Research Topics
Species | S M ResnickSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Longitudinal magnetic resonance imaging studies of older adults: a shrinking brainSusan M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
J Neurosci 23:3295-301. 2003....
Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processesSuzanne Craft
Department of Psychiatry and Behavioral Sciences, University of Washington, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Seattle, USA
J Gerontol A Biol Sci Med Sci 67:754-9. 2012..These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults...- The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive declineSusan M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
Clin Trials 1:440-50. 2004.... - Effects of combination estrogen plus progestin hormone treatment on cognition and affectSusan M Resnick
National Institute on Aging, Baltimore, Maryland 21224 6825, USA
J Clin Endocrinol Metab 91:1802-10. 2006..Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory... - Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changesSusan M Resnick
Intramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224 6825, USA
Ann N Y Acad Sci 1121:562-75. 2007..Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes... - Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiBS M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, 251 Bayview Blvd BRC Room 4B335, Baltimore, MD 21224 6825, USA
Neurology 74:807-15. 2010..To investigate whether longitudinal declines in cognition are associated with higher fibrillar amyloid-beta (Abeta) deposition in vivo in individuals without dementia... - Effects of hormone replacement therapy on cognitive and brain agingS M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 949:203-14. 2001.... - Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomySusan M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland 21224 6825, USA
J Clin Endocrinol Metab 94:4152-61. 2009..We previously reported that conjugated equine estrogens (CEE) with medroxyprogesterone acetate had a negative impact on verbal memory but tended to impact figural memory positively over time in older postmenopausal women... - Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI StudyS M Resnick
Laboratory of Personality and Cognition, Biomedical Research Center 04B317, Baltimore, MD 21224, USA
Neurology 72:135-42. 2009..To determine whether menopausal hormone therapy (HT) affects regional brain volumes, including hippocampal and frontal regions... - One-year age changes in MRI brain volumes in older adultsS M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224 6825, USA
Cereb Cortex 10:464-72. 2000..Definition of the pattern and rate of longitudinal brain changes will facilitate the detection of pathological brain changes, which may be predictors of dementia... - The relationship between longitudinal declines in dehydroepiandrosterone sulfate concentrations and cognitive performance in older menS D Moffat
Laboratory of Personality and Cognition, National Institute on Aging, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Arch Intern Med 160:2193-8. 2000..In the United States, DHEA is widely available as an over-the-counter supplement that individuals are using in an effort to ameliorate age-related cognitive and physical changes... - Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognitionP M Maki
Laboratory of Personality and Cognition, Gerontology Research Center, NIA NIH, Box 3, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Neurobiol Aging 21:373-83. 2000..Group differences in longitudinal change in rCBF patterns may reflect one way through which hormones modulate brain activity and contribute to enhanced memory performance among ERT users... - Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapyP M Maki
Laboratory of Personality and Cognition, Gerontology Research Center, Baltimore, MD 21224, USA
Am J Psychiatry 158:227-33. 2001..This study examined the effects of hormone-replacement therapy on memory and other cognitive abilities in cognitively intact older women... - I. Longitudinal changes in aging brain functionL L Beason-Held
Laboratory of Personality and Cognition, National Institute on Aging, NIH, NIA LPC, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
Neurobiol Aging 29:483-96. 2008..In view of the stable memory performance, the task-dependent results suggest that age-related changes in brain activity help maintain cognitive function with advancing age... - Longitudinal pattern of regional brain volume change differentiates normal aging from MCII Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Neurology 72:1906-13. 2009..We predict that the regions that show early pathologic changes in association with Alzheimer disease will show accelerated volume loss in mild cognitive impairment (MCI) compared to normal aging... - Verbal and figural recognition memory: task development and age associationsS Golski
Laboratory of Personality and Cognition, Gerontology Research Center, National Institutes on Aging, Baltimore, Maryland 21224 6825, USA
Exp Aging Res 24:359-85. 1998.... - Free testosterone and risk for Alzheimer disease in older menS D Moffat
Laboratory of Personality and Cognition, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
Neurology 62:188-93. 2004..Future research may determine whether higher endogenous free testosterone levels offer protection against a diagnosis of Alzheimer disease in older men... - Voxel-based morphometry using the RAVENS maps: methods and validation using simulated longitudinal atrophyC Davatzikos
Center for Biomedical Image Computing, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Neuroimage 14:1361-9. 2001..Improved sensitivity was achieved at the expense of human effort involved in defining a number of sulcal curves that serve as constraints on the 3D elastic warping... - Effect of a clinical stroke on the risk of dementia in a prospective cohortA Gamaldo
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Neurology 67:1363-9. 2006..Pathologic data indicate that both vascular and Alzheimer pathology leads to the prestroke impairment. CONCLUSION: Dementia after stroke may be determined by cognitive impairments that exist prior to the stroke... - In vivo human amyloid imagingJ Sojkova
Laboratory of Personality and Cognition, NIH Biomedical Research Center, National Institute on Aging, IRP, Baltimore, MD 21224, USA
Curr Alzheimer Res 8:366-72. 2011.... - II. Temporal patterns of longitudinal change in aging brain functionL L Beason-Held
Laboratory of Personality and Cognition, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
Neurobiol Aging 29:497-513. 2008..The precise patterns of regional involvement and the temporal dynamics of rCBF change within specific regions vary based on cognitive processing demands... - Intima-media thickness and regional cerebral blood flow in older adultsJitka Sojkova
National Institute on Aging, NIH, Baltimore, MD 21224, USA
Stroke 41:273-9. 2010..Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease... - Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly menScott D Moffat
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, United States
Neurobiol Aging 28:914-20. 2007..These findings suggest that endogenous T influences brain physiology in regions critical for memory and attention and provide one mechanism through which T may affect cognitive function... - Age differences in spatial memory in a virtual environment navigation taskS D Moffat
Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore MD 21224, USA
Neurobiol Aging 22:787-96. 2001..Performance on the VE navigation task was positively correlated with measures of mental rotation and verbal and visual memory... - Program for Assisted Labeling of Sulcal Regions (PALS): description and reliabilityMaryam E Rettmann
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Neuroimage 24:398-416. 2005..Reliability experiments are performed to assess both the long-term stability and short-term repeatability of the proposed techniques. These experiments indicate the proposed methodology gives both highly stable and repeatable results... - Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's diseaseYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Neuroimage 36:298-312. 2007..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies... - Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly menScott D Moffat
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging/National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Clin Endocrinol Metab 87:5001-7. 2002..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men... - Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging studyVonetta M Dotson
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
J Psychiatry Neurosci 34:367-75. 2009..Our objective was to investigate both cross-sectional and longitudinal relations between sub-threshold depressive symptoms and brain volumes in older adults and to examine whether these associations are modified by age... - No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studiesC A Szekely
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neurology 70:2291-8. 2008..One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is responsible for this apparent reduction in AD risk... - Brain activation during encoding and recognition of verbal and figural information in older adultsL L Beason-Held
Laboratory of Personality and Cognition, National Institute on Aging, NIH, NIA LPC, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
Neurobiol Aging 26:237-50. 2005.... - Effects of estrogen on patterns of brain activity at rest and during cognitive activity: a review of neuroimaging studiesP M Maki
Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21231, USA
Neuroimage 14:789-801. 2001..General procedural guidelines for controlling and investigating hormone effects in neuroimaging studies are discussed... - In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adultsJitka Sojkova
National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
Arch Neurol 68:232-40. 2011..In demented older adults, in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid (Aβ). However, the extent of agreement in nondemented older adults remains unclear... - Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individualsMadhav Thambisetty
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Alzheimers Dis 22:1099-109. 2010..Our strategy combining proteomics with in vivo brain amyloid imaging holds promise for the discovery of biologically relevant peripheral markers in those at risk for AD... - Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adultsVonetta M Dotson
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Am J Geriatr Psychiatry 16:318-30. 2008..This study investigated the effect of concurrent, baseline, and average depressive symptoms on cognitive functioning and decline, and examined the interactive effect of age and depressive symptoms on cognition... - Subjective cognitive complaints and longitudinal changes in memory and brain functionTimothy J Hohman
Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224
Neuropsychology 25:125-30. 2011..This study examined whether cognitive complaints are associated with longitudinal changes in cognition and cross-sectional differences in regional brain function during memory performance in 98 participants with a mean age of 75... - The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older womenAngelina R Sutin
Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
J Affect Disord 127:241-7. 2010..The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms... - Sex differences in resting-state neural correlates of openness to experience among older adultsAngelina R Sutin
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Cereb Cortex 19:2797-802. 2009..The results challenge the implicit assumption that the same trait will rely on the same neural mechanisms across all who express it... - Longitudinal changes in cortical thickness associated with normal agingMadhav Thambisetty
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224 2816, USA
Neuroimage 52:1215-23. 2010..Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right... - Longitudinal study of chronic depressive symptoms and regional cerebral blood flow in older men and womenVonetta M Dotson
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Int J Geriatr Psychiatry 24:809-19. 2009..Additionally, the neural correlates of depression have not been fully explored in men and women separately. This study investigated cross-sectional and longitudinal relationships between SDS and rCBF in older men and women... - APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal agingMadhav Thambisetty
Department of Radiology and Radiological Sciences, Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University, Baltimore, Maryland 21224 6825, USA
Arch Neurol 67:93-8. 2010..Design, Setting, and.. - Testosterone and cognition in normal aging and Alzheimer's disease: an updateIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Curr Alzheimer Res 4:33-45. 2007..In addition, a number of potential explanations of the discrepancy between data obtained in humans and non-human animals are discussed... - Longitudinal changes in verbal memory in older adults: distinguishing the effects of age from repeat testingMelissa Lamar
National Institute on Aging, Gerontology Research Center, Laboratory of Personality and Cognition, Baltimore, MD 21224, USA
Neurology 60:82-6. 2003.... - Longitudinal changes in cerebral blood flow in the older hypertensive brainLori L Beason-Held
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
Stroke 38:1766-73. 2007.... - Age differences in the neural systems supporting human allocentric spatial navigationScott D Moffat
Laboratory of Personality, Cognition and National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Neurobiol Aging 27:965-72. 2006..These results provide evidence of age specific neural networks supporting spatial navigation and identify a putative neural substrate for age-related differences in spatial memory and navigational skill... - Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderlyIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 60:688-95. 2006..We investigated whether cognitive trajectories differ between clinically normal elderly individuals with and without AD neuropathology and how they compare with trajectories of clinically impaired individuals before dementia diagnosis... - Cross-sectional and longitudinal analyses of anatomical sulcal changes associated with agingMaryam E Rettmann
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Cereb Cortex 16:1584-94. 2006..In addition, we found longitudinal decreases in surface area, mean thickness, GM volume, and sulcal depth measures as well as changes in sulcal curvature... - Cortical surface segmentation and mappingDuygu Tosun
Department of Electrical and Computer, Engineering Johns Hopkins University, Baltimore, MD 21218, USA
Neuroimage 23:S108-18. 2004..Results demonstrating the application of this approach to a study of cortical thickness changes in aging are presented... - Accuracy and sensitivity of detection of activation foci in the brain via statistical parametric mapping: a study using a PET simulatorC Davatzikos
Department of Radiology, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, Maryland, 21287, USA
Neuroimage 13:176-84. 2001..The results indicate some limitations of statistical parametric mapping, assist in the correct interpretation of the SPM maps, and point to future research directions in functional image analysis... - Visual memory predicts Alzheimer's disease more than a decade before diagnosisC H Kawas
Alzheimer s Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 60:1089-93. 2003.... - Cortical reconstruction using implicit surface evolution: accuracy and precision analysisDuygu Tosun
Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
Neuroimage 29:838-52. 2006..Parameters were adjusted on the basis of this analysis in order to improve the algorithm's overall performance... - Effect of infarcts on dementia in the Baltimore longitudinal study of agingJuan C Troncoso
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 64:168-76. 2008..To define the magnitude and mechanism of the effect of brain infarcts on the odds of dementia in a prospective study... - The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flowMichael A Kraut
Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 28:190-7. 2008..The longitudinal increases may reflect cortical compensation mechanisms for reduced efficacy of interregional neural communications that result from white matter deterioration... - Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohortHillary Dolan
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 68:231-40. 2010.... - Age differences in orbitofrontal activation: an fMRI investigation of delayed match and nonmatch to sampleMelissa Lamar
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
Neuroimage 21:1368-76. 2004..Results suggest that OFC recruitment during these cognitive tasks changes with age and should be evaluated within the context of other prefrontal subregions to further define differential age effects on frontal functions... - Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilitiesMelissa Lamar
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224 USA
Neurobiol Aging 25:553-8. 2004..Reasons for this difference in magnitude may stem from differential aging of prefrontal cortex or differential recruitment of alternative brain regions for successful task completion... - Effects of age on virtual environment place navigation and allocentric cognitive mappingScott D Moffat
Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA
Behav Neurosci 116:851-9. 2002..These findings demonstrate age-related deficits on a laboratory measure of place learning and suggest that deficiencies in allocentric mapping may contribute to these deficits... - Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of AgeingDavid Dolan
Department of Neurology, Johns Hopkins Bayview Medical Centre, Baltimore, MD 21224, USA
Brain 133:2225-31. 2010..In the most elderly, atherosclerosis also emerged as a cause of dementia in subjects with low Alzheimer's pathology scores. We found no evidence for a significant number of elderly subjects having dementia without an apparent cause... - Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neuronsMiguel Angel Riudavets
Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neurobiol Aging 28:1484-92. 2007..This nuclear hypertrophy may represent an early neuronal reaction to Abeta or Tau, or a compensatory mechanism which forestalls the progression of AD and allows the brain to resist the development of dementia... - Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)RICHARD J O'BRIEN
Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Alzheimers Dis 18:665-75. 2009..e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease... - Morphometry of the human substantia nigra in ageing and Parkinson's diseaseGay Rudow
Neuropathology, Johns Hopkins School of Medicine, Ross Research Building 555, 720 Rutland Avenue, Baltimore, MD 21205, USA
Acta Neuropathol 115:461-70. 2008..Presumably, this compensatory mechanism breaks down or is overwhelmed by the pathological events of PD leading to the onset of the characteristic motor disturbances... - Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)Irina Mikolaenko
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA
J Neuropathol Exp Neurol 64:156-62. 2005..Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar... - Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?Jitka Sojkova
National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
J Nucl Med 49:1465-71. 2008.... - Neuronal hypertrophy in asymptomatic Alzheimer diseaseDiego Iacono
Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neuropathol Exp Neurol 67:578-89. 2008.... - Measuring size and shape of the hippocampus in MR images using a deformable shape modelDinggang Shen
Center for Biomedical Image Computing, Department of Radiology, Johns Hokins University School of Medicine, Baltimore, Maryland 21287, USA
Neuroimage 15:422-34. 2002..97 and algorithm/rater differences statistically equivalent to interrater differences for manual definitions... - Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imagingChristos Davatzikos
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cereb Cortex 12:767-71. 2002..To our knowledge, our study is the first documentation of longitudinal age- and region-dependent changes in magnetic resonance signal characteristics of WM fibers, reflecting underlying degenerative effects of aging... - Hormone therapy and risk of Alzheimer disease: a critical timeSusan M Resnick
JAMA 288:2170-2. 2002 - Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's diseaseEllen Grober
Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
J Int Neuropsychol Soc 14:266-78. 2008..It also supports the view that VIQ as estimated by the AMNART does not decline during the preclinical onset of AD... - Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain functionPauline M Maki
Center for Cognitive Medicine, Neuropsychiatric Institute MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, Illinois 60612, USA
J Clin Endocrinol Metab 92:4107-14. 2007..Recent clinical trials of im testosterone in eugonadal men suggest positive effects on verbal memory, but other studies find no effect... - Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imagingChristos Davatzikos
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurobiol Aging 29:514-23. 2008..Detecting complex patterns of brain abnormality in very early stages of cognitive impairment has pivotal importance for the detection and management of AD... - Morphological classification of brains via high-dimensional shape transformations and machine learning methodsZhiqiang Lao
Section for Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 21:46-57. 2004.... - Association between alcohol intake and domain-specific cognitive function in older womenMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Neuroepidemiology 27:1-12. 2006..However, our observational study cannot rule out confounding associations with unmeasured factors... - Structural and functional biomarkers of prodromal Alzheimer's disease: a high-dimensional pattern classification studyYong Fan
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, PA 19104, USA
Neuroimage 41:277-85. 2008..Detecting complex patterns of brain abnormality in early stages of cognitive impairment has pivotal importance for the detection and management of AD...