 660-701, South Korea
Cell 117:625-35. 2004..The chaperone function of these proteins enhances yeast resistance to heat shock... - Identification of phospholipase C-gamma1 as a mitogen-activated protein kinase substrateColin T Buckley
Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
J Biol Chem 279:41807-14. 2004..These studies have uncovered a previously unidentified mechanism for the integration of PLC-gamma1- and ERK2-dependent signaling... - Phospholipase C-delta1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytesKi Chul Hwang
Department of Internal Medicine, Cardiovascular Research Institute, Yonsei University College of Medicine, Yonsei University, Seoul 120 752, South Korea
J Steroid Biochem Mol Biol 91:131-8. 2004..It is suggested that PLC isozyme-changes may contribute to the alterations in calcium homeostasis in myocardial ischemia... - Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2Yeun Ju Kim
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Mol Cell Biol 24:9986-99. 2004..Finally, phosphorylation of Y1217 and that of Y753 and Y759 occurred on different PLC-gamma2 molecules... - Membrane targeting of C2 domains of phospholipase C-delta isoformsBharath Ananthanarayanan
Department of Chemistry, University of Illinois, Chicago 60607, USA
J Biol Chem 277:3568-75. 2002..Together, these results establish the C2 domains of PLC-delta isoforms as Ca(2+)-dependent membrane targeting domains that have distinct membrane binding properties that control their subcellular localization behaviors...