Ludmila Prokunina-Olsson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010
  2. pmc Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer
    Indu Kohaar
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Cir, Bethesda, MD 20892 4605, USA
    J Natl Cancer Inst 105:69-73. 2013
  3. pmc A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:164-71. 2013
  4. pmc No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
    Ellen L Goode
    Health Sciences Research, Mayo Clinic College of Medicine, Rochester, USA
    BMC Cancer 9:312. 2009
  5. pmc Evidence for neuroendocrine function of a unique splicing form of TCF7L2 in human brain, islets and gut
    L Prokunina-Olsson
    Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Diabetologia 53:712-6. 2010
  6. pmc Tissue-specific alternative splicing of TCF7L2
    Ludmila Prokunina-Olsson
    Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 18:3795-804. 2009
  7. pmc Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7231. 2009
  8. pmc No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA
    Mol Cancer 8:96. 2009
  9. pmc Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4974-9. 2012
  10. pmc NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Cancer 9:113. 2010

Detail Information

Publications26

  1. pmc Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010
    ..2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7))...
  2. pmc Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer
    Indu Kohaar
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Cir, Bethesda, MD 20892 4605, USA
    J Natl Cancer Inst 105:69-73. 2013
    ..Future clinical studies will be needed to validate PSCA as a therapeutic target for bladder cancer...
  3. pmc A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:164-71. 2013
    ..Our findings provide new insights into the genetic regulation of HCV clearance and its clinical management...
  4. pmc No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
    Ellen L Goode
    Health Sciences Research, Mayo Clinic College of Medicine, Rochester, USA
    BMC Cancer 9:312. 2009
    ..No studies of ovarian cancer have been reported to date...
  5. pmc Evidence for neuroendocrine function of a unique splicing form of TCF7L2 in human brain, islets and gut
    L Prokunina-Olsson
    Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Diabetologia 53:712-6. 2010
    ..The goal of this study was to further characterise this unique TCF7L2 splicing form in human tissues...
  6. pmc Tissue-specific alternative splicing of TCF7L2
    Ludmila Prokunina-Olsson
    Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 18:3795-804. 2009
    ..Alternative splicing of TCF7L2 in pancreatic islets warrants future studies. GenBank Accession Numbers: FJ010164-FJ010174...
  7. pmc Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7231. 2009
    ..We hypothesized that these genetic variants might increase the risk of T2D through regulation of alternative splicing or expression level of TCF7L2 in human adipose tissue...
  8. pmc No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA
    Mol Cancer 8:96. 2009
    ..These findings suggest that some splicing forms of TCF7L2 may be functionally important for regulation of MYC expression in colon tissue but this regulation is not directly dependent on rs6983267...
  9. pmc Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4974-9. 2012
    ....
  10. pmc NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Cancer 9:113. 2010
    ..2 region as a novel genetic risk factor for breast cancer, and this association was stronger in patients with estrogen receptor (ER)+ versus ER- cancer...
  11. pmc Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer
    Wei Tang
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 21:1918-30. 2012
    ..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer...
  12. doi request reprint Fine mapping of 14q24.1 breast cancer susceptibility locus
    Phoebe Lee
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 131:479-90. 2012
    ..Therefore, we conclude that rs999737 is an optimal tag SNP for common variants in the 14q24.1 region and thus narrow the candidate variants that should be investigated in follow-up laboratory evaluation...
  13. pmc A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 20:4282-9. 2011
    ..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis...
  14. pmc IFNL4-ΔG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin
    Eric G Meissner
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland
    J Infect Dis 209:1700-4. 2014
    ..039) and decreased drug efficacy (P = .048), suggesting functional relevance of IFN-λ4 in IFN-α-free DAA therapies. ..
  15. pmc Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Res 73:2211-20. 2013
    ..Our findings could have implications for targeted prevention strategies. However, other smoking-related diseases, as well as practical and ethical considerations, need to be considered before any recommendations could be made...
  16. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  17. pmc Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Int J Cancer 133:3008-13. 2013
    ....
  18. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  19. pmc Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29396. 2012
    ..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis...
  20. pmc IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection
    Heiyoung Park
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Hepatology 56:2060-70. 2012
    ..Furthermore, IL-29 production by HCV-infected PHH occurred independently from type I IFN signaling and was not enhanced by the presence of plasmacytoid dendritic cells...
  21. pmc IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association
    Fatma M Shebl
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Infect Dis 204:1843-7. 2011
    ....
  22. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  23. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  24. pmc Common genetic variants in miR-1206 (8q24.2) and miR-612 (11q13.3) affect biogenesis of mature miRNA forms
    Hye Kyung Kim
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e47454. 2012
    ..Future studies should identify targets of miR-1206 and miR-612 and help understand the biological roles of these miRNAs and their possible role in carcinogenesis...
  25. pmc Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry
    Indu Kohaar
    Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    J Virol 84:6987-94. 2010
    ..Genetic factors crucial for regulation of OCLN expression and susceptibility to HCV infection remain to be elucidated...
  26. doi request reprint Cancer sequencing gets a little more personal
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 4605, USA
    Sci Transl Med 2:20ps8. 2010
    ..More validation and a reduction in cost are required for this approach to become common in clinics...