Vishnudutt Purohit

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint National Institute on Drug Abuse symposium report: drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 6001 Executive Boulevard Room 4282, MSC 9555, Bethesda, MD 20892 9555, USA
    J Neurovirol 19:119-22. 2013
  2. doi request reprint Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
    Life Sci 92:3-9. 2013
  3. doi request reprint Do opioids activate latent HIV-1 by down-regulating anti-HIV microRNAs?
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 6001 Executive Boulevard Room 4275, MSC 9555, Bethesda, MD 20892 9555, USA
    J Neuroimmune Pharmacol 7:519-23. 2012
  4. pmc Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
  5. doi request reprint Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard Room 4277, MSC 9555, Bethesda, MD 20892 9555, USA
    Mol Neurobiol 44:102-10. 2011
  6. doi request reprint Mother-to-child transmission (MTCT) of HIV and drugs of abuse in post-highly active antiretroviral therapy (HAART) era
    Vishnudutt Purohit
    Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Bethesda, MD 20892 9555, USA
    J Neuroimmune Pharmacol 5:507-15. 2010
  7. pmc Role of cannabinoids in the development of fatty liver (steatosis)
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health, Bethesda, Maryland 20892 9555, USA
    AAPS J 12:233-7. 2010
  8. ncbi request reprint Mechanisms of alcohol-associated cancers: introduction and summary of the symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, Bethesda, MD 20892 9304, USA
    Alcohol 35:155-60. 2005
  9. ncbi request reprint Cellular and molecular mechanisms of alcoholic hepatitis: introduction and summary of the symposium
    Vishnudutt Purohit
    Biomedical Research Branch Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 6000 Executive Boulevard, Suite 402, Bethesda, MD 20892 7003, USA
    Alcohol 27:3-6. 2002
  10. ncbi request reprint Role of iron in alcoholic liver disease: introduction and summary of the symposium
    Vishnudutt Purohit
    Biomedical Research Branch Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 6000 Executive Boulevard, Suite 402, Bethesda, MD 20892 7003, USA
    Alcohol 30:93-7. 2003

Detail Information

Publications18

  1. doi request reprint National Institute on Drug Abuse symposium report: drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 6001 Executive Boulevard Room 4282, MSC 9555, Bethesda, MD 20892 9555, USA
    J Neurovirol 19:119-22. 2013
    ..The purpose of this symposium was to evaluate the potential role of dopamine in the potentiation of HAND/HAD by drugs of abuse. A summary of the symposium has been presented in this report...
  2. doi request reprint Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
    Life Sci 92:3-9. 2013
    ..Simultaneous exposure to alcohol and tobacco is expected to promote the development of HCC in an additive and/or synergistic manner...
  3. doi request reprint Do opioids activate latent HIV-1 by down-regulating anti-HIV microRNAs?
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 6001 Executive Boulevard Room 4275, MSC 9555, Bethesda, MD 20892 9555, USA
    J Neuroimmune Pharmacol 7:519-23. 2012
    ....
  4. pmc Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
    ..Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries...
  5. doi request reprint Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard Room 4277, MSC 9555, Bethesda, MD 20892 9555, USA
    Mol Neurobiol 44:102-10. 2011
    ..Increased cell death of dopaminergic neurons can eventually lead to dopamine deficit that may exacerbate the severity and/or accelerate the progression of HAND/HAD...
  6. doi request reprint Mother-to-child transmission (MTCT) of HIV and drugs of abuse in post-highly active antiretroviral therapy (HAART) era
    Vishnudutt Purohit
    Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Bethesda, MD 20892 9555, USA
    J Neuroimmune Pharmacol 5:507-15. 2010
    ....
  7. pmc Role of cannabinoids in the development of fatty liver (steatosis)
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health, Bethesda, Maryland 20892 9555, USA
    AAPS J 12:233-7. 2010
    ....
  8. ncbi request reprint Mechanisms of alcohol-associated cancers: introduction and summary of the symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, Bethesda, MD 20892 9304, USA
    Alcohol 35:155-60. 2005
    ..Nicotine may promote carcinogenesis through activation of extracellular signal-regulated kinase/cyclooxygenase-2/vascular endothelial growth factor signaling pathway...
  9. ncbi request reprint Cellular and molecular mechanisms of alcoholic hepatitis: introduction and summary of the symposium
    Vishnudutt Purohit
    Biomedical Research Branch Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 6000 Executive Boulevard, Suite 402, Bethesda, MD 20892 7003, USA
    Alcohol 27:3-6. 2002
    ..This article provides an introduction to the problem and a summary of the 10 scientific presentations delivered at the symposium...
  10. ncbi request reprint Role of iron in alcoholic liver disease: introduction and summary of the symposium
    Vishnudutt Purohit
    Biomedical Research Branch Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 6000 Executive Boulevard, Suite 402, Bethesda, MD 20892 7003, USA
    Alcohol 30:93-7. 2003
    ..Dietary iron supplements may further exacerbate the severity of alcoholic liver disease by increasing the magnitude of oxidative stress. We hope that the studies presented will stimulate further research in this exciting area...
  11. ncbi request reprint Workshop on Alcohol Use and Health Disparities 2002: a call to arms
    Denise Russo
    Biomedical Research Branch Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 6000 Executive Boulevard, Suite 402, Bethesda MD 20892 7003, USA
    Alcohol 32:37-43. 2004
    ..7). The incidence rate for cancer is greater for African-Americans than for Caucasians, and part of the higher risk may be attributed to heavier drinking...
  12. ncbi request reprint Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 86:14-24. 2007
    ..Additionally, decreased concentrations of homocysteine can down-regulate endoplasmic reticulum stress, which leads to the attenuation of apoptosis and fatty acid synthesis...
  13. ncbi request reprint Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, Bethesda, MD 20892 9304, USA
    Alcohol 34:3-8. 2004
    ..Finally, alcoholic fatty liver transplant failure may be linked to oxidative stress. In vitro treatment of fatty livers with interleukin-6 may render allografts safer for clinical transplantation...
  14. ncbi request reprint Role of S-adenosyl-L-methionine in the treatment of alcoholic liver disease: introduction and summary of the symposium
    Vishnudutt Purohit
    Biomedical Research Branch Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 6000 Executive Boulevard, Suite 402, Bethesda, MD 20892 7003, USA
    Alcohol 27:151-4. 2002
    ..Further studies are required to evaluate the safety and effectiveness of SAMe treatment...
  15. ncbi request reprint Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Hepatology 43:872-8. 2006
    ..Hepatic fibrosis can be reversed by inducing selective apoptosis or necrosis of activated HSCs, or by reverse trans-differentiation of activated HSCs into the quiescent phenotype...
  16. pmc Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease
    Byoung Joon Song
    Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Oxid Med Cell Longev 2013:781050. 2013
    ..Finally, we discuss various applications of this method in studying oxidatively modified mitochondrial proteins in extrahepatic tissues or different subcellular organelles and translational research...
  17. pmc Molecular mechanisms of alcoholic fatty liver
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 33:191-205. 2009
    ..Furthermore, oxidative modifications and inactivation of the enzymes involved in the mitochondrial and/or peroxisomal beta-oxidation of fatty acids could contribute to fat accumulation in the liver...
  18. ncbi request reprint International collaboration on alcoholic liver disease and pancreatitis: opportunities
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9304, USA
    J Gastroenterol Hepatol 21:S107-8. 2006