Will Prinz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides
    Sumana Raychaudhuri
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892, USA
    J Cell Biol 173:107-19. 2006
  2. doi request reprint Membrane proteins of the endoplasmic reticulum induce high-curvature tubules
    Junjie Hu
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Science 319:1247-50. 2008
  3. pmc Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues
    Timothy A Schulz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 187:889-903. 2009
  4. pmc The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum
    Yoko Shibata
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:18892-904. 2008
  5. pmc The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae
    Kamran Anwar
    Laboratory of Molecular and Cell Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:209-17. 2012
  6. pmc Membrane-bending proteins
    William A Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Crit Rev Biochem Mol Biol 44:278-91. 2009
  7. ncbi request reprint Cholesterol trafficking in the secretory and endocytic systems
    Will Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Cell Dev Biol 13:197-203. 2002
  8. pmc Non-vesicular sterol transport in cells
    William A Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Prog Lipid Res 46:297-314. 2007
  9. pmc Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family
    Timothy A Schulz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1771:769-80. 2007
  10. pmc Lipid trafficking sans vesicles: where, why, how?
    William A Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 143:870-4. 2010

Collaborators

Detail Information

Publications19

  1. pmc Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides
    Sumana Raychaudhuri
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892, USA
    J Cell Biol 173:107-19. 2006
    ..Our findings argue that ORPs move sterols among cellular compartments and that sterol transport and intracellular distribution are regulated by PIPs...
  2. doi request reprint Membrane proteins of the endoplasmic reticulum induce high-curvature tubules
    Junjie Hu
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Science 319:1247-50. 2008
    ..Tubules made in vitro were narrower than normal ER tubules, due to a higher concentration of tubule-inducing proteins. The shape and oligomerization of the "morphogenic" proteins could explain the formation of the tubular ER...
  3. pmc Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues
    Timothy A Schulz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 187:889-903. 2009
    ..Together, these findings suggest a new model of how ORPs could sense and regulate the lipid composition of adjacent membranes...
  4. pmc The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum
    Yoko Shibata
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:18892-904. 2008
    ..We propose that oligomerization of the reticulons and DP1/Yop1p is important for both their localization to the tubular domains of the ER and for their ability to form tubules...
  5. pmc The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae
    Kamran Anwar
    Laboratory of Molecular and Cell Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:209-17. 2012
    ..Collectively, our results show that Sey1p and its homologues function analogously to ATLs in mediating ER fusion. They also indicate that S. cerevisiae has an alternative fusion mechanism that requires ER SNAREs...
  6. pmc Membrane-bending proteins
    William A Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Crit Rev Biochem Mol Biol 44:278-91. 2009
    ..Still other proteins may use novel but poorly understood mechanisms. In this review, we summarize what is known about how different families of proteins bend membranes...
  7. ncbi request reprint Cholesterol trafficking in the secretory and endocytic systems
    Will Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Cell Dev Biol 13:197-203. 2002
    ..This review summarizes what is known about the pathways and mechanisms of intracellular sterol trafficking...
  8. pmc Non-vesicular sterol transport in cells
    William A Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Prog Lipid Res 46:297-314. 2007
    ..In most cases, the mechanisms and regulation of these proteins remains poorly understood. This review summarizes our current knowledge of these proteins and how they could contribute to intracellular sterol trafficking and distribution...
  9. pmc Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family
    Timothy A Schulz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1771:769-80. 2007
    ..This review summarizes the current body of knowledge regarding this family and its potential functions, placing it in the context of known and hypothesized pathways of sterol transport in yeast...
  10. pmc Lipid trafficking sans vesicles: where, why, how?
    William A Prinz
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 143:870-4. 2010
    ..In the past few years, considerable progress has been made in characterizing the mechanisms of nonvesicular lipid transport and how it may go awry in particular diseases, but many fundamental questions remain for this rising field...
  11. pmc Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation
    John A Hanover
    Laboratory of Cell Biochemistry and Biology, NIDDK, NIH, Bethesda, MD 20892, USA
    J Biol Chem 284:12593-7. 2009
    ..Ca(2+)-calmodulin-triggered nuclear entry of key architectural transcription factors is a potentially key epigenetic regulator of terminal differentiation in response to cell signaling...
  12. pmc Structural mechanism for sterol sensing and transport by OSBP-related proteins
    Young Jun Im
    Laboratory of Molecular Biology, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nature 437:154-8. 2005
    ..On the basis of these observations, we propose a model in which sterol and membrane binding promote reciprocal conformational changes that facilitate a sterol transfer and signalling cycle...
  13. ncbi request reprint ATP-binding cassette (ABC) transporters mediate nonvesicular, raft-modulated sterol movement from the plasma membrane to the endoplasmic reticulum
    Yifu Li
    Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:45226-34. 2004
    ..Our findings suggest that raft association is a primary determinant of sterol accumulation in the PM and that Aus1p and Pdr11p facilitate sterol uptake by increasing the cycling of sterol between the PM and ER...
  14. ncbi request reprint The High Mobility Group Box Transcription Factor Nhp6Ap enters the nucleus by a calmodulin-dependent, Ran-independent pathway
    John A Hanover
    Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    J Biol Chem 282:33743-51. 2007
    ..The finding that Nhp6Ap nuclear entry requires calmodulin but not Ran indicates that Nhp6Ap is a good model for studying this poorly understood but evolutionarily conserved calmodulin-dependent nuclear import pathway...
  15. pmc Dynamics of cholesterol exchange in the oxysterol binding protein family
    Bertram J Canagarajah
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892, USA
    J Mol Biol 378:737-48. 2008
    ....
  16. pmc The diverse functions of oxysterol-binding proteins
    Sumana Raychaudhuri
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Cell Dev Biol 26:157-77. 2010
    ..This review will summarize recent advances in our understanding of how ORPs bind lipids and membranes and how they function in diverse cellular processes...
  17. pmc Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum
    Sumana Raychaudhuri
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:15785-90. 2008
    ..Our findings indicate that lipids are directly transferred from the ER to peroxisomes by a nonvesicular pathway and suggest that ER to peroxisome vesicular transport is not required to provide lipids for peroxisomal growth...
  18. ncbi request reprint A class of membrane proteins shaping the tubular endoplasmic reticulum
    Gia K Voeltz
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 124:573-86. 2006
    ..The simultaneous absence of the reticulons and Yop1p in S. cerevisiae results in disrupted tubular ER. We propose that these "morphogenic" proteins partition into and stabilize highly curved ER membrane tubules...
  19. ncbi request reprint Sheets, ribbons and tubules - how organelles get their shape
    Gia K Voeltz
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Nat Rev Mol Cell Biol 8:258-64. 2007
    ....