Research Topics
Genomes and Genes
| Rosa PuertollanoSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Interactions of TOM1L1 with the multivesicular body sorting machineryRosa Puertollano
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:9258-64. 2005..Moreover, expression of a constitutive active form of Fyn also promoted the recruitment of Tom1L1 to enlarged endosomes. Taken together, we propose that Tom1L1 could act as an intermediary between signaling and degradative pathways...
Clathrin-mediated transport: assembly required. Workshop on Molecular Mechanisms of Vesicle SelectivityRosa Puertollano
Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
EMBO Rep 5:942-6. 2004- TRPMLs: in sickness and in healthRosa Puertollano
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Physiol Renal Physiol 296:F1245-54. 2009..Since mucolipins are ubiquitously expressed, this review may be useful for a wide audience of basic biologists and clinicians... - Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi networkRosa Puertollano
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development and Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Biol Cell 14:1545-57. 2003.... - Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor traffickingJoanna C Bakowska
Cellular Neurology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biol Cell 18:1683-92. 2007..Taken together, our data suggest that spartin is involved in the intracellular trafficking of EGFR and that impaired endocytosis may underlie the pathogenesis of Troyer syndrome... - Interactions of GGA3 with the ubiquitin sorting machineryRosa Puertollano
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Cell Biol 6:244-51. 2004..The VHS and GAT domains of GGA3 are responsible for this binding, as well as for interactions with TSG101, a component of the ubiquitin-dependent sorting machinery. Thus, GGAs may have additional roles in sorting of ubiquitinated cargo... - The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sitesRafael Mattera
Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:31409-18. 2004..The different GAT binding partners engage in both competitive and cooperative interactions that may be important for the function of the GGAs in protein sorting... - Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1Silvia Vergarajauregui
Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 284:36357-66. 2009..Overall, our data provide new insight into the molecular mechanisms that regulate MCOLN1 activity. We propose that ALG-2 acts as a Ca(2+) sensor that modulates the function of MCOLN1 along the late endosomal-lysosomal pathway... - LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IVSilvia Vergarajauregui
Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 124:459-68. 2011..Overall, our data provide new insight into the molecular mechanisms of MCOLN1 function and suggest a potential role for LAPTMs in MLIV pathogenesis... 
Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomesSilvia Vergarajauregui
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Traffic 7:337-53. 2006..Taken together, these results reveal novel information regarding the motifs that regulate mucolipin-1 trafficking and suggest a role for palmitoylation in protein sorting...- STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi traffickingNeggy Rismanchi
Cellular Neurology Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Traffic 10:201-17. 2009..Thus, in addition to their roles in signaling and endocytosis, STAMs function prominently in ER-to-Golgi trafficking, most likely through direct interactions with the COPII complex... - MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEBJose A Martina
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD USA
Autophagy 8:903-14. 2012..Our results unveil a novel role for MTORC1 in the maintenance of cellular homeostasis by regulating autophagy at the transcriptional level... - Activation of p38 mitogen-activated protein kinase promotes epidermal growth factor receptor internalizationSilvia Vergarajauregui
The Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Traffic 7:686-98. 2006.... - The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathwayJose A Martina
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Traffic 10:1143-56. 2009..Therefore, MCOLN3 is a novel Ca(2+) channel that plays a crucial role in the regulation of cargo trafficking along the endosomal pathway... - Arf regulates interaction of GGA with mannose-6-phosphate receptorDianne Snow Hirsch
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bldg 37 Room 6032 and Cell Biology and Metabolism Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda. MD 20892, USA
Traffic 4:26-35. 2003..GGA and mannose-6-phosphate receptor are then incorporated into a transport intermediate that excludes Arf... - Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylationSilvia Vergarajauregui
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Biochem J 410:417-25. 2008..This paper presents the first example of regulation of a member of the mucolipin family by phosphorylation... - Mucolipin-3 regulates luminal calcium, acidification, and membrane fusion in the endosomal pathwayBenjamin Lelouvier
Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 286:9826-32. 2011..Our findings reveal a prominent role for MCOLN3 in regulating Ca(2+) homeostasis at the endosomal pathway and confirm the importance of luminal Ca(2+) for proper acidification and membrane fusion... - Autophagic dysfunction in mucolipidosis type IV patientsSilvia Vergarajauregui
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Hum Mol Genet 17:2723-37. 2008..Our data are in agreement with recent evidence showing that autophagic defects may be a common characteristic of many neurodegenerative disorders... - Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagySilvia Vergarajauregui
Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Autophagy 4:832-4. 2008..These findings corroborate recent evidence indicating that defects in autophagy may be a common feature of many neurodegenerative disorders... - Adaptor and clathrin exchange at the plasma membrane and trans-Golgi networkXufeng Wu
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Biol Cell 14:516-28. 2003..We conclude that clathrin-coated pits are dynamic structures with rapid exchange of both clathrin and adaptors and that adaptors are able to exchange independently of clathrin when clathrin exchange is blocked... - Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APsClaudia Karacsonyi
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Traffic 8:1404-14. 2007..Therefore, our results indicate that MCOLN2 localizes to the Arf6-regulated pathway and regulates sorting of GPI-APs... - Role of TRP channels in the regulation of the endosomal pathwayKen Abe
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Physiology (Bethesda) 26:14-22. 2011..The unique properties of the TRP channels confer cells the ability to integrate cytosolic and intraluminal stimuli and allow maintained and regulated release of Ca(2+) from endosomes and lysosomes... - Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanismYukio Kato
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Struct Biol 9:532-6. 2002.... - Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domainsSaurav Misra
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 415:933-7. 2002..The rigid spatial alignment of the three binding subsites leads to high specificity... - Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomicsSylwia Wasiak
Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal Quebec H3A 2B4, Canada
J Cell Biol 158:855-62. 2002..These data suggest a role for enthoprotin in clathrin-mediated budding on internal membranes. Our study reveals the utility of proteomics in the identification of novel vesicle trafficking proteins... - Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cellsMaría C de Marco
Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid and Consejo Superior de Investigaciones Científicas, Cantoblanco, Madrid, Spain
Traffic 7:61-73. 2006..Other GPI-anchored proteins examined behave similarly. As MAL2 is expressed by many types of epithelia, the sorting events described herein are probably of quite general utility...