Christophe E Redon

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e15544. 2010
  2. doi request reprint Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing
    Brandon J Baird
    Laboratory of Molecular Pharmacology, CCR, NCI, Bethesda, MD 20892, USA
    Mutat Res 711:142-9. 2011
  3. ncbi request reprint DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions
    Olivier Sordet
    Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 9:274-8. 2010
  4. pmc Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Nucleic Acids Res 40:10274-86. 2012
  5. pmc Systemic DNA damage related to cancer
    Olga A Martin
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 71:3437-41. 2011
  6. pmc Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Cancer Res 16:4532-42. 2010
  7. doi request reprint γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Methods Mol Biol 682:249-70. 2011
  8. pmc H2AX: functional roles and potential applications
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Chromosoma 118:683-92. 2009
  9. pmc Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model
    Maria Moroni
    Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Int J Mol Sci 14:14119-35. 2013
  10. pmc GammaH2AX and cancer
    William M Bonner
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:957-67. 2008

Collaborators

Detail Information

Publications22

  1. pmc The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e15544. 2010
    ..However, knowledge of individual exposures is essential for early triage during radiological incidents to provide optimum possible life-sparing medical procedures to each person...
  2. doi request reprint Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing
    Brandon J Baird
    Laboratory of Molecular Pharmacology, CCR, NCI, Bethesda, MD 20892, USA
    Mutat Res 711:142-9. 2011
    ....
  3. ncbi request reprint DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions
    Olivier Sordet
    Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 9:274-8. 2010
    ..We also address the potential roles of ATM in response to transcription-blocking TOP1cc...
  4. pmc Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Nucleic Acids Res 40:10274-86. 2012
    ..These results indicate that cell vulnerability to bystander DSB damage may result from transcription as well as replication. The findings offer insights into which tissues may be vulnerable to bystander genomic destabilization in vivo...
  5. pmc Systemic DNA damage related to cancer
    Olga A Martin
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 71:3437-41. 2011
    ..Here, we discuss some of the implications of these observations...
  6. pmc Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Cancer Res 16:4532-42. 2010
    ..We also discuss the choices of relevant samples for γH2AX and PAR analyses...
  7. doi request reprint γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Methods Mol Biol 682:249-70. 2011
    ..This chapter presents techniques for γ-H2AX detection in a variety of human and mouse samples...
  8. pmc H2AX: functional roles and potential applications
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Chromosoma 118:683-92. 2009
    ..Recent work indicates that gamma-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression...
  9. pmc Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model
    Maria Moroni
    Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Int J Mol Sci 14:14119-35. 2013
    ..8 and 5 Gy with residual γ-H2AX foci proportional to the initial radiation doses. These findings show that the Gottingen minipig provides a useful in vivo model for validation of γ-H2AX biodosimetry for dose assessment in humans...
  10. pmc GammaH2AX and cancer
    William M Bonner
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:957-67. 2008
    ..Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs...
  11. ncbi request reprint NADPH Oxidases NOXs and DUOXs as putative targets for cancer therapy
    Urbain Weyemi
    Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Anticancer Agents Med Chem 13:502-14. 2013
    ..This review provides an overview of the current knowledge concerning these enzymes, their roles in cancer, and their potential as targets in future cancer therapies...
  12. pmc γ-H2AX and other histone post-translational modifications in the clinic
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA
    Biochim Biophys Acta 1819:743-56. 2012
    ..This article is part of a Special Issue entitled: Chromatin in time and space...
  13. pmc Tumors induce complex DNA damage in distant proliferative tissues in vivo
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:17992-7. 2010
    ..Importantly, these findings suggest that tumors may have more profound effects on their hosts than heretofore expected...
  14. pmc Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK
    Benu Brata Das
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    EMBO J 28:3667-80. 2009
    ..Finally, we provide evidence that TDP1-S81 phosphorylation promotes cell survival and DNA repair in response to CPT-induced DSBs. Together; our findings provide a new mechanism for TDP1 post-translational regulation by ATM and DNA-PK...
  15. pmc Recent developments in the use of γ-H2AX as a quantitative DNA double-strand break biomarker
    Christophe E Redon
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Aging (Albany NY) 3:168-74. 2011
    ..We will highlight recent developments of the assay in four areas: radiation biodosimetry, the evaluation or validation of new cancer drugs in clinical studies, chronic inflammation, and environmental genotoxicity...
  16. pmc Role of oxidatively induced DNA lesions in human pathogenesis
    Olga A Sedelnikova
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mutat Res 704:152-9. 2010
    ..If unrepaired, these lesions can lead to the formation of mutations, DNA DSBs, and chromosome abnormalities. We discuss the roles of these lesions in human pathologies including aging and cancer, and in bystander effects...
  17. pmc Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
    Asako J Nakamura
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Aging (Albany NY) 1:212-8. 2009
    ..This characterization of DNA damage in tumor cells helps clarify the contribution of non-telomeric DSBs and damaged telomeres to major genomic alterations...
  18. pmc Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism
    Céline Douarre
    Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e41094. 2012
    ..Relaxation of the circular, double-stranded mtDNA relies on the presence of topoisomerase activity. Three different topoisomerases have been identified in mitochondria: Top1mt, Top3α and a truncated form of Top2β...
  19. pmc Intercellular communication of cellular stress monitored by gamma-H2AX induction
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Carcinogenesis 30:1686-95. 2009
    ....
  20. pmc Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model
    Jennifer S Dickey
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS ONE 8:e70575. 2013
    ..Our findings also emphasize the novel role of specific protein oxidation markers and autophagic mechanisms for cardioprotection. ..
  21. pmc SOD2 deficiency promotes aging phenotypes in mouse skin
    Urbain Weyemi
    Laboratory of Molecular Pharmacology, CCR, NCI, NIH, Bethesda MD 20892, USA
    Aging (Albany NY) 4:116-8. 2012
    ..e., 20% oxygen. Now, the same group has generated some insights into how oxidative stress contributes to cellular senescence and aging phenotypes in mouse skin...
  22. pmc Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks
    Olivier Sordet
    Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    EMBO Rep 10:887-93. 2009
    ..Thus, we propose that Top1cc produce transcription arrests with R-loop formation and generate DSBs that activate ATM in post-mitotic cells...