Imke Puls

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mutant dynactin in motor neuron disease
    Imke Puls
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 33:455-6. 2003
  2. pmc Distal spinal and bulbar muscular atrophy caused by dynactin mutation
    Imke Puls
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1416, USA
    Ann Neurol 57:687-94. 2005
  3. pmc A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation
    Jennifer R Levy
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 172:733-45. 2006

Collaborators

Detail Information

Publications3

  1. ncbi request reprint Mutant dynactin in motor neuron disease
    Imke Puls
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 33:455-6. 2003
    ..Binding assays show decreased binding of the mutant protein to microtubules. Our results show that dysfunction of dynactin-mediated transport can lead to human motor neuron disease...
  2. pmc Distal spinal and bulbar muscular atrophy caused by dynactin mutation
    Imke Puls
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1416, USA
    Ann Neurol 57:687-94. 2005
    ..This mutation of dynactin, a ubiquitously expressed protein, causes a unique pattern of motor neuron degeneration that is associated with the accumulation of dynein and dynactin in neuronal inclusions...
  3. pmc A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation
    Jennifer R Levy
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 172:733-45. 2006
    ..These data support a model in which a point mutation in p150Glued causes both loss of dynein/dynactin function and gain of toxic function, which together lead to motor neuron cell death...