Jagadeesh S Rao
Affiliation: National Institutes of Health
Rao J, Langenbach R, Bosetti F. Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse. Brain Res Mol Brain Res. 2005;139:217-24 pubmed
..Overall, our data indicate that constitutive brain NF-kappaB activity is decreased in COX-2 deficient mice and suggest a reciprocal coupling between NF-kappaB and COX-2. ..
Rao J, Ertley R, DeMar J, Rapoport S, Bazinet R, Lee H. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry. 2007;12:151-7 pubmed
Rao J, Harry G, Rapoport S, Kim H. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry. 2010;15:384-92 pubmed publisher
..The changes may account for reported evidence of disease progression in BD and be a target for future therapy. ..
Rao J, Rapoport S. Mood-stabilizers target the brain arachidonic acid cascade. Curr Mol Pharmacol. 2009;2:207-14 pubmed
..In this review, we discuss the mechanisms of action of mood stabilizers and the effects of docosahexaenoic acid on AA cascade enzymes in relation to BD. ..
Rao J, Kim H, Harry G, Rapoport S, Reese E. RETRACTED: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients. Schizophr Res. 2013;147:24-31 pubmed publisher
Rao J, Keleshian V, Klein S, Rapoport S. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry. 2012;2:e132 pubmed publisher
..These epigenetic modifications involving neuroinflammatory, AA cascade and synaptic markers may contribute to progression in AD and BD and identify new targets for drug development. ..