Research Topics
Genomes and Genes
| M P PurdueSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
A case-control study of peripheral blood mitochondrial DNA copy number and risk of renal cell carcinomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
PLoS ONE 7:e43149. 2012..In an attempt to replicate that finding, we measured mtDNA copy number in peripheral blood DNA from a U.S. population-based case-control study of RCC...
A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumorsMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 8009, 6120 Executive Boulevard, Rockville, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 16:77-83. 2007..In conclusion, our findings suggest that polymorphisms in TGFB1 and LTA/TNF, and possibly other immune function genes, may influence susceptibility to TGCT...- A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
Environ Health Perspect 119:232-8. 2011..Previous epidemiologic findings suggest an association between exposure to trichloroethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL)... - Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8009, Rockville, MD 20892, USA
Cancer Causes Control 18:989-99. 2007.... - Variation in innate immunity genes and risk of multiple myelomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD, USA
Hematol Oncol 29:42-6. 2011..0 × 10(-5) , P(permutation) = 0.07). Our findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies... - Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health StudyMark P Purdue
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
Int J Cancer 120:642-9. 2007.... - Genetic variation in the inhibin pathway and risk of testicular germ cell tumorsMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA
Cancer Res 68:3043-8. 2008..89-2.99; TT: OR, 4.54; 95% CI 2.00-10.3; P(trend) = 0.0008). We found no evidence of association with variants in the other investigated genes. These findings suggest that genetic variation in the INHA locus influences TGCT development... - Degreasing and risk of non-Hodgkin lymphomaM P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, 6120 Executive Blvd, Bethesda, MD 20892, USA
Occup Environ Med 66:557-60. 2009..To investigate the relationship between selected solvent-related workplace tasks (degreasing, painting, gluing, stripping paint, staining) and risk of non-Hodgkin lymphoma (NHL)... - A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Carcinogenesis 30:275-81. 2009..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL... - Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE ConsortiumMark P Purdue
National Cancer Institute, Bethesda, Maryland, USA
Am J Epidemiol 169:132-42. 2009..Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution... - Prediagnostic serum concentrations of organochlorine compounds and risk of testicular germ cell tumorsMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Environ Health Perspect 117:1514-9. 2009..Recent findings suggest that exposure to organochlorine (OC) compounds, chlordanes and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in particular, may increase the risk of developing testicular germ cell tumors (TGCTs)... - Prediagnostic serum levels of cytokines and other immune markers and risk of non-hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Res 71:4898-907. 2011..Our findings for sTNF-R1 and sCD27, possible markers for inflammatory and B-cell stimulatory states, respectively, support a role for subclinical inflammation and chronic B-cell stimulation in lymphomagenesis... - Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma StudyMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7240, USA
Carcinogenesis 28:704-12. 2007..06, 95% CI=0.88-4.83; trend test, P=0.02). Our findings offer further evidence that variation in the IL10 and TNF loci influences NHL risk. Additional studies are needed to clarify the genetic and biologic basis for these relationships... - Dietary factors and risk of non-Hodgkin lymphoma by histologic subtype: a case-control analysisMark P Purdue
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Canada
Cancer Epidemiol Biomarkers Prev 13:1665-76. 2004..In conclusion, these findings generally do not support the existence of etiologic heterogeneity between histologic subtypes of NHL in their associations with components of dietary intake... - International patterns and trends in testis cancer incidenceMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Int J Cancer 115:822-7. 2005..Rates appear to be leveling off in some populations. The increases in testis cancer remain unexplained, although changes in the prevalence of important risk factors for this disease may be responsible... - Etiologic factors associated with p53 immunostaining in cutaneousmalignant melanomaMark P Purdue
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, Canada
Int J Cancer 117:486-93. 2005.... - A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphomaMark P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Blood 114:2730-2. 2009.... - Etiologic and other factors predicting nevus-associated cutaneous malignant melanomaMark P Purdue
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Canada
Cancer Epidemiol Biomarkers Prev 14:2015-22. 2005..However, it is possible that high UV exposure causes involution of nevi, thus reducing the density of nevi in exposed skin and thereby the probability of N+ melanoma... - Hormone replacement therapy, reproductive history, and colorectal adenomas: data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (United States)Mark P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, MSC 7240, Executive Plaza South 8121, Rockville, MD 20892, USA
Cancer Causes Control 16:965-73. 2005.... - A case-control study of reproductive factors and renal cell carcinoma among black and white women in the United StatesMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Bethesda, MD 20892 7240, USA
Cancer Causes Control 22:1537-44. 2011..We investigated whether reproductive factors are associated with RCC, overall and by race, within a population-based case-control study... - Impaired lung function and lung cancer incidence in a cohort of Swedish construction workersMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8121, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
Thorax 62:51-6. 2007..To deal with this question further, data from a large (n = 176 997) cohort of male Swedish construction workers, for whom spirometry measurements before follow-up were available, were analysed... - Occupational exposures and head and neck cancers among Swedish construction workersMark P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8111, Rockville, MD 20852, USA
Scand J Work Environ Health 32:270-5. 2006..In an attempt to address this issue, the relationship between selected occupational exposures and head and neck cancer risk was investigated using data from a large cohort of Swedish construction workers... - Family history of cancer and renal cell cancer risk in Caucasians and African AmericansS Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, Bethesda, MD 20892 7242, USA
Br J Cancer 102:1676-80. 2010..The association between renal cell carcinoma (RCC) risk and family history of cancer has not been examined with an adequate number of African Americans (AAs)... - Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer CancersMark P Purdue
National Cancer Institute, Bethesda, Maryland, USA
Am J Epidemiol 172:58-69. 2010..Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects... - Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studiesMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Br J Haematol 151:239-44. 2010..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL... - Risk of renal cell carcinoma in relation to blood telomere length in a population-based case-control studyJ N Hofmann
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7240, USA
Br J Cancer 105:1772-5. 2011..There are few known risk factors for renal cell carcinoma (RCC). Two small hospital-based case-control studies suggested an association between short blood telomere length (TL) and increased RCC risk... - Meat-cooking mutagens and risk of renal cell carcinomaC R Daniel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
Br J Cancer 105:1096-104. 2011.... - Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in ConnecticutKyoung Mu Lee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Am J Hematol 85:560-3. 2010..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy... - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis... - Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studiesQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Blood 114:264-7. 2009..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis... - Chemical exposures and risk of chronic lymphocytic leukaemiaAaron Blair
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Br J Haematol 139:753-61. 2007..Pooled analyses of CLL studies within consortia offer an opportunity to investigate the possible aetiological role of chemical exposures with improved statistical power... - One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in AustraliaKyoung Mu Lee
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
Hum Genet 122:525-33. 2007..01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL... - Polymorphisms in DNA repair genes and risk of non-Hodgkin's lymphoma in New South Wales, AustraliaMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7240, USA
Haematologica 92:1180-5. 2007..We investigated whether putatively functional single-nucleotide polymorphisms (SNP) in DNA repair genes influence susceptibility to NHL in a population-based case-control study conducted in Australia... - Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong KongQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Eur J Haematol 85:492-5. 2010..5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese... - Rising melanoma incidence rates of the trunk among younger women in the United StatesPorcia T Bradford
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA
Cancer Epidemiol Biomarkers Prev 19:2401-6. 2010..Therefore, we examined melanoma incidence trends by age, gender, and body site. Descriptive methods were complemented with the age-period-cohort parameters net drift and longitudinal age trend... - Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte developmentLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009..Replication of our findings and further study to identify functional SNPs are warranted... - Risk of germ cell tumors among men with HIV/acquired immunodeficiency syndromeJames J Goedert
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 16:1266-9. 2007..Men with HIV/acquired immunodeficiency syndrome (AIDS) are reported to be at increased risk for germ cell tumors (GCT), particularly testicular seminoma. We investigated correlates of this association to improve understanding of GCTs... - Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer CancersRachael Z Stolzenberg-Solomon
National Cancer Institute, Bethesda, Maryland 20852, USA
Am J Epidemiol 172:81-93. 2010..12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered... 
Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trialD Michal Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 17:889-94. 2008....- Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma riskSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
PLoS ONE 4:e5360. 2009..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk... - Long-term variation in serum 25-hydroxyvitamin D concentration among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialJonathan N Hofmann
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8109, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 19:927-31. 2010..These findings suggest that serum 25(OH)D concentration at a single time point may be a useful biomarker of long-term vitamin D status in population-based studies of various diseases... - Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studiesWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 19:973-7. 2010..Here, we report the method that we used to simultaneously recover DNA and RNA from FFPE tissue specimens with appreciable quantity and quality and discuss briefly the application of tumor markers in epidemiologic studies... - Serum vitamin D concentration and prostate cancer risk: a nested case-control studyJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
J Natl Cancer Inst 100:796-804. 2008.... - Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control dataJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
Am J Epidemiol 171:1250-61. 2010.... - Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markersQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Carcinogenesis 31:1592-6. 2010..Given that altered immunity is an established risk factor for NHL, these results add to the biologic plausibility that TCE is a possible lymphomagen... - Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer CancersChristian C Abnet
National Cancer Institute, Bethesda, Maryland 20852, USA
Am J Epidemiol 172:94-106. 2010..31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers... - International trends in the incidence of testicular cancer, 1973-2002Victoria M Chia
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 19:1151-9. 2010..In a prior report, global testicular cancer incidence rates and trends for the years 1973 to 1997 were summarized. The current report extends these analyses with an additional 5 years of data from Cancer Incidence in Five Continents... - Predictors of sun protection in Canadian adultsMark P Purdue
Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Suite 1500, Toronto, ON M5G 2L7
Can J Public Health 93:470-4. 2002..An analysis of Canadian survey data was performed to identify independent predictors of different protective behaviours and of their use in combination... 
Workshop report: environmental exposures and cancer preventionNancy Kreiger
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, Canada
Environ Health Perspect 111:105-8. 2003....- Vitamin D receptor gene polymorphisms and risk of non-Hodgkin's lymphomaMark P Purdue
Haematologica 92:1145-6. 2007..The BsmI B and TaqI t alleles were associated with an increased risk of diffuse large B-cell lymphoma. These findings suggest that variants in VDR may influence lymphomagenesis... - Asthma history, occupational exposure to pesticides and the risk of non-Hodgkin's lymphomaWon Jin Lee
Department of Preventive Medicine, College of Medicine, Korea University, Seoul
Int J Cancer 118:3174-6. 2006..2-29.0) or daily medication for asthma (OR = infinite) than those among asthmatics who did not have such histories. Our results support the previous finding that the risk of NHL from pesticide exposure may be greater among asthmatics... - Re: Determinants of BRAF mutations in primary melanomasMark P Purdue
J Natl Cancer Inst 97:401-2; author reply 402. 2005