William C Reinhold

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. Reinhold W, Varma S, Sunshine M, Rajapakse V, Luna A, Kohn K, et al. The NCI-60 Methylome and Its Integration into CellMiner. Cancer Res. 2017;77:601-612 pubmed publisher
    ..Overall, our database provides a resource of pharmacologic data that can reinforce known therapeutic strategies and identify novel drugs and drug targets across multiple cancer types. Cancer Res; 77(3); 601-12. ©2016 AACR. ..
  2. Reinhold W, Erliandri I, Liu H, Zoppoli G, Pommier Y, Larionov V. Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability. PLoS ONE. 2011;6:e25991 pubmed publisher
    ..We propose that the comparison of expression profiles in the NCI-60 cell line panel could be a tool for the identification of other gene groups whose products are involved in the assembly of organelle protein complexes. ..
  3. Reinhold W, Reimers M, Lorenzi P, Ho J, Shankavaram U, Ziegler M, et al. Multifactorial regulation of E-cadherin expression: an integrative study. Mol Cancer Ther. 2010;9:1-16 pubmed publisher
    ..Finally, levels of cellular E-cad expression are associated with levels of cell-cell adhesion and response to drug treatment. ..
  4. Reinhold W, Mergny J, Liu H, Ryan M, Pfister T, Kinders R, et al. Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res. 2010;70:2191-203 pubmed publisher
    ..The observations reported here suggest the hypothesis that there is a conserved negative transcription regulator within intron 1 of the TOP1 gene associated with a quadruplex-prone region. ..

Collaborators

Detail Information

Publications4

  1. Reinhold W, Varma S, Sunshine M, Rajapakse V, Luna A, Kohn K, et al. The NCI-60 Methylome and Its Integration into CellMiner. Cancer Res. 2017;77:601-612 pubmed publisher
    ..Overall, our database provides a resource of pharmacologic data that can reinforce known therapeutic strategies and identify novel drugs and drug targets across multiple cancer types. Cancer Res; 77(3); 601-12. ©2016 AACR. ..
  2. Reinhold W, Erliandri I, Liu H, Zoppoli G, Pommier Y, Larionov V. Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability. PLoS ONE. 2011;6:e25991 pubmed publisher
    ..We propose that the comparison of expression profiles in the NCI-60 cell line panel could be a tool for the identification of other gene groups whose products are involved in the assembly of organelle protein complexes. ..
  3. Reinhold W, Reimers M, Lorenzi P, Ho J, Shankavaram U, Ziegler M, et al. Multifactorial regulation of E-cadherin expression: an integrative study. Mol Cancer Ther. 2010;9:1-16 pubmed publisher
    ..Finally, levels of cellular E-cad expression are associated with levels of cell-cell adhesion and response to drug treatment. ..
  4. Reinhold W, Mergny J, Liu H, Ryan M, Pfister T, Kinders R, et al. Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res. 2010;70:2191-203 pubmed publisher
    ..The observations reported here suggest the hypothesis that there is a conserved negative transcription regulator within intron 1 of the TOP1 gene associated with a quadruplex-prone region. ..