S M Resnick

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Neurosci 23:3295-301. 2003
  2. pmc Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes
    Suzanne Craft
    Department of Psychiatry and Behavioral Sciences, University of Washington, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Seattle, USA
    J Gerontol A Biol Sci Med Sci 67:754-9. 2012
  3. ncbi request reprint The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    Clin Trials 1:440-50. 2004
  4. ncbi request reprint Effects of combination estrogen plus progestin hormone treatment on cognition and affect
    Susan M Resnick
    National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 91:1802-10. 2006
  5. ncbi request reprint Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changes
    Susan M Resnick
    Intramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224 6825, USA
    Ann N Y Acad Sci 1121:562-75. 2007
  6. pmc Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB
    S M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, 251 Bayview Blvd BRC Room 4B335, Baltimore, MD 21224 6825, USA
    Neurology 74:807-15. 2010
  7. ncbi request reprint Effects of hormone replacement therapy on cognitive and brain aging
    S M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 949:203-14. 2001
  8. pmc Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 94:4152-61. 2009
  9. pmc Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study
    S M Resnick
    Laboratory of Personality and Cognition, Biomedical Research Center 04B317, Baltimore, MD 21224, USA
    Neurology 72:135-42. 2009
  10. ncbi request reprint One-year age changes in MRI brain volumes in older adults
    S M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224 6825, USA
    Cereb Cortex 10:464-72. 2000

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Neurosci 23:3295-301. 2003
    ....
  2. pmc Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes
    Suzanne Craft
    Department of Psychiatry and Behavioral Sciences, University of Washington, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Seattle, USA
    J Gerontol A Biol Sci Med Sci 67:754-9. 2012
    ..These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults...
  3. ncbi request reprint The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    Clin Trials 1:440-50. 2004
    ....
  4. ncbi request reprint Effects of combination estrogen plus progestin hormone treatment on cognition and affect
    Susan M Resnick
    National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 91:1802-10. 2006
    ..Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory...
  5. ncbi request reprint Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changes
    Susan M Resnick
    Intramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224 6825, USA
    Ann N Y Acad Sci 1121:562-75. 2007
    ..Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes...
  6. pmc Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB
    S M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, 251 Bayview Blvd BRC Room 4B335, Baltimore, MD 21224 6825, USA
    Neurology 74:807-15. 2010
    ..To investigate whether longitudinal declines in cognition are associated with higher fibrillar amyloid-beta (Abeta) deposition in vivo in individuals without dementia...
  7. ncbi request reprint Effects of hormone replacement therapy on cognitive and brain aging
    S M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 949:203-14. 2001
    ....
  8. pmc Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 94:4152-61. 2009
    ..We previously reported that conjugated equine estrogens (CEE) with medroxyprogesterone acetate had a negative impact on verbal memory but tended to impact figural memory positively over time in older postmenopausal women...
  9. pmc Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study
    S M Resnick
    Laboratory of Personality and Cognition, Biomedical Research Center 04B317, Baltimore, MD 21224, USA
    Neurology 72:135-42. 2009
    ..To determine whether menopausal hormone therapy (HT) affects regional brain volumes, including hippocampal and frontal regions...
  10. ncbi request reprint One-year age changes in MRI brain volumes in older adults
    S M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224 6825, USA
    Cereb Cortex 10:464-72. 2000
    ..Definition of the pattern and rate of longitudinal brain changes will facilitate the detection of pathological brain changes, which may be predictors of dementia...
  11. ncbi request reprint The relationship between longitudinal declines in dehydroepiandrosterone sulfate concentrations and cognitive performance in older men
    S D Moffat
    Laboratory of Personality and Cognition, National Institute on Aging, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Arch Intern Med 160:2193-8. 2000
    ..In the United States, DHEA is widely available as an over-the-counter supplement that individuals are using in an effort to ameliorate age-related cognitive and physical changes...
  12. ncbi request reprint Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognition
    P M Maki
    Laboratory of Personality and Cognition, Gerontology Research Center, NIA NIH, Box 3, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 21:373-83. 2000
    ..Group differences in longitudinal change in rCBF patterns may reflect one way through which hormones modulate brain activity and contribute to enhanced memory performance among ERT users...
  13. ncbi request reprint Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy
    P M Maki
    Laboratory of Personality and Cognition, Gerontology Research Center, Baltimore, MD 21224, USA
    Am J Psychiatry 158:227-33. 2001
    ..This study examined the effects of hormone-replacement therapy on memory and other cognitive abilities in cognitively intact older women...
  14. pmc I. Longitudinal changes in aging brain function
    L L Beason-Held
    Laboratory of Personality and Cognition, National Institute on Aging, NIH, NIA LPC, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Neurobiol Aging 29:483-96. 2008
    ..In view of the stable memory performance, the task-dependent results suggest that age-related changes in brain activity help maintain cognitive function with advancing age...
  15. pmc Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
    I Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Neurology 72:1906-13. 2009
    ..We predict that the regions that show early pathologic changes in association with Alzheimer disease will show accelerated volume loss in mild cognitive impairment (MCI) compared to normal aging...
  16. ncbi request reprint Verbal and figural recognition memory: task development and age associations
    S Golski
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institutes on Aging, Baltimore, Maryland 21224 6825, USA
    Exp Aging Res 24:359-85. 1998
    ....
  17. ncbi request reprint Free testosterone and risk for Alzheimer disease in older men
    S D Moffat
    Laboratory of Personality and Cognition, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Neurology 62:188-93. 2004
    ..To investigate the relationships between age-associated decreases in endogenous serum total testosterone (T) and a free T index (FTI) in men and the subsequent development of Alzheimer disease (AD)...
  18. ncbi request reprint Voxel-based morphometry using the RAVENS maps: methods and validation using simulated longitudinal atrophy
    C Davatzikos
    Center for Biomedical Image Computing, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuroimage 14:1361-9. 2001
    ..Improved sensitivity was achieved at the expense of human effort involved in defining a number of sulcal curves that serve as constraints on the 3D elastic warping...
  19. ncbi request reprint Effect of a clinical stroke on the risk of dementia in a prospective cohort
    A Gamaldo
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 67:1363-9. 2006
    ..To examine the risk and determinants of dementia following a clinically overt stroke in a prospectively followed cohort of elderly subjects...
  20. pmc In vivo human amyloid imaging
    J Sojkova
    Laboratory of Personality and Cognition, NIH Biomedical Research Center, National Institute on Aging, IRP, Baltimore, MD 21224, USA
    Curr Alzheimer Res 8:366-72. 2011
    ....
  21. pmc II. Temporal patterns of longitudinal change in aging brain function
    L L Beason-Held
    Laboratory of Personality and Cognition, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Neurobiol Aging 29:497-513. 2008
    ..The precise patterns of regional involvement and the temporal dynamics of rCBF change within specific regions vary based on cognitive processing demands...
  22. pmc Intima-media thickness and regional cerebral blood flow in older adults
    Jitka Sojkova
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Stroke 41:273-9. 2010
    ..Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease...
  23. ncbi request reprint Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, United States
    Neurobiol Aging 28:914-20. 2007
    ..These findings suggest that endogenous T influences brain physiology in regions critical for memory and attention and provide one mechanism through which T may affect cognitive function...
  24. ncbi request reprint Age differences in spatial memory in a virtual environment navigation task
    S D Moffat
    Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore MD 21224, USA
    Neurobiol Aging 22:787-96. 2001
    ..Performance on the VE navigation task was positively correlated with measures of mental rotation and verbal and visual memory...
  25. ncbi request reprint Program for Assisted Labeling of Sulcal Regions (PALS): description and reliability
    Maryam E Rettmann
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neuroimage 24:398-416. 2005
    ..Reliability experiments are performed to assess both the long-term stability and short-term repeatability of the proposed techniques. These experiments indicate the proposed methodology gives both highly stable and repeatable results...
  26. pmc Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 36:298-312. 2007
    ..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies...
  27. ncbi request reprint Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Clin Endocrinol Metab 87:5001-7. 2002
    ..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men...
  28. pmc Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging study
    Vonetta M Dotson
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    J Psychiatry Neurosci 34:367-75. 2009
    ..Our objective was to investigate both cross-sectional and longitudinal relations between sub-threshold depressive symptoms and brain volumes in older adults and to examine whether these associations are modified by age...
  29. pmc No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
    C A Szekely
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 70:2291-8. 2008
    ..One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is responsible for this apparent reduction in AD risk...
  30. ncbi request reprint Brain activation during encoding and recognition of verbal and figural information in older adults
    L L Beason-Held
    Laboratory of Personality and Cognition, National Institute on Aging, NIH, NIA LPC, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Neurobiol Aging 26:237-50. 2005
    ....
  31. ncbi request reprint Effects of estrogen on patterns of brain activity at rest and during cognitive activity: a review of neuroimaging studies
    P M Maki
    Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21231, USA
    Neuroimage 14:789-801. 2001
    ..General procedural guidelines for controlling and investigating hormone effects in neuroimaging studies are discussed...
  32. pmc In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults
    Jitka Sojkova
    National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:232-40. 2011
    ..In demented older adults, in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid (Aβ). However, the extent of agreement in nondemented older adults remains unclear...
  33. pmc Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals
    Madhav Thambisetty
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Alzheimers Dis 22:1099-109. 2010
    ..Our strategy combining proteomics with in vivo brain amyloid imaging holds promise for the discovery of biologically relevant peripheral markers in those at risk for AD...
  34. pmc Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults
    Vonetta M Dotson
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Geriatr Psychiatry 16:318-30. 2008
    ..This study investigated the effect of concurrent, baseline, and average depressive symptoms on cognitive functioning and decline, and examined the interactive effect of age and depressive symptoms on cognition...
  35. pmc Subjective cognitive complaints and longitudinal changes in memory and brain function
    Timothy J Hohman
    Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224
    Neuropsychology 25:125-30. 2011
    ..This study examined whether cognitive complaints are associated with longitudinal changes in cognition and cross-sectional differences in regional brain function during memory performance in 98 participants with a mean age of 75...
  36. pmc The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older women
    Angelina R Sutin
    Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
    J Affect Disord 127:241-7. 2010
    ..The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms...
  37. pmc Sex differences in resting-state neural correlates of openness to experience among older adults
    Angelina R Sutin
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Cereb Cortex 19:2797-802. 2009
    ..The results challenge the implicit assumption that the same trait will rely on the same neural mechanisms across all who express it...
  38. pmc Longitudinal changes in cortical thickness associated with normal aging
    Madhav Thambisetty
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224 2816, USA
    Neuroimage 52:1215-23. 2010
    ..Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right...
  39. pmc Longitudinal study of chronic depressive symptoms and regional cerebral blood flow in older men and women
    Vonetta M Dotson
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Int J Geriatr Psychiatry 24:809-19. 2009
    ..Additionally, the neural correlates of depression have not been fully explored in men and women separately. This study investigated cross-sectional and longitudinal relationships between SDS and rCBF in older men and women...
  40. pmc APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging
    Madhav Thambisetty
    Department of Radiology and Radiological Sciences, Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University, Baltimore, Maryland 21224 6825, USA
    Arch Neurol 67:93-8. 2010
    ..Design, Setting, and..
  41. ncbi request reprint Testosterone and cognition in normal aging and Alzheimer's disease: an update
    Ira Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Curr Alzheimer Res 4:33-45. 2007
    ..In addition, a number of potential explanations of the discrepancy between data obtained in humans and non-human animals are discussed...
  42. ncbi request reprint Longitudinal changes in verbal memory in older adults: distinguishing the effects of age from repeat testing
    Melissa Lamar
    National Institute on Aging, Gerontology Research Center, Laboratory of Personality and Cognition, Baltimore, MD 21224, USA
    Neurology 60:82-6. 2003
    ....
  43. ncbi request reprint Longitudinal changes in cerebral blood flow in the older hypertensive brain
    Lori L Beason-Held
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Stroke 38:1766-73. 2007
    ....
  44. ncbi request reprint Age differences in the neural systems supporting human allocentric spatial navigation
    Scott D Moffat
    Laboratory of Personality, Cognition and National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 27:965-72. 2006
    ..These results provide evidence of age specific neural networks supporting spatial navigation and identify a putative neural substrate for age-related differences in spatial memory and navigational skill...
  45. ncbi request reprint Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly
    Ira Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Neurol 60:688-95. 2006
    ..We investigated whether cognitive trajectories differ between clinically normal elderly individuals with and without AD neuropathology and how they compare with trajectories of clinically impaired individuals before dementia diagnosis...
  46. ncbi request reprint Cross-sectional and longitudinal analyses of anatomical sulcal changes associated with aging
    Maryam E Rettmann
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cereb Cortex 16:1584-94. 2006
    ..In addition, we found longitudinal decreases in surface area, mean thickness, GM volume, and sulcal depth measures as well as changes in sulcal curvature...
  47. ncbi request reprint Cortical surface segmentation and mapping
    Duygu Tosun
    Department of Electrical and Computer, Engineering Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 23:S108-18. 2004
    ..Results demonstrating the application of this approach to a study of cortical thickness changes in aging are presented...
  48. ncbi request reprint Accuracy and sensitivity of detection of activation foci in the brain via statistical parametric mapping: a study using a PET simulator
    C Davatzikos
    Department of Radiology, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, Maryland, 21287, USA
    Neuroimage 13:176-84. 2001
    ..The results indicate some limitations of statistical parametric mapping, assist in the correct interpretation of the SPM maps, and point to future research directions in functional image analysis...
  49. ncbi request reprint Visual memory predicts Alzheimer's disease more than a decade before diagnosis
    C H Kawas
    Alzheimer s Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 60:1089-93. 2003
    ....
  50. ncbi request reprint Cortical reconstruction using implicit surface evolution: accuracy and precision analysis
    Duygu Tosun
    Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Neuroimage 29:838-52. 2006
    ..Parameters were adjusted on the basis of this analysis in order to improve the algorithm's overall performance...
  51. pmc Effect of infarcts on dementia in the Baltimore longitudinal study of aging
    Juan C Troncoso
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 64:168-76. 2008
    ..To define the magnitude and mechanism of the effect of brain infarcts on the odds of dementia in a prospective study...
  52. ncbi request reprint The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flow
    Michael A Kraut
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 28:190-7. 2008
    ..The longitudinal increases may reflect cortical compensation mechanisms for reduced efficacy of interregional neural communications that result from white matter deterioration...
  53. pmc Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort
    Hillary Dolan
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 68:231-40. 2010
    ....
  54. ncbi request reprint Age differences in orbitofrontal activation: an fMRI investigation of delayed match and nonmatch to sample
    Melissa Lamar
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    Neuroimage 21:1368-76. 2004
    ..Results suggest that OFC recruitment during these cognitive tasks changes with age and should be evaluated within the context of other prefrontal subregions to further define differential age effects on frontal functions...
  55. ncbi request reprint Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilities
    Melissa Lamar
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224 USA
    Neurobiol Aging 25:553-8. 2004
    ..Reasons for this difference in magnitude may stem from differential aging of prefrontal cortex or differential recruitment of alternative brain regions for successful task completion...
  56. ncbi request reprint Effects of age on virtual environment place navigation and allocentric cognitive mapping
    Scott D Moffat
    Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA
    Behav Neurosci 116:851-9. 2002
    ..These findings demonstrate age-related deficits on a laboratory measure of place learning and suggest that deficiencies in allocentric mapping may contribute to these deficits...
  57. pmc Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing
    David Dolan
    Department of Neurology, Johns Hopkins Bayview Medical Centre, Baltimore, MD 21224, USA
    Brain 133:2225-31. 2010
    ..In the most elderly, atherosclerosis also emerged as a cause of dementia in subjects with low Alzheimer's pathology scores. We found no evidence for a significant number of elderly subjects having dementia without an apparent cause...
  58. pmc Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons
    Miguel Angel Riudavets
    Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neurobiol Aging 28:1484-92. 2007
    ..This nuclear hypertrophy may represent an early neuronal reaction to Abeta or Tau, or a compensatory mechanism which forestalls the progression of AD and allows the brain to resist the development of dementia...
  59. pmc Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)
    RICHARD J O'BRIEN
    Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Alzheimers Dis 18:665-75. 2009
    ..e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease...
  60. pmc Morphometry of the human substantia nigra in ageing and Parkinson's disease
    Gay Rudow
    Neuropathology, Johns Hopkins School of Medicine, Ross Research Building 555, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Acta Neuropathol 115:461-70. 2008
    ..Presumably, this compensatory mechanism breaks down or is overwhelmed by the pathological events of PD leading to the onset of the characteristic motor disturbances...
  61. ncbi request reprint Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    Irina Mikolaenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neuropathol Exp Neurol 64:156-62. 2005
    ..Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar...
  62. pmc Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?
    Jitka Sojkova
    National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 49:1465-71. 2008
    ....
  63. pmc Neuronal hypertrophy in asymptomatic Alzheimer disease
    Diego Iacono
    Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neuropathol Exp Neurol 67:578-89. 2008
    ....
  64. ncbi request reprint Measuring size and shape of the hippocampus in MR images using a deformable shape model
    Dinggang Shen
    Center for Biomedical Image Computing, Department of Radiology, Johns Hokins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuroimage 15:422-34. 2002
    ..97 and algorithm/rater differences statistically equivalent to interrater differences for manual definitions...
  65. ncbi request reprint Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imaging
    Christos Davatzikos
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cereb Cortex 12:767-71. 2002
    ..To our knowledge, our study is the first documentation of longitudinal age- and region-dependent changes in magnetic resonance signal characteristics of WM fibers, reflecting underlying degenerative effects of aging...
  66. ncbi request reprint Hormone therapy and risk of Alzheimer disease: a critical time
    Susan M Resnick
    JAMA 288:2170-2. 2002
  67. pmc Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
    Ellen Grober
    Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    J Int Neuropsychol Soc 14:266-78. 2008
    ..It also supports the view that VIQ as estimated by the AMNART does not decline during the preclinical onset of AD...
  68. ncbi request reprint Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain function
    Pauline M Maki
    Center for Cognitive Medicine, Neuropsychiatric Institute MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 92:4107-14. 2007
    ..Recent clinical trials of im testosterone in eugonadal men suggest positive effects on verbal memory, but other studies find no effect...
  69. pmc Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging
    Christos Davatzikos
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 29:514-23. 2008
    ..Detecting complex patterns of brain abnormality in very early stages of cognitive impairment has pivotal importance for the detection and management of AD...
  70. ncbi request reprint Morphological classification of brains via high-dimensional shape transformations and machine learning methods
    Zhiqiang Lao
    Section for Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 21:46-57. 2004
    ....
  71. ncbi request reprint Association between alcohol intake and domain-specific cognitive function in older women
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuroepidemiology 27:1-12. 2006
    ..However, our observational study cannot rule out confounding associations with unmeasured factors...
  72. pmc Structural and functional biomarkers of prodromal Alzheimer's disease: a high-dimensional pattern classification study
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, PA 19104, USA
    Neuroimage 41:277-85. 2008
    ..Detecting complex patterns of brain abnormality in early stages of cognitive impairment has pivotal importance for the detection and management of AD...