Rosa Puertollano

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Activation of p38 mitogen-activated protein kinase promotes epidermal growth factor receptor internalization
    Silvia Vergarajauregui
    The Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Traffic 7:686-98. 2006
  2. pmc Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes
    Silvia Vergarajauregui
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Traffic 7:337-53. 2006
  3. pmc TRPMLs: in sickness and in health
    Rosa Puertollano
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 296:F1245-54. 2009
  4. ncbi request reprint Interactions of TOM1L1 with the multivesicular body sorting machinery
    Rosa Puertollano
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:9258-64. 2005
  5. pmc Clathrin-mediated transport: assembly required. Workshop on Molecular Mechanisms of Vesicle Selectivity
    Rosa Puertollano
    Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    EMBO Rep 5:942-6. 2004
  6. ncbi request reprint Interactions of GGA3 with the ubiquitin sorting machinery
    Rosa Puertollano
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Cell Biol 6:244-51. 2004
  7. ncbi request reprint Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism
    Yukio Kato
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Biol 9:532-6. 2002
  8. pmc Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network
    Rosa Puertollano
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development and Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 14:1545-57. 2003
  9. ncbi request reprint The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites
    Rafael Mattera
    Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:31409-18. 2004
  10. pmc Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking
    Joanna C Bakowska
    Cellular Neurology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:1683-92. 2007

Collaborators

Detail Information

Publications30

  1. pmc Activation of p38 mitogen-activated protein kinase promotes epidermal growth factor receptor internalization
    Silvia Vergarajauregui
    The Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Traffic 7:686-98. 2006
    ....
  2. pmc Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes
    Silvia Vergarajauregui
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Traffic 7:337-53. 2006
    ..Taken together, these results reveal novel information regarding the motifs that regulate mucolipin-1 trafficking and suggest a role for palmitoylation in protein sorting...
  3. pmc TRPMLs: in sickness and in health
    Rosa Puertollano
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 296:F1245-54. 2009
    ..Since mucolipins are ubiquitously expressed, this review may be useful for a wide audience of basic biologists and clinicians...
  4. ncbi request reprint Interactions of TOM1L1 with the multivesicular body sorting machinery
    Rosa Puertollano
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:9258-64. 2005
    ..Moreover, expression of a constitutive active form of Fyn also promoted the recruitment of Tom1L1 to enlarged endosomes. Taken together, we propose that Tom1L1 could act as an intermediary between signaling and degradative pathways...
  5. pmc Clathrin-mediated transport: assembly required. Workshop on Molecular Mechanisms of Vesicle Selectivity
    Rosa Puertollano
    Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    EMBO Rep 5:942-6. 2004
  6. ncbi request reprint Interactions of GGA3 with the ubiquitin sorting machinery
    Rosa Puertollano
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Cell Biol 6:244-51. 2004
    ..The VHS and GAT domains of GGA3 are responsible for this binding, as well as for interactions with TSG101, a component of the ubiquitin-dependent sorting machinery. Thus, GGAs may have additional roles in sorting of ubiquitinated cargo...
  7. ncbi request reprint Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism
    Yukio Kato
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Biol 9:532-6. 2002
    ....
  8. pmc Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network
    Rosa Puertollano
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development and Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 14:1545-57. 2003
    ....
  9. ncbi request reprint The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites
    Rafael Mattera
    Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:31409-18. 2004
    ..The different GAT binding partners engage in both competitive and cooperative interactions that may be important for the function of the GGAs in protein sorting...
  10. pmc Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking
    Joanna C Bakowska
    Cellular Neurology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:1683-92. 2007
    ..Taken together, our data suggest that spartin is involved in the intracellular trafficking of EGFR and that impaired endocytosis may underlie the pathogenesis of Troyer syndrome...
  11. pmc Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1
    Silvia Vergarajauregui
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:36357-66. 2009
    ..Overall, our data provide new insight into the molecular mechanisms that regulate MCOLN1 activity. We propose that ALG-2 acts as a Ca(2+) sensor that modulates the function of MCOLN1 along the late endosomal-lysosomal pathway...
  12. pmc LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV
    Silvia Vergarajauregui
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 124:459-68. 2011
    ..Overall, our data provide new insight into the molecular mechanisms of MCOLN1 function and suggest a potential role for LAPTMs in MLIV pathogenesis...
  13. pmc STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking
    Neggy Rismanchi
    Cellular Neurology Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Traffic 10:201-17. 2009
    ..Thus, in addition to their roles in signaling and endocytosis, STAMs function prominently in ER-to-Golgi trafficking, most likely through direct interactions with the COPII complex...
  14. pmc The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway
    Jose A Martina
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Traffic 10:1143-56. 2009
    ..Therefore, MCOLN3 is a novel Ca(2+) channel that plays a crucial role in the regulation of cargo trafficking along the endosomal pathway...
  15. pmc MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
    Jose A Martina
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD USA
    Autophagy 8:903-14. 2012
    ..Our results unveil a novel role for MTORC1 in the maintenance of cellular homeostasis by regulating autophagy at the transcriptional level...
  16. pmc Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network
    Xufeng Wu
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 14:516-28. 2003
    ..We conclude that clathrin-coated pits are dynamic structures with rapid exchange of both clathrin and adaptors and that adaptors are able to exchange independently of clathrin when clathrin exchange is blocked...
  17. ncbi request reprint Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation
    Silvia Vergarajauregui
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochem J 410:417-25. 2008
    ..This paper presents the first example of regulation of a member of the mucolipin family by phosphorylation...
  18. pmc Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes
    Jose A Martina
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 200:475-91. 2013
    ..Our work provides new insight into the molecular mechanisms that link nutrient availability and TFEB localization and activation...
  19. ncbi request reprint Arf regulates interaction of GGA with mannose-6-phosphate receptor
    Dianne Snow Hirsch
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bldg 37 Room 6032 and Cell Biology and Metabolism Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda MD 20892, USA
    Traffic 4:26-35. 2003
    ..GGA and mannose-6-phosphate receptor are then incorporated into a transport intermediate that excludes Arf...
  20. pmc RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis
    Jose A Martina
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Autophagy 9:928-30. 2013
    ..Redistribution to lysosomes is critical for MTORC1-dependent inactivation of TFEB under nutrient-rich conditions. Therefore, RRAGs play a critical role coordinating nutrient availability and cellular clearance...
  21. pmc Mucolipin-3 regulates luminal calcium, acidification, and membrane fusion in the endosomal pathway
    Benjamin Lelouvier
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:9826-32. 2011
    ..Our findings reveal a prominent role for MCOLN3 in regulating Ca(2+) homeostasis at the endosomal pathway and confirm the importance of luminal Ca(2+) for proper acidification and membrane fusion...
  22. pmc Autophagic dysfunction in mucolipidosis type IV patients
    Silvia Vergarajauregui
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2723-37. 2008
    ..Our data are in agreement with recent evidence showing that autophagic defects may be a common characteristic of many neurodegenerative disorders...
  23. pmc Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy
    Silvia Vergarajauregui
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Autophagy 4:832-4. 2008
    ..These findings corroborate recent evidence indicating that defects in autophagy may be a common feature of many neurodegenerative disorders...
  24. ncbi request reprint Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs
    Claudia Karacsonyi
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Traffic 8:1404-14. 2007
    ..Therefore, our results indicate that MCOLN2 localizes to the Arf6-regulated pathway and regulates sorting of GPI-APs...
  25. pmc Role of TRP channels in the regulation of the endosomal pathway
    Ken Abe
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Physiology (Bethesda) 26:14-22. 2011
    ..The unique properties of the TRP channels confer cells the ability to integrate cytosolic and intraluminal stimuli and allow maintained and regulated release of Ca(2+) from endosomes and lysosomes...
  26. pmc Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
    Jose A Martina
    Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 50 3537, Bethesda, MD, 20892, USA
    Cell Mol Life Sci 71:2483-97. 2014
    ....
  27. ncbi request reprint Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains
    Saurav Misra
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:933-7. 2002
    ..The rigid spatial alignment of the three binding subsites leads to high specificity...
  28. doi request reprint The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris
    Jose A Martina
    1Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Building 50 3537, Bethesda, MD 20892, USA
    Sci Signal 7:ra9. 2014
    ....
  29. pmc Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics
    Sylwia Wasiak
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal Quebec H3A 2B4, Canada
    J Cell Biol 158:855-62. 2002
    ..These data suggest a role for enthoprotin in clathrin-mediated budding on internal membranes. Our study reveals the utility of proteomics in the identification of novel vesicle trafficking proteins...
  30. ncbi request reprint Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells
    María C de Marco
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid and Consejo Superior de Investigaciones Científicas, Cantoblanco, Madrid, Spain
    Traffic 7:61-73. 2006
    ..Other GPI-anchored proteins examined behave similarly. As MAL2 is expressed by many types of epithelia, the sorting events described herein are probably of quite general utility...