Sumati Rajagopalan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:20596-601. 2012
  2. ncbi request reprint Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells
    S Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 167:1877-81. 2001
  3. doi request reprint Endosomal signaling and a novel pathway defined by the natural killer receptor KIR2DL4 (CD158d)
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Traffic 11:1381-90. 2010
  4. doi request reprint DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 3:ra14. 2010
  5. pmc Activation of NK cells by an endocytosed receptor for soluble HLA-G
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS Biol 4:e9. 2006
  6. pmc Stress signals activate natural killer cells
    Eric O Long
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Exp Med 196:1399-402. 2002
  7. ncbi request reprint TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852
    J Immunol 192:714-21. 2014
  8. ncbi request reprint Viral evasion of NK-cell activation
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Trends Immunol 26:403-5. 2005
  9. pmc Controlling natural killer cell responses: integration of signals for activation and inhibition
    Eric O Long
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Annu Rev Immunol 31:227-58. 2013
  10. pmc Understanding how combinations of HLA and KIR genes influence disease
    Sumati Rajagopalan
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Exp Med 201:1025-9. 2005

Detail Information

Publications12

  1. pmc Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:20596-601. 2012
    ..We propose that a positive function of senescence in healthy tissue is to favor reproduction through the sustained activation of NK cells to remodel maternal vasculature in early pregnancy...
  2. ncbi request reprint Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells
    S Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 167:1877-81. 2001
    ..These results reveal a functional dichotomy (cytokine production vs cytotoxicity) in the response of resting NK cells, as dictated by the signals of individual receptors...
  3. doi request reprint Endosomal signaling and a novel pathway defined by the natural killer receptor KIR2DL4 (CD158d)
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Traffic 11:1381-90. 2010
    ....
  4. doi request reprint DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 3:ra14. 2010
    ..The sequential requirement for DNA-PKcs, Akt, and NF-kappaB in signaling by CD158d delineates a previously uncharacterized endosomal signaling pathway for a proinflammatory response in NK cells...
  5. pmc Activation of NK cells by an endocytosed receptor for soluble HLA-G
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS Biol 4:e9. 2006
    ....
  6. pmc Stress signals activate natural killer cells
    Eric O Long
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Exp Med 196:1399-402. 2002
  7. ncbi request reprint TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852
    J Immunol 192:714-21. 2014
    ..Our results reveal that a prototypic TLR and TNFR signaling pathway is used by a killer cell Ig-like receptor that promotes secretion of proinflammatory and proangiogenic mediators as part of a unique senescence phenotype in NK cells. ..
  8. ncbi request reprint Viral evasion of NK-cell activation
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Trends Immunol 26:403-5. 2005
    ..A recent report documents an antagonistic effect of the main HCMV tegument protein, pp65, on NKp30, a natural cytotoxicity-inducing receptor expressed uniquely on NK cells...
  9. pmc Controlling natural killer cell responses: integration of signals for activation and inhibition
    Eric O Long
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Annu Rev Immunol 31:227-58. 2013
    ..These different facets of inhibitory signaling are incorporated into a revocable license model for the reversible tuning of NK cell responsiveness...
  10. pmc Understanding how combinations of HLA and KIR genes influence disease
    Sumati Rajagopalan
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Exp Med 201:1025-9. 2005
    ....