K L Preston

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Urinary elimination of cocaine metabolites in chronic cocaine users during cessation
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 26:393-400. 2002
  2. pmc Stress in the daily lives of cocaine and heroin users: relationship to mood, craving, relapse triggers, and cocaine use
    Kenzie L Preston
    Treatment Section, Clinical Pharmacology and Therapeutics Branch, NIDA Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Room 01B 602, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 218:29-37. 2011
  3. ncbi request reprint Abstinence reinforcement maintenance contingency and one-year follow-up
    Kenzie L Preston
    National Institute on Drug Abuse NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 67:125-37. 2002
  4. ncbi request reprint Effects of agonist-antagonist opioids in humans trained in a hydromorphone/not hydromorphone discrimination
    K L Preston
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 295:114-24. 2000
  5. ncbi request reprint Shaping cocaine abstinence by successive approximation
    K L Preston
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Consult Clin Psychol 69:643-54. 2001
  6. pmc Cocaine craving and use during daily life
    Kenzie L Preston
    Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 207:291-301. 2009
  7. ncbi request reprint Cocaine use early in treatment predicts outcome in a behavioral treatment program
    K L Preston
    Intramural Research Program, National Institute on Drug Abuse NIDA, Baltimore, Maryland 21224, USA
    J Consult Clin Psychol 66:691-6. 1998
  8. ncbi request reprint Methadone and metabolite urine concentrations in patients maintained on methadone
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 27:332-41. 2003
  9. ncbi request reprint Cyclazocine: comparison to hydromorphone and interaction with cocaine
    K L Preston
    National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Behav Pharmacol 15:91-102. 2004
  10. ncbi request reprint Broad beneficial effects of cocaine abstinence reinforcement among methadone patients
    K Silverman
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Consult Clin Psychol 66:811-24. 1998

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Urinary elimination of cocaine metabolites in chronic cocaine users during cessation
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 26:393-400. 2002
    ....
  2. pmc Stress in the daily lives of cocaine and heroin users: relationship to mood, craving, relapse triggers, and cocaine use
    Kenzie L Preston
    Treatment Section, Clinical Pharmacology and Therapeutics Branch, NIDA Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Room 01B 602, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 218:29-37. 2011
    ..Quantitative real-time data on the stress experienced by drug misusers in their daily lives may provide additional insight into stress's role in drug use...
  3. ncbi request reprint Abstinence reinforcement maintenance contingency and one-year follow-up
    Kenzie L Preston
    National Institute on Drug Abuse NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 67:125-37. 2002
    ..In the prior study (induction phase, 8 weeks) participants received vouchers for each opiate-negative urine screen or noncontingently...
  4. ncbi request reprint Effects of agonist-antagonist opioids in humans trained in a hydromorphone/not hydromorphone discrimination
    K L Preston
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 295:114-24. 2000
    ..These results suggest that instructions are an important factor in the outcome of human drug discrimination studies...
  5. ncbi request reprint Shaping cocaine abstinence by successive approximation
    K L Preston
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Consult Clin Psychol 69:643-54. 2001
    ..A 2nd phase of the study showed that abstinence induced by escalating-value vouchers can be maintained by a nonescalating schedule, suggesting that contingency management can be practical as a maintenance treatment...
  6. pmc Cocaine craving and use during daily life
    Kenzie L Preston
    Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 207:291-301. 2009
    ..Craving is often assumed to cause ongoing drug use and relapse and is a major focus of addiction research. However, its relationship to drug use has not been adequately documented...
  7. ncbi request reprint Cocaine use early in treatment predicts outcome in a behavioral treatment program
    K L Preston
    Intramural Research Program, National Institute on Drug Abuse NIDA, Baltimore, Maryland 21224, USA
    J Consult Clin Psychol 66:691-6. 1998
    ..Cocaine use during baseline provided critical predictors of response to the experimental treatment...
  8. ncbi request reprint Methadone and metabolite urine concentrations in patients maintained on methadone
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 27:332-41. 2003
    ..Nevertheless, variability was too great to permit estimation of methadone dose (or detect a single missed administration) from any single specimen...
  9. ncbi request reprint Cyclazocine: comparison to hydromorphone and interaction with cocaine
    K L Preston
    National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Behav Pharmacol 15:91-102. 2004
    ..This study is suggestive but not strongly supportive for the use of kappa-opiate drugs to diminish acute effects of cocaine administration or for the use of these kappa agonists in drug abuse treatment applications...
  10. ncbi request reprint Broad beneficial effects of cocaine abstinence reinforcement among methadone patients
    K Silverman
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Consult Clin Psychol 66:811-24. 1998
    ..These results replicate the efficacy of cocaine abstinence reinforcement and show that it can have broad beneficial effects...
  11. ncbi request reprint Monitoring opiate use in substance abuse treatment patients with sweat and urine drug testing
    M A Huestis
    Chemistry and Drug Metabolism Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Anal Toxicol 24:509-21. 2000
    ..However, the percentage of false-negative results, at least in this treatment population, indicates that weekly sweat testing may be less sensitive than thrice weekly urine testing in detecting opiate use...
  12. ncbi request reprint Evaluation of the abuse potential of methocarbamol
    K L Preston
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Pharmacol Exp Ther 248:1146-57. 1989
    ....
  13. ncbi request reprint Low-dose oral cocaine in humans: acquisition of discrimination and time-course of effects
    D H Epstein
    NIH, NIDA Intramural Research Program, Baltimore, Maryland, USA
    Behav Pharmacol 10:531-42. 1999
    ..Overall, the results support the sensitivity of the behavioral-testing procedure used, and show that 50 mg oral cocaine can serve as a discriminative stimulus in adult humans...
  14. ncbi request reprint Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays
    A C Spanbauer
    IRP, NIDA, NIH, Baltimore, Maryland 21224, USA
    J Anal Toxicol 25:515-9. 2001
    ..Increasing the opiate screening and confirmation cutoffs for the federal workplace drug-testing program resulted in 8% fewer opiate-positive tests; however, recent heroin use was not affected by this change...
  15. ncbi request reprint Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716
    M A Huestis
    National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 58:322-8. 2001
    ..These findings suggest that CB1 receptors mediate many of the effects of marijuana, but this has not been evaluated in humans...
  16. ncbi request reprint Family history influence on drug abuse severity and treatment outcome
    R W Pickens
    Clinical Neurogenetics Section and Treatment Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Drug Alcohol Depend 61:261-70. 2001
    ..Both effects remained significant after adjusting for gender and race. These results suggest that common genetic factors may underlie both susceptibility to heroin dependence and response to therapeutic methadone treatment...
  17. ncbi request reprint Naltrexone shortened opioid detoxification with buprenorphine
    A Umbricht
    NIDA Intramural Research Program, Addiction Research Center, Baltimore, MD, USA
    Drug Alcohol Depend 56:181-90. 1999
    ..Peak withdrawal symptoms after naltrexone were of moderate intensity, suggesting that naltrexone combined with buprenorphine is an acceptable and safe treatment for shortened opioid detoxification and induction of naltrexone maintenance...
  18. pmc Does cannabis use predict poor outcome for heroin-dependent patients on maintenance treatment? Past findings and more evidence against
    D H Epstein
    Clinical Pharmacology and Therapeutics Branch, Treatment Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Addiction 98:269-79. 2003
    ....
  19. ncbi request reprint Opioid drug discrimination in humans: stability, specificity and relation to self-reported drug effect
    W K Bickel
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Pharmacol Exp Ther 251:1053-63. 1989
    ..o.; and secobarbital, 100-200 mg p.o.) did not generalize to hydromorphone, but showed partial generalization to both pentazocine and saline. In general, drug-discrimination performance paralleled the patterns of self reports...
  20. ncbi request reprint Opioid discrimination in humans: discriminative and subjective effects of progressively lower training dose
    K L Preston
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Behav Pharmacol 9:533-43. 1998
    ..These data indicate covariation of subjective effects and discrimination performance and suggest that discrimination behavior may be more sensitive for differentiating among drug conditions than traditional subjective effects measures...
  21. pmc Intravenous buprenorphine and norbuprenorphine pharmacokinetics in humans
    M A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Drug Alcohol Depend 131:258-62. 2013
    ..Prescribed sublingual (SL) buprenorphine is sometimes diverted for intravenous (IV) abuse, but no human pharmacokinetic data are available following high-dose IV buprenorphine...
  22. pmc Cigarette smoking and short-term addiction treatment outcome
    P T Harrell
    Intramural Research Program, National Institute on Drug Abuse NIH, Baltimore, MD 21224, USA
    Drug Alcohol Depend 115:161-6. 2011
    ....
  23. ncbi request reprint Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability
    K L Preston
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Pharmacol Exp Ther 262:707-20. 1992
    ..The considerable overlap in subjective effect measures of positive mood make further differentiation with respect to abuse liability difficult...
  24. pmc A model for pharmacological research-treatment of cocaine dependence
    I D Montoya
    National Institutes of Health, National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224, USA
    J Subst Abuse Treat 12:415-21. 1995
    ..This model represents an effort to standardize data collection to make results more valid and comparable...
  25. pmc Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin
    Udi E Ghitza
    Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institute of Health NIH, MD, USA
    J Consult Clin Psychol 75:765-74. 2007
    ..Computerized drawing with higher-density prizes enhanced reduction of cocaine use; abstinence reinforcement had long-term therapeutic benefits...
  26. pmc Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol
    David H Epstein
    NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biol Psychol 73:90-9. 2006
    ..Nonetheless, it is suggested that abuse-potential screening of new medications would benefit from an organized, integrated cross-species program...
  27. ncbi request reprint The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokers
    David A Gorelick
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Am Heart J 151:754.e1-754.e5. 2006
    ..In human studies, activation of CB1 receptors by cannabis or its active ingredient, Delta9-tetrahydrocannabinol (THC), has modest and inconsistent effects on BP...
  28. ncbi request reprint Assessment of agonist and antagonist effects of tramadol in opioid-dependent humans
    C Patrick Carroll
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 14:109-20. 2006
    ..In contrast, tramadol's pattern of effects was more similar to that of hydromorphone and suggestive of mild opioid-agonist effects (withdrawal suppression), though not to a statistically significant degree...
  29. ncbi request reprint Nonreporting of cannabis use: Predictors and relationship to treatment outcome in methadone maintained patients
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Branch, Treatment Section Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 5500 Nathan Shock Drive Baltimore, MD 21224, USA
    Addict Behav 32:938-49. 2007
    ..Nonreporting of THC use is a significant predictor of greater cocaine and heroin use. This association can be eliminated with contingency management therapy...
  30. pmc Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:1-16. 2006
    ..The reinstatement model is widely used to study relapse to drug addiction. However, the model's validity is open to question...
  31. ncbi request reprint Heroin and cocaine craving and use during treatment: measurement validation and potential relationships
    Adrienne J Heinz
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    J Subst Abuse Treat 31:355-64. 2006
    ..Treatment dropout and in-treatment drug use were more frequently predicted by scores on the 14- or 45-item CCQ than by VAS ratings. Results suggest that the CCQ/HCQ and the 14-item CCQ provide information that unidimensional VASs do not...
  32. ncbi request reprint Spiritual/Religious experiences and in-treatment outcome in an inner-city program for heroin and cocaine dependence
    Adrienne Heinz
    Clinical Pharmacology and Treatment Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
    J Psychoactive Drugs 39:41-9. 2007
    ..The results suggest that spiritual and religious experience plays a role in substance abuse recovery and that demographic characteristics should be considered in the design of spiritually oriented behavioral interventions for addiction...
  33. pmc Contingency management reduces injection-related HIV risk behaviors in heroin and cocaine using outpatients
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Addict Behav 33:593-604. 2008
    ..CM targeted toward cocaine and heroin use produces significant reductions in injection-related drug-taking behaviors associated with heightened risk for getting or transmitting HIV...
  34. pmc Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users
    Marilyn A Huestis
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 194:505-15. 2007
    ..A single 90-mg dose of the cannabinoid CB1 receptor antagonist rimonabant attenuates effects of smoked cannabis in humans...
  35. pmc Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing method
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 91:169-77. 2007
    ..Cocaine use during treatment, especially when measured with New Uses criteria, can predict psychosocial functioning, but cannot substitute for direct measures of psychosocial functioning...
  36. pmc Hepatitis C and human immunodeficiency virus risk behaviors in polydrug users on methadone maintenance
    Jessica Willner-Reid
    National Institute on Drug Abuse, Baltimore, MD 21224, USA
    J Subst Abuse Treat 35:78-86. 2008
    ..These findings demonstrate that both drug- and sex-related risk behaviors decrease during MMT and emphasize the benefits of methadone programs for public health and HIV/HCV prevention...
  37. ncbi request reprint Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Pharmacotherapy 27:1111-9. 2007
    ..To determine the hemodynamic and cognitive effects of lofexidine and methadone coadministration...
  38. ncbi request reprint Adverse events among patients in a behavioral treatment trial for heroin and cocaine dependence: effects of age, race, and gender
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 80:45-51. 2005
    ..Nonetheless, the data reported here should help provide a context in which investigators and IRBs can interpret the patterns of AEs they encounter...
  39. ncbi request reprint Changes in HIV risk behaviors among patients receiving combined pharmacological and behavioral interventions for heroin and cocaine dependence
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Addict Behav 31:868-79. 2006
    ..034) but this effect was no longer significant after adjusting for drug-negative urines. These results suggest broad beneficial effects of methadone maintenance augmented with behavioral interventions for reducing HIV risk behaviors...
  40. ncbi request reprint Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection
    Annie Umbricht
    National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 69:263-72. 2003
    ..05). These findings suggest buprenorphine, clonidine, and methadone regimens each decrease opioid withdrawal in medically ill HIV-infected patients...
  41. pmc Cognitive-behavioral therapy plus contingency management for cocaine use: findings during treatment and across 12-month follow-up
    David H Epstein
    Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Intramural Research Program Treatment Section, Baltimore, Maryland 21224, USA
    Psychol Addict Behav 17:73-82. 2003
    ..Posttreatment, there were signs of additive benefits, significant in 3- versus 12-month contrasts. Former CBT participants were also more likely to acknowledge cocaine use and its effects and to report employment...
  42. pmc The reinstatement model and relapse prevention: a clinical perspective
    David H Epstein
    NIDA IRP Treatment Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:31-41. 2003
    ..This commentary assesses the degree to which the reinstatement model is homologous to the human experience of relapse...
  43. ncbi request reprint Do noncontingent vouchers increase drug use?
    Jennifer R Schroeder
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Exp Clin Psychopharmacol 11:195-201. 2003
    ..05, 95% confidence interval: 1.01-1.09). Overall, results do not indicate a causal relationship between noncontingent voucher receipt and increased drug use...
  44. ncbi request reprint A dose response study of cognitive behavioral therapy in cocaine abusers
    Lino Covi
    National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Subst Abuse Treat 23:191-7. 2002
    ..05) amounts in all treatment groups. Findings suggest that cognitive behavioral therapy is effective in reducing cocaine use even if a less intensive schedule is used...
  45. pmc Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependence
    Ivan D Montoya
    Division of Treatment Research and Development and Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Clin Pharmacol Ther 75:34-48. 2004
    ..Its efficacy for cocaine dependence is uncertain. This study evaluated buprenorphine for the treatment of concomitant cocaine and opiate dependence...
  46. ncbi request reprint A laboratory study of hydromorphone and cyclazocine on smoking behavior in residential polydrug users
    Wallace B Pickworth
    National Institute on Drug Abuse NIDA, Intramural Research Program, Clinical Pharmacology and Therapeutics Branch, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 77:711-5. 2004
    ..4 mg) reduced exhaled carbon monoxide (CO) boost, a measure of smoke exposure. Further studies of the effects of kappa opioid agonists on smoking behavior may lead to a better understanding of the role of opiates in smoking behavior...
  47. ncbi request reprint Effects of high-dose intravenous buprenorphine in experienced opioid abusers
    Annie Umbricht
    National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
    J Clin Psychopharmacol 24:479-87. 2004
    ..v. dose. Buprenorphine appears to have a ceiling for cardiorespiratory and subjective effects and a high safety margin even when taken by the i.v. route...
  48. ncbi request reprint Gender differences in indices of opioid dependency and medical comorbidity in a population of hospitalized HIV-infected African-Americans
    Susan J Boyd
    NIDA IRP, Baltimore, MD, USA
    Am J Addict 13:281-91. 2004
    ..These gender differences in opioid dependency and medical comorbidity may indicate a need for alternative treatment approaches for men and women...
  49. pmc QT interval increased after single dose of lofexidine
    John Schmittner
    National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    BMJ 329:1075. 2004
  50. pmc Influence of psychotherapy attendance on buprenorphine treatment outcome
    Ivan D Montoya
    Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    J Subst Abuse Treat 28:247-54. 2005
    ..02). These results suggest that psychotherapy can improve the outcome of buprenorphine maintenance treatment for patients with dual (cocaine and opioid) dependence...
  51. ncbi request reprint Toxicologic aspects of heroin substitution treatment
    Edward J Cone
    ConeChem Research, Baltimore, Maryland, USA
    Ther Drug Monit 24:193-8. 2002
    ..Overall, the many recent developments in testing methodology provide more effective means to assess patients in heroin substitution programs and should contribute to improvements in public health...
  52. ncbi request reprint Menstrual cycle length during methadone maintenance
    John Schmittner
    Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD 21224, USA
    Addiction 100:829-36. 2005
    ..This study was conducted to evaluate whether cycle length was more regular during methadone maintenance...
  53. ncbi request reprint Methadone treatment induces attenuation of cerebrovascular deficits associated with the prolonged abuse of cocaine and heroin
    Ronald I Herning
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropsychopharmacology 28:562-8. 2003
    ..These findings suggest that maintenance on methadone might have significant beneficial neurovascular effects on this population of patients...
  54. ncbi request reprint Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection
    Maria Esther Rodriguez Rosas
    Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 796:355-70. 2003
    ..0%) and accuracy (CVs<4.0%) were obtained. These findings demonstrate the accuracy and precision of the method used to successfully analyze saliva obtained from patients enrolled in a methadone-maintenance program...
  55. ncbi request reprint Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection
    Maria Esther Rodriguez-Rosas
    Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    J Chromatogr A 1073:237-48. 2005
    ..S.D. for the intra- and inter-day precision of the method were < 5.3% and the R.S.D. for accuracy was < 5.0%. The method was used to analyze plasma samples obtained from patients enrolled in a Met-maintenance program...
  56. pmc Open-label pilot study of bupropion plus bromocriptine for treatment of cocaine dependence
    Ivan D Montoya
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Drug Alcohol Abuse 28:189-96. 2002
    ..There were no significant differences in outcome between groups. These results suggest that the combination of bupropion and bromocriptine is safe in cocaine addicts, but provide ambiguous evidence of its efficacy...