Jagadeesh S Rao

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. request reprint
    Rao J, Rapoport S, Bosetti F. Decrease in the AP-2 DNA-binding activity and in the protein expression of AP-2 alpha and AP-2 beta in frontal cortex of rats treated with lithium for 6 weeks. Neuropsychopharmacology. 2005;30:2006-13 pubmed
    ....
  2. request reprint
    Rao J, Ertley R, Lee H, Rapoport S, Bazinet R. Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex. Pharmacogenomics J. 2006;6:413-20 pubmed
    ..Chronic fluoxetine's effect on cPLA(2) expression was opposite to the effect reported with chronic lithium or carbamazepine administration, and may be part of fluoxetine's mode of action...
  3. request reprint
    Rao J, Bazinet R, Rapoport S, Lee H. RETRACTED: Chronic administration of carbamazepine down-regulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortex. Biol Psychiatry. 2007;61:154-61 pubmed
  4. request reprint
    Rao J, Ertley R, Lee H, DeMar J, Arnold J, Rapoport S, et al. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry. 2007;12:36-46 pubmed
    ..DHA's ability to regulate BDNF via a p38 MAPK-dependent mechanism may contribute to its therapeutic efficacy in brain diseases having disordered cell survival and neuroplasticity. ..
  5. request reprint
    Rao J, Ertley R, DeMar J, Rapoport S, Bazinet R, Lee H. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry. 2007;12:151-7 pubmed
    ....
  6. Rao J, Harry G, Rapoport S, Kim H. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry. 2010;15:384-92 pubmed publisher
    ..The changes may account for reported evidence of disease progression in BD and be a target for future therapy. ..
  7. Rao J, Rapoport S. Mood-stabilizers target the brain arachidonic acid cascade. Curr Mol Pharmacol. 2009;2:207-14 pubmed
    ..In this review, we discuss the mechanisms of action of mood stabilizers and the effects of docosahexaenoic acid on AA cascade enzymes in relation to BD. ..
  8. Rao J, Kim H, Harry G, Rapoport S, Reese E. RETRACTED: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients. Schizophr Res. 2013;147:24-31 pubmed publisher
  9. Rao J, Kim H, Kellom M, Greenstein D, Chen M, Kraft A, et al. Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats. J Neuroinflammation. 2011;8:101 pubmed publisher
    ..These changes are associated with viral proteins and may contribute to cognitive impairment. The HIV-1 Tg rat may be a useful model for understanding progression and treatment of cognitive impairment in HIV-1 patients. ..
  10. Rao J, Keleshian V, Klein S, Rapoport S. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry. 2012;2:e132 pubmed publisher
    ..These epigenetic modifications involving neuroinflammatory, AA cascade and synaptic markers may contribute to progression in AD and BD and identify new targets for drug development. ..

Locale

Collaborators

Detail Information

Publications10

  1. request reprint
    Rao J, Rapoport S, Bosetti F. Decrease in the AP-2 DNA-binding activity and in the protein expression of AP-2 alpha and AP-2 beta in frontal cortex of rats treated with lithium for 6 weeks. Neuropsychopharmacology. 2005;30:2006-13 pubmed
    ....
  2. request reprint
    Rao J, Ertley R, Lee H, Rapoport S, Bazinet R. Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex. Pharmacogenomics J. 2006;6:413-20 pubmed
    ..Chronic fluoxetine's effect on cPLA(2) expression was opposite to the effect reported with chronic lithium or carbamazepine administration, and may be part of fluoxetine's mode of action...
  3. request reprint
    Rao J, Bazinet R, Rapoport S, Lee H. RETRACTED: Chronic administration of carbamazepine down-regulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortex. Biol Psychiatry. 2007;61:154-61 pubmed
  4. request reprint
    Rao J, Ertley R, Lee H, DeMar J, Arnold J, Rapoport S, et al. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry. 2007;12:36-46 pubmed
    ..DHA's ability to regulate BDNF via a p38 MAPK-dependent mechanism may contribute to its therapeutic efficacy in brain diseases having disordered cell survival and neuroplasticity. ..
  5. request reprint
    Rao J, Ertley R, DeMar J, Rapoport S, Bazinet R, Lee H. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry. 2007;12:151-7 pubmed
    ....
  6. Rao J, Harry G, Rapoport S, Kim H. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry. 2010;15:384-92 pubmed publisher
    ..The changes may account for reported evidence of disease progression in BD and be a target for future therapy. ..
  7. Rao J, Rapoport S. Mood-stabilizers target the brain arachidonic acid cascade. Curr Mol Pharmacol. 2009;2:207-14 pubmed
    ..In this review, we discuss the mechanisms of action of mood stabilizers and the effects of docosahexaenoic acid on AA cascade enzymes in relation to BD. ..
  8. Rao J, Kim H, Harry G, Rapoport S, Reese E. RETRACTED: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients. Schizophr Res. 2013;147:24-31 pubmed publisher
  9. Rao J, Kim H, Kellom M, Greenstein D, Chen M, Kraft A, et al. Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats. J Neuroinflammation. 2011;8:101 pubmed publisher
    ..These changes are associated with viral proteins and may contribute to cognitive impairment. The HIV-1 Tg rat may be a useful model for understanding progression and treatment of cognitive impairment in HIV-1 patients. ..
  10. Rao J, Keleshian V, Klein S, Rapoport S. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry. 2012;2:e132 pubmed publisher
    ..These epigenetic modifications involving neuroinflammatory, AA cascade and synaptic markers may contribute to progression in AD and BD and identify new targets for drug development. ..