Judith L Rapoport

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Neurodevelopmental model of schizophrenia: update 2012
    J L Rapoport
    Child Psychiatry Branch, NIH, NIMH, Bethesda, MD 20892, USA
    Mol Psychiatry 17:1228-38. 2012
  2. pmc Personal reflections on observational and experimental research approaches to childhood psychopathology
    Judith L Rapoport
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892 1600, USA
    J Child Psychol Psychiatry 50:36-43. 2009
  3. ncbi request reprint Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:921-31. 2007
  4. pmc Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA 20892, USA
    Neuroimage 57:1517-23. 2011
  5. pmc Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia
    Kristin N Maher
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 23:110-6. 2013
  6. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008
  7. pmc General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study
    Jennifer L Bakalar
    Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 115:12-6. 2009
  8. ncbi request reprint Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Arch Gen Psychiatry 61:17-22. 2004
  9. ncbi request reprint Dynamic mapping of hippocampal development in childhood onset schizophrenia
    Tom F Nugent
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Schizophr Res 90:62-70. 2007
  10. ncbi request reprint Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:721-30. 2006

Collaborators

Detail Information

Publications63

  1. pmc Neurodevelopmental model of schizophrenia: update 2012
    J L Rapoport
    Child Psychiatry Branch, NIH, NIMH, Bethesda, MD 20892, USA
    Mol Psychiatry 17:1228-38. 2012
    ..Biological nonspecificity, such as in timing or nature of early brain development, carries the possibility of new targets for broad preventive treatments...
  2. pmc Personal reflections on observational and experimental research approaches to childhood psychopathology
    Judith L Rapoport
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892 1600, USA
    J Child Psychol Psychiatry 50:36-43. 2009
    ..Predicted future trends are: more informed subgrouping of our heterogeneous phenotypes, reliance on multicenter trials, and documentation of non-conventional methods of care delivery...
  3. ncbi request reprint Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:921-31. 2007
    ..Attention-deficit/hyperactivity disorder (ADHD) is one of the most heritable neuropsychiatric disorders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated in its pathogenesis...
  4. pmc Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA 20892, USA
    Neuroimage 57:1517-23. 2011
    ..These findings suggest that cortical abnormalities in pedigrees affected by schizophrenia may be contributed to by a disruption of dopaminergic infleunces on cortical maturation...
  5. pmc Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia
    Kristin N Maher
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 23:110-6. 2013
    ..The purpose of this study was to retrospectively analyze rates of neutropenia and risk factors for neutropenia in hospitalized children and adolescents treated with clozapine...
  6. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008
    ..We hypothesized that total, frontal, temporal, and parietal gray matter thickness would be greater in patients who subsequently remit...
  7. pmc General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study
    Jennifer L Bakalar
    Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 115:12-6. 2009
    ..Recent studies show dynamic changes in brain asymmetry during childhood and adolescence. We hypothesized that COS patients would show a lack of normal development of asymmetry and decreased overall asymmetry...
  8. ncbi request reprint Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Arch Gen Psychiatry 61:17-22. 2004
    ..We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses...
  9. ncbi request reprint Dynamic mapping of hippocampal development in childhood onset schizophrenia
    Tom F Nugent
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Schizophr Res 90:62-70. 2007
    ....
  10. ncbi request reprint Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:721-30. 2006
    ..The psychiatrist has a limited evidence base to guide treatment, particularly as there are no trials in children comparing atypical antipsychotics, the mainstay of current treatment...
  11. ncbi request reprint Sleep disturbances in childhood-onset schizophrenia
    Anand A Mattai
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    Schizophr Res 86:123-9. 2006
    ..As there are numerous health implications of poor sleep, clinicians should have a low threshold for treating sleep disturbances in this population...
  12. ncbi request reprint Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:852-62. 2007
    ..We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset...
  13. ncbi request reprint Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 69:875-84. 2012
    ..As reported before for gray matter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with age...
  14. ncbi request reprint Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?
    Alexandra L Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:989-94. 2004
    ..In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an independent risk factor for COS...
  15. ncbi request reprint Progressive brain volume loss during adolescence in childhood-onset schizophrenia
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Am J Psychiatry 160:2181-9. 2003
    ..This study examined the rate of loss in cortical gray matter volume in relation to age and clinical status in adolescent patients over a follow-up period of 2-6 years...
  16. ncbi request reprint Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Lancet Neurol 6:494-500. 2007
    ....
  17. pmc Childhood onset schizophrenia and early onset schizophrenia spectrum disorders
    David I Driver
    Child Psychiatry Branch, National Institutes of Mental Health NIMH, National Institutes Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Child Adolesc Psychiatr Clin N Am 22:539-55. 2013
    ..Once a diagnosis is affirmed, aggressive medication treatment combined with family education and individual counseling may defer further deterioration. ..
  18. ncbi request reprint Looking for childhood schizophrenia: case series of false positives
    Catherine Stayer
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 43:1026-9. 2004
    ..16). These cases illustrate that transient psychotic illnesses can be misdiagnosed as childhood-onset schizophrenia. Proper identification can prevent years of inappropriate therapies...
  19. ncbi request reprint Childhood onset schizophrenia: familial neurocognitive measures
    Peter A Gochman
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 71:43-7. 2004
    ..Neurocognitive deficits which are seen in families of adult onset schizophrenic patients were examined in healthy family members of patients with childhood-onset schizophrenia (COS)...
  20. ncbi request reprint Support for association between ADHD and two candidate genes: NET1 and DRD1
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
    Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005
    ..Because family-based and case-control methods gave divergent results, both should be used in genetic studies of ADHD...
  21. ncbi request reprint Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family members
    Alexandra Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institute of Health, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Schizophr Res 73:243-52. 2005
    ..Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia...
  22. ncbi request reprint Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 44:925-33. 2005
    ..In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment...
  23. doi request reprint Neurodevelopmental trajectories of the human cerebral cortex
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:3586-94. 2008
    ....
  24. ncbi request reprint Dynamic mapping of normal human hippocampal development
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
    Hippocampus 16:664-72. 2006
    ..These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development...
  25. ncbi request reprint Multidimensionally impaired: the good news
    Catherine Stayer
    Child Psychiatry Branch at the National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 15:510-9. 2005
    ..Despite severe preadmission morbidity, some patients have successfully remained neuroleptic-free since discharge. Predictors of good versus poor outcome were sought...
  26. pmc Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia
    Anand A Mattai
    Child Psychiatry Branch, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 50:697-704. 2011
    ..Here we present a replication with nonoverlapping groups of healthy full siblings and healthy controls...
  27. ncbi request reprint Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcome
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 46:1349-56. 2007
    ..Here we evaluate these as well as other measures in an effort to find predictors of response to clozapine in our early-onset treatment-refractory population...
  28. ncbi request reprint Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
    Biol Psychiatry 55:976-80. 2004
    ..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder...
  29. ncbi request reprint Stimulant drug treatment in childhood-onset schizophrenia with comorbid ADHD: an open-label case series
    Julia W Tossell
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Room 3N202, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 14:448-54. 2004
    ..Our results suggest that ADHD comorbid with COS may be safely treated with a stimulant, once the psychosis is stabilized. A systematic investigation of this question may be warranted...
  30. pmc Psychotic symptoms and gray matter deficits in clinical pediatric populations
    Nitin Gogtay
    Child Psychiatry Branch, National Institutes of Health, Building 10, Center Dr, Bethesda, MD 20892, USA
    Schizophr Res 140:149-54. 2012
    ..We explored the relationship of cortical GM thickness to psychotic phenotypes in children...
  31. doi request reprint Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder
    Judith L Rapoport
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Int J Dev Neurosci 29:251-8. 2011
    ....
  32. pmc Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:15979-84. 2008
    ..Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth...
  33. pmc Childhood onset schizophrenia: high rate of visual hallucinations
    Christopher N David
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 50:681-686.e3. 2011
    ..To document high rates and clinical correlates of nonauditory hallucinations in childhood onset schizophrenia (COS)...
  34. pmc Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescence
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:16988-93. 2010
    ....
  35. pmc Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Bldg 10, Center Dr, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 166:58-63. 2009
    ..The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD) was associated with differences in the development of the cerebral cortex during adolescence...
  36. ncbi request reprint IQ stabilization in childhood-onset schizophrenia
    Peter A Gochman
    Child Psychiatry Branch, NIMH Bldg 10, Rm 3N202 Bethesda, MD 20892 1600, USA
    Schizophr Res 77:271-7. 2005
    ..To examine the long term IQ trajectory for childhood-onset schizophrenia (COS) in an expanded, prospective longitudinal study...
  37. pmc Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophrenia
    Yohan Lee
    Child Psychiatry Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Psychiatr Genet 22:206-9. 2012
    ..14%, odds ratio=16.6, P=0.01). This report adds to the growing body of literature implicating rare CNVs as risk factors for schizophrenia and shows that some risk CNVs are more common among extreme early-onset cases...
  38. ncbi request reprint Clozapine-induced neutropenia in children: management with lithium carbonate
    Alexandra Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 13:401-4. 2003
    ..8-1.1 microg/mL. This report supports the use of adjunct lithium for clozapine-induced neutropenia as a safe and successful strategy in children...
  39. ncbi request reprint Molecular genetic studies of ADHD: 1991 to 2004
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Am J Med Genet B Neuropsychiatr Genet 132:109-25. 2005
    ..All candidate gene approaches continue to face the problem of relatively low power, given modest odds ratios for even the best replicated genes...
  40. ncbi request reprint Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder
    Jacquelyn R Idol
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Autism Dev Disord 38:668-77. 2008
    ..Our efforts provide sequence-based information about a schizophrenia/autism-associated translocation, and may facilitate future studies investigating the genetic bases of these disorders...
  41. doi request reprint Annual research review: impact of advances in genetics in understanding developmental psychopathology
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 53:510-8. 2012
    ..This is particularly important, as subtle abnormalities in timing and expression of gene pathways underlying brain development may well link these disorders and be the ultimate target of treatments...
  42. ncbi request reprint Corpus callosum development in childhood-onset schizophrenia
    Audrey Keller
    Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3N 202, 10 Center Drive MSC 1600, Bethesda, MD 20892 1600, USA
    Schizophr Res 62:105-14. 2003
    ..Corpus callosal area was examined for COS at initial scan and prospectively through adolescence, and related to other developmental abnormalities for this group...
  43. pmc Structural MRI of pediatric brain development: what have we learned and where are we going?
    Jay N Giedd
    Child Psychiatry Branch NIMH, Bethesda, MD 20892, USA
    Neuron 67:728-34. 2010
    ..In this review we summarize general contributions of structural MRI to our understanding of neurodevelopment in health and illness...
  44. ncbi request reprint Decision making about children with psychotic symptoms: using the best evidence in choosing a treatment
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20932 1600, USA
    J Am Acad Child Adolesc Psychiatry 45:1381-6. 2006
  45. pmc Dynamic mapping of human cortical development during childhood through early adulthood
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:8174-9. 2004
    ..Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism...
  46. pmc Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11
    Mauricio Arcos-Burgos
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3717, USA
    Am J Hum Genet 75:998-1014. 2004
    ..The concordance between results from different analytical methods of linkage and the replication of data between two independent studies suggest that these loci truly harbor ADHD susceptibility genes...
  47. pmc A Novel Microduplication in the Neurodevelopmental Gene SRGAP3 That Segregates with Psychotic Illness in the Family of a COS Proband
    Nicole K A Wilson
    Child Psychiatry Branch, National Institute of Mental Health, 10 Center Drive, Building 10 Room 3N202, Bethesda, MD 20892, USA
    Case Rep Genet 2011:585893. 2011
    ..Considering that SRGAP3 is important in neural development, we conclude that this SRGAP3 duplication may be an important factor contributing to the psychotic phenotype in this family...
  48. ncbi request reprint Correlation of antipsychotic and prolactin concentrations in children and adolescents acutely treated with haloperidol, clozapine, or olanzapine
    Cara L Alfaro
    National Institutes of Health, Clinical Center Pharmacy Department, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 12:83-91. 2002
    ..91, p = 0.03); the patient with the highest serum prolactin experienced galactorrhea. Further studies evaluating the prolactin-elevating properties of antipsychotics are warranted in this population...
  49. ncbi request reprint Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, NationalInstitutes of Health, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 160:569-71. 2003
    ....
  50. ncbi request reprint Progressive loss of cerebellar volume in childhood-onset schizophrenia
    Audrey Keller
    Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Rm 3N 202, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 160:128-33. 2003
    ....
  51. pmc Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis
    Christopher N David
    Child Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Building 10, Room 3N202, 10 Center Drive, Bethesda, MD 20890, USA
    Expert Rev Neurother 13:447-58. 2013
    ..Transcranial direct current stimulation may provide a safe and effective adjuvant treatment for continued residual symptoms of schizophrenia...
  52. pmc Childhood-onset schizophrenia: the challenge of diagnosis
    Peter Gochman
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    Curr Psychiatry Rep 13:321-2. 2011
    ..Historically, medication-free observation was standard clinical care for difficult and unusual patients; this should be employed when possible in similar situations...
  53. ncbi request reprint The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction
    Susan E Swedo
    Pediatrics and Developmental Neuropsychiatry Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Pediatrics 113:907-11. 2004
  54. ncbi request reprint Clozapine-induced akathisia in children with schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 12:347-9. 2002
    ..Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described. Akathisia should be considered in all cases of apparent nonresponse to atypical antipsychotics...
  55. ncbi request reprint Brain neuroplasticity in healthy, hyperactive and psychotic children: insights from neuroimaging
    Judith L Rapoport
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 33:181-97. 2008
    ....
  56. ncbi request reprint Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder
    F Xavier Castellanos
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    JAMA 288:1740-8. 2002
    ..Various anatomic brain abnormalities have been reported for attention-deficit/hyperactivity disorder (ADHD), with varying methods, small samples, cross-sectional designs, and without accounting for stimulant drug exposure...
  57. ncbi request reprint The neurodevelopmental model of schizophrenia: what can very early onset cases tell us?
    Judith L Rapoport
    Child Psychiatry Branch, Building 10, 9000 Rockville Pike, National Institutes of Mental Health NIH, Bethesda, MD 20892, USA
    Curr Psychiatry Rep 7:81-2. 2005
  58. ncbi request reprint Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder
    F Xavier Castellanos
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD, USA
    Am J Psychiatry 160:1693-6. 2003
    ..To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD...
  59. pmc The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 3N202, Bethesda, MD 20892, USA
    Curr Psychiatry Rep 11:156-61. 2009
    ..Populations with COS may have more salient genetic influence than adult-onset cases. The relationship of rare CNVs to prepsychotic development is being studied further...
  60. pmc The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans
    Madhav Thambisetty
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 32:676-84. 2012
    ..1-(11)C]AA PET may be useful for studying disturbances of dopaminergic neurotransmission in conditions such as Parkinson's disease and schizophrenia...
  61. ncbi request reprint Parental schizophrenia spectrum disorders in childhood-onset and adult-onset schizophrenia
    Rob Nicolson
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Psychiatry 160:490-5. 2003
    ..In this study, the rates of schizophrenia spectrum disorders among parents of patients with childhood-onset and adult-onset schizophrenia and parents of community comparison subjects were compared...
  62. ncbi request reprint An immunological marker (D8/17) associated with rheumatic fever as a predictor of childhood psychiatric disorders in a community sample
    Gale Inoff-Germain
    Child Psychiatry Branch, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland 20892 1600, USA
    J Child Psychol Psychiatry 44:782-90. 2003
    ..Possible associations with other disorders accompanying Sydenham's chorea--hyperactivity, anxiety, and depression, also were explored...
  63. ncbi request reprint Brain development in healthy, hyperactive, and psychotic children
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bldg 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Arch Neurol 59:1244-8. 2002