E F Remmers

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    BMC Proc 3:S2. 2009
  2. pmc Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
  3. pmc Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    Nat Genet 42:698-702. 2010
  4. ncbi request reprint An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Transplant Proc 31:1549-54. 1999
  5. ncbi request reprint Application of interval haplotype analysis facilitates efficient mapping of the mutation causing osteopetrosis in tl rats
    Elaine F Remmers
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 9000 Rockville Pike, Building 10 Room 9N228, Bethesda, MD 20892, USA
    Mamm Genome 13:299-301. 2002
  6. ncbi request reprint Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland20892, USA
    Arthritis Rheum 46:2225-34. 2002
  7. ncbi request reprint Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases
    R L Wilder
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplant Proc 31:1585-8. 1999
  8. ncbi request reprint An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains
    S V Dracheva
    The Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Genomics 63:202-26. 2000
  9. ncbi request reprint Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats
    S V Dracheva
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, 10 Center Drive MSC 1820, Bethesda, MD 20892, USA
    Immunogenetics 49:787-91. 1999
  10. ncbi request reprint Linkage map of seven polymorphic markers on rat chromosome 18
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 4:265-70. 1993

Detail Information

Publications61

  1. pmc Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    BMC Proc 3:S2. 2009
    ..Several questions could be addressed using the data, including analysis of genetic associations using single SNPs or haplotypes, as well as gene-gene and genetic analysis of SNPs for qualitative and quantitative factors...
  2. pmc Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
    ....
  3. pmc Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    Nat Genet 42:698-702. 2010
    ..34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production...
  4. ncbi request reprint An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Transplant Proc 31:1549-54. 1999
  5. ncbi request reprint Application of interval haplotype analysis facilitates efficient mapping of the mutation causing osteopetrosis in tl rats
    Elaine F Remmers
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 9000 Rockville Pike, Building 10 Room 9N228, Bethesda, MD 20892, USA
    Mamm Genome 13:299-301. 2002
  6. ncbi request reprint Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland20892, USA
    Arthritis Rheum 46:2225-34. 2002
    ..In the present study, we sought to characterize the independent arthritis-modulating effects of these 5 QTLs...
  7. ncbi request reprint Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases
    R L Wilder
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplant Proc 31:1585-8. 1999
  8. ncbi request reprint An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains
    S V Dracheva
    The Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Genomics 63:202-26. 2000
    ..Two hundred forty genes are incorporated in the map. This integrated map should allow comparison of rat genetic maps from different groups and thereby facilitate genetic studies of rat autoimmune and related disease models...
  9. ncbi request reprint Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats
    S V Dracheva
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, 10 Center Drive MSC 1820, Bethesda, MD 20892, USA
    Immunogenetics 49:787-91. 1999
    ....
  10. ncbi request reprint Linkage map of seven polymorphic markers on rat chromosome 18
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 4:265-70. 1993
    ..However, genes associated with these markers have been mapped to three different human chromosomes (Chrs 5, 6, and 18). The markers described here should be useful for genetic mapping studies and genetic monitoring of inbred rat strains...
  11. ncbi request reprint Genetic dissection of collagen-induced arthritis in Chromosome 10 quantitative trait locus speed congenic rats: evidence for more than one regulatory locus and sex influences
    B Joe
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Immunogenetics 51:930-44. 2000
    ..Regulatory loci for multiple autoimmune/inflammatory diseases in rats (RNO10), mice (MMU11), and humans (HSA17 and HSA5q23-q31) map to chromosomal segments homologous to Cia5 and Cia5a...
  12. ncbi request reprint Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci
    T Furuya
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1820, USA
    Hum Mol Genet 9:2241-50. 2000
    ..Our data support the view that multiple autoimmune diseases may share genetic risk factors, and suggest that many of these loci are gender influenced...
  13. ncbi request reprint A single linkage group comprising 11 polymorphic DNA markers on rat chromosome 3
    H Zha
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 5:538-41. 1994
    ..Chromosomal syntenic conservation among rats, mice and humans is also discussed...
  14. ncbi request reprint Polymorphisms of the tumor necrosis factor receptor type 1 locus among autoimmune susceptible and resistant inbred rat strains
    T Furuya
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 9000 Rockville Pike, Building 10, Room 9N228, Bethesda, MD 20892 1820, USA
    Immunogenetics 53:427-9. 2001
  15. ncbi request reprint Genetic maps of polymorphic DNA loci on rat chromosome 1
    Y P Ding
    Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:320-7. 1996
    ..Homologs of the rat chromosome 1 genes that we mapped are located on human chromosomes 6, 10, 11, 12, 15, 16, and 19...
  16. ncbi request reprint Linkage map of 10 polymorphic markers on rat chromosome 2
    H Zha
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
    Cytogenet Cell Genet 63:117-23. 1993
    ..Comparative gene mapping analysis indicated that a portion of the mapped region of rat chromosome 2 exhibits synteny conservation with regions of human chromosome 1 and mouse Chromosome 3...
  17. ncbi request reprint Linkage map of nine loci defined by polymorphic DNA markers assigned to rat chromosome 13
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 18:277-82. 1993
    ..An examination of human and mouse comparative map information for all loci assigned to rat chromosome 13 shows significant synteny conservation with the q arm of human chromosome 1 and the distal portion of mouse chromosome 1...
  18. ncbi request reprint Map of seven polymorphic markers on rat chromosome 14: linkage conservation with human chromosome 4
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 4:90-4. 1993
    ..These polymorphic markers should be useful in genetic linkage studies of important phenotypes in rats...
  19. ncbi request reprint Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases
    Y Kawahito
    The Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 1820, USA
    J Immunol 161:4411-9. 1998
    ..The rat models appear to provide a powerful complementary approach to identify and characterize candidate genes that may contribute to autoimmune diseases in several species...
  20. ncbi request reprint Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function?
    R L Wilder
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 917:784-96. 2000
    ..These initial data, however, indicate that the genetic control of the autoimmune disease traits is highly complex...
  21. ncbi request reprint Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
    P S Gulko
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 41:2122-31. 1998
    ..To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type II collagen-induced arthritis (CIA)...
  22. ncbi request reprint Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats
    S H Sun
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA
    Int Immunol 11:529-34. 1999
    ..Further analysis of these genomic regions may lead to identification of the susceptibility genes and to characterization of their function...
  23. ncbi request reprint Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5
    E A Goldmuntz
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 4:670-5. 1993
    ..These markers, located on rat Chr 5, will be useful in genetic studies of inbred rats...
  24. ncbi request reprint Genetic mapping of the athymic nude (RNU) locus in the rat to a region on chromosome 10
    J M Cash
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 4:37-42. 1993
    ..The position of the RNU locus in the rat corresponds closely with that of the recently reported nu locus in the mouse. This finding suggests that the nude phenotype in the rat and the mouse arise from defects in homologous genes...
  25. ncbi request reprint A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Genet 14:82-5. 1996
    ..These genes may also represent novel targets for therapy...
  26. ncbi request reprint Genetic factors involved in central nervous system/immune interactions
    R L Wilder
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Adv Exp Med Biol 493:59-67. 2001
    ..Further genetic dissection and identification of the underlying genes will be necessary to infer a mechanistic link between autoimmune and neuroendocrine traits...
  27. ncbi request reprint Genomic cloning and genetic mapping of the rat Nramp1 (Bcg) gene on chromosome 9
    L Ge
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Mamm Genome 7:856-7. 1996
  28. ncbi request reprint Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains
    T Furuya
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 9000 Rockville Pike, Building 10, Room 9N240, Bethesda, MD 20892, USA
    Genes Immun 2:229-32. 2001
    ..These polymorphisms may serve as good candidates for analysis of TNF expression to elucidate the mechanism(s) by which the MHC regulates susceptibility and/or severity of autoimmune diseases...
  29. ncbi request reprint Evaluation of quantitative trait loci regulating severity of mycobacterial adjuvant-induced arthritis in monocongenic and polycongenic rats: identification of a new regulatory locus on rat chromosome 10 and evidence of overlap with rheumatoid arthritis su
    Bina Joe
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:1075-85. 2002
    ..To evaluate the regulatory potential of genetic loci controlling Mycobacterium butyricum adjuvant-induced arthritis (Mbt-AIA) using mono- and polycongenic rats...
  30. doi request reprint Variant form of STAT4 is associated with primary Sjögren's syndrome
    B D Korman
    Complex Disease Genetics Unit, Genetics and Genomics Branch, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, Bethesda, MD 20892, USA
    Genes Immun 9:267-70. 2008
    ..6%) than in controls (22.3%), leading to a P-value for association of 0.01. These results implicate polymorphisms in the STAT4 gene in the pathogenesis of pSS...
  31. ncbi request reprint De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:3340-8. 2002
    ....
  32. pmc Clinical features and functional significance of the P369S/R408Q variant in pyrin, the familial Mediterranean fever protein
    J G Ryan
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Building 10, Magnuson Clinical Center, 10C101C, Bethesda, Maryland 20892, USA
    Ann Rheum Dis 69:1383-8. 2010
    ..The aim was to characterise the phenotype of patients with these substitutions and to determine their functional significance...
  33. ncbi request reprint The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12
    H Zha
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 37:386-9. 1996
    ..The mouse and human homologs of this gene were localized on mouse chromosome 5 and human chromosome 7 by linkage analysis and chromosomal in situ hybridization, respectively...
  34. ncbi request reprint Genetic map of nine polymorphic loci comprising a single linkage group on rat chromosome 10: evidence for linkage conservation with human chromosome 17 and mouse chromosome 11
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 14:618-23. 1992
    ..Comparative gene mapping analysis indicated that this region of rat chromosome 10 exhibits linkage conservation with regions of human chromosome 17 and mouse chromosome 11...
  35. ncbi request reprint Analysis of CARD15/NOD2 haplotypes fails to identify common variants associated with rheumatoid arthritis susceptibility
    A Addo
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 0908, USA
    Scand J Rheumatol 34:198-203. 2005
    ..In this study we sought to determine whether CD-associated mutations or any common variants of this gene might contribute to susceptibility to another chronic inflammatory disease, rheumatoid arthritis (RA)...
  36. ncbi request reprint The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model
    Ivona Aksentijevich
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:1273-85. 2007
    ..This study was undertaken to investigate the structural effect of disease-causing mutations on cryopyrin, in order to gain better understanding of the impact of disease-associated mutations on protein function...
  37. pmc Common genetic determinants of uveitis shared with other autoimmune disorders
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA
    J Immunol 180:6751-9. 2008
    ..Our results suggest that uveitis shares some of the pathogenic mechanisms associated with other autoimmune diseases, and lends support to the "common gene, common pathway" hypothesis for autoimmune disorders...
  38. pmc STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    N Engl J Med 357:977-86. 2007
    ..Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q...
  39. pmc Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors
    Anelia Horvath
    Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 10 Center Drive, CRC, Room 1 3330, Bethesda, MD 20892, USA
    Cancer Res 69:5301-6. 2009
    ..In conclusion, we report that PDE11A-inactivating sequence variants may modify the risk of familial and bilateral TGCT...
  40. ncbi request reprint Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population
    Anelia Horvath
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Resources, NIH, Bethesda, MD 20892, USA
    Cancer Res 66:11571-5. 2006
    ..We speculate that PDE11A genetic defects may be associated with adrenal pathology in a wider than previously suspected clinical spectrum that includes asymptomatic individuals...
  41. ncbi request reprint Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat
    David E Dobbins
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Biochem Biophys Res Commun 294:1114-20. 2002
    ..These data suggest that osteopetrosis develops in tl/tl rats because they cannot produce functional mCsf, a growth factor required for osteoclast differentiation and activation...
  42. pmc Familial Mediterranean fever with a single MEFV mutation: where is the second hit?
    Matthew G Booty
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 60:1851-61. 2009
    ..The purpose of this study was to perform an extensive search for a second MEFV mutation in 46 patients diagnosed clinically as having FMF and carrying only 1 high-penetrance FMF mutation...
  43. pmc STAT4: genetics, mechanisms, and implications for autoimmunity
    Benjamin D Korman
    National Institute of Arthritis, Musculoskeletal, and Skin Diseases, 9 Memorial Drive, NIH Building 9, Room 1W108, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 8:398-403. 2008
    ..In concert with the identification of other disease-associated loci, elucidating how the variant form of STAT4 modulates immune function should lead to an improved understanding of the pathophysiology of autoimmunity...
  44. pmc The chromosome 7q region association with rheumatoid arthritis in females in a British population is not replicated in a North American case-control series
    Benjamin D Korman
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892 1849, USA
    Arthritis Rheum 60:47-52. 2009
    ..We sought to replicate this finding and to better characterize susceptibility alleles in the region in a North American population...
  45. ncbi request reprint Localization of the mutation responsible for osteopetrosis in the op rat to a 1.5-cM genetic interval on rat chromosome 10: identification of positional candidate genes by radiation hybrid mapping
    David E Dobbins
    Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Bone Miner Res 17:1761-7. 2002
    ....
  46. ncbi request reprint Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
    J Rheumatol 18:7-13. 1991
    ....
  47. pmc An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    N Engl J Med 360:2426-37. 2009
    ..We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement of skin and bone...
  48. ncbi request reprint The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis
    Max Brenner
    Laboratory of Experimental Rheumatology, Robert S Boas Center for Genomics and Human Genetics and Graduate School of Molecular Medicine, North Shore Long Island Jewish LIJ Research Institute, Manhasset, NY 11030, USA
    J Immunol 174:7894-903. 2005
    ..These loci are syntenic to regions on human chromosomes 17q and 5q implicated in the susceptibility to rheumatoid arthritis, suggesting that the identification of these genes will be relevant to human disease...
  49. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  50. ncbi request reprint Identification of two novel female-specific non-major histocompatibility complex loci regulating collagen-induced arthritis severity and chronicity, and evidence of epistasis
    Hsiang Chi Meng
    North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Arthritis Rheum 50:2695-705. 2004
    ....
  51. ncbi request reprint Genomic regions controlling corticosterone levels in rats
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 55:634-41. 2004
    ..The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness...
  52. pmc Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4
    Robert M Plenge
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Am J Hum Genet 77:1044-60. 2005
    ....
  53. pmc Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus
    Hye Soon Lee
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, United States of America
    Mol Med 14:293-300. 2008
    ..These data emphasize that further analysis of the MHC is likely to reveal genetic risk factors for rheumatoid arthritis that are independent of the DRB1 shared epitope alleles...
  54. ncbi request reprint Mutational analysis in neonatal-onset multisystem inflammatory disease: comment on the articles by Frenkel et al and Saito et al
    Ivona Aksentijevich
    Arthritis Rheum 54:2703-4; author reply 2704-5. 2006
  55. ncbi request reprint The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage
    Max Brenner
    Laboratory of Experimental Rheumatology, R S Boas Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Arthritis Rheum 52:322-32. 2005
    ....
  56. pmc TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
    Robert M Plenge
    Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA
    N Engl J Med 357:1199-209. 2007
    ..We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis...
  57. pmc Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus
    Kimberly E Taylor
    Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, California, USA
    PLoS Genet 4:e1000084. 2008
    ..We conclude that this common polymorphism of STAT4 contributes to the phenotypic heterogeneity of SLE, predisposing specifically to more severe disease...
  58. ncbi request reprint Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles
    Patricia Irigoyen
    North Shore Long Island Jewish Institute for Medical Research, Manhasset, New York 11030, USA
    Arthritis Rheum 52:3813-8. 2005
    ..To examine the association between HLA-DRB1 alleles and the production of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) autoantibodies in patients with rheumatoid arthritis (RA)...
  59. ncbi request reprint The functional -169T-->C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans
    Xiaolan Hu
    Celera Diagnostics, Alameda, CA
    Arthritis Rheum 54:1022-5. 2006
  60. pmc Association of STAT4 with rheumatoid arthritis in the Korean population
    Hye Soon Lee
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    Mol Med 13:455-60. 2007
    ....
  61. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...