Judith L Rapoport

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Imaging normal and abnormal brain development: new perspectives for child psychiatry
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
    Aust N Z J Psychiatry 35:272-81. 2001
  2. ncbi request reprint Childhood obsessive-compulsive disorder in the NIMH MECA study: parent versus child identification of cases. Methods for the Epidemiology of Child and Adolescent Mental Disorders
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
    J Anxiety Disord 14:535-48. 2000
  3. ncbi request reprint Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Arch Gen Psychiatry 56:649-54. 1999
  4. ncbi request reprint Treatment of obsessive-compulsive disorder in children and adolescents
    J L Rapoport
    National Institute of Mental Health, Bethesda 20892 1600, USA
    J Child Psychol Psychiatry 41:419-31. 2000
  5. ncbi request reprint The neurodevelopmental model of schizophrenia: what can very early onset cases tell us?
    Judith L Rapoport
    Child Psychiatry Branch, Building 10, 9000 Rockville Pike, National Institutes of Mental Health NIH, Bethesda, MD 20892, USA
    Curr Psychiatry Rep 7:81-2. 2005
  6. ncbi request reprint Update on childhood-onset schizophrenia
    J L Rapoport
    Child Psychiatry Branch Building 10, Room 3N202, National Institute of Mental Health, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Curr Psychiatry Rep 2:410-5. 2000
  7. ncbi request reprint The neurodevelopmental model of schizophrenia: update 2005
    J L Rapoport
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1600, USA
    Mol Psychiatry 10:434-49. 2005
  8. ncbi request reprint Responses to methylphenidate in Attention-Deficit/Hyperactivity Disorder and normal children: update 2002
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
    J Atten Disord 6:S57-60. 2002
  9. ncbi request reprint Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:921-31. 2007
  10. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Imaging normal and abnormal brain development: new perspectives for child psychiatry
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
    Aust N Z J Psychiatry 35:272-81. 2001
    ....
  2. ncbi request reprint Childhood obsessive-compulsive disorder in the NIMH MECA study: parent versus child identification of cases. Methods for the Epidemiology of Child and Adolescent Mental Disorders
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
    J Anxiety Disord 14:535-48. 2000
    ..These findings support clinical data that children with OCD often hide their illness and underscore the importance of child interviews for its detection...
  3. ncbi request reprint Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Arch Gen Psychiatry 56:649-54. 1999
    ....
  4. ncbi request reprint Treatment of obsessive-compulsive disorder in children and adolescents
    J L Rapoport
    National Institute of Mental Health, Bethesda 20892 1600, USA
    J Child Psychol Psychiatry 41:419-31. 2000
    ..Adaptation of cognitive-behavioral therapy for children and adolescents, use of augmenting agents in drug treatment, and subtyping of OCD cases are developments relevant for current practice...
  5. ncbi request reprint The neurodevelopmental model of schizophrenia: what can very early onset cases tell us?
    Judith L Rapoport
    Child Psychiatry Branch, Building 10, 9000 Rockville Pike, National Institutes of Mental Health NIH, Bethesda, MD 20892, USA
    Curr Psychiatry Rep 7:81-2. 2005
  6. ncbi request reprint Update on childhood-onset schizophrenia
    J L Rapoport
    Child Psychiatry Branch Building 10, Room 3N202, National Institute of Mental Health, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Curr Psychiatry Rep 2:410-5. 2000
    ..Updated findings involve risk factors (birth complications, cytogenic abnormalities, early language and motor problems, and familial psychopathology), treatment trials, and brain magnetic resonance imaging studies...
  7. ncbi request reprint The neurodevelopmental model of schizophrenia: update 2005
    J L Rapoport
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1600, USA
    Mol Psychiatry 10:434-49. 2005
    ....
  8. ncbi request reprint Responses to methylphenidate in Attention-Deficit/Hyperactivity Disorder and normal children: update 2002
    J L Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
    J Atten Disord 6:S57-60. 2002
    ..This brief report is an update (as of August 2002) on studies of stimulants in ADHD and normal children, with particular focus on MPH...
  9. ncbi request reprint Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:921-31. 2007
    ..Attention-deficit/hyperactivity disorder (ADHD) is one of the most heritable neuropsychiatric disorders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated in its pathogenesis...
  10. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008
    ..We hypothesized that total, frontal, temporal, and parietal gray matter thickness would be greater in patients who subsequently remit...
  11. pmc Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA 20892, USA
    Neuroimage 57:1517-23. 2011
    ..These findings suggest that cortical abnormalities in pedigrees affected by schizophrenia may be contributed to by a disruption of dopaminergic infleunces on cortical maturation...
  12. ncbi request reprint Progressive brain volume loss during adolescence in childhood-onset schizophrenia
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Am J Psychiatry 160:2181-9. 2003
    ..This study examined the rate of loss in cortical gray matter volume in relation to age and clinical status in adolescent patients over a follow-up period of 2-6 years...
  13. ncbi request reprint Dynamic mapping of hippocampal development in childhood onset schizophrenia
    Tom F Nugent
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Schizophr Res 90:62-70. 2007
    ....
  14. ncbi request reprint Sleep disturbances in childhood-onset schizophrenia
    Anand A Mattai
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    Schizophr Res 86:123-9. 2006
    ..As there are numerous health implications of poor sleep, clinicians should have a low threshold for treating sleep disturbances in this population...
  15. ncbi request reprint Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Arch Gen Psychiatry 61:17-22. 2004
    ..We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses...
  16. doi request reprint Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 69:875-84. 2012
    ..As reported before for gray matter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with age...
  17. ncbi request reprint Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:721-30. 2006
    ..The psychiatrist has a limited evidence base to guide treatment, particularly as there are no trials in children comparing atypical antipsychotics, the mainstay of current treatment...
  18. pmc General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study
    Jennifer L Bakalar
    Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 115:12-6. 2009
    ..Recent studies show dynamic changes in brain asymmetry during childhood and adolescence. We hypothesized that COS patients would show a lack of normal development of asymmetry and decreased overall asymmetry...
  19. ncbi request reprint Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?
    Alexandra L Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:989-94. 2004
    ..In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an independent risk factor for COS...
  20. ncbi request reprint Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:852-62. 2007
    ..We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset...
  21. ncbi request reprint Support for association between ADHD and two candidate genes: NET1 and DRD1
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
    Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005
    ..Because family-based and case-control methods gave divergent results, both should be used in genetic studies of ADHD...
  22. ncbi request reprint Looking for childhood schizophrenia: case series of false positives
    Catherine Stayer
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 43:1026-9. 2004
    ..16). These cases illustrate that transient psychotic illnesses can be misdiagnosed as childhood-onset schizophrenia. Proper identification can prevent years of inappropriate therapies...
  23. ncbi request reprint Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Lancet Neurol 6:494-500. 2007
    ....
  24. ncbi request reprint Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family members
    Alexandra Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institute of Health, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Schizophr Res 73:243-52. 2005
    ..Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia...
  25. ncbi request reprint Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 44:925-33. 2005
    ..In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment...
  26. ncbi request reprint Multidimensionally impaired: the good news
    Catherine Stayer
    Child Psychiatry Branch at the National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 15:510-9. 2005
    ..Despite severe preadmission morbidity, some patients have successfully remained neuroleptic-free since discharge. Predictors of good versus poor outcome were sought...
  27. ncbi request reprint Stimulant drug treatment in childhood-onset schizophrenia with comorbid ADHD: an open-label case series
    Julia W Tossell
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Room 3N202, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 14:448-54. 2004
    ..Our results suggest that ADHD comorbid with COS may be safely treated with a stimulant, once the psychosis is stabilized. A systematic investigation of this question may be warranted...
  28. ncbi request reprint Childhood onset schizophrenia: familial neurocognitive measures
    Peter A Gochman
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 71:43-7. 2004
    ..Neurocognitive deficits which are seen in families of adult onset schizophrenic patients were examined in healthy family members of patients with childhood-onset schizophrenia (COS)...
  29. doi request reprint Neurodevelopmental trajectories of the human cerebral cortex
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:3586-94. 2008
    ....
  30. ncbi request reprint Corpus callosum development in childhood-onset schizophrenia
    Audrey Keller
    Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3N 202, 10 Center Drive MSC 1600, Bethesda, MD 20892 1600, USA
    Schizophr Res 62:105-14. 2003
    ..Corpus callosal area was examined for COS at initial scan and prospectively through adolescence, and related to other developmental abnormalities for this group...
  31. ncbi request reprint Dynamic mapping of normal human hippocampal development
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
    Hippocampus 16:664-72. 2006
    ..These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development...
  32. ncbi request reprint Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
    Biol Psychiatry 55:976-80. 2004
    ..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder...
  33. pmc Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia
    Anand A Mattai
    Child Psychiatry Branch, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 50:697-704. 2011
    ..Here we present a replication with nonoverlapping groups of healthy full siblings and healthy controls...
  34. ncbi request reprint Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcome
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 46:1349-56. 2007
    ..Here we evaluate these as well as other measures in an effort to find predictors of response to clozapine in our early-onset treatment-refractory population...
  35. pmc Psychotic symptoms and gray matter deficits in clinical pediatric populations
    Nitin Gogtay
    Child Psychiatry Branch, National Institutes of Health, Building 10, Center Dr, Bethesda, MD 20892, USA
    Schizophr Res 140:149-54. 2012
    ..We explored the relationship of cortical GM thickness to psychotic phenotypes in children...
  36. doi request reprint Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder
    Judith L Rapoport
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Int J Dev Neurosci 29:251-8. 2011
    ....
  37. pmc Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Bldg 10, Center Dr, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 166:58-63. 2009
    ..The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD) was associated with differences in the development of the cerebral cortex during adolescence...
  38. ncbi request reprint Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophrenia
    Christine N Vidal
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, David Geffen School of Medicine at UCLA, 90095 1769, USA
    Arch Gen Psychiatry 63:25-34. 2006
    ....
  39. pmc Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:15979-84. 2008
    ..Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth...
  40. pmc Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescence
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:16988-93. 2010
    ....
  41. pmc Childhood onset schizophrenia: high rate of visual hallucinations
    Christopher N David
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 50:681-686.e3. 2011
    ..To document high rates and clinical correlates of nonauditory hallucinations in childhood onset schizophrenia (COS)...
  42. pmc Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia
    Kristin N Maher
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 23:110-6. 2013
    ..The purpose of this study was to retrospectively analyze rates of neutropenia and risk factors for neutropenia in hospitalized children and adolescents treated with clozapine...
  43. pmc Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophrenia
    Yohan Lee
    Child Psychiatry Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Psychiatr Genet 22:206-9. 2012
    ..14%, odds ratio=16.6, P=0.01). This report adds to the growing body of literature implicating rare CNVs as risk factors for schizophrenia and shows that some risk CNVs are more common among extreme early-onset cases...
  44. ncbi request reprint Clozapine-induced neutropenia in children: management with lithium carbonate
    Alexandra Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 13:401-4. 2003
    ..8-1.1 microg/mL. This report supports the use of adjunct lithium for clozapine-induced neutropenia as a safe and successful strategy in children...
  45. ncbi request reprint Molecular genetic studies of ADHD: 1991 to 2004
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Am J Med Genet B Neuropsychiatr Genet 132:109-25. 2005
    ..All candidate gene approaches continue to face the problem of relatively low power, given modest odds ratios for even the best replicated genes...
  46. ncbi request reprint IQ stabilization in childhood-onset schizophrenia
    Peter A Gochman
    Child Psychiatry Branch, NIMH Bldg 10, Rm 3N202 Bethesda, MD 20892 1600, USA
    Schizophr Res 77:271-7. 2005
    ..To examine the long term IQ trajectory for childhood-onset schizophrenia (COS) in an expanded, prospective longitudinal study...
  47. ncbi request reprint Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)
    M C Gornick
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    J Autism Dev Disord 35:831-8. 2005
    ..Four adjacent SNPs were associated (p values=.0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment...
  48. ncbi request reprint Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder
    Jacquelyn R Idol
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Autism Dev Disord 38:668-77. 2008
    ..Our efforts provide sequence-based information about a schizophrenia/autism-associated translocation, and may facilitate future studies investigating the genetic bases of these disorders...
  49. pmc Dynamic mapping of human cortical development during childhood through early adulthood
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:8174-9. 2004
    ..Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism...
  50. ncbi request reprint Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder
    F X Castellanos
    Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Room 3N-202, 10 Center Dr-MSC 1600, Bethesda, MD 20892-1600, USA
    Arch Gen Psychiatry 58:289-95. 2001
    ..CONCLUSIONS: These results confirm previous findings for boys in the posterior-inferior lobules of the cerebellar vermis. The influence of the cerebellar vermis on prefrontal and striatal circuitry should be explored...
  51. ncbi request reprint Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry
    Daniel H Mathalon
    Arch Gen Psychiatry 60:846-8; author reply 848-9. 2003
  52. doi request reprint Annual research review: impact of advances in genetics in understanding developmental psychopathology
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 53:510-8. 2012
    ..This is particularly important, as subtle abnormalities in timing and expression of gene pathways underlying brain development may well link these disorders and be the ultimate target of treatments...
  53. pmc Structural MRI of pediatric brain development: what have we learned and where are we going?
    Jay N Giedd
    Child Psychiatry Branch NIMH, Bethesda, MD 20892, USA
    Neuron 67:728-34. 2010
    ..In this review we summarize general contributions of structural MRI to our understanding of neurodevelopment in health and illness...
  54. ncbi request reprint Progressive loss of cerebellar volume in childhood-onset schizophrenia
    Audrey Keller
    Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Rm 3N 202, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 160:128-33. 2003
    ....
  55. ncbi request reprint Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, NationalInstitutes of Health, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 160:569-71. 2003
    ....
  56. ncbi request reprint Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate
    M Arcos-Burgos
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1852, USA
    Mol Psychiatry 9:252-9. 2004
    ..These results provide further evidence for the association of ADHD to genetic variation in or near to DRD4 and replicate the previously reported association between ADHD and the 7R allele...
  57. ncbi request reprint Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia
    Jean A Frazier
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Psychopharmacol 23:87-91. 2003
    ..In addition, clinical response and total number of side effects correlated with NOR concentrations. NOR (a neuropharmacologically active metabolite) and free CLZ may contribute to the effectiveness and adverse effects in youth...
  58. pmc Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia
    Hui Liu
    Human Neurogenetics Laboratory, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3717-22. 2002
    ..Our results have implications for understanding the genetic basis of the 22q11-associated psychiatric phenotypes and provide further insights into the genomic instability of this region...
  59. pmc A Novel Microduplication in the Neurodevelopmental Gene SRGAP3 That Segregates with Psychotic Illness in the Family of a COS Proband
    Nicole K A Wilson
    Child Psychiatry Branch, National Institute of Mental Health, 10 Center Drive, Building 10 Room 3N202, Bethesda, MD 20892, USA
    Case Rep Genet 2011:585893. 2011
    ..Considering that SRGAP3 is important in neural development, we conclude that this SRGAP3 duplication may be an important factor contributing to the psychotic phenotype in this family...
  60. pmc Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11
    Mauricio Arcos-Burgos
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3717, USA
    Am J Hum Genet 75:998-1014. 2004
    ..The concordance between results from different analytical methods of linkage and the replication of data between two independent studies suggest that these loci truly harbor ADHD susceptibility genes...
  61. ncbi request reprint Parental schizophrenia spectrum disorders in childhood-onset and adult-onset schizophrenia
    Rob Nicolson
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Psychiatry 160:490-5. 2003
    ..In this study, the rates of schizophrenia spectrum disorders among parents of patients with childhood-onset and adult-onset schizophrenia and parents of community comparison subjects were compared...
  62. pmc Personal reflections on observational and experimental research approaches to childhood psychopathology
    Judith L Rapoport
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892 1600, USA
    J Child Psychol Psychiatry 50:36-43. 2009
    ..Predicted future trends are: more informed subgrouping of our heterogeneous phenotypes, reliance on multicenter trials, and documentation of non-conventional methods of care delivery...
  63. ncbi request reprint Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder
    F Xavier Castellanos
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD, USA
    Am J Psychiatry 160:1693-6. 2003
    ..To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD...
  64. ncbi request reprint Decision making about children with psychotic symptoms: using the best evidence in choosing a treatment
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20932 1600, USA
    J Am Acad Child Adolesc Psychiatry 45:1381-6. 2006
  65. ncbi request reprint Correlation of antipsychotic and prolactin concentrations in children and adolescents acutely treated with haloperidol, clozapine, or olanzapine
    Cara L Alfaro
    National Institutes of Health, Clinical Center Pharmacy Department, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 12:83-91. 2002
    ..91, p = 0.03); the patient with the highest serum prolactin experienced galactorrhea. Further studies evaluating the prolactin-elevating properties of antipsychotics are warranted in this population...
  66. ncbi request reprint Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories
    A M Addington
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Mol Psychiatry 12:195-205. 2007
    ..This replication further documents the role of NRG1 in the abnormal brain development in schizophrenia. This is the first demonstration of a disease-specific pattern of gene action in schizophrenia...
  67. ncbi request reprint Autonomic activity in relation to cerebrospinal fluid neurochemistry in obsessive and disruptive children and adolescents
    T P Zahn
    Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD, USA
    Psychophysiology 33:731-9. 1996
    ..Diagnosis may affect these relationships...
  68. ncbi request reprint Regional MRI measurements of the corpus callosum: a methodological and developmental study
    J C Rajapakse
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1600, USA
    Brain Dev 18:379-88. 1996
    ..These significant and consistent results indicate that the method is reliable and sensitive to developmental changes of the CC...
  69. ncbi request reprint Statistical approach to segmentation of single-channel cerebral MR images
    J C Rajapakse
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    IEEE Trans Med Imaging 16:176-86. 1997
    ..The algorithm constitutes a significant step toward a complete data driven unsupervised approach to segmentation of MR images in the presence of the random noise and intensity inhomogeneities...
  70. pmc Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
    P Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Room 3N202, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:19649-54. 2007
    ..Neuroanatomic documentation of a delay in regional cortical maturation in ADHD has not been previously reported...
  71. ncbi request reprint Smooth pursuit eye-tracking impairment in childhood-onset psychotic disorders
    S Kumra
    NIMH Child Psychiatry Branch, 10 Center Dr, Building 10, Rm. 3N202, Bethesda, MD 20892-1600, USA
    Am J Psychiatry 158:1291-8. 2001
    ..Also, family studies are planned to establish whether eye-tracking dysfunction represents a trait- or state-related phenomenon in subjects with psychotic disorder not otherwise specified...
  72. ncbi request reprint A quantitative MRI study of the corpus callosum in children and adolescents
    J N Giedd
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    Brain Res Dev Brain Res 91:274-80. 1996
    ..These findings support anatomical studies indicating ongoing myelination of higher association areas throughout adolescence, but raise intriguing questions about anterior-posterior gradients of interhemispheric myelination...
  73. ncbi request reprint Clinical and neurobiological correlates of cytogenetic abnormalities in childhood-onset schizophrenia
    R Nicolson
    Child Psychiatry Branch, Yale University, New Haven, Conn, USA
    Am J Psychiatry 156:1575-9. 1999
    ....
  74. ncbi request reprint Three-dimensional cortical morphometry of the planum temporale in childhood-onset schizophrenia
    L K Jacobsen
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 154:685-7. 1997
    ..Anomalous planum temporale asymmetry has been linked to both schizophrenia and dyslexia. The authors examined the planum temporale of adolescents with childhood-onset schizophrenia who had a high rate of prepsychotic language disorders...
  75. ncbi request reprint Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4-18 years
    J N Giedd
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
    J Comp Neurol 366:223-30. 1996
    ....
  76. ncbi request reprint Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease
    B B Mittleman
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 159:2994-9. 1997
    ..These data provide a rationale for immune-based strategies of study and therapeutics in childhood neuropsychiatric disease...
  77. ncbi request reprint Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia
    L K Jacobsen
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 154:1663-9. 1997
    ..The authors found further support for this hypothesis by examining cerebellar morphology in severely ill children and adolescents with childhood-onset schizophrenia...
  78. ncbi request reprint Chromosome 22q11.2 interstitial deletions among childhood-onset schizophrenics and "multidimensionally impaired"
    W Yan
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Am J Med Genet 81:41-3. 1998
    ..quot; Fluorescent in situ hybridization screening of 32 COS and 21 multidimensionally impaired patients revealed 1 COS patient with an interstitial deletion spanning at least 2.5 megabases...
  79. ncbi request reprint Attention deficits in childhood-onset schizophrenia: reaction time studies
    T P Zahn
    Laboratory of Brain and Cognition, NIMH, Bethesda, Maryland 20892 1366, USA
    J Abnorm Psychol 107:97-108. 1998
    ..Overall, patients were much slower than controls in both paradigms. The results suggest similar attention dysfunction as is found in adult schizophrenia and thus are consistent with the continuity hypothesis...
  80. ncbi request reprint Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses
    F X Castellanos
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    Mol Psychiatry 3:431-4. 1998
    ..These data do not support the reported association between DRD4*7R and the behavioral or brain morphometric phenotype associated with ADHD...
  81. ncbi request reprint Sexual dimorphism of the developing human brain
    J N Giedd
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Prog Neuropsychopharmacol Biol Psychiatry 21:1185-201. 1997
    ..5. These sexually dimorphic patterns of brain development may be related to the observed sex differences in age of onset, prevalence, and symptomatology seen in nearly all neuropsychiatric disorders of childhood...
  82. ncbi request reprint An open trial of plasma exchange in childhood-onset obsessive-compulsive disorder without poststreptococcal exacerbations
    R Nicolson
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 39:1313-5. 2000
    ..All 5 patients completed the trial with few side effects, but none showed significant improvement. Plasma exchange does not benefit children and adolescents with OCD who do not have streptococcus-related exacerbations...
  83. ncbi request reprint Obstetrical complications and childhood-onset schizophrenia
    R Nicolson
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 156:1650-2. 1999
    ..Consequently, obstetrical records were examined for individuals with childhood-onset schizophrenia to determine if birth complications were more prevalent...
  84. ncbi request reprint Elevated prolactin in pediatric patients on typical and atypical antipsychotics
    M Wudarsky
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
    J Child Adolesc Psychopharmacol 9:239-45. 1999
    ....
  85. ncbi request reprint Abnormal neurologic maturation in adolescents with early-onset schizophrenia
    B I Karp
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 158:118-22. 2001
    ..This study evaluated neurologic functioning in adolescents with schizophrenia with onset of psychosis before age 13...
  86. ncbi request reprint MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection
    J N Giedd
    Child Psychiatry and Pediatrics and Developmental Neuropsychiatry Branch of NIMH, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 157:281-3. 2000
    ..The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection...
  87. ncbi request reprint Premorbid speech and language impairments in childhood-onset schizophrenia: association with risk factors
    R Nicolson
    The Child Psychiatry Branch, NIMH, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 157:794-800. 2000
    ..As both premorbid neurodevelopmental impairments and familial risk factors for schizophrenia are prominent in childhood-onset cases (with onset of psychosis by age 12), their relationship was examined...
  88. ncbi request reprint GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss
    A M Addington
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Mol Psychiatry 10:581-8. 2005
    ..These observations, when taken together with the positive results reported recently in two independent adult-onset schizophrenia pedigree samples, suggest that the gene encoding GAD67 may be a common risk factor for schizophrenia...
  89. ncbi request reprint Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21
    W L Yan
    Child Psychiatry, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Am J Med Genet 96:749-53. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:749-753, 2000. Published 2000 Wiley-Liss, Inc...
  90. ncbi request reprint Deformation-based surface morphometry applied to gray matter deformation
    Moo K Chung
    Department of Statistics, University of Wisconsin, 1210 West Dayton Street, Madison, WI 53706 1685, USA
    Neuroimage 18:198-213. 2003
    ....
  91. ncbi request reprint Clozapine-induced akathisia in children with schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 12:347-9. 2002
    ..Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described. Akathisia should be considered in all cases of apparent nonresponse to atypical antipsychotics...
  92. pmc Childhood-onset schizophrenia: the challenge of diagnosis
    Peter Gochman
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    Curr Psychiatry Rep 13:321-2. 2011
    ..Historically, medication-free observation was standard clinical care for difficult and unusual patients; this should be employed when possible in similar situations...
  93. ncbi request reprint Brain neuroplasticity in healthy, hyperactive and psychotic children: insights from neuroimaging
    Judith L Rapoport
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 33:181-97. 2008
    ....
  94. ncbi request reprint The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction
    Susan E Swedo
    Pediatrics and Developmental Neuropsychiatry Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Pediatrics 113:907-11. 2004
  95. ncbi request reprint A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting)
    H L Leonard
    National Institute of Mental Health, Child Psychiatry Branch, Bethesda, MD 20892
    Arch Gen Psychiatry 48:821-7. 1991
    ..From a neuroethologic perspective, similar biologic systems are hypothesized to mediate a spectrum of grooming behaviors, including onychophagia, trichotillomania, and obsessive-compulsive disorder...
  96. ncbi request reprint Cerebellar development and clinical outcome in attention deficit hyperactivity disorder
    Susan Mackie
    Columbia University School of Medicine, New York, NY, USA
    Am J Psychiatry 164:647-55. 2007
    ....
  97. ncbi request reprint Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia
    Paul M Thompson
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Neuroimage 23:S2-18. 2004
    ..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages...
  98. doi request reprint Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Science 320:539-43. 2008
    ..These results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia...
  99. ncbi request reprint An immunological marker (D8/17) associated with rheumatic fever as a predictor of childhood psychiatric disorders in a community sample
    Gale Inoff-Germain
    Child Psychiatry Branch, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland 20892 1600, USA
    J Child Psychol Psychiatry 44:782-90. 2003
    ..Possible associations with other disorders accompanying Sydenham's chorea--hyperactivity, anxiety, and depression, also were explored...
  100. pmc The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 3N202, Bethesda, MD 20892, USA
    Curr Psychiatry Rep 11:156-61. 2009
    ..Populations with COS may have more salient genetic influence than adult-onset cases. The relationship of rare CNVs to prepsychotic development is being studied further...
  101. ncbi request reprint Association of the dopamine receptor D4 (DRD4) gene 7-repeat allele with children with attention-deficit/hyperactivity disorder (ADHD): an update
    M C Gornick
    Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
    Am J Med Genet B Neuropsychiatr Genet 144:379-82. 2007
    ..This provides further evidence of the role of the DRD4 7-repeat allele in the etiology of ADHD and suggests that this allele may be associated with a more benign form of the disorder...