Research Topics
Species | Susan M ResnickSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Amyloid imaging and memory change for prediction of cognitive impairmentSusan M Resnick
Laboratory of Behavioral Neuroscience, NIH Biomedical Research Center, National Institute on Aging, IRP, 251 Bayview Blvd, Room 4B335, Baltimore, MD 21224, USA
Alzheimers Res Ther 3:3. 2011....- Longitudinal patterns of β-amyloid deposition in nondemented older adultsJitka Sojkova
Laboratory of Behavioral Neuroscience, National Institutes of Health Biomedical Research Center, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
Arch Neurol 68:644-9. 2011..High levels of β-amyloid (Aβ) characterize Alzheimer disease... - Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and declineMay A Beydoun
National Institute on Aging, NIA NIH IRP, Baltimore, MD 21224, USA
Neurobiol Aging 33:720-731.e4. 2012..While ApoE4(+) status appears to be a sex neutral risk factor for dementia, its association with verbal memory and learning decline and impairment was stronger among women... - Hearing loss and cognition in the Baltimore Longitudinal Study of AgingFrank R Lin
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Neuropsychology 25:763-70. 2011..We hypothesized a priori that greater hearing loss is associated with lower cognitive test scores on tests of memory and executive function... - Intima-media thickness and regional cerebral blood flow in older adultsJitka Sojkova
National Institute on Aging, NIH, Baltimore, MD 21224, USA
Stroke 41:273-9. 2010..Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease... - Neuronal hypertrophy in asymptomatic Alzheimer diseaseDiego Iacono
Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neuropathol Exp Neurol 67:578-89. 2008.... - Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)RICHARD J O'BRIEN
Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Alzheimers Dis 18:665-75. 2009..e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease... - Midlife obesity and trajectories of brain volume changes in older adultsIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Hum Brain Mapp 33:2204-10. 2012..Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences... - Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individualsIra Driscoll
NIH Biomedical Research Center, 251 Bayview Blvd, Suite 100, Baltimore, MD 21224, USA
Neurobiol Aging 32:2123-30. 2011..Consistent with a threshold model of disease, our findings suggest that Aβ load does not seem to affect brain volume changes in individuals without dementia... - Longitudinal changes in cortical thickness associated with normal agingMadhav Thambisetty
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224 2816, USA
Neuroimage 52:1215-23. 2010..Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right... - The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older womenAngelina R Sutin
Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
J Affect Disord 127:241-7. 2010..The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms... - In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adultsJitka Sojkova
National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
Arch Neurol 68:232-40. 2011..In demented older adults, in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid (Aβ). However, the extent of agreement in nondemented older adults remains unclear... - Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of AgeingDavid Dolan
Department of Neurology, Johns Hopkins Bayview Medical Centre, Baltimore, MD 21224, USA
Brain 133:2225-31. 2010..In the most elderly, atherosclerosis also emerged as a cause of dementia in subjects with low Alzheimer's pathology scores. We found no evidence for a significant number of elderly subjects having dementia without an apparent cause... - Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?Jitka Sojkova
National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
J Nucl Med 49:1465-71. 2008.... 
Effects of combination estrogen plus progestin hormone treatment on cognition and affectSusan M Resnick
National Institute on Aging, Baltimore, Maryland 21224 6825, USA
J Clin Endocrinol Metab 91:1802-10. 2006..Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory...- Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaquesIra Driscoll
National Institute on Aging, Baltimore, MD, USA
Acta Neuropathol 124:823-31. 2012..The strong associations of PiB retention with region-matched, quantitative analyses of Aβ in postmortem tissue offer support for the validity of (11)C-PiB-PET imaging as a method for evaluation of plaque burden in vivo... - Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of AgingRebecca F Gottesman
Department of Neurology, Johns Hopkins University School of Medicine, Meyer 6 113, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Gerontol A Biol Sci Med Sci 67:963-9. 2012..We investigated whether lower hemoglobin is associated with regional increases in relative CBF in older individuals, and if these increases occur in watershed regions... - Baseline cardiovascular risk predicts subsequent changes in resting brain functionLori L Beason-Held
Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Stroke 43:1542-7. 2012.... - Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderlyIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 60:688-95. 2006..We investigated whether cognitive trajectories differ between clinically normal elderly individuals with and without AD neuropathology and how they compare with trajectories of clinically impaired individuals before dementia diagnosis... - Effect of infarcts on dementia in the Baltimore longitudinal study of agingJuan C Troncoso
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 64:168-76. 2008..To define the magnitude and mechanism of the effect of brain infarcts on the odds of dementia in a prospective study... - Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomySusan M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland 21224 6825, USA
J Clin Endocrinol Metab 94:4152-61. 2009..We previously reported that conjugated equine estrogens (CEE) with medroxyprogesterone acetate had a negative impact on verbal memory but tended to impact figural memory positively over time in older postmenopausal women... - Morphometry of the human substantia nigra in ageing and Parkinson's diseaseGay Rudow
Neuropathology, Johns Hopkins School of Medicine, Ross Research Building 555, 720 Rutland Avenue, Baltimore, MD 21205, USA
Acta Neuropathol 115:461-70. 2008..Presumably, this compensatory mechanism breaks down or is overwhelmed by the pathological events of PD leading to the onset of the characteristic motor disturbances... - Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neuronsMiguel Angel Riudavets
Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neurobiol Aging 28:1484-92. 2007..This nuclear hypertrophy may represent an early neuronal reaction to Abeta or Tau, or a compensatory mechanism which forestalls the progression of AD and allows the brain to resist the development of dementia... - Subjective cognitive complaints and longitudinal changes in memory and brain functionTimothy J Hohman
Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224
Neuropsychology 25:125-30. 2011..This study examined whether cognitive complaints are associated with longitudinal changes in cognition and cross-sectional differences in regional brain function during memory performance in 98 participants with a mean age of 75... - Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individualsMadhav Thambisetty
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Alzheimers Dis 22:1099-109. 2010..Our strategy combining proteomics with in vivo brain amyloid imaging holds promise for the discovery of biologically relevant peripheral markers in those at risk for AD... - Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging studyVonetta M Dotson
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
J Psychiatry Neurosci 34:367-75. 2009..Our objective was to investigate both cross-sectional and longitudinal relations between sub-threshold depressive symptoms and brain volumes in older adults and to examine whether these associations are modified by age... - Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adultsIra Driscoll
Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America
PLoS ONE 7:e35217. 2012..Together, our findings contribute to furthering the understanding of the relationships between plasma BDNF, structural brain integrity and cognition. Potential mechanisms mediating these relationships merit further investigation... - APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal agingMadhav Thambisetty
Department of Radiology and Radiological Sciences, Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University, Baltimore, Maryland 21224 6825, USA
Arch Neurol 67:93-8. 2010..Design, Setting, and.. - Longitudinal magnetic resonance imaging studies of older adults: a shrinking brainSusan M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
J Neurosci 23:3295-301. 2003.... - Longitudinal study of chronic depressive symptoms and regional cerebral blood flow in older men and womenVonetta M Dotson
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Int J Geriatr Psychiatry 24:809-19. 2009..Additionally, the neural correlates of depression have not been fully explored in men and women separately. This study investigated cross-sectional and longitudinal relationships between SDS and rCBF in older men and women... - Weight change and cognitive function: findings from the Women's Health Initiative Study of Cognitive AgingIra Driscoll
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Obesity (Silver Spring) 19:1595-600. 2011..Relationships were largely independent of initial BMI, self-reported caloric intake or dieting. The lack of associations between weight gain and cognition in women is consistent with the existing literature... - Cortical reconstruction using implicit surface evolution: accuracy and precision analysisDuygu Tosun
Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
Neuroimage 29:838-52. 2006..Parameters were adjusted on the basis of this analysis in order to improve the algorithm's overall performance... - Cross-sectional and longitudinal analyses of anatomical sulcal changes associated with agingMaryam E Rettmann
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Cereb Cortex 16:1584-94. 2006..In addition, we found longitudinal decreases in surface area, mean thickness, GM volume, and sulcal depth measures as well as changes in sulcal curvature... - Age differences in the neural systems supporting human allocentric spatial navigationScott D Moffat
Laboratory of Personality, Cognition and National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Neurobiol Aging 27:965-72. 2006..These results provide evidence of age specific neural networks supporting spatial navigation and identify a putative neural substrate for age-related differences in spatial memory and navigational skill... - Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohortHillary Dolan
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 68:231-40. 2010.... - Program for Assisted Labeling of Sulcal Regions (PALS): description and reliabilityMaryam E Rettmann
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Neuroimage 24:398-416. 2005..Reliability experiments are performed to assess both the long-term stability and short-term repeatability of the proposed techniques. These experiments indicate the proposed methodology gives both highly stable and repeatable results... - Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairmentMadhav Thambisetty
Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA
Neuroimage 59:212-7. 2012..These findings in combination suggest an influence of this multi-functional protein on early stages of progression in AD pathology... - Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adultsVonetta M Dotson
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Am J Geriatr Psychiatry 16:318-30. 2008..This study investigated the effect of concurrent, baseline, and average depressive symptoms on cognitive functioning and decline, and examined the interactive effect of age and depressive symptoms on cognition... - Hearing loss and incident dementiaFrank R Lin
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, JHOC 6120, 601 N Caroline St, Baltimore, MD 21287, USA
Arch Neurol 68:214-20. 2011..To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD)... - Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohortAbhay Moghekar
Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
Alzheimers Dement 8:S71-7. 2012.... - Statins and serum cholesterol's associations with incident dementia and mild cognitive impairmentMay A Beydoun
NIH Biomedical Research Center, National Institute on Aging, Baltimore, MD 21224, USA
J Epidemiol Community Health 65:949-57. 2011..Statin use and serum cholesterol reduction have been proposed as preventions for dementia and mild cognitive impairment (MCI)... - Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly menScott D Moffat
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, United States
Neurobiol Aging 28:914-20. 2007..These findings suggest that endogenous T influences brain physiology in regions critical for memory and attention and provide one mechanism through which T may affect cognitive function... - The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flowMichael A Kraut
Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 28:190-7. 2008..The longitudinal increases may reflect cortical compensation mechanisms for reduced efficacy of interregional neural communications that result from white matter deterioration... - Longitudinal changes in cerebral blood flow in the older hypertensive brainLori L Beason-Held
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
Stroke 38:1766-73. 2007.... - The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive declineSusan M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
Clin Trials 1:440-50. 2004.... - Cognitive complaints, depressive symptoms, and cognitive impairment: are they related?Timothy J Hohman
Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Am Geriatr Soc 59:1908-12. 2011..To examine whether concurrent depressive symptoms and self- and informant-reported cognitive impairments are related to cognitive complaints... - Testosterone and cognition in normal aging and Alzheimer's disease: an updateIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Curr Alzheimer Res 4:33-45. 2007..In addition, a number of potential explanations of the discrepancy between data obtained in humans and non-human animals are discussed... - Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's diseaseYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Neuroimage 36:298-312. 2007..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies... - Cortical surface segmentation and mappingDuygu Tosun
Department of Electrical and Computer, Engineering Johns Hopkins University, Baltimore, MD 21218, USA
Neuroimage 23:S108-18. 2004..Results demonstrating the application of this approach to a study of cortical thickness changes in aging are presented... - Longitudinal changes in verbal memory in older adults: distinguishing the effects of age from repeat testingMelissa Lamar
National Institute on Aging, Gerontology Research Center, Laboratory of Personality and Cognition, Baltimore, MD 21224, USA
Neurology 60:82-6. 2003.... - Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilitiesMelissa Lamar
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224 USA
Neurobiol Aging 25:553-8. 2004..Reasons for this difference in magnitude may stem from differential aging of prefrontal cortex or differential recruitment of alternative brain regions for successful task completion... - Age differences in orbitofrontal activation: an fMRI investigation of delayed match and nonmatch to sampleMelissa Lamar
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
Neuroimage 21:1368-76. 2004..Results suggest that OFC recruitment during these cognitive tasks changes with age and should be evaluated within the context of other prefrontal subregions to further define differential age effects on frontal functions... - Sex differences in resting-state neural correlates of openness to experience among older adultsAngelina R Sutin
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Cereb Cortex 19:2797-802. 2009..The results challenge the implicit assumption that the same trait will rely on the same neural mechanisms across all who express it... - Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changesSusan M Resnick
Intramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224 6825, USA
Ann N Y Acad Sci 1121:562-75. 2007..Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes... 
Temporal relationships between depressive symptoms and white matter hyperintensities in older men and womenVonetta M Dotson
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Int J Geriatr Psychiatry 28:66-74. 2013..Whether depression is an etiology or a consequence of vascular disease is still unknown. We investigated the temporal relationship between depressive symptoms and WMHs in older men and women...- Relative equilibrium plot improves graphical analysis and allows bias correction of standardized uptake value ratio in quantitative 11C-PiB PET studiesYun Zhou
Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21287 0807, USA
J Nucl Med 53:622-8. 2012..The objective of this study was to use a recently developed relative equilibrium-based graphical (RE) plot method to improve and simplify the 2 commonly used methods for quantification of (11)C-Pittsburgh compound B ((11)C-PiB) PET... - Simple paradigm for extra-cerebral tissue removal: algorithm and analysisAaron Carass
Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
Neuroimage 56:1982-92. 2011.... - Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly menScott D Moffat
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging/National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Clin Endocrinol Metab 87:5001-7. 2002..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men... - Alcohol consumption and premotor corpus callosum in older adultsDimitrios Kapogiannis
National Institute on Aging National Institutes of Health NIA NIH, Clinical Research Branch, 3001 South Hanover St, Baltimore, MD 21225, USA
Eur Neuropsychopharmacol 22:704-10. 2012..This finding suggests that even moderate amounts of alcohol may be detrimental to corpus callosum and white matter integrity... - Effects of age on virtual environment place navigation and allocentric cognitive mappingScott D Moffat
Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA
Behav Neurosci 116:851-9. 2002..These findings demonstrate age-related deficits on a laboratory measure of place learning and suggest that deficiencies in allocentric mapping may contribute to these deficits... - Differential trajectories of age-related changes in components of executive and memory processesJoshua O Goh
Laboratory of Behavioral Neuroscience, Intramural Research Project, National Institute on Aging, Bethesda, MD, USA
Psychol Aging 27:707-19. 2012.... - Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)Irina Mikolaenko
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA
J Neuropathol Exp Neurol 64:156-62. 2005..Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar... - Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imagingChristos Davatzikos
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cereb Cortex 12:767-71. 2002..To our knowledge, our study is the first documentation of longitudinal age- and region-dependent changes in magnetic resonance signal characteristics of WM fibers, reflecting underlying degenerative effects of aging... - Measuring size and shape of the hippocampus in MR images using a deformable shape modelDinggang Shen
Center for Biomedical Image Computing, Department of Radiology, Johns Hokins University School of Medicine, Baltimore, Maryland 21287, USA
Neuroimage 15:422-34. 2002..97 and algorithm/rater differences statistically equivalent to interrater differences for manual definitions... - In vivo human amyloid imagingJ Sojkova
Laboratory of Personality and Cognition, NIH Biomedical Research Center, National Institute on Aging, IRP, Baltimore, MD 21224, USA
Curr Alzheimer Res 8:366-72. 2011....