A T Remaley

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Antiatherogenic functionality of high density lipoprotein: how much versus how good
    Dmitri Sviridov
    Baker Heart Research Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Atheroscler Thromb 15:52-62. 2008
  2. pmc Diverse range of small peptides associated with high-density lipoprotein
    Glen L Hortin
    Department of Laboratory Medicine, National Institutes of Health, Building 10, Room 2C 407, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 340:909-15. 2006
  3. ncbi request reprint The role of exercise in modulating the impact of an ultralow-fat diet on serum lipids and apolipoproteins in patients with or at risk for coronary artery disease
    Debra A Marshall
    Walter Reed Army Medical Center Cardiology Service, Washington, DC 20307 5001, USA
    Am Heart J 151:484-91. 2006
  4. doi request reprint High-density lipoprotein: what is the best way to measure its antiatherogenic potential?
    Alan T Remaley
    National Institute of Health, National Heart, Lung and Blood Institute, Lipoprotein Metabolism Section, Pulmonary and Vascular Medicine Branch, Building 10, Room 2C 433, 10 Center Dr, Bethesda, MD 20892, USA 1 301 402 9796 1 301 402 1885
    Expert Opin Med Diagn 2:773-88. 2008
  5. ncbi request reprint Prevalence-value-accuracy plots: a new method for comparing diagnostic tests based on misclassification costs
    A T Remaley
    National Institutes of Health, Clinical Center, Clinical Pathology Department, Bethesda, MD 20892, USA
    Clin Chem 45:934-41. 1999
  6. ncbi request reprint Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway
    Alan T Remaley
    National Institutes of Health Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Lipid Res 44:828-36. 2003
  7. ncbi request reprint Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster
    Alan T Remaley
    National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10 2C 433, 10 Center Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 295:276-82. 2002
  8. ncbi request reprint Apolipoprotein specificity for lipid efflux by the human ABCAI transporter
    A T Remaley
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20982, USA
    Biochem Biophys Res Commun 280:818-23. 2001
  9. ncbi request reprint Cellular localization and trafficking of the human ABCA1 transporter
    E B Neufeld
    NHLBI, National Institutes of Health and the NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:27584-90. 2001
  10. ncbi request reprint Regulation and intracellular trafficking of the ABCA1 transporter
    S Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 42:1339-45. 2001

Detail Information

Publications54

  1. ncbi request reprint Antiatherogenic functionality of high density lipoprotein: how much versus how good
    Dmitri Sviridov
    Baker Heart Research Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Atheroscler Thromb 15:52-62. 2008
    ..A single common denominator reflecting the multiple HDL functions is yet to be found and may not exist leaving direct measurements of each HDL function as the way to assess atheroprotective capacity of HDL...
  2. pmc Diverse range of small peptides associated with high-density lipoprotein
    Glen L Hortin
    Department of Laboratory Medicine, National Institutes of Health, Building 10, Room 2C 407, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 340:909-15. 2006
    ..It is unclear whether the peptides have any significant functional role as apolipopeptides, but they may represent a pathway for peptide delivery or scavenging and a significant reservoir of plasma peptides for diagnostic evaluation...
  3. ncbi request reprint The role of exercise in modulating the impact of an ultralow-fat diet on serum lipids and apolipoproteins in patients with or at risk for coronary artery disease
    Debra A Marshall
    Walter Reed Army Medical Center Cardiology Service, Washington, DC 20307 5001, USA
    Am Heart J 151:484-91. 2006
    ..In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and HDL-C levels were examined to determine whether exercise moderates this dietary effect on serum lipids and apolipoproteins...
  4. doi request reprint High-density lipoprotein: what is the best way to measure its antiatherogenic potential?
    Alan T Remaley
    National Institute of Health, National Heart, Lung and Blood Institute, Lipoprotein Metabolism Section, Pulmonary and Vascular Medicine Branch, Building 10, Room 2C 433, 10 Center Dr, Bethesda, MD 20892, USA 1 301 402 9796 1 301 402 1885
    Expert Opin Med Diagn 2:773-88. 2008
    ..New methods for the subfractionation of HDL and new compositional and functional tests for HDL that show promise in improving CHD risk prediction are also be discussed...
  5. ncbi request reprint Prevalence-value-accuracy plots: a new method for comparing diagnostic tests based on misclassification costs
    A T Remaley
    National Institutes of Health, Clinical Center, Clinical Pathology Department, Bethesda, MD 20892, USA
    Clin Chem 45:934-41. 1999
    ....
  6. ncbi request reprint Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway
    Alan T Remaley
    National Institutes of Health Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Lipid Res 44:828-36. 2003
    ..In addition, unlike apoA-I, synthetic peptides can also efflux lipid by a passive, energy-independent pathway that does not involve ABCA1 but does depend upon their lipid affinity...
  7. ncbi request reprint Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster
    Alan T Remaley
    National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10 2C 433, 10 Center Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 295:276-82. 2002
    ..In summary, several potential regulatory elements were found for the ABCG5 and ABCG8 genes, and the intergenic region was found to act as a bidirectional promoter...
  8. ncbi request reprint Apolipoprotein specificity for lipid efflux by the human ABCAI transporter
    A T Remaley
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20982, USA
    Biochem Biophys Res Commun 280:818-23. 2001
    ..In summary, ABCAI-mediated cellular binding of apolipoproteins and lipid efflux is not specific for only apoA-I but can also occur with other apolipoproteins that contain multiple amphipathic helical domains...
  9. ncbi request reprint Cellular localization and trafficking of the human ABCA1 transporter
    E B Neufeld
    NHLBI, National Institutes of Health and the NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:27584-90. 2001
    ..These studies establish a complex intracellular trafficking pathway for human ABCA1 that may play important roles in modulating ABCA1 transporter activity and cellular cholesterol homeostasis...
  10. ncbi request reprint Regulation and intracellular trafficking of the ABCA1 transporter
    S Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 42:1339-45. 2001
    ..Given the key role that ABCA1 plays in cholesterol homeostasis, it is likely that there are multiple mechanisms for controlling the overall transporter activity of ABCA1...
  11. pmc ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
    B L Vaisman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1666, USA
    J Clin Invest 108:303-9. 2001
    ..Similar metabolic changes may modify atherogenic risk in humans...
  12. pmc Helix stabilization of amphipathic peptides by hydrocarbon stapling increases cholesterol efflux by the ABCA1 transporter
    D O Sviridov
    Lipoprotein Metabolism Section, Cardiopulmonary Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Biochem Biophys Res Commun 410:446-51. 2011
    ....
  13. pmc Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred
    A T Remaley
    National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:12685-90. 1999
    ..These results will be useful in the future characterization of the structure and function of the ABC1 gene and the analysis of additional ABC1 mutations in patients with Tangier disease...
  14. ncbi request reprint Triple lipid screening test: a homogeneous sequential assay for HDL-cholesterol, total cholesterol, and triglycerides
    M L Sampson
    Clinical Chemistry Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Chem 47:532-9. 2001
    ..04x - 0.28 (R = 0.980). CONCLUSIONS: The TLS test is a single-tube homogeneous assay for the analysis of all of the major serum lipoprotein fractions and can be used as a simple screening test for the detection of hyperlipidemia...
  15. ncbi request reprint Increased levothyroxine requirements presenting as "inappropriate" TSH secretion syndrome in a patient with nephrotic syndrome
    M T Collins
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Endocrinol Invest 23:383-92. 2000
    ..This pattern of extreme dysregulation in thyroid function indices due to urinary loss of thyroid hormones has not been previously described in NS, and, therefore, extends the spectrum of endocrine manifestations of NS...
  16. ncbi request reprint A case of spurious hypercalcitoninemia: a cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia
    G I Uwaifo
    Developmental Endocrinology Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Endocrinol Invest 24:361-9. 2001
    ..Finally, the assay selected should detect only the mature CT molecule...
  17. ncbi request reprint The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man
    Z Orban
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 84:2126-33. 1999
    ..The regulations of adipose leptin, TNF alpha, and IL-6 secretion seem distinct from each other and different in the fed vs. fasting state...
  18. ncbi request reprint Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice
    G Lambert
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:15090-8. 2001
    ....
  19. ncbi request reprint Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer
    Raffit Hassan
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 12:447-53. 2006
    ..To determine whether mesothelin, a cell surface protein highly expressed in mesothelioma and ovarian cancer, is shed into serum and if so to accurately measure it...
  20. ncbi request reprint ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis
    Charles W Joyce
    Molecular Disease Section, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 281:33053-65. 2006
    ....
  21. ncbi request reprint Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity
    Marianna Müller
    National Medical Center, Institute of Haematology and Immunology, Membrane Research Group of the Hungarian Academy of Sciences, H 1113 Budapest, Hungary
    FEBS Lett 580:6139-44. 2006
    ..Our results provide a new aspect of biochemical and functional characterization of the ABCG5/ABCG8 proteins and their possible involvement in steroid hormone transport or regulation...
  22. ncbi request reprint Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited
    Federica Basso
    Molecular Disease Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 48:114-26. 2007
    ..These findings identify distinct roles for liver and intestinal ABCG5/G8 in modulating sterol metabolism and atherosclerosis...
  23. pmc Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet
    Federica Basso
    Lipoprotein Metabolism Section, NHLBI, NIH, 10 Center Drive, 7N102, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 351:398-404. 2006
    ..2-fold) were also increased in ABCG1xLDLr-KO mice. In summary, these findings suggest that enhanced expression of ABCG1 increases atherosclerosis in LDLr-KO mice, despite its role in promoting cholesterol efflux from cells...
  24. ncbi request reprint Human lecithin:cholesterol acyltransferase deficiency: in vivo kinetics of low-density lipoprotein and lipoprotein-X
    Masato Nishiwaki
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Arterioscler Thromb Vasc Biol 26:1370-5. 2006
    ..In addition, the mechanism(s) for LpX accumulation is not known. The aim of the present study is to elucidate the mechanism(s) responsible for the low LDL and determine the plasma kinetics of LpX in LCAT-def...
  25. ncbi request reprint Apolipoprotein AI mimetic peptides: possible new agents for the treatment of atherosclerosis
    Amar A Sethi
    National Institutes of Health, Lipoprotein Metabolism Section, Vascular Medicine Branch, National Heart, Lung and Blood Institute, Bldg 10, Room 7N 115, 10 Center Drive, Bethesda, MD 20892 1508, USA
    Curr Opin Investig Drugs 8:201-12. 2007
    ..This review focuses on apolipoprotein AI mimetic peptides, which are currently being explored as therapeutic agents for a new treatment strategy known as acute HDL therapy...
  26. ncbi request reprint Old drug, new tricks: the unexpected effect of doxazosin on high-density lipoprotein
    Alan T Remaley
    Circ Res 101:116-8. 2007
  27. ncbi request reprint The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux
    Nigora Mukhamedova
    Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008 Australia
    Biochemistry 46:9388-98. 2007
    ..We conclude that a site on the first extracellular loop is required for cholesterol efflux, whereas a site on the fourth extracellular loop may be responsible for ABCA1 stability...
  28. ncbi request reprint Gynecologic and hormonal effects of raloxifene in premenopausal women
    Ahalya Premkumar
    Department of Diagnostic Radiology, Warren G Magnuson Clinical Center, Bethesda, Maryland, USA
    Fertil Steril 88:1637-44. 2007
    ..To assess the effects of raloxifene on the ovaries, uterus, and serum hormone levels in premenopausal women...
  29. ncbi request reprint Anti-inflammatory and cardioprotective activities of synthetic high-density lipoprotein containing apolipoprotein A-I mimetic peptides
    Monica Gomaraschi
    National Institutes of Health, 10 Center Dr, Bldg 10 Rm 2C 433, Bethesda, MD 20892, USA
    J Pharmacol Exp Ther 324:776-83. 2008
    ....
  30. doi request reprint High-density lipoprotein reduces the human monocyte inflammatory response
    Andrew J Murphy
    Laboratories of Vascular Pharmacology, Research Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 28:2071-7. 2008
    ..Whereas the anti-inflammatory effects of high-density lipoprotein (HDL) on endothelial cells are well described, such effects on monocytes are less studied...
  31. ncbi request reprint Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1
    Tatyana G Vishnyakova
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:22771-80. 2003
    ..In summary, Cla-1 was found to bind and internalize monomerized and HDL-associated LPS, indicating that Cla-1 may play important role in septic shock by affecting LPS cellular uptake and clearance...
  32. ncbi request reprint Controlled study of citrate effects and response to i.v. calcium administration during allogeneic peripheral blood progenitor cell donation
    Charles D Bolan
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892 1184, USA
    Transfusion 42:935-46. 2002
    ..However, neither the metabolic effects nor the management of associated symptoms have been critically evaluated during leukapheresis in healthy donors...
  33. ncbi request reprint Phosphorylation and stabilization of ATP binding cassette transporter A1 by synthetic amphiphilic helical peptides
    Reijiro Arakawa
    Biochemistry, Cell Biology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8 601, Japan
    J Biol Chem 279:6217-20. 2004
    ..We thus concluded that an amphiphilic helical motif is the minimum structural requirement for a protein to stabilize ABCA1 against proteolytic degradation...
  34. ncbi request reprint The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease
    Edward B Neufeld
    Molecular Disease Branch, NHLBI, NHLBI Light Microscopy Core Facility, and Laboratory for Cellular Biology and Biochemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:15571-8. 2004
    ..The combined results of this study suggest that ABCA1 converts pools of late endocytic lipids that retain NPC1 to pools that can associate with endocytosed apoA-I, and be released from the cell as nascent high density lipoprotein...
  35. ncbi request reprint The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter
    Lita A Freeman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 45:1197-206. 2004
    ....
  36. ncbi request reprint Targeting of scavenger receptor class B type I by synthetic amphipathic alpha-helical-containing peptides blocks lipopolysaccharide (LPS) uptake and LPS-induced pro-inflammatory cytokine responses in THP-1 monocyte cells
    Alexander V Bocharov
    Department of Laboratory Medicine, W G Magnuson Clinical Center, NIDDK, National Institutes of Health Bethesda, Maryland 20892, USA
    J Biol Chem 279:36072-82. 2004
    ..These results demonstrate that amphipathic helices of exchangeable apolipoproteins may represent a general host defense mechanism against inflammation...
  37. ncbi request reprint Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease
    H Bryan Brewer
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 24:1755-60. 2004
    ....
  38. pmc Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells
    Irina Baranova
    National Heart, Lung and Blood Institute, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland 20892, USA
    Infect Immun 70:2995-3003. 2002
    ..These data indicate that the LPS effects on cholesterol metabolism may contribute to the proatherogenic properties of LPS...
  39. ncbi request reprint Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases
    Irina N Baranova
    Department of Laboratory Medicine, W G Magnuson Clinical Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:8031-40. 2005
    ..The results of this study demonstrate for the first time that CLA-1 functions as an endocytic SAA receptor and is involved in SAA-mediated cell signaling events associated with the immune-related and inflammatory effects of SAA...
  40. ncbi request reprint The ABCA1 transporter functions on the basolateral surface of hepatocytes
    Edward B Neufeld
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 7N115, 10 Center Drive, 20892, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 297:974-9. 2002
    ..These findings suggest an important role for hepatocyte basolateral membrane ABCA1 in the regulation of the levels of intracellular hepatic cholesterol, as well as plasma HDL...
  41. ncbi request reprint Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Lipid Res 47:794-803. 2006
    ..We conclude that ABCA1 transduces signals from apoA-I by complexing and activating Cdc42 and downstream kinases and, therefore, acts as a full apoA-I receptor...
  42. pmc The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice
    Charles W Joyce
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:407-12. 2002
    ....
  43. ncbi request reprint Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells
    John A Stonik
    National Institutes of Health Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Biochem Biophys Res Commun 321:936-41. 2004
    ..These results suggest that SAA may play a unique role as an auxiliary lipid acceptor in the removal of lipid from sites of inflammation...
  44. doi request reprint Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Herlev Hospital
    JAMA 299:2524-32. 2008
    ..Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Whether this is a causal effect is unclear...
  45. ncbi request reprint Rapid measurement of insulin using the Abbott IMx: application to the management of insulinoma
    Suzanne V Albright
    Department of Laboratory Medicine, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Ann Clin Biochem 39:513-5. 2002
    ..The objective of this study was to develop a rapid insulin assay that could be used intraoperatively for identifying insulinomas from pancreatic aspirates...
  46. ncbi request reprint Elevated serum concentrations of insulin and glucose increase risk of recurrent colorectal adenomas
    Andrew Flood
    Division of Epidemiology and Community Health and the Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Gastroenterology 133:1423-9. 2007
    ..Indicators of insulin resistance have been hypothesized to promote colorectal cancer...
  47. ncbi request reprint Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway
    Isaac Yi Kim
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 62:3649-53. 2002
    ..Taken together, these results demonstrate that raloxifene, a selective ER modulator, induces apoptosis in the androgen-sensitive human prostate cancer cell line LNCaP through an androgen-independent pathway...
  48. ncbi request reprint Utility of rapid intraoperative parathyroid hormone assay to predict severe postoperative hypocalcemia after reoperation for hyperparathyroidism
    Dina M Elaraj
    Surgery Branch, National Cancer Institute, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Building 10, Room 2B07, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Surgery 132:1028-33; discussion 1033-4. 2002
    ..This study's purpose was to determine the utility of intraoperative parathyroid hormone (IO-PTH) values in predicting the development of severe hypocalcemia for patients undergoing reoperation for primary hyperparathyroidism...
  49. ncbi request reprint Human serum albumin levels and cardiovascular risk factors in elderly Japanese-American men: the Honolulu Heart Program
    Chung Eun Ha
    Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i, Honolulu 96813, USA
    Hawaii Med J 66:148, 150-2. 2007
    ..However, the model R-square for all variables was only 0.10. In conclusion, HSA levels are significantly associated with several traditional cardiovascular risk factors, particularly serum lipid levels...
  50. ncbi request reprint Immunoassay interference by a commonly used blood collection tube additive, the organosilicone surfactant silwet L-720
    Raffick A R Bowen
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Molecular Disease Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Clin Chem 51:1874-82. 2005
    ..We examined the effect of a commonly used tube surfactant, Silwet L-720, on immunoassays and the mechanism for the interference...
  51. ncbi request reprint Inflammation and IGF-I activate the Akt pathway in breast cancer
    Robyn L Prueitt
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 120:796-805. 2007
    ..In summary, a proinflammatory environment was found to activate the Akt pathway in breast cancer, and may modify the association between the Akt phosphorylation status and breast cancer survival...
  52. ncbi request reprint Endogenous sex hormones, cognitive decline, and future dementia in old men
    Mirjam I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Ann Neurol 60:346-55. 2006
    ..To estimate the association of endogenous levels of bioavailable testosterone and estradiol with risk for cognitive decline and dementia in old men...
  53. ncbi request reprint Potential interferences from blood collection tubes in mass spectrometric analyses of serum polypeptides
    Steven K Drake
    Departmentof Critical Care Medicine, Warren Magnuson Clinical Center, NIH, Bethesda, MD 20892, USA
    Clin Chem 50:2398-401. 2004
  54. ncbi request reprint Differential effect of blood collection tubes on total free fatty acids (FFA) and total triiodothyronine (TT3) concentration: a model for studying interference from tube constituents
    Raffick A R Bowen
    Clinical Chemistry Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Chim Acta 378:181-93. 2007
    ..Besides total triiodothyronine (TT3), total free fatty acids (FFA) concentrations were higher with serum separator tube (SST) than Vacuette tubes...