V Koneti Rao

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc How I treat autoimmune lymphoproliferative syndrome
    V Koneti Rao
    ALPS Unit, Laboratory of Clinical and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 118:5741-51. 2011
  2. doi request reprint Autoimmune lymphoproliferative syndrome due to FAS mutations outside the signal-transducing death domain: molecular mechanisms and clinical penetrance
    Amy P Hsu
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Genet Med 14:81-9. 2012
  3. pmc Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
    Julie E Niemela
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Bethesda, MD, USA
    Blood 117:2883-6. 2011
  4. pmc Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States
    Jeffrey I Cohen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 117:5835-49. 2011
  5. pmc FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndrome
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 186:6035-43. 2011
  6. pmc Autoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis
    Amanda Rudman Spergel
    ALPS Unit, LI NIAID, National Institutes of Health, DHHS, Room 12C106, Building 10, 10 Center Dr, Bethesda, MD 20892 1899
    Pediatrics 132:e1440-4. 2013
  7. pmc A rapid ex vivo clinical diagnostic assay for fas receptor-induced T lymphocyte apoptosis
    Bernice Lo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Immunol 33:479-88. 2013
  8. doi request reprint Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
    Carrie L Lucas
    1 Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Immunol 15:88-97. 2014
  9. pmc Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome
    Kennichi C Dowdell
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
    Blood 115:5164-9. 2010

Collaborators

Detail Information

Publications9

  1. pmc How I treat autoimmune lymphoproliferative syndrome
    V Koneti Rao
    ALPS Unit, Laboratory of Clinical and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 118:5741-51. 2011
    ..The best approaches to diagnosis, follow-up, and management of ALPS, its associated cytopenias, and other complications resulting from infiltrative lymphoproliferation and autoimmunity are presented...
  2. doi request reprint Autoimmune lymphoproliferative syndrome due to FAS mutations outside the signal-transducing death domain: molecular mechanisms and clinical penetrance
    Amy P Hsu
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Genet Med 14:81-9. 2012
    ....
  3. pmc Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
    Julie E Niemela
    Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Bethesda, MD, USA
    Blood 117:2883-6. 2011
    ..We suggest the use of the term RAS-associated autoimmune leukoproliferative disease to differentiate this disorder from autoimmune lymphoproliferative syndrome...
  4. pmc Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States
    Jeffrey I Cohen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 117:5835-49. 2011
    ..These studies are registered at http://www.clinicaltrials.gov as NCT00032513 for CAEBV, NCT00062868 and NCT00058812 for EBV-specific T-cell studies, and NCT00578539 for the hematopoietic stem cell transplantation protocol...
  5. pmc FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndrome
    Hye Sun Kuehn
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 186:6035-43. 2011
    ..The apoptosis defect could be corrected by FAS overexpression in vitro. Our findings define haploinsufficiency as a common disease mechanism in ALPS patients with extracellular FAS mutations...
  6. pmc Autoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis
    Amanda Rudman Spergel
    ALPS Unit, LI NIAID, National Institutes of Health, DHHS, Room 12C106, Building 10, 10 Center Dr, Bethesda, MD 20892 1899
    Pediatrics 132:e1440-4. 2013
    ....
  7. pmc A rapid ex vivo clinical diagnostic assay for fas receptor-induced T lymphocyte apoptosis
    Bernice Lo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Immunol 33:479-88. 2013
    ..Hence, this rapid apoptosis assay can expedite the diagnosis of new ALPS patients, including those with somatic mutations, and facilitate clinical and molecular investigation of these diseases...
  8. doi request reprint Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
    Carrie L Lucas
    1 Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Immunol 15:88-97. 2014
    ..Notably, treatment with rapamycin to inhibit mTOR activity in vivo partially restored the abundance of naive T cells, largely 'rescued' the in vitro T cell defects and improved the clinical course. ..
  9. pmc Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome
    Kennichi C Dowdell
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
    Blood 115:5164-9. 2010
    ..These findings also highlight the potential role for somatic mutations in the pathogenesis of nonmalignant and/or autoimmune hematologic conditions in adults and children...