William C Reinhold

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines
    Philip L Lorenzi
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Mol Cancer Ther 7:3123-8. 2008
  2. pmc mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities
    Hongfang Liu
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cancer Ther 9:1080-91. 2010
  3. pmc CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set
    William C Reinhold
    Laboratory of Molecular Pharmacology, CCR, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 72:3499-511. 2012
  4. pmc RedundancyMiner: De-replication of redundant GO categories in microarray and proteomics analysis
    Barry R Zeeberg
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Room 5068, Building 37, 37 Convent Drive, Bethesda, MD 20892, USA
    BMC Bioinformatics 12:52. 2011
  5. pmc Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron
    William C Reinhold
    Laboratory of Molecular Pharmacology and Developmental Therapeutics Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20894, USA
    Cancer Res 70:2191-203. 2010
  6. ncbi request reprint Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 63:1000-11. 2003
  7. pmc Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e25991. 2011
  8. ncbi request reprint Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 5056, Bethesda, MD 20892 4255, USA
    Mol Cancer Ther 6:391-403. 2007
  9. pmc Multifactorial regulation of E-cadherin expression: an integrative study
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cancer Ther 9:1-16. 2010
  10. ncbi request reprint Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study
    Uma T Shankavaram
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Mol Cancer Ther 6:820-32. 2007

Detail Information

Publications31

  1. doi request reprint Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines
    Philip L Lorenzi
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Mol Cancer Ther 7:3123-8. 2008
    ..These findings provide rationale for evaluation of ASNS protein expression as a predictive biomarker of clinical L-ASP activity in ovarian cancer...
  2. pmc mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities
    Hongfang Liu
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cancer Ther 9:1080-91. 2010
    ..The data sets presented here will facilitate the identification of groups of mRNAs, microRNAs, and drugs that potentially affect and interact with one another...
  3. pmc CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set
    William C Reinhold
    Laboratory of Molecular Pharmacology, CCR, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 72:3499-511. 2012
    ..CellMiner greatly broadens applications of the extensive NCI-60 database for discovery by creating web-based processes that are rapid, flexible, and readily applied by users without bioinformatics expertise...
  4. pmc RedundancyMiner: De-replication of redundant GO categories in microarray and proteomics analysis
    Barry R Zeeberg
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Room 5068, Building 37, 37 Convent Drive, Bethesda, MD 20892, USA
    BMC Bioinformatics 12:52. 2011
    ..The redundancy might typically inflate the report of significant categories by a factor of three-fold, create an illusion of an overly long list of significant categories, and obscure the relevant biological interpretation...
  5. pmc Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron
    William C Reinhold
    Laboratory of Molecular Pharmacology and Developmental Therapeutics Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20894, USA
    Cancer Res 70:2191-203. 2010
    ..The observations reported here suggest the hypothesis that there is a conserved negative transcription regulator within intron 1 of the TOP1 gene associated with a quadruplex-prone region...
  6. ncbi request reprint Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 63:1000-11. 2003
    ..This model is analogous to one suggested previously for the relationship between oncogene function and apoptosis in carcinogenesis...
  7. pmc Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e25991. 2011
    ..We propose that the comparison of expression profiles in the NCI-60 cell line panel could be a tool for the identification of other gene groups whose products are involved in the assembly of organelle protein complexes...
  8. ncbi request reprint Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 5056, Bethesda, MD 20892 4255, USA
    Mol Cancer Ther 6:391-403. 2007
    ..As has been shown in recent years, DNA methylation status can serve as a biomarker for use in choosing therapy...
  9. pmc Multifactorial regulation of E-cadherin expression: an integrative study
    William C Reinhold
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cancer Ther 9:1-16. 2010
    ..Finally, levels of cellular E-cad expression are associated with levels of cell-cell adhesion and response to drug treatment...
  10. ncbi request reprint Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study
    Uma T Shankavaram
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Mol Cancer Ther 6:820-32. 2007
    ..71). Because the transcript-based technologies are more mature and are currently able to assess larger numbers of genes at one time, they continue to be useful, even when the ultimate aim is information about proteins...
  11. ncbi request reprint Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects
    Yi Zhou
    Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:1688-95. 2002
    ....
  12. pmc Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel
    Kimberly J Bussey
    Laboratory of Molecular Pharmacology, National Cancer Institute, Building 37, Room 5056, NIH, MSC 4255, 9000 Rockville Pike, Bethesda, MD 20892 4255, USA
    Mol Cancer Ther 5:853-67. 2006
    ..The DNA copy number database presented here will enable other investigators to explore DNA transcript-drug relationships in their own domains of research focus...
  13. pmc Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
    Satoshi Nishizuka
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:14229-34. 2003
    ....
  14. pmc CellMiner: a relational database and query tool for the NCI-60 cancer cell lines
    Uma T Shankavaram
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Centre for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    BMC Genomics 10:277. 2009
    ..S. National Cancer Institute to screen compounds for anticancer activity. To our knowledge, CellMiner is the first online database resource for integration of the diverse molecular types of NCI-60 and related meta data...
  15. pmc MatchMiner: a tool for batch navigation among gene and gene product identifiers
    Kimberly J Bussey
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH Building 37, Bethesda, MD 20892 4255, USA
    Genome Biol 4:R27. 2003
    ..The user inputs a list of gene identifiers and then uses the Merge function to find the overlap with a second list of identifiers of either the same or a different type or uses the LookUp function to find corresponding identifiers...
  16. doi request reprint DNA fingerprinting of the NCI-60 cell line panel
    Philip L Lorenzi
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Cancer Ther 8:713-24. 2009
    ..As expected, DNA fingerprints were not able to distinguish different tissues-of-origin. The fingerprints serve principally as a barcodes...
  17. ncbi request reprint Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells
    Philip L Lorenzi
    Genomics and Bioinformatics Group, Room 5056B, 37 Convent Drive, Bethesda, MD 20892, USA
    Mol Cancer Ther 5:2613-23. 2006
    ..Overall, this pharmacogenomic/pharmacoproteomic study suggests the use of l-ASP for treatment of a subset of ovarian cancers (and perhaps other tumor types), with ASNS as a biomarker for patient selection...
  18. ncbi request reprint Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling
    Satoshi Nishizuka
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, NIH, Bethesda, Maryland 20814, USA
    Cancer Res 63:5243-50. 2003
    ..The multistep process introduced here has the potential to produce additional markers for cancer diagnosis, prognosis, and therapy...
  19. pmc GoMiner: a resource for biological interpretation of genomic and proteomic data
    Barry R Zeeberg
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 4:R28. 2003
    ..The first is a tree-like structure analogous to that in the AmiGO browser and the second is a compact, dynamically interactive 'directed acyclic graph'. Genes displayed in GoMiner are linked to major public bioinformatics resources...
  20. pmc Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents
    Gabriele Zoppoli
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:15030-5. 2012
    ....
  21. ncbi request reprint AffyProbeMiner: a web resource for computing or retrieving accurately redefined Affymetrix probe sets
    Hongfang Liu
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Bioinformatics 23:2385-90. 2007
    ..Otherwise, analysis and interpretation of an Affymetrix microarray experiment will be in error...
  22. pmc Genome-wide depletion of replication initiation events in highly transcribed regions
    Melvenia M Martin
    Laboratory of Molecular Pharmacology, CCR, NCI, Bethesda, Maryland 20892, USA
    Genome Res 21:1822-32. 2011
    ..Data presented here identify replication initiation sites throughout the genome, providing a foundation for further analyses of DNA-replication dynamics and cell-cycle progression...
  23. ncbi request reprint The bioinformatics of microarray gene expression profiling
    John N Weinstein
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, USA
    Cytometry 47:46-9. 2002
  24. pmc Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes
    Kurt W Kohn
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    PLoS ONE 7:e35716. 2012
    ..The MIMs and associated text comprise a detailed and integrated summary of what is currently known or surmised about the role of the expression cross-correlated genes in molecular networks governing those processes...
  25. pmc G4 motifs correlate with promoter-proximal transcriptional pausing in human genes
    Johanna Eddy
    Molecular and Cellular Biology Graduate Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nucleic Acids Res 39:4975-83. 2011
    ..These results suggest potential roles for dynamic G4 DNA and G4 RNA structures in cis-regulation of pausing, and thus genome-wide regulation of gene expression, in human cells...
  26. doi request reprint The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology
    Ogan D Abaan
    Genetics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, and Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD 20982, USA
    Cancer Res 73:4372-82. 2013
    ..To enhance the utility of the data for the greater research community, the genomic variants are freely available in different formats and from multiple sources including the CellMiner and Ingenuity websites...
  27. pmc Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction
    Lea Cunningham
    Oncogenesis and Development Section, National Institute of Allergy and Infectious Diseases, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:14592-7. 2012
    ..Our data thus confirmed that RUNX1-CBFβ interaction can be targeted for leukemia treatment and we have identified a promising lead compound for this purpose...
  28. pmc Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families
    Natalay Kouprina
    Laboratory of Molecular Pharmacology, NCI, NIH, Bethesda, MD, USA
    Genes Chromosomes Cancer 51:933-48. 2012
    ..Our results exclude the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy. Adjacent regions appear to be the most likely candidates to identify the elusive HPCX1 locus...
  29. pmc Entry tropism of BK and Merkel Cell Polyomaviruses in cell culture
    Rachel M Schowalter
    Tumor Virus Molecular Biology Section, Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e42181. 2012
    ....
  30. doi request reprint MicroRNAs modulate the chemosensitivity of tumor cells
    Paul E Blower
    Program of Pharmacogenomics, Department of Pharmacology, Ohio State University, 333 West Tenth Street, Columbus, OH 43210, USA
    Mol Cancer Ther 7:1-9. 2008
    ..Ten of those microRNAs have already been implicated in cancer biology. Our results support a substantial role for microRNAs in anticancer drug response, suggesting novel potential approaches to the improvement of chemotherapy...
  31. ncbi request reprint Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance
    Ying Huang
    Program of Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, 43210, USA
    Cancer Res 64:4294-301. 2004
    ..Measurement of transporter gene expression may prove useful in predicting anticancer drug response...