S A Priola

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 188:699-705. 2003
  2. ncbi request reprint Abnormal properties of prion protein with insertional mutations in different cell types
    S A Priola
    Laboratory of Persistent Viral Diseases, NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Biol Chem 273:11980-5. 1998
  3. ncbi request reprint Porphyrin and phthalocyanine antiscrapie compounds
    S A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Science 287:1503-6. 2000
  4. ncbi request reprint Biomedicine. A view from the top--prion diseases from 10,000 feet
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Science 300:917-9. 2003
  5. pmc Efficient conversion of normal prion protein (PrP) by abnormal hamster PrP is determined by homology at amino acid residue 155
    S A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 75:4673-80. 2001
  6. ncbi request reprint Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    Mol Biotechnol 33:71-88. 2006
  7. pmc Glycosylation influences cross-species formation of protease-resistant prion protein
    S A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    EMBO J 20:6692-9. 2001
  8. pmc Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier
    D A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergies and Infectious Diseases, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 92:3923-7. 1995
  9. ncbi request reprint N-terminal truncation of prion protein affects both formation and conformation of abnormal protease-resistant prion protein generated in vitro
    V A Lawson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 276:35265-71. 2001
  10. ncbi request reprint Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. An update
    B Caughey
    NIH Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Mol Biotechnol 13:45-55. 1999

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 188:699-705. 2003
    ..These findings suggest that cyclic tetrapyrroles may be useful both prophylactically and therapeutically against TSE diseases in vivo, as well as for inactivation of TSE infectivity suspended in solution...
  2. ncbi request reprint Abnormal properties of prion protein with insertional mutations in different cell types
    S A Priola
    Laboratory of Persistent Viral Diseases, NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Biol Chem 273:11980-5. 1998
    ..However, these abnormal molecules were at least 1000-fold less protease-resistant than bona fide PrP-res derived from TSE-infected brain tissue, and they showed no increased ability to form PrP-res in a cell-free system...
  3. ncbi request reprint Porphyrin and phthalocyanine antiscrapie compounds
    S A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Science 287:1503-6. 2000
    ..The significant inhibition of TSE disease by structurally dissimilar tetrapyrroles identifies these compounds as anti-TSE drugs...
  4. ncbi request reprint Biomedicine. A view from the top--prion diseases from 10,000 feet
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Science 300:917-9. 2003
  5. pmc Efficient conversion of normal prion protein (PrP) by abnormal hamster PrP is determined by homology at amino acid residue 155
    S A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 75:4673-80. 2001
    ..Thus, our data suggest that PrP-res molecules isolated from scrapie-infected brains of different animal species have different PrP-sen structural requirements for the efficient formation of protease-resistant PrP...
  6. ncbi request reprint Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    Mol Biotechnol 33:71-88. 2006
    ..This review provides an overview of the molecular mechanisms that underlie this enigmatic group of diseases...
  7. pmc Glycosylation influences cross-species formation of protease-resistant prion protein
    S A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    EMBO J 20:6692-9. 2001
    ..In vivo, these modifications might contribute to the resistance to infection associated with transmission of TSE infectivity across species barriers...
  8. pmc Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier
    D A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergies and Infectious Diseases, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 92:3923-7. 1995
    ..This specificity may be the molecular basis for the barriers to interspecies transmission of scrapie and other transmissible spongiform encephalopathies in vivo...
  9. ncbi request reprint N-terminal truncation of prion protein affects both formation and conformation of abnormal protease-resistant prion protein generated in vitro
    V A Lawson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 276:35265-71. 2001
    ..Thus, regions within the flexible N-terminal tail of PrP influenced interactions required for both generating and disrupting PrP-res formation...
  10. ncbi request reprint Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. An update
    B Caughey
    NIH Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Mol Biotechnol 13:45-55. 1999
    ..These studies have shed light on the mechanism of PrP-res formation and suggest molecular bases for TSE species barrier effects and agent strain propagation...
  11. pmc Deletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoform
    I Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 75:10024-32. 2001
    ..Thus, our results demonstrate that deletion of the beta-strands and the first alpha-helix of PrP-sen can fundamentally affect PrP-res formation and/or PrP-sen processing...
  12. ncbi request reprint DNA aptamers that bind to PrP(C) and not PrP(Sc) show sequence and structure specificity
    Kaori Takemura
    Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, Ohio State University, Wooster 44691, USA
    Exp Biol Med (Maywood) 231:204-14. 2006
    ....
  13. pmc Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity
    Winslow S Caughey
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 51:3887-94. 2007
    ..Similar comparisons of iron- and manganese-bound porphyrin sulfonates confirmed that stacking ability correlates with anti-TSE activity among cyclic tetrapyrroles...
  14. ncbi request reprint Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity
    Sevda Dirikoc
    Institut de Pharmacologie Moleculaire et Cellulaire, Unité Mixte de Recherche 6097, Centre National de la Recherche Scientifique, 06560 Valbonne, France
    J Neurosci 27:9537-44. 2007
    ..When combined with its ability to target the brain and its lack of toxic side effects, CBD may represent a promising new anti-prion drug...
  15. doi request reprint Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, Montana 59840, USA
    Nat Methods 5:211-2. 2008
  16. ncbi request reprint Identification of possible animal origins of prion disease in human beings
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Lancet 363:2013-4. 2004
  17. ncbi request reprint Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies
    Suzette A Priola
    National Institute of Allergy and Infectious Diseases, Rocky Montain Laboratories, Hamilton, MT, USA
    Methods Mol Biol 268:517-40. 2004
    ..The hypothesis that vCJD was the consequence of exposure of humans to BSE has now been supported by several different studies, and over 140 cases of vCJD have been confirmed...
  18. ncbi request reprint Molecular basis of scrapie strain glycoform variation
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Biol Chem 277:36775-81. 2002
    ....
  19. ncbi request reprint Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro
    Victoria A Lawson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:13689-95. 2004
    ..Thus, by its effects on PrP-res conformation, the flexible N-terminal region of PrP seemed to influence TSE pathogenesis and cross-species TSE transmission...
  20. pmc Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent
    Christopher S Greil
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, 903 S 4th Street, Hamilton, Montana 59840, USA
    Virology 379:284-93. 2008
    ..Our results suggest that PrP-res aggregate size, the PrP-res microenvironment, and/or host cell-specific factors can all influence whether or not a cell takes up PrP-res following exposure to TSE infectivity...
  21. ncbi request reprint Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 189:431-9. 2004
    ..Thus, testing of cells for TSE susceptibility might be necessary for all cell lines that are routinely used in vaccine production and in other medical applications...
  22. ncbi request reprint Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:29218-25. 2004
    ..This may, at least in part, explain the observation that not all PrP-sen-expressing cells appear to support transmissible spongiform encephalopathy agent replication...
  23. ncbi request reprint Amyloid formation via supramolecular peptide assemblies
    Roger A Moore
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Biochemistry 46:7079-87. 2007
    ..Our data suggest that simply changing the physical microenvironment can profoundly influence the mechanism of amyloid formation and yield fibrils with novel ultrastructural properties...
  24. pmc Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation
    Roger A Moore
    The Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Protein Sci 15:609-19. 2006
    ..Our data from both models support the hypothesis that extra octapeptide repeats in PrP increase the rate at which protease resistant PrP is formed which in turn may affect the rate of disease onset in familial forms of CJD...
  25. pmc Multiple amino acid residues within the rabbit prion protein inhibit formation of its abnormal isoform
    Ina Vorberg
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 77:2003-9. 2003
    ....
  26. pmc Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1
    Fabiana A Caetano
    Programa de Farmacologia Bioquímica e Molecular, Departamento de Farmacologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, MG 30270 910, Belo Horizonte, Brazil
    J Neurosci 28:6691-702. 2008
    ..These results show that PrP(C) endocytosis is a necessary step to modulate STI1-dependent ERK1/2 signaling involved in neuritogenesis...
  27. ncbi request reprint Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Nat Methods 4:645-50. 2007
    ..This method should facilitate the development of rapid, ultrasensitive prion assays and diagnostic tests, in addition to aiding fundamental studies of structure and mechanism of PrPSc formation...