Research Topics
| B RehermannSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Immune responses in hepatitis B virus infectionBarbara Rehermann
Liver Diseases Section, NIDDK, National Institutes of Health, HHS, Bethesda, Maryland 20892, USA
Semin Liver Dis 23:21-38. 2003..This review summarizes the immune response in acute, self-limited and chronic hepatitis B; its differential effects on viral replication and liver injury; and prospects for immunotherapy...- Hepatitis C virus infection: when silence is deceptionVito Racanelli
Liver Diseases Section, NIDDK, National Institutes of Health, 10 Center Drive, Room 9B16, Bethesda, MD 20892, USA
Trends Immunol 24:456-64. 2003.... - Interaction between the hepatitis C virus and the immune systemB Rehermann
Liver Diseases Section, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
Semin Liver Dis 20:127-41. 2000.... 
Private aspects of heterologous immunityBarbara Rehermann
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 201:667-70. 2005..Private T cell receptor specificities of these preexisting memory T cell populations influence both disease severity and outcome of subsequent, unrelated virus infections...- Immunological techniques in viral hepatitisBarbara Rehermann
Immunology Section, Liver Diseases Branch NIDDK, National Institutes of Health, DHHS, 10 Center Drive, Room 9B16, Bethesda, MD 20892, USA
J Hepatol 46:508-20. 2007..Our aim is to highlight topics and issues that were supported by general agreement and those that were controversial, as well as to provide suggestions for future work... - Immunology of hepatitis B virus and hepatitis C virus infectionBarbara Rehermann
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA
Nat Rev Immunol 5:215-29. 2005..This review assesses recent advances in our understanding of viral hepatitis, contrasts mechanisms of virus-host interaction in acute hepatitis B and hepatitis C, and outlines areas for future studies... - Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistenceBarbara Rehermann
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH DHHS, Bethesda, MD 20892, USA
J Clin Invest 119:1745-54. 2009..This review discusses the clinical, virological, and immunological features of acute and chronic hepatitis C and the role of the immune response in spontaneous and treatment-induced HCV clearance... 
The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomesR Loomba
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Aliment Pharmacol Ther 33:559-65. 2011..Acute hepatitis C has variable modes of presentation and frequently results in chronic infection. Its optimal management has yet to be defined...- Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cellsH Wedemeyer
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20982, USA
J Virol 75:11392-400. 2001..These results exemplify that host responses to an infectious agent are influenced by cross-reactive memory cells induced by past exposure to heterologous viruses, which could have important consequences for vaccine development... - Hepatitis C vaccines: Inducing and challenging memory T cellsMasaaki Shiina
Immunology Section, Liver Diseases Branch NIDDK, National Institutes of Health, DHHS, Bethesda, MD, USA
Hepatology 43:1395-8. 2006.... - Previously infected and recovered chimpanzees exhibit rapid responses that control hepatitis C virus replication upon rechallengeMarian E Major
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 8800 Rockville Pike, Bethesda, MD 20892, USA
J Virol 76:6586-95. 2002..These observations have encouraging implications for the development of a vaccine for HCV... - Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis CTobias Manigold
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 107:4424-32. 2006..This result suggests that HCV infection alters the population of Foxp3(+)CD4(+)CD25(+) T(Reg) cells... - Chronic infections with hepatotropic viruses: mechanisms of impairment of cellular immune responsesBarbara Rehermann
Immunology Section, Liver Diseases Branch, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA
Semin Liver Dis 27:152-60. 2007..These endogenous mechanisms and potential avenues to revert them are the subject of this review... - Effects of antiviral therapy on the cellular immune response in acute hepatitis CFareed Rahman
Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Hepatology 40:87-97. 2004..In conclusion, a sustained response to antiviral therapy was not associated with a lasting enhancement of HCV-specific T-cell responsiveness in the blood... - Cellular immune responses to the hepatitis B virus polymeraseEishiro Mizukoshi
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Immunol 173:5863-71. 2004..These newly described HBV polymerase epitopes could be a valuable component of a therapeutic vaccine for a large and ethnically diverse patient population... - Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liverEui Cheol Shin
Immunology Section, Liver Diseases Branch, NIDDK, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
J Interferon Cytokine Res 27:985-90. 2007..This mechanism may contribute to the high effectiveness of type I IFN-based therapies if administered early during acute HCV infection... - Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzeesMichelina Nascimbeni
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:4781-93. 2003..The rate of HCV clearance following reexposure depends on the cellular immune response, the quality and quantity of which may vary among chimpanzees that recovered from HCV infection... - Chronic hepatitis B and hepatocarcinogenesis: does prevention of "collateral damage" bring the cure?Tobias Manigold
Liver Diseases Section, NIDDK, National Institutes of Health, DHHS, Bethesda, MD, USA
Hepatology 37:707-10. 2003 - Dendritic cells transfected with cytopathic self-replicating RNA induce crosspriming of CD8+ T cells and antiviral immunityVito Racanelli
Liver Diseases Section, Digestive Diseases Branch, NIDDK, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Immunity 20:47-58. 2004..The findings are relevant for the rational design of vaccines against noncytopathic pathogens like HCV... - Liver-directed gamma interferon gene delivery in chronic hepatitis CEui-Cheol Shin
Liver Diseases Branch, NIDDK, National Institutes of Health, DHHS, 10 Center Drive, Room 9B16, Bethesda, MD 20892, USA
J Virol 79:13412-20. 2005..In conclusion, liver-directed IFN-gamma gene delivery resulted in HCV-specific and nonspecific activation of cellular immune responses but did not result in effective control of HCV replication... - Hepatitis C virus and the threshold of natural killer cell inhibitionGolo Ahlenstiel
Liver Diseases Section, NIDDK, National Institutes of Health, DHHS, Bethesda, MD, USA
Hepatology 41:675-7. 2005 - Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCVEishiro Mizukoshi
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
J Infect Dis 198:203-12. 2008..To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years)... - The kinetics of hepatitis C virus-specific CD8 T-cell responses in the blood mirror those in the liver in acute hepatitis C virus infectionEui Cheol Shin
Immunology Section, LDB, NIDDK, NIH, Bethesda, MD 20892 1800, USA
J Virol 82:9782-8. 2008..Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity... - Emergence of a distinct pattern of viral mutations in chimpanzees infected with a homogeneous inoculum of hepatitis C virusM Thomson
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1800, USA
Gastroenterology 121:1226-33. 2001..In addition, a limited virus-specific immunity may contribute to HCV persistence... - Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell functionMasaaki Shiina
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Hepatology 47:385-95. 2008..CONCLUSION: HCVcc inhibited plasmacytoid DCs but not myeloid-derived and monocytoid-derived DCs via a direct interaction that did not require infection. The response of plasmacytoid DCs to influenza A virus infection was not impaired... - Determination of HCV-specific T-cell activityJoo Chun Yoon
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Methods Mol Biol 510:403-13. 2009.... - Analysis of HCV-specific T cells by flow cytometryMasaaki Shiina
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Methods Mol Biol 510:415-26. 2009..Here, we provide both an overview of available techniques as well as standard protocols that have proven valuable in the assessment of HCV-specific T-cell responses... - Natural killer cell function is intact after direct exposure to infectious hepatitis C virionsJoo Chun Yoon
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Hepatology 49:12-21. 2009..Without direct inhibition by HCV, NK cells may become activated by cytokines in acute HCV infection and contribute to infection outcome and disease pathogenesis... - Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent mannerGolo Ahlenstiel
Immunology Section, National Institute for Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1800, USA
Gastroenterology 138:325-35.e1-2. 2010.... - Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infectionEui-Cheol Shin
Immunology Section and Liver Diseases Branch, NIDDK, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Clin Invest 116:3006-14. 2006..This mechanism may contribute to the high effectiveness (95%) of type I IFN-based therapies if administered early during HCV infection... - The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunityMichael Thomson
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:862-70. 2003.... - Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primatesSook-Hyang Jeong
Liver Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 78:6995-7003. 2004..Our results suggest that HCV-LP is a potent immunogen to induce HCV-specific humoral and cellular immune responses in primates and may be a promising approach to develop novel preventive and therapeutic modalities... - Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune response and vaccination studiesEishiro Mizukoshi
Liver Diseases Section, NIDDK, National Institutes of Health Laboratory of Hepatitis Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Virol 76:6093-103. 2002..These results are relevant for the design and evaluation of vaccines in chimpanzees that can now be selected according to the most frequent human MHC haplotypes... - Oral immunization with HCV-NS3-transformed Salmonella: induction of HCV-specific CTL in a transgenic mouse modelH Wedemeyer
Liver Diseases Section, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1800, USA
Gastroenterology 121:1158-66. 2001..CONCLUSIONS: Oral immunization with attenuated Salmonella typhimurium as a carrier for HCV DNA induces long-lasting T-cell responses... - Genetic immunization of wild-type and hepatitis C virus transgenic mice reveals a hierarchy of cellular immune response and tolerance induction against hepatitis C virus structural proteinsJ Satoi
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1800, USA
J Virol 75:12121-7. 2001..The HCV transgenic mice can be induced by DNA immunization to generate anti-HCV antibodies and anticore CTLs. However, they are tolerant at the CTL level against the E2 protein despite DNA immunization... - Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functionsMichelina Nascimbeni
Liver Diseases Section, DDB, NIDDK, National Institutes of Health, DHHS 10 Center Drive, Bldg 10, Room 9B16, Bethesda, MD 20892-1800, USA
Blood 104:478-86. 2004.... - Acute hepatitis C: a multifaceted diseaseTheo Heller
Liver Diseases Branch, NIDDK, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Semin Liver Dis 25:7-17. 2005.... - Determination of hepatitis B virus-specific CD8+ T-cell activity in the liverMichelina Nascimbeni
Liver Diseases Section, NIDDK, National Institutes of Health, Bethesda, MD, USA
Methods Mol Med 96:65-83. 2004 - Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responsesGolo Ahlenstiel
Immunology Section, Liver Diseases Branch, NIDDK, NIH, Bethesda, Maryland 20892 1800, USA
J Clin Invest 118:1017-26. 2008..These results provide functional evidence for differential NK cell responsiveness depending on KIR/HLA genotype and may provide useful insights into differential innate immune responsiveness to viral infections such as IAV... - Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infectionHeiner Wedemeyer
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 169:3447-58. 2002..Thus, the defective functions of HCV-specific CD8+ T cells might contribute to viral persistence in chronically infected patients, and knowledge on their reversibility may facilitate the development of immunotherapeutic vaccines... - Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivoThomas von Hahn
Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
Gastroenterology 132:667-78. 2007.... - Potent enhancement of cellular and humoral immune responses against recombinant hepatitis B antigens using AS02A adjuvant in healthy adultsPierre Vandepapeliere
GlaxoSmithKline Biologicals, 89 Rue de 1 institut, B 1330 Rixensart, Belgium
Vaccine 23:2591-601. 2005..AS02A can be considered as a useful adjuvant that strongly enhances the cellular and humoral responses of subunit protein vaccines... - Chronic HCV infection and the clonality of intrahepatic T cellsMichelina Nascimbeni
J Hepatol 38:677-80. 2003 - The liver as an immunological organVito Racanelli
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Hepatology 43:S54-62. 2006.... - Hepatitis C virus mutation affects proteasomal epitope processingUlrike Seifert
Institute of Biochemistry, Charit, Humboldt University, Berlin, Germany
J Clin Invest 114:250-9. 2004.... - High levels of subgenomic HCV plasma RNA in immunosilent infectionsFlavien Bernardin
Blood Systems Research Institute, San Francisco, CA 94118, USA
Virology 365:446-56. 2007..The absence of immunological pressure and a high viral load may therefore promote the emergence of truncated HCV subgenomic replicons in vivo...