William C Reinhold
Affiliation: National Institutes of Health
Reinhold W, Sunshine M, Varma S, Doroshow J, Pommier Y. Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60. Clin Cancer Res. 2015;21:3841-52 pubmed publisher
..Examples for both gain- (RAS) and loss-of-function (PTEN) alterations are provided. ..
Reinhold W, Varma S, Sunshine M, Rajapakse V, Luna A, Kohn K, et al
. The NCI-60 Methylome and Its Integration into CellMiner. Cancer Res. 2017;77:601-612 pubmed publisher
..Overall, our database provides a resource of pharmacologic data that can reinforce known therapeutic strategies and identify novel drugs and drug targets across multiple cancer types. Cancer Res; 77(3); 601-12. Â©2016 AACR. ..
Reinhold W, Reimers M, Maunakea A, Kim S, Lababidi S, Scherf U, et al
. Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells. Mol Cancer Ther. 2007;6:391-403 pubmed
..As has been shown in recent years, DNA methylation status can serve as a biomarker for use in choosing therapy. ..
Reinhold W, Sunshine M, Liu H, Varma S, Kohn K, Morris J, et al
. CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set. Cancer Res. 2012;72:3499-511 pubmed publisher
..CellMiner greatly broadens applications of the extensive NCI-60 database for discovery by creating web-based processes that are rapid, flexible, and readily applied by users without bioinformatics expertise. ..
Reinhold W, Varma S, Rajapakse V, Luna A, Sousa F, Kohn K, et al
. Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancer. Hum Genet. 2015;134:3-11 pubmed publisher
..The ultimate goal is to provide a paradigm shift in the way that drugs are selected to provide a more targeted and efficacious outcome for the patient. ..
Reinhold W, Erliandri I, Liu H, Zoppoli G, Pommier Y, Larionov V. Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability. PLoS ONE. 2011;6:e25991 pubmed publisher
..We propose that the comparison of expression profiles in the NCI-60 cell line panel could be a tool for the identification of other gene groups whose products are involved in the assembly of organelle protein complexes. ..
Reinhold W, Reimers M, Lorenzi P, Ho J, Shankavaram U, Ziegler M, et al
. Multifactorial regulation of E-cadherin expression: an integrative study. Mol Cancer Ther. 2010;9:1-16 pubmed publisher
..Finally, levels of cellular E-cad expression are associated with levels of cell-cell adhesion and response to drug treatment. ..
Reinhold W, Mergny J, Liu H, Ryan M, Pfister T, Kinders R, et al
. Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res. 2010;70:2191-203 pubmed publisher
..The observations reported here suggest the hypothesis that there is a conserved negative transcription regulator within intron 1 of the TOP1 gene associated with a quadruplex-prone region. ..