Suzette A Priola

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity
    Andrew G Timmes
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, USA
    PLoS ONE 8:e71081. 2013
  2. pmc Co-infection with the friend retrovirus and mouse scrapie does not alter prion disease pathogenesis in susceptible mice
    Pascal Leblanc
    Universite de Lyon, Lyon, France
    PLoS ONE 7:e30872. 2012
  3. pmc Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 87:9501-10. 2013
  4. pmc The role of the prion protein membrane anchor in prion infection
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Prion 3:134-8. 2009
  5. ncbi request reprint Identification of possible animal origins of prion disease in human beings
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Lancet 363:2013-4. 2004
  6. doi request reprint Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, Montana 59840, USA
    Nat Methods 5:211-2. 2008
  7. ncbi request reprint Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:29218-25. 2004
  8. pmc Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity
    Winslow S Caughey
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 51:3887-94. 2007
  9. pmc Susceptibilities of nonhuman primates to chronic wasting disease
    Brent Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Emerg Infect Dis 15:1366-76. 2009
  10. pmc Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent
    Christopher S Greil
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, 903 S 4th Street, Hamilton, Montana 59840, USA
    Virology 379:284-93. 2008

Collaborators

Detail Information

Publications29

  1. pmc Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity
    Andrew G Timmes
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, USA
    PLoS ONE 8:e71081. 2013
    ..They suggest that the presence of RNA and lipid cofactors may facilitate the spontaneous refolding of PrP into an infectious form while also allowing the de novo formation of self-propagating, but non-infectious, rPrP-res. ..
  2. pmc Co-infection with the friend retrovirus and mouse scrapie does not alter prion disease pathogenesis in susceptible mice
    Pascal Leblanc
    Universite de Lyon, Lyon, France
    PLoS ONE 7:e30872. 2012
    ..Thus, retroviral co-infection does not necessarily alter prion disease pathogenesis in vivo, most likely because of different cell-specific sites of replication for scrapie and F-MuLV...
  3. pmc Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 87:9501-10. 2013
    ..Thus, our results suggest that prion infectivity is not likely present in cardiac tissue from sCJD or amyloid heart disease patients. ..
  4. pmc The role of the prion protein membrane anchor in prion infection
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Prion 3:134-8. 2009
    ..In combination with previously published data, our results suggest that GPI anchored PrP is important in the amplification and spread of prion infectivity from cell to cell...
  5. ncbi request reprint Identification of possible animal origins of prion disease in human beings
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Lancet 363:2013-4. 2004
  6. doi request reprint Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, Montana 59840, USA
    Nat Methods 5:211-2. 2008
  7. ncbi request reprint Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:29218-25. 2004
    ..This may, at least in part, explain the observation that not all PrP-sen-expressing cells appear to support transmissible spongiform encephalopathy agent replication...
  8. pmc Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity
    Winslow S Caughey
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 51:3887-94. 2007
    ..Similar comparisons of iron- and manganese-bound porphyrin sulfonates confirmed that stacking ability correlates with anti-TSE activity among cyclic tetrapyrroles...
  9. pmc Susceptibilities of nonhuman primates to chronic wasting disease
    Brent Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Emerg Infect Dis 15:1366-76. 2009
    ..Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD...
  10. pmc Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent
    Christopher S Greil
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, 903 S 4th Street, Hamilton, Montana 59840, USA
    Virology 379:284-93. 2008
    ..Our results suggest that PrP-res aggregate size, the PrP-res microenvironment, and/or host cell-specific factors can all influence whether or not a cell takes up PrP-res following exposure to TSE infectivity...
  11. ncbi request reprint Amyloid formation via supramolecular peptide assemblies
    Roger A Moore
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Biochemistry 46:7079-87. 2007
    ..Our data suggest that simply changing the physical microenvironment can profoundly influence the mechanism of amyloid formation and yield fibrils with novel ultrastructural properties...
  12. pmc Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure
    Roger A Moore
    Rocky Mountain Laboratories Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th St, Hamilton, MT 59840, USA
    Proteomics 11:3853-65. 2011
    ..Our results show that contaminating proteins alter the FTIR spectrum attributed to PrP(Sc) and suggest that the α-helical, loop/turn and β-sheet secondary structure that remains following their removal are derived from PrP(Sc) itself...
  13. ncbi request reprint Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies
    Suzette A Priola
    National Institute of Allergy and Infectious Diseases, Rocky Montain Laboratories, Hamilton, MT, USA
    Methods Mol Biol 268:517-40. 2004
    ..The hypothesis that vCJD was the consequence of exposure of humans to BSE has now been supported by several different studies, and over 140 cases of vCJD have been confirmed...
  14. ncbi request reprint Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Nat Methods 4:645-50. 2007
    ..This method should facilitate the development of rapid, ultrasensitive prion assays and diagnostic tests, in addition to aiding fundamental studies of structure and mechanism of PrPSc formation...
  15. pmc Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations
    Roger A Moore
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proteomics 10:2858-69. 2010
    ..The similarities between PrP(Sc) samples from 22L and Chandler TSE strains suggest that the non-PrP(Sc) protein components found in standard enrichment protocols are not strain specific...
  16. ncbi request reprint Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 189:431-9. 2004
    ..Thus, testing of cells for TSE susceptibility might be necessary for all cell lines that are routinely used in vaccine production and in other medical applications...
  17. pmc Cells expressing anchorless prion protein are resistant to scrapie infection
    Kristin L McNally
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Virol 83:4469-75. 2009
    ..Our data suggest that cells expressing anchorless PrP-sen are not directly infected with scrapie. Thus, PrP-res formation in transgenic mice expressing anchorless PrP-sen may be occurring extracellularly...
  18. ncbi request reprint Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro
    Victoria A Lawson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:13689-95. 2004
    ..Thus, by its effects on PrP-res conformation, the flexible N-terminal region of PrP seemed to influence TSE pathogenesis and cross-species TSE transmission...
  19. pmc Prion protein misfolding and disease
    Roger A Moore
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, United States
    Curr Opin Struct Biol 19:14-22. 2009
    ..The purpose of this review is to provide an overview of the existing structural information for PrP within the context of what is known about the biology of prion disease...
  20. pmc A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner
    Young Pyo Choi
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 87:11552-61. 2013
    ..Rapid disaggregation of 87V PrP(Sc) by the cell may contribute, at least in part, to the inability of 87V to infect cells in vitro. ..
  21. pmc Multiple amino acid residues within the rabbit prion protein inhibit formation of its abnormal isoform
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 77:2003-9. 2003
    ....
  22. ncbi request reprint Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    Mol Biotechnol 33:71-88. 2006
    ..This review provides an overview of the molecular mechanisms that underlie this enigmatic group of diseases...
  23. ncbi request reprint Biomedicine. A view from the top--prion diseases from 10,000 feet
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Science 300:917-9. 2003
  24. ncbi request reprint Molecular basis of scrapie strain glycoform variation
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Biol Chem 277:36775-81. 2002
    ....
  25. ncbi request reprint Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 188:699-705. 2003
    ..These findings suggest that cyclic tetrapyrroles may be useful both prophylactically and therapeutically against TSE diseases in vivo, as well as for inactivation of TSE infectivity suspended in solution...
  26. pmc Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation
    Roger A Moore
    The Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Protein Sci 15:609-19. 2006
    ..Our data from both models support the hypothesis that extra octapeptide repeats in PrP increase the rate at which protease resistant PrP is formed which in turn may affect the rate of disease onset in familial forms of CJD...
  27. ncbi request reprint DNA aptamers that bind to PrP(C) and not PrP(Sc) show sequence and structure specificity
    Kaori Takemura
    Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, Ohio State University, Wooster 44691, USA
    Exp Biol Med (Maywood) 231:204-14. 2006
    ....
  28. ncbi request reprint Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity
    Sevda Dirikoc
    Institut de Pharmacologie Moleculaire et Cellulaire, Unité Mixte de Recherche 6097, Centre National de la Recherche Scientifique, 06560 Valbonne, France
    J Neurosci 27:9537-44. 2007
    ..When combined with its ability to target the brain and its lack of toxic side effects, CBD may represent a promising new anti-prion drug...
  29. pmc Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1
    Fabiana A Caetano
    Programa de Farmacologia Bioquímica e Molecular, Departamento de Farmacologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, MG 30270 910, Belo Horizonte, Brazil
    J Neurosci 28:6691-702. 2008
    ..These results show that PrP(C) endocytosis is a necessary step to modulate STI1-dependent ERK1/2 signaling involved in neuritogenesis...