Kalina Ranguelova

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc (Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:970-5. 2010
  2. pmc Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 01, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 47:11377-85. 2008
  3. pmc New insights into the detection of sulfur trioxide anion radical by spin trapping: radical trapping versus nucleophilic addition
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 47:128-34. 2009
  4. pmc Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite
    Kalina Ranguelova
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 285:24195-205. 2010
  5. pmc Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate
    Kalina Ranguelova
    Laboratory of Pharmacology and Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:589-94. 2012
  6. pmc Evaluation of the Forrester-Hepburn mechanism as an artifact source in ESR spin-trapping
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 24:2217-26. 2011
  7. pmc The fidelity of spin trapping with DMPO in biological systems
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Magn Reson Chem 49:152-8. 2011
  8. pmc Formation of reactive sulfite-derived free radicals by the activation of human neutrophils: an ESR study
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:1264-71. 2012
  9. pmc Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle
    Marcelo G Bonini
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    J Biol Chem 284:14618-27. 2009
  10. pmc Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:98-106. 2013

Collaborators

Detail Information

Publications15

  1. pmc (Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:970-5. 2010
    ..This free radical further reacts with oxygen to form the peroxymonosulfate anion radical (-O(3)SOO*) and sulfate anion radical (SO(4)*-)...
  2. pmc Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 01, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 47:11377-85. 2008
    ..Furthermore, the formation of protein-DMPO nitrone adducts was accelerated in the presence of isoniazid...
  3. pmc New insights into the detection of sulfur trioxide anion radical by spin trapping: radical trapping versus nucleophilic addition
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 47:128-34. 2009
    ..1 M and the incubations are for longer times...
  4. pmc Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite
    Kalina Ranguelova
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 285:24195-205. 2010
    ..These studies suggest that EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders...
  5. pmc Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate
    Kalina Ranguelova
    Laboratory of Pharmacology and Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:589-94. 2012
    ..It is proposed that the dissociation of His61 from the active site Cu(I) in SOD-Cu(I) contributes to this chemistry by facilitating the binding of larger anions, such as peroxymonocarbonate...
  6. pmc Evaluation of the Forrester-Hepburn mechanism as an artifact source in ESR spin-trapping
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 24:2217-26. 2011
    ....
  7. pmc The fidelity of spin trapping with DMPO in biological systems
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Magn Reson Chem 49:152-8. 2011
    ....
  8. pmc Formation of reactive sulfite-derived free radicals by the activation of human neutrophils: an ESR study
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:1264-71. 2012
    ..Therefore, we propose that the potential toxicity of (bi)sulfite during pulmonary inflammation or lung-associated diseases such as asthma may be related to free radical formation...
  9. pmc Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle
    Marcelo G Bonini
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    J Biol Chem 284:14618-27. 2009
    ..The results gathered herein indicate that peroxymonocarbonate (HOOCO(2)(-)) is a key intermediate in the SOD1 peroxidase cycle and identify this species as the precursor of carbonate radical anions...
  10. pmc Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:98-106. 2013
    ..Our present study demonstrates that myeloperoxidase initiates (bi)sulfite oxidation leading to MPO radical damage, possibly leading to (bi)sulfite-exacerbated allergic reactions...
  11. pmc Studies on the photosensitized reduction of resorufin and implications for the detection of oxidative stress with Amplex Red
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 51:153-9. 2011
    ..The suppression of oxygen consumption by addition of SOD or catalase further confirmed the production of superoxide and hydrogen peroxide...
  12. pmc Radical sites in Mycobacterium tuberculosis KatG identified using electron paramagnetic resonance spectroscopy, the three-dimensional crystal structure, and electron transfer couplings
    Kalina Ranguelova
    Department of Chemistry, Brooklyn College, Brooklyn, New York 11210, USA
    J Biol Chem 282:6255-64. 2007
    ..The radical processing of enzyme lacking the Trp(107)-Tyr(229)-Met(255) adduct (found as a unique structural feature of catalase-peroxidases) is suggested to be a reasonable assignment of the phenomena...
  13. ncbi request reprint Reaction of Mycobacterium tuberculosis truncated hemoglobin O with hydrogen peroxide: evidence for peroxidatic activity and formation of protein-based radicals
    Hugues Ouellet
    Department of Biochemistry and Microbiology, Laval University, Quebec G1K 7P4, Canada
    J Biol Chem 282:7491-503. 2007
    ..These findings suggest an oxidation/reduction function for trHbO and, by analogy, for other Group II trHbs...
  14. ncbi request reprint Spectroscopic and biochemical studies on protein variants of quinaldine 4-oxidase: Role of E736 in catalysis and effects of serine ligands on the FeSI and FeSII clusters
    Reinhard Kappl
    Institut fur Biophysik, Universitat des Saarlandes, D 66421 Homburg, Germany
    Biochemistry 45:14853-68. 2006
    ..The location of the reducible iron sites of FeSI and FeSII appears to be conserved in enzymes of the xanthine oxidase family...
  15. ncbi request reprint Dioxygenases without requirement for cofactors and their chemical model reaction: compulsory order ternary complex mechanism of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase involving general base catalysis by histidine 251 and single-electron oxidation of
    Ursula Frerichs-Deeken
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Biochemistry 43:14485-99. 2004
    ..Subsequent intramolecular attack would result in the 2,4-endoperoxy (di)anion that may collapse to the reaction products...