Susan M Resnick

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Amyloid imaging and memory change for prediction of cognitive impairment
    Susan M Resnick
    Laboratory of Behavioral Neuroscience, NIH Biomedical Research Center, National Institute on Aging, IRP, 251 Bayview Blvd, Room 4B335, Baltimore, MD 21224, USA
    Alzheimers Res Ther 3:3. 2011
  2. pmc Longitudinal patterns of β-amyloid deposition in nondemented older adults
    Jitka Sojkova
    Laboratory of Behavioral Neuroscience, National Institutes of Health Biomedical Research Center, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:644-9. 2011
  3. pmc Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 73:422-8. 2013
  4. pmc Alzheimer risk variant CLU and brain function during aging
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Biol Psychiatry 73:399-405. 2013
  5. pmc Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults
    May A Beydoun
    National Institute on Aging, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, USA
    J Am Geriatr Soc 61:525-34. 2013
  6. pmc Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline
    May A Beydoun
    National Institute on Aging, NIA NIH IRP, Baltimore, MD 21224, USA
    Neurobiol Aging 33:720-731.e4. 2012
  7. pmc Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Neuropsychology 25:763-70. 2011
  8. pmc Intima-media thickness and regional cerebral blood flow in older adults
    Jitka Sojkova
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Stroke 41:273-9. 2010
  9. pmc Mild Cognitive Impairment and Asymptomatic Alzheimer Disease Subjects: Equivalent β-Amyloid and Tau Loads With Divergent Cognitive Outcomes
    Diego Iacono
    From the Departments of Pathology DI, OP, GR, BC, JT, and Neurology RO, JT, Johns Hopkins University School of Medicine and Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health SMR, ABZ, YA, Baltimore, Maryland and Neuropathology Research, Biomedical Research Institute of New Jersey, Cedar Knolls, New Jersey DI
    J Neuropathol Exp Neurol 73:295-304. 2014
  10. pmc Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 34:1045-50. 2013

Detail Information

Publications75

  1. pmc Amyloid imaging and memory change for prediction of cognitive impairment
    Susan M Resnick
    Laboratory of Behavioral Neuroscience, NIH Biomedical Research Center, National Institute on Aging, IRP, 251 Bayview Blvd, Room 4B335, Baltimore, MD 21224, USA
    Alzheimers Res Ther 3:3. 2011
    ....
  2. pmc Longitudinal patterns of β-amyloid deposition in nondemented older adults
    Jitka Sojkova
    Laboratory of Behavioral Neuroscience, National Institutes of Health Biomedical Research Center, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:644-9. 2011
    ..High levels of β-amyloid (Aβ) characterize Alzheimer disease...
  3. pmc Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 73:422-8. 2013
    ..We examined the association between rs3818361 and brain amyloid deposition in nondemented older individuals...
  4. pmc Alzheimer risk variant CLU and brain function during aging
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Biol Psychiatry 73:399-405. 2013
    ....
  5. pmc Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults
    May A Beydoun
    National Institute on Aging, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, USA
    J Am Geriatr Soc 61:525-34. 2013
    ..To confirm associations of apolipoprotein E (ApoE) ε4 carrier status, sex, and time-dependent cognitive status with mortality risk and to investigate these joint effects of these associations in a cohort of community-dwelling U.S. adults...
  6. pmc Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline
    May A Beydoun
    National Institute on Aging, NIA NIH IRP, Baltimore, MD 21224, USA
    Neurobiol Aging 33:720-731.e4. 2012
    ..While ApoE4(+) status appears to be a sex neutral risk factor for dementia, its association with verbal memory and learning decline and impairment was stronger among women...
  7. pmc Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Neuropsychology 25:763-70. 2011
    ..We hypothesized a priori that greater hearing loss is associated with lower cognitive test scores on tests of memory and executive function...
  8. pmc Intima-media thickness and regional cerebral blood flow in older adults
    Jitka Sojkova
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Stroke 41:273-9. 2010
    ..Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease...
  9. pmc Mild Cognitive Impairment and Asymptomatic Alzheimer Disease Subjects: Equivalent β-Amyloid and Tau Loads With Divergent Cognitive Outcomes
    Diego Iacono
    From the Departments of Pathology DI, OP, GR, BC, JT, and Neurology RO, JT, Johns Hopkins University School of Medicine and Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health SMR, ABZ, YA, Baltimore, Maryland and Neuropathology Research, Biomedical Research Institute of New Jersey, Cedar Knolls, New Jersey DI
    J Neuropathol Exp Neurol 73:295-304. 2014
    ..These findings imply that cognitive impairment in AD may be caused or modulated by factors other than insoluble forms of Aβ and tau. ..
  10. pmc Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 34:1045-50. 2013
    ..In sum, a resilient personality profile is associated with lower risk or delay of clinical dementia even in persons with AD neuropathology...
  11. pmc Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)
    RICHARD J O'BRIEN
    Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Alzheimers Dis 18:665-75. 2009
    ..e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease...
  12. pmc Neuronal hypertrophy in asymptomatic Alzheimer disease
    Diego Iacono
    Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neuropathol Exp Neurol 67:578-89. 2008
    ....
  13. pmc Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques
    Ira Driscoll
    National Institute on Aging, Baltimore, MD, USA
    Acta Neuropathol 124:823-31. 2012
    ..The strong associations of PiB retention with region-matched, quantitative analyses of Aβ in postmortem tissue offer support for the validity of (11)C-PiB-PET imaging as a method for evaluation of plaque burden in vivo...
  14. pmc Midlife obesity and trajectories of brain volume changes in older adults
    Ira Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Hum Brain Mapp 33:2204-10. 2012
    ..Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences...
  15. pmc Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals
    Ira Driscoll
    NIH Biomedical Research Center, 251 Bayview Blvd, Suite 100, Baltimore, MD 21224, USA
    Neurobiol Aging 32:2123-30. 2011
    ..Consistent with a threshold model of disease, our findings suggest that Aβ load does not seem to affect brain volume changes in individuals without dementia...
  16. pmc Longitudinal changes in cortical thickness associated with normal aging
    Madhav Thambisetty
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224 2816, USA
    Neuroimage 52:1215-23. 2010
    ..Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right...
  17. doi request reprint Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging
    Madhav Thambisetty
    Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 34:2271-6. 2013
    ..Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals. ..
  18. pmc Changes in brain function occur years before the onset of cognitive impairment
    Lori L Beason-Held
    Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei 100, Taiwan, Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224
    J Neurosci 33:18008-14. 2013
    ..These changes also occurred within regions that show early accumulation of pathology in Alzheimer's disease, suggesting that there may be a connection between early pathologic change and early changes in brain function. ..
  19. pmc In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults
    Jitka Sojkova
    National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:232-40. 2011
    ..In demented older adults, in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid (Aβ). However, the extent of agreement in nondemented older adults remains unclear...
  20. pmc The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older women
    Angelina R Sutin
    Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
    J Affect Disord 127:241-7. 2010
    ..The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms...
  21. ncbi request reprint Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly
    Ira Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Neurol 60:688-95. 2006
    ..We investigated whether cognitive trajectories differ between clinically normal elderly individuals with and without AD neuropathology and how they compare with trajectories of clinically impaired individuals before dementia diagnosis...
  22. pmc Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohort
    Abhay Moghekar
    Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Alzheimers Dement 8:S71-7. 2012
    ....
  23. pmc Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing
    David Dolan
    Department of Neurology, Johns Hopkins Bayview Medical Centre, Baltimore, MD 21224, USA
    Brain 133:2225-31. 2010
    ..In the most elderly, atherosclerosis also emerged as a cause of dementia in subjects with low Alzheimer's pathology scores. We found no evidence for a significant number of elderly subjects having dementia without an apparent cause...
  24. pmc Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?
    Jitka Sojkova
    National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 49:1465-71. 2008
    ....
  25. ncbi request reprint Effects of combination estrogen plus progestin hormone treatment on cognition and affect
    Susan M Resnick
    National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 91:1802-10. 2006
    ..Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory...
  26. pmc Frontal function and executive processing in older adults: process and region specific age-related longitudinal functional changes
    Joshua O Goh
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Neuroimage 69:43-50. 2013
    ....
  27. pmc Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of Aging
    Rebecca F Gottesman
    Department of Neurology, Johns Hopkins University School of Medicine, Meyer 6 113, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 67:963-9. 2012
    ..We investigated whether lower hemoglobin is associated with regional increases in relative CBF in older individuals, and if these increases occur in watershed regions...
  28. pmc Baseline cardiovascular risk predicts subsequent changes in resting brain function
    Lori L Beason-Held
    Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Stroke 43:1542-7. 2012
    ....
  29. pmc Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals
    Madhav Thambisetty
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Alzheimers Dis 22:1099-109. 2010
    ..Our strategy combining proteomics with in vivo brain amyloid imaging holds promise for the discovery of biologically relevant peripheral markers in those at risk for AD...
  30. pmc Morphometry of the human substantia nigra in ageing and Parkinson's disease
    Gay Rudow
    Neuropathology, Johns Hopkins School of Medicine, Ross Research Building 555, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Acta Neuropathol 115:461-70. 2008
    ..Presumably, this compensatory mechanism breaks down or is overwhelmed by the pathological events of PD leading to the onset of the characteristic motor disturbances...
  31. pmc Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 94:4152-61. 2009
    ..We previously reported that conjugated equine estrogens (CEE) with medroxyprogesterone acetate had a negative impact on verbal memory but tended to impact figural memory positively over time in older postmenopausal women...
  32. pmc Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging study
    Vonetta M Dotson
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    J Psychiatry Neurosci 34:367-75. 2009
    ..Our objective was to investigate both cross-sectional and longitudinal relations between sub-threshold depressive symptoms and brain volumes in older adults and to examine whether these associations are modified by age...
  33. pmc Subjective cognitive complaints and longitudinal changes in memory and brain function
    Timothy J Hohman
    Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224
    Neuropsychology 25:125-30. 2011
    ..This study examined whether cognitive complaints are associated with longitudinal changes in cognition and cross-sectional differences in regional brain function during memory performance in 98 participants with a mean age of 75...
  34. pmc Effect of infarcts on dementia in the Baltimore longitudinal study of aging
    Juan C Troncoso
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 64:168-76. 2008
    ..To define the magnitude and mechanism of the effect of brain infarcts on the odds of dementia in a prospective study...
  35. pmc Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons
    Miguel Angel Riudavets
    Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neurobiol Aging 28:1484-92. 2007
    ..This nuclear hypertrophy may represent an early neuronal reaction to Abeta or Tau, or a compensatory mechanism which forestalls the progression of AD and allows the brain to resist the development of dementia...
  36. pmc Alcohol consumption and premotor corpus callosum in older adults
    Dimitrios Kapogiannis
    National Institute on Aging National Institutes of Health NIA NIH, Clinical Research Branch, 3001 South Hanover St, Baltimore, MD 21225, USA
    Eur Neuropsychopharmacol 22:704-10. 2012
    ..This finding suggests that even moderate amounts of alcohol may be detrimental to corpus callosum and white matter integrity...
  37. pmc Temporal relationships between depressive symptoms and white matter hyperintensities in older men and women
    Vonetta M Dotson
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Int J Geriatr Psychiatry 28:66-74. 2013
    ..Whether depression is an etiology or a consequence of vascular disease is still unknown. We investigated the temporal relationship between depressive symptoms and WMHs in older men and women...
  38. pmc Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults
    Ira Driscoll
    Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 7:e35217. 2012
    ..Together, our findings contribute to furthering the understanding of the relationships between plasma BDNF, structural brain integrity and cognition. Potential mechanisms mediating these relationships merit further investigation...
  39. pmc Longitudinal study of chronic depressive symptoms and regional cerebral blood flow in older men and women
    Vonetta M Dotson
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Int J Geriatr Psychiatry 24:809-19. 2009
    ..Additionally, the neural correlates of depression have not been fully explored in men and women separately. This study investigated cross-sectional and longitudinal relationships between SDS and rCBF in older men and women...
  40. ncbi request reprint Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Neurosci 23:3295-301. 2003
    ....
  41. pmc Weight change and cognitive function: findings from the Women's Health Initiative Study of Cognitive Aging
    Ira Driscoll
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Obesity (Silver Spring) 19:1595-600. 2011
    ..Relationships were largely independent of initial BMI, self-reported caloric intake or dieting. The lack of associations between weight gain and cognition in women is consistent with the existing literature...
  42. ncbi request reprint Cortical reconstruction using implicit surface evolution: accuracy and precision analysis
    Duygu Tosun
    Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Neuroimage 29:838-52. 2006
    ..Parameters were adjusted on the basis of this analysis in order to improve the algorithm's overall performance...
  43. ncbi request reprint Program for Assisted Labeling of Sulcal Regions (PALS): description and reliability
    Maryam E Rettmann
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neuroimage 24:398-416. 2005
    ..Reliability experiments are performed to assess both the long-term stability and short-term repeatability of the proposed techniques. These experiments indicate the proposed methodology gives both highly stable and repeatable results...
  44. ncbi request reprint Age differences in the neural systems supporting human allocentric spatial navigation
    Scott D Moffat
    Laboratory of Personality, Cognition and National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 27:965-72. 2006
    ..These results provide evidence of age specific neural networks supporting spatial navigation and identify a putative neural substrate for age-related differences in spatial memory and navigational skill...
  45. ncbi request reprint Cross-sectional and longitudinal analyses of anatomical sulcal changes associated with aging
    Maryam E Rettmann
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cereb Cortex 16:1584-94. 2006
    ..In addition, we found longitudinal decreases in surface area, mean thickness, GM volume, and sulcal depth measures as well as changes in sulcal curvature...
  46. pmc APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging
    Madhav Thambisetty
    Department of Radiology and Radiological Sciences, Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University, Baltimore, Maryland 21224 6825, USA
    Arch Neurol 67:93-8. 2010
    ..Design, Setting, and..
  47. pmc Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort
    Hillary Dolan
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 68:231-40. 2010
    ....
  48. pmc Differential trajectories of age-related changes in components of executive and memory processes
    Joshua O Goh
    Laboratory of Behavioral Neuroscience, Intramural Research Project, National Institute on Aging, Bethesda, MD, USA
    Psychol Aging 27:707-19. 2012
    ....
  49. pmc Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA
    Neuroimage 59:212-7. 2012
    ..These findings in combination suggest an influence of this multi-functional protein on early stages of progression in AD pathology...
  50. pmc Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults
    Vonetta M Dotson
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Geriatr Psychiatry 16:318-30. 2008
    ..This study investigated the effect of concurrent, baseline, and average depressive symptoms on cognitive functioning and decline, and examined the interactive effect of age and depressive symptoms on cognition...
  51. pmc Hearing loss and incident dementia
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, JHOC 6120, 601 N Caroline St, Baltimore, MD 21287, USA
    Arch Neurol 68:214-20. 2011
    ..To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD)...
  52. pmc Personality and risk of Alzheimer's disease: New data and meta-analysis
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Baltimore, MD, USA Florida State University College of Medicine, Tallahassee, FL, USA Electronic address
    Alzheimers Dement 10:179-86. 2014
    ..We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies...
  53. pmc Change in brain and lesion volumes after CEE therapies: The WHIMS-MRI studies
    Laura H Coker
    From the Division of Public Health Sciences L H C, M A E, P E H, S A S, and Departments of Internal Medicine and Geriatrics J D W and Neurology C D B, Wake Forest School of Medicine, Winston Salem, NC Intramural Research Program S M R, National Institute on Aging, NIH, Baltimore, MD Department of Radiology R N B, C D, University of Pennsylvania, Philadelphia Department of Internal Medicine and Epidemiology J G R, University of Iowa, Iowa City Department of Psychiatry and Behavioral Medicine J S G, Medical College of Wisconsin, Milwaukee and Department of Epidemiology L H K, University of Pittsburgh, PA
    Neurology 82:427-34. 2014
    ..1 to 7.7 years later in WHIMS-MRI2...
  54. pmc Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment
    May A Beydoun
    NIH Biomedical Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    J Epidemiol Community Health 65:949-57. 2011
    ..Statin use and serum cholesterol reduction have been proposed as preventions for dementia and mild cognitive impairment (MCI)...
  55. ncbi request reprint Longitudinal changes in cerebral blood flow in the older hypertensive brain
    Lori L Beason-Held
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Stroke 38:1766-73. 2007
    ....
  56. ncbi request reprint The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flow
    Michael A Kraut
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 28:190-7. 2008
    ..The longitudinal increases may reflect cortical compensation mechanisms for reduced efficacy of interregional neural communications that result from white matter deterioration...
  57. ncbi request reprint Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, United States
    Neurobiol Aging 28:914-20. 2007
    ..These findings suggest that endogenous T influences brain physiology in regions critical for memory and attention and provide one mechanism through which T may affect cognitive function...
  58. ncbi request reprint Testosterone and cognition in normal aging and Alzheimer's disease: an update
    Ira Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Curr Alzheimer Res 4:33-45. 2007
    ..In addition, a number of potential explanations of the discrepancy between data obtained in humans and non-human animals are discussed...
  59. pmc Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 36:298-312. 2007
    ..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies...
  60. ncbi request reprint Cortical surface segmentation and mapping
    Duygu Tosun
    Department of Electrical and Computer, Engineering Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 23:S108-18. 2004
    ..Results demonstrating the application of this approach to a study of cortical thickness changes in aging are presented...
  61. pmc Cognitive complaints, depressive symptoms, and cognitive impairment: are they related?
    Timothy J Hohman
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 59:1908-12. 2011
    ..To examine whether concurrent depressive symptoms and self- and informant-reported cognitive impairments are related to cognitive complaints...
  62. ncbi request reprint The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    Clin Trials 1:440-50. 2004
    ....
  63. ncbi request reprint Age differences in orbitofrontal activation: an fMRI investigation of delayed match and nonmatch to sample
    Melissa Lamar
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    Neuroimage 21:1368-76. 2004
    ..Results suggest that OFC recruitment during these cognitive tasks changes with age and should be evaluated within the context of other prefrontal subregions to further define differential age effects on frontal functions...
  64. ncbi request reprint Longitudinal changes in verbal memory in older adults: distinguishing the effects of age from repeat testing
    Melissa Lamar
    National Institute on Aging, Gerontology Research Center, Laboratory of Personality and Cognition, Baltimore, MD 21224, USA
    Neurology 60:82-6. 2003
    ....
  65. pmc Sex differences in resting-state neural correlates of openness to experience among older adults
    Angelina R Sutin
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Cereb Cortex 19:2797-802. 2009
    ..The results challenge the implicit assumption that the same trait will rely on the same neural mechanisms across all who express it...
  66. ncbi request reprint Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilities
    Melissa Lamar
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224 USA
    Neurobiol Aging 25:553-8. 2004
    ..Reasons for this difference in magnitude may stem from differential aging of prefrontal cortex or differential recruitment of alternative brain regions for successful task completion...
  67. ncbi request reprint Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changes
    Susan M Resnick
    Intramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224 6825, USA
    Ann N Y Acad Sci 1121:562-75. 2007
    ..Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes...
  68. pmc Relative equilibrium plot improves graphical analysis and allows bias correction of standardized uptake value ratio in quantitative 11C-PiB PET studies
    Yun Zhou
    Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21287 0807, USA
    J Nucl Med 53:622-8. 2012
    ..The objective of this study was to use a recently developed relative equilibrium-based graphical (RE) plot method to improve and simplify the 2 commonly used methods for quantification of (11)C-Pittsburgh compound B ((11)C-PiB) PET...
  69. pmc Simple paradigm for extra-cerebral tissue removal: algorithm and analysis
    Aaron Carass
    Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 56:1982-92. 2011
    ....
  70. ncbi request reprint Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Clin Endocrinol Metab 87:5001-7. 2002
    ..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men...
  71. ncbi request reprint Effects of age on virtual environment place navigation and allocentric cognitive mapping
    Scott D Moffat
    Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA
    Behav Neurosci 116:851-9. 2002
    ..These findings demonstrate age-related deficits on a laboratory measure of place learning and suggest that deficiencies in allocentric mapping may contribute to these deficits...
  72. ncbi request reprint Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    Irina Mikolaenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neuropathol Exp Neurol 64:156-62. 2005
    ..Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar...
  73. ncbi request reprint Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imaging
    Christos Davatzikos
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cereb Cortex 12:767-71. 2002
    ..To our knowledge, our study is the first documentation of longitudinal age- and region-dependent changes in magnetic resonance signal characteristics of WM fibers, reflecting underlying degenerative effects of aging...
  74. ncbi request reprint Measuring size and shape of the hippocampus in MR images using a deformable shape model
    Dinggang Shen
    Center for Biomedical Image Computing, Department of Radiology, Johns Hokins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuroimage 15:422-34. 2002
    ..97 and algorithm/rater differences statistically equivalent to interrater differences for manual definitions...
  75. pmc In vivo human amyloid imaging
    J Sojkova
    Laboratory of Personality and Cognition, NIH Biomedical Research Center, National Institute on Aging, IRP, Baltimore, MD 21224, USA
    Curr Alzheimer Res 8:366-72. 2011
    ....