Preetha Rajaraman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genome-wide association study of glioma and meta-analysis
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Genet 131:1877-88. 2012
  2. pmc Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    BMJ 342:d472. 2011
  3. pmc Risk of meningioma and common variation in genes related to innate immunity
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, Neuro Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7058, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 19:1356-61. 2010
  4. pmc DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892 7238, USA
    Neuro Oncol 12:37-48. 2010
  5. pmc Hunting for the causes of meningioma--obesity is a suspect
    Preetha Rajaraman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD 20852, USA
    Cancer Prev Res (Phila) 4:1353-5. 2011
  6. pmc Common variation in genes related to innate immunity and risk of adult glioma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1651-8. 2009
  7. doi request reprint Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists
    Preetha Rajaraman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 123:2713-6. 2008
  8. pmc Oxidative response gene polymorphisms and risk of adult brain tumors
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Neuro Oncol 10:709-15. 2008
  9. pmc Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Environ Health Perspect 113:1209-11. 2005
  10. ncbi request reprint Occupation and risk of meningioma and acoustic neuroma in the United States
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
    Am J Ind Med 45:395-407. 2004

Detail Information

Publications43

  1. pmc Genome-wide association study of glioma and meta-analysis
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Genet 131:1877-88. 2012
    ..Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk...
  2. pmc Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    BMJ 342:d472. 2011
    ..To examine childhood cancer risks associated with exposure to diagnostic radiation and ultrasound scans in utero and in early infancy (age 0-100 days)...
  3. pmc Risk of meningioma and common variation in genes related to innate immunity
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, Neuro Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7058, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 19:1356-61. 2010
    ..The etiology of meningioma, the second most common type of adult brain tumor in the United States, is largely unknown. Prior studies indicate that history of immune-related conditions may affect the risk of meningioma...
  4. pmc DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892 7238, USA
    Neuro Oncol 12:37-48. 2010
    ..03). Decreased glioma risk was observed with the XRCC1 rs1799782 variant (P(trend) .04). Our results suggest that common DNA repair variants may affect the risk of adult brain tumors, especially meningioma...
  5. pmc Hunting for the causes of meningioma--obesity is a suspect
    Preetha Rajaraman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD 20852, USA
    Cancer Prev Res (Phila) 4:1353-5. 2011
    ....
  6. pmc Common variation in genes related to innate immunity and risk of adult glioma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1651-8. 2009
    ..We have identified a promising set of innate immunity-related genetic regions for further investigation...
  7. doi request reprint Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists
    Preetha Rajaraman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 123:2713-6. 2008
    ..1-21.3; EOR/Gy(AC/CC) = 0.6, 95% CI = <0, 4.6; p(het) = 0.01). These results suggest that common variants in nucleotide excision repair genes may modify the association between occupational radiation exposure and breast cancer risk...
  8. pmc Oxidative response gene polymorphisms and risk of adult brain tumors
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Neuro Oncol 10:709-15. 2008
    ..6; 95% CI, 0.3-1.0). These relationships persisted when major groups of disease controls were excluded from the analysis. Our results suggest that common variants in the SOD2, SOD3, and CAT genes may influence brain tumor risk...
  9. pmc Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Environ Health Perspect 113:1209-11. 2005
    ..2; 95% CI, 0.7-2.2). No increased risk associated with the ALAD2 variant was observed for glioma or acoustic neuroma. These findings suggest that the ALAD2 allele may increase genetic susceptibility to meningioma...
  10. ncbi request reprint Occupation and risk of meningioma and acoustic neuroma in the United States
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
    Am J Ind Med 45:395-407. 2004
    ..Workplace exposures may be related to the development of brain tumors. In this case-control study, we examine occupation as a risk factor for meningioma and acoustic neuroma...
  11. ncbi request reprint Lung cancer risk among US radiologic technologists, 1983-1998
    Preetha Rajaraman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Int J Cancer 119:2481-6. 2006
    ..Overall, we find very limited evidence that chronic low-to-moderate dose occupational exposure increased lung cancer risk in the US Radiologic Technologist cohort...
  12. ncbi request reprint Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS Room 7085, 6120 Executive Boulevard, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:1655-61. 2007
    ..Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways...
  13. ncbi request reprint Lead, genetic susceptibility, and risk of adult brain tumors
    Preetha Rajaraman
    Division of Cancer Epidemiology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7085, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 15:2514-20. 2006
    ..The ALAD G177C polymorphism affects the toxicokinetics of lead and may confer genetic susceptibility to adverse effects of lead exposure...
  14. pmc Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7060, MSC 7238, Bethesda, MD, 20892 7238, USA
    Breast Cancer Res Treat 118:177-84. 2009
    ..06). We found suggestive evidence that common variants in selected estrogen metabolizing genes may modify the association between ionizing radiation exposure and breast cancer risk...
  15. pmc A prospective study of medical diagnostic radiography and risk of thyroid cancer
    Gila Neta
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Am J Epidemiol 177:800-9. 2013
    ....
  16. ncbi request reprint Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:2000-7. 2007
    ..For this reason, potential modification of the relationship between ionizing radiation exposure and breast cancer risk by polymorphic apoptosis gene variants have not been investigated among radiation-exposed women...
  17. pmc Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors
    Parveen Bhatti
    Department of Health ad Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 18:1841-8. 2009
    ..Although the results of this study provide some evidence that lead may cause glioblastoma multiforme and meningioma through mechanisms related to oxidative damage, the results must be confirmed in other populations...
  18. pmc Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 50:285-90. 2009
    ..Integrin/receptor and complement pathways as well as IgE regulation are particularly noteworthy...
  19. pmc Sunlight and other determinants of circulating 25-hydroxyvitamin D levels in black and white participants in a nationwide U.S. study
    D Michal Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7238, USA
    Am J Epidemiol 177:180-92. 2013
    ..Despite detailed data on UVR and other factors near the time of blood collection, the ability to explain 25(OH)D was modest...
  20. pmc Occupational exposure to chlorinated solvents and risks of glioma and meningioma in adults
    Gila Neta
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS, Room 7092, 6120 Executive Boulevard, Bethesda, MD 20852 7244, USA
    Occup Environ Med 69:793-801. 2012
    ..e., dichloromethane, chloroform, carbon tetrachloride, 1,1,1-trichloroethane, trichloroethylene and perchloroethylene)...
  21. ncbi request reprint The mortality risk of smoking and obesity combined
    D Michal Freedman
    National Cancer Institute, Division of Epidemiology and Genetics, Bethesda, Maryland 20892, USA
    Am J Prev Med 31:355-62. 2006
    ..This nationwide, prospective mortality study of U.S. radiologic technologists was designed to evaluate the combined mortality risks of obesity and smoking...
  22. doi request reprint Occupational exposure to pesticides and risk of adult brain tumors
    Claudine M Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Am J Epidemiol 167:976-85. 2008
    ..01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations...
  23. pmc Association between adult height, genetic susceptibility and risk of glioma
    Cari M Kitahara
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Epidemiol 41:1075-85. 2012
    ..In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease...
  24. pmc Basal cell carcinoma and anthropometric factors in the U.S. radiologic technologists cohort study
    Meg R Gerstenblith
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 131:E149-55. 2012
    ..Nevertheless, it may at least partly reflect residual UVR confounding. Further research with more detailed sun exposure data, including clothing patterns, would help clarify the relationship between BMI and BCC...
  25. pmc Use of nonsteroidal anti-inflammatory drugs and risk of basal cell carcinoma in the United States Radiologic Technologists study
    Elizabeth K Cahoon
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7238, USA
    Int J Cancer 130:2939-48. 2012
    ..In this large nationwide study, we observed no association between NSAID use and subsequent BCC risk...
  26. doi request reprint Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies
    Cari M Kitahara
    Authors Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Core Genotyping Facility, National Cancer Institute, SAIC Frederick, Inc, Gaithersburg, Maryland Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, California Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Division of Preventive Medicine Division of Aging, Brigham and Women s Hospital, Harvard Medical School Massachusetts Veterans Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, Massachusetts Fred Hutchinson Cancer Research Center Department of Epidemiology, University of Washington, Seattle, Washington Vanderbilt University Medical Center, Nashville, Tennessee Department of Radiation Sciences, Oncology, Umea University, Umeå and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 23:47-54. 2014
    ..Brain glioma is a relatively rare and fatal malignancy in adulthood with few known risk factors. Some observational studies have reported inverse associations between diabetes and subsequent glioma risk, but possible mechanisms are unclear...
  27. pmc Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship
    Amy Berrington de Gonzalez
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Int J Radiat Oncol Biol Phys 86:224-33. 2013
    ..The results can be used to refine the development of second solid cancer risk projection models for novel radiation therapy techniques...
  28. pmc Nonsteroidal anti-inflammatory drugs and glioma in the NIH-AARP Diet and Health Study cohort
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 4:2027-34. 2011
    ..90; 95% CI, 0.65-1.25 and HR for glioblastoma = 0.83; 95% CI, 0.56-1.20) as compared with no use. Our findings from this large prospective study do not support an inverse association between NSAIDs and risk of all glioma or glioblastoma...
  29. pmc Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
    H Dean Hosgood
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 29:1938-43. 2008
    ..These results should be viewed as exploratory until they are replicated in a larger study...
  30. doi request reprint Joint effects between five identified risk variants, allergy, and autoimmune conditions on glioma risk
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 24:1885-91. 2013
    ..Our results do not provide evidence that allergies or AIC modulate the association between the four GWAS-identified SNPs examined and risk of glioma...
  31. pmc A subset-based approach improves power and interpretation for the combined analysis of genetic association studies of heterogeneous traits
    Samsiddhi Bhattacharjee
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Am J Hum Genet 90:821-35. 2012
    ..The proposed framework has applications beyond genetic association studies...
  32. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  33. pmc Common genetic variants in sex hormone pathway genes and papillary thyroid cancer risk
    Sara J Schonfeld
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
    Thyroid 22:151-6. 2012
    ..We hypothesized that polymorphic variation in hormone pathway genes is associated with the risk of developing papillary thyroid cancer...
  34. pmc Children's exposure to diagnostic medical radiation and cancer risk: epidemiologic and dosimetric considerations
    Martha S Linet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Pediatr Radiol 39:S4-26. 2009
    ....
  35. pmc RadRAT: a radiation risk assessment tool for lifetime cancer risk projection
    Amy Berrington de Gonzalez
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, MD, USA
    J Radiol Prot 32:205-22. 2012
    ..It is most appropriate for low-LET radiation doses < 1 Gy, and for individuals with life-expectancy and cancer rates similar to the general population in the US...
  36. pmc The impact of delayed blood centrifuging, choice of collection tube, and type of assay on 25-hydroxyvitamin D concentrations
    Chu Ling Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Mailstop 7238, Rockville, MD 20852, USA
    Cancer Causes Control 21:643-8. 2010
    ..01), but the difference was significant only after substantial centrifuging delays (96 h). Our study suggests no necessity for requiring immediate processing of blood samples after collection or for the choice of a tube type or assay...
  37. doi request reprint Blood lead levels, ALAD gene polymorphisms, and mortality
    Dana M Van Bemmel
    Cancer Prevention Fellowship Program, National Cancer Institute, Rockville, MD 20852, USA
    Epidemiology 22:273-8. 2011
    ..We examined whether the ALAD G177C single nucleotide polymorphism (SNP) affects the relationship between lead and mortality...
  38. pmc Height, body mass index, and physical activity in relation to glioma risk
    Steven C Moore
    Nutritional Epidemiology Branch and Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Rockville, Maryland, USA
    Cancer Res 69:8349-55. 2009
    ..Adult height, BMI during adolescence, and physical activity during adolescence were each associated with glioma risk, supporting a role for early-life energy balance in glioma carcinogenesis...
  39. doi request reprint Telomere length and risk of glioma
    Farzana Walcott
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, United States
    Cancer Epidemiol 37:935-8. 2013
    ..Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk. Therefore, we evaluated the association between relative telomere length (RTL) and glioma in a prospective study...
  40. pmc Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review
    Melissa Z Braganza
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Neuro Oncol 14:1316-24. 2012
    ....
  41. pmc Sunlight, hormone replacement status and colorectal cancer risk in postmenopausal women
    D Michal Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Int J Cancer 126:1997-2001. 2010
    ....
  42. pmc Sarcoma risk after radiation exposure
    Amy Berrington de Gonzalez
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI NIH, 6120 Executive Boulevard Rm 7034, Bethesda, MD 20892, USA
    Clin Sarcoma Res 2:18. 2012
    ..Efforts to limit unnecessary high-dose radiation exposure, particularly in children, therefore remain important given the high fatality rates associated with this disease...
  43. pmc Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium
    Melissa L Bondy
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 113:1953-68. 2008
    ..In this report, BTEC epidemiologists reviewed the group's consensus on the current state of scientific findings, and they present a consensus on research priorities to identify which important areas the science should move to address...