Research Topics
| David A PriceSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infectionDavid A Price
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 206:923-36. 2009..Thus, the pattern of antigen-specific clonotype recruitment within a protective CD8(+) T cell population is a prognostic indicator of vaccine efficacy and biological outcome in an AIDS virus infection...- Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturationJoseph P Casazza
Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID, National Institutes of Health (NIH, Bethesda, MD 20892, USA
J Exp Med 203:2865-77. 2006..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes... - Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemiaKatayoun Rezvani
Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
Blood 110:1924-32. 2007..Our results support the immunogenicity of WT1 after SCT for ALL and highlight the potential for WT1 vaccines to boost GVL after SCT for ALL... - The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donorPhillip Scheinberg
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Blood 114:5071-80. 2009.... - Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
J Immunol 183:1120-32. 2009..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection... - Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA virusesDavid A Price
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 202:1349-61. 2005..Vaccine strategies that reconstruct these biological processes could generate T cell populations that mediate optimal delivery of antiviral effector function... - SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
Blood 110:928-36. 2007..Manipulation of the interaction of PD-1 with its ligands could thus potentially restore the CD8+ T-cell responses in SIV infection... - In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteinsHiroshi Fujiwara
Stem Cell Allotransplant Section, Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 11:4495-503. 2005..This study emphasizes the clinical potential of PGP for expansion and adoptive transfer of polyclonal leukemia antigen-specific T cells to treat leukemia... - Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramersPratip K Chattopadhyay
Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Cytometry A 73:1001-9. 2008.... - High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrowJ Joseph Melenhorst
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 113:2238-44. 2009..These data suggest that concomitant examination of bone marrow specimens in patients with myeloid leukemias might yield more definitive information in the search for immunologic prognosticators of clinical outcome... - Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell responseChristof Geldmacher
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Blood 114:1553-62. 2009..Thus, minor viral and host genetic polymorphisms can dramatically alter the immunologic and virologic outcome of an epitope-specific CD8 T-cell response... 
The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentrationMichael R Betts
Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:6407-17. 2004..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response...- Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infectionTakuya Yamamoto
Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
J Virol 86:5877-84. 2012..The ability to elicit such virus-specific EM CD8(+) T cells might contribute substantially to an efficacious HIV/AIDS vaccine, even after breakthrough infection... - Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infectionMichael R Betts
Laboratory of Immunology, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:4512-7. 2005..These data suggest that control of HIV by vaccine-elicited HIV-specific T cell responses may be difficult, even when the T cell response has those characteristics predicted to provide optimal protection... - Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responsesMelissa L Precopio
Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:1405-16. 2007..This quality of the CD8(+) T cell response may be at least partially responsible for the profound efficacy of these vaccines in protection against smallpox and serves as a benchmark against which other vaccines can be evaluated... - The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangementsPhillip Scheinberg
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol Methods 321:107-20. 2007..Clonotypes shared between the CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- subsets were observed in all 3 UCB and in one adult PBMCs, suggesting that naïve and memory CD4+ T(R) can share the same clonotypes as CD4+ non-T(R) in humans... - The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expressionPratip K Chattopadhyay
Immunotechnology Section, Laboratory of Immunology, Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA
J Leukoc Biol 85:88-97. 2009..Thus, the use of CD57 provides a means to easily isolate viable cells with high cytolytic potential, without the need for lethal fixation/permeabilization techniques... - Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cellsMarybeth Daucher
National Institute of Allergy and Infectious Diseases, Bldg 10 Rm 11B13, Bethesda, MD 20892, USA
J Virol 82:4102-14. 2008.... - T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterizationKatayoun Rezvani
Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung Blood Institute and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 11:8799-807. 2005..Four HLA-A*0201-restricted WT1-derived epitopes have been identified: WT37, WT126, WT187, and WT235. We determined the natural immunogenecity of these antigens in patients with hematologic malignancies and healthy donor... - Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometryPratip K Chattopadhyay
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA
Nat Med 12:972-7. 2006.... - PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:2281-92. 2006.... - T cell receptor recognition motifs govern immune escape patterns in acute SIV infectionDavid A Price
Human Immunology Section, Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892, USA
Immunity 21:793-803. 2004..These findings have profound implications for the development of vaccines that elicit T cell immunity to combat pathogens with unstable genomes... - Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infectionTakuya Yamamoto
National Institutes of Health, Bethesda, MD, USA
Blood 117:4805-15. 2011..Thus, multiple coinhibitory receptors can affect the development of HIV-specific CD8(+) T-cell responses and, by extension, represent potential targets for new immune-based interventions in HIV-infected persons... - Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivoJason M Brenchley
Human Virology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
J Virol 80:6801-9. 2006.... - Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastaseHiroshi Fujiwara
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 103:3076-83. 2004..HNE could, therefore, be used in an HLA-unrestricted manner to induce leukemia-reactive CTLs for adoptive immunotherapy... - Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infectionsJason M Brenchley
Human Immunology Section, Vaccine Research Center VRC, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
Blood 112:2826-35. 2008..Finally, these data may help account for the nonprogressive nature of nonpathogenic SIV infection in sooty mangabeys... - Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicityMatthew J Johnson
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 188:6109-18. 2012..Taken together, our results demonstrate that rAd-induced IFN-α production has multiple effects on T cell immunogenicity, the understanding of which should be considered in the design of rAd vaccine vectors... - Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: implications for graft engineeringPhillip Scheinberg
Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1202, USA
Exp Hematol 34:788-95. 2006..To better understand the alloresponse between HLA-identical related pairs, we characterized the alloreactive T cells generated in a mixed lymphocyte reaction (MLR) assay system... - Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapyJoseph P Casazza
Immunology Laboratory, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 79:3653-63. 2005.... - Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramersJ Joseph Melenhorst
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol Methods 338:31-9. 2008.... - Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaquesLevelle D Harris
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Blood 116:4148-57. 2010..These findings may lead to novel therapeutic interventions that improve the immune responses against microbial antigens, and thus, decrease microbial translocation-induced immune activation... - A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion techniqueStephan Mielke
Allotransplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
Blood 111:4392-402. 2008..This procedure is currently being investigated in a clinical trial of allotransplantation... - Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaquesAnna Hryniewicz
Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
J Immunol 178:3492-504. 2007..These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals... - T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesisJason M Brenchley
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 78:1160-8. 2004..These data illuminate the underlying mechanisms that distort T-cell homeostasis in HIV infection... - Microbial translocation is a cause of systemic immune activation in chronic HIV infectionJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 12:1365-71. 2006..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection... - HLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cellsDaniel Mendoza
HIV Specific Immunity Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:4014-8. 2012..Thus, HIV-specific CD8(+) T-cell responses in LTNP/EC are not differentiated from those of progressors on the basis of clonal diversity or TCR sharing... - Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoireMaire F Quigley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:19414-9. 2010..These findings provide a framework for understanding the early mobilization of public CD8(+) T-cell clonotypes, which can exert profound biological effects during acute infectious processes... - T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapyElaine M Sloand
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 117:2691-9. 2011..Thus, our results suggest that WT1 is one of the antigens that triggers T cell-mediated myelosuppression in MDS... - Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent mannerRuth Seggewiss
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI, the Immunology Laboratory, NIH/DHHS, Bldg 10, CRC, Rm 4-5140, 10 Center Dr, MSC 1202, Bethesda, MD 20892, USA
Blood 105:2473-9. 2005.... - Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjectsJ Joseph Melenhorst
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Blood 116:4700-2. 2010..These data indicate that the adoptive transfer of partially HLA-mismatched virus-specific CTL is safe despite in vitro recognition of recipient HLA molecules... - Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoireJ Joseph Melenhorst
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 180:6484-9. 2008..We therefore conclude that the correlation in Vbeta expression patterns between CD4(+) and CD8(+) T cells can be explained predominantly by germline TCR-beta locus factors and not TCR-beta allelic or HLA effects... - HIV disease: fallout from a mucosal catastrophe?Jason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 7:235-9. 2006.... - CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
J Exp Med 200:749-59. 2004.... - Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificityMitsuo Honda
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 183:2425-34. 2009..These findings suggest that different gene-based vectors generate peptides with alternative conformations within MHC-I that elicit distinct T cell responses after vaccination... - A human memory T cell subset with stem cell-like propertiesLuca Gattinoni
Center for Cancer Research, National Cancer Institute, US National Institutes of Health NIH, Bethesda, Maryland, USA
Nat Med 17:1290-7. 2011..The identification of a human stem cell-like memory T cell population is of direct relevance to the design of vaccines and T cell therapies... 
Allogeneic HLA-A*02-restricted WT1-specific T cells from mismatched donors are highly reactive but show off-target promiscuityWillem J J Falkenburg
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 187:2824-33. 2011..As a result of this, administration of WT1-specific T cells generated from HLA-mismatched donors should be performed with appropriate precautions against potential off-target effects...- Brilliant violet fluorophores: a new class of ultrabright fluorescent compounds for immunofluorescence experimentsPratip K Chattopadhyay
Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
Cytometry A 81:456-66. 2012.... - Unbiased molecular analysis of T cell receptor expression using template-switch anchored RT-PCRMaire F Quigley
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Curr Protoc Immunol . 2011..The approach is based on a template-switch anchored reverse transcription-polymerase chain reaction (RT-PCR) and is optimized for the analysis of antigen-specific T cells isolated directly ex vivo... - Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulationMichael R Betts
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
J Immunol Methods 281:65-78. 2003.... - Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantationKatayoun Rezvani
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 102:2892-900. 2003..The increased response in patients after SCT suggests a quantitative explanation for the greater effect of allogeneic SCT... - HIV preferentially infects HIV-specific CD4+ T cellsDaniel C Douek
Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
Nature 417:95-8. 2002..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption... - Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaquesDavid A Price
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 180:269-80. 2008.... - Holoendemic malaria exposure is associated with altered Epstein-Barr virus-specific CD8(+) T-cell differentiationPratip K Chattopadhyay
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 87:1779-88. 2013..These observations define a malaria-associated aberration localized to the EBV-specific CD8(+) T-cell compartment that illuminates the etiology of eBL... - Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cellsEnrico Lugli
Immunotechnology Section, Vaccine Research Center VRC, National Institute of Allergy and Infectious Diseases, US National Institutes of Health NIH, Bethesda, MD, USA
Nat Protoc 8:33-42. 2013..We also indicate multiple strategies for their efficient expansion in vitro at consistent numbers for functional characterization or adoptive transfer experiments... - Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected miceTracy J Ruckwardt
Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 7:e1002377. 2011..Thus, the functional properties of T cells are selectively modified by developmental factors in an epitope-specific and age-dependent manner... - Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cellsSebastien M Maloveste
Non Human Primate Immunogenetics and Cellular Immunology Unit, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 189:4338-48. 2012..This degenerate, yet peptide-dependent, MHC reactivity differs markedly from the fine specificity of human KIRs...