Research Topics
| K L PrestonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Cocaine craving and use during daily lifeKenzie L Preston
Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 207:291-301. 2009..Craving is often assumed to cause ongoing drug use and relapse and is a major focus of addiction research. However, its relationship to drug use has not been adequately documented...- Abstinence reinforcement maintenance contingency and one-year follow-upKenzie L Preston
National Institute on Drug Abuse NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 67:125-37. 2002..In the prior study (induction phase, 8 weeks) participants received vouchers for each opiate-negative urine screen or noncontingently... - Effects of agonist-antagonist opioids in humans trained in a hydromorphone/not hydromorphone discriminationK L Preston
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Pharmacol Exp Ther 295:114-24. 2000..These results suggest that instructions are an important factor in the outcome of human drug discrimination studies... - Urinary elimination of cocaine metabolites in chronic cocaine users during cessationKenzie L Preston
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Anal Toxicol 26:393-400. 2002.... - Methadone and metabolite urine concentrations in patients maintained on methadoneKenzie L Preston
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Anal Toxicol 27:332-41. 2003..Nevertheless, variability was too great to permit estimation of methadone dose (or detect a single missed administration) from any single specimen... - Cocaine use early in treatment predicts outcome in a behavioral treatment programK L Preston
Intramural Research Program, National Institute on Drug Abuse NIDA, Baltimore, Maryland 21224, USA
J Consult Clin Psychol 66:691-6. 1998..Cocaine use during baseline provided critical predictors of response to the experimental treatment... - Cyclazocine: comparison to hydromorphone and interaction with cocaineK L Preston
National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
Behav Pharmacol 15:91-102. 2004..This study is suggestive but not strongly supportive for the use of kappa-opiate drugs to diminish acute effects of cocaine administration or for the use of these kappa agonists in drug abuse treatment applications... - Stress in the daily lives of cocaine and heroin users: relationship to mood, craving, relapse triggers, and cocaine useKenzie L Preston
Treatment Section, Clinical Pharmacology and Therapeutics Branch, NIDA Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Room 01B 602, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 218:29-37. 2011..Quantitative real-time data on the stress experienced by drug misusers in their daily lives may provide additional insight into stress's role in drug use... - Shaping cocaine abstinence by successive approximationK L Preston
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Consult Clin Psychol 69:643-54. 2001..A 2nd phase of the study showed that abstinence induced by escalating-value vouchers can be maintained by a nonescalating schedule, suggesting that contingency management can be practical as a maintenance treatment... - Broad beneficial effects of cocaine abstinence reinforcement among methadone patientsK Silverman
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Consult Clin Psychol 66:811-24. 1998..These results replicate the efficacy of cocaine abstinence reinforcement and show that it can have broad beneficial effects... - Evaluation of the abuse potential of methocarbamolK L Preston
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
J Pharmacol Exp Ther 248:1146-57. 1989.... - Monitoring opiate use in substance abuse treatment patients with sweat and urine drug testingM A Huestis
Chemistry and Drug Metabolism Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
J Anal Toxicol 24:509-21. 2000..However, the percentage of false-negative results, at least in this treatment population, indicates that weekly sweat testing may be less sensitive than thrice weekly urine testing in detecting opiate use... - Low-dose oral cocaine in humans: acquisition of discrimination and time-course of effectsD H Epstein
NIH, NIDA Intramural Research Program, Baltimore, Maryland, USA
Behav Pharmacol 10:531-42. 1999..Overall, the results support the sensitivity of the behavioral-testing procedure used, and show that 50 mg oral cocaine can serve as a discriminative stimulus in adult humans... - Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716M A Huestis
National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
Arch Gen Psychiatry 58:322-8. 2001..These findings suggest that CB1 receptors mediate many of the effects of marijuana, but this has not been evaluated in humans... - Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assaysA C Spanbauer
IRP, NIDA, NIH, Baltimore, Maryland 21224, USA
J Anal Toxicol 25:515-9. 2001..Increasing the opiate screening and confirmation cutoffs for the federal workplace drug-testing program resulted in 8% fewer opiate-positive tests; however, recent heroin use was not affected by this change... - Family history influence on drug abuse severity and treatment outcomeR W Pickens
Clinical Neurogenetics Section and Treatment Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Drug Alcohol Depend 61:261-70. 2001..Both effects remained significant after adjusting for gender and race. These results suggest that common genetic factors may underlie both susceptibility to heroin dependence and response to therapeutic methadone treatment... - Naltrexone shortened opioid detoxification with buprenorphineA Umbricht
NIDA Intramural Research Program, Addiction Research Center, Baltimore, MD, USA
Drug Alcohol Depend 56:181-90. 1999..Peak withdrawal symptoms after naltrexone were of moderate intensity, suggesting that naltrexone combined with buprenorphine is an acceptable and safe treatment for shortened opioid detoxification and induction of naltrexone maintenance... - Does cannabis use predict poor outcome for heroin-dependent patients on maintenance treatment? Past findings and more evidence againstD H Epstein
Clinical Pharmacology and Therapeutics Branch, Treatment Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Addiction 98:269-79. 2003.... - Opioid drug discrimination in humans: stability, specificity and relation to self-reported drug effectW K Bickel
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
J Pharmacol Exp Ther 251:1053-63. 1989..o.; and secobarbital, 100-200 mg p.o.) did not generalize to hydromorphone, but showed partial generalization to both pentazocine and saline. In general, drug-discrimination performance paralleled the patterns of self reports... - Opioid discrimination in humans: discriminative and subjective effects of progressively lower training doseK L Preston
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Behav Pharmacol 9:533-43. 1998..These data indicate covariation of subjective effects and discrimination performance and suggest that discrimination behavior may be more sensitive for differentiating among drug conditions than traditional subjective effects measures... - Cigarette smoking and short-term addiction treatment outcomeP T Harrell
Intramural Research Program, National Institute on Drug Abuse NIH, Baltimore, MD 21224, USA
Drug Alcohol Depend 115:161-6. 2011.... - Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liabilityK L Preston
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
J Pharmacol Exp Ther 262:707-20. 1992..The considerable overlap in subjective effect measures of positive mood make further differentiation with respect to abuse liability difficult... - A model for pharmacological research-treatment of cocaine dependenceI D Montoya
National Institutes of Health, National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224, USA
J Subst Abuse Treat 12:415-21. 1995..This model represents an effort to standardize data collection to make results more valid and comparable... - The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokersDavid A Gorelick
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Am Heart J 151:754.e1-754.e5. 2006..In human studies, activation of CB1 receptors by cannabis or its active ingredient, Delta9-tetrahydrocannabinol (THC), has modest and inconsistent effects on BP... - Assessment of agonist and antagonist effects of tramadol in opioid-dependent humansC Patrick Carroll
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 14:109-20. 2006..In contrast, tramadol's pattern of effects was more similar to that of hydromorphone and suggestive of mild opioid-agonist effects (withdrawal suppression), though not to a statistically significant degree... - Toward a model of drug relapse: an assessment of the validity of the reinstatement procedureDavid H Epstein
Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 189:1-16. 2006..The model's construct validity faces more substantial challenges and is yet to be established, but we argue that some of the criticisms of the model in this regard may have been overstated... - Heroin and cocaine craving and use during treatment: measurement validation and potential relationshipsAdrienne J Heinz
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
J Subst Abuse Treat 31:355-64. 2006..Treatment dropout and in-treatment drug use were more frequently predicted by scores on the 14- or 45-item CCQ than by VAS ratings. Results suggest that the CCQ/HCQ and the 14-item CCQ provide information that unidimensional VASs do not... - Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadolDavid H Epstein
NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Biol Psychol 73:90-9. 2006..Nonetheless, it is suggested that abuse-potential screening of new medications would benefit from an organized, integrated cross-species program... - Spiritual/Religious experiences and in-treatment outcome in an inner-city program for heroin and cocaine dependenceAdrienne Heinz
Clinical Pharmacology and Treatment Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
J Psychoactive Drugs 39:41-9. 2007..The results suggest that spiritual and religious experience plays a role in substance abuse recovery and that demographic characteristics should be considered in the design of spiritually oriented behavioral interventions for addiction... - Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis usersMarilyn A Huestis
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 194:505-15. 2007..A single 90-mg dose of the cannabinoid CB1 receptor antagonist rimonabant attenuates effects of smoked cannabis in humans... - Nonreporting of cannabis use: Predictors and relationship to treatment outcome in methadone maintained patientsUdi E Ghitza
Clinical Pharmacology and Therapeutics Branch, Treatment Section Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 5500 Nathan Shock Drive Baltimore, MD 21224, USA
Addict Behav 32:938-49. 2007..Nonreporting of THC use is a significant predictor of greater cocaine and heroin use. This association can be eliminated with contingency management therapy... - Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing methodUdi E Ghitza
Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 91:169-77. 2007..Cocaine use during treatment, especially when measured with New Uses criteria, can predict psychosocial functioning, but cannot substitute for direct measures of psychosocial functioning... - Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot studyJennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Pharmacotherapy 27:1111-9. 2007..To determine the hemodynamic and cognitive effects of lofexidine and methadone coadministration... - Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroinUdi E Ghitza
Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institute of Health NIH, MD, USA
J Consult Clin Psychol 75:765-74. 2007..Computerized drawing with higher-density prizes enhanced reduction of cocaine use; abstinence reinforcement had long-term therapeutic benefits... - Hepatitis C and human immunodeficiency virus risk behaviors in polydrug users on methadone maintenanceJessica Willner-Reid
National Institute on Drug Abuse, Baltimore, MD 21224, USA
J Subst Abuse Treat 35:78-86. 2008..These findings demonstrate that both drug- and sex-related risk behaviors decrease during MMT and emphasize the benefits of methadone programs for public health and HIV/HCV prevention... - Contingency management reduces injection-related HIV risk behaviors in heroin and cocaine using outpatientsUdi E Ghitza
Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Addict Behav 33:593-604. 2008..CM targeted toward cocaine and heroin use produces significant reductions in injection-related drug-taking behaviors associated with heightened risk for getting or transmitting HIV... - Adverse events among patients in a behavioral treatment trial for heroin and cocaine dependence: effects of age, race, and genderJennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 80:45-51. 2005..Nonetheless, the data reported here should help provide a context in which investigators and IRBs can interpret the patterns of AEs they encounter... - Changes in HIV risk behaviors among patients receiving combined pharmacological and behavioral interventions for heroin and cocaine dependenceJennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Addict Behav 31:868-79. 2006..034) but this effect was no longer significant after adjusting for drug-negative urines. These results suggest broad beneficial effects of methadone maintenance augmented with behavioral interventions for reducing HIV risk behaviors... - Menstrual cycle length during methadone maintenanceJohn Schmittner
Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD 21224, USA
Addiction 100:829-36. 2005..This study was conducted to evaluate whether cycle length was more regular during methadone maintenance... - Toxicologic aspects of heroin substitution treatmentEdward J Cone
ConeChem Research, Baltimore, Maryland, USA
Ther Drug Monit 24:193-8. 2002..Overall, the many recent developments in testing methodology provide more effective means to assess patients in heroin substitution programs and should contribute to improvements in public health... - A dose response study of cognitive behavioral therapy in cocaine abusersLino Covi
National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
J Subst Abuse Treat 23:191-7. 2002..05) amounts in all treatment groups. Findings suggest that cognitive behavioral therapy is effective in reducing cocaine use even if a less intensive schedule is used... - Methadone treatment induces attenuation of cerebrovascular deficits associated with the prolonged abuse of cocaine and heroinRonald I Herning
Molecular Neuropsychiatry Section, National Institute on Drug Abuse IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropsychopharmacology 28:562-8. 2003..These findings suggest that maintenance on methadone might have significant beneficial neurovascular effects on this population of patients... - Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infectionAnnie Umbricht
National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 69:263-72. 2003..05). These findings suggest buprenorphine, clonidine, and methadone regimens each decrease opioid withdrawal in medically ill HIV-infected patients... - Cognitive-behavioral therapy plus contingency management for cocaine use: findings during treatment and across 12-month follow-upDavid H Epstein
Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Intramural Research Program Treatment Section, Baltimore, Maryland 21224, USA
Psychol Addict Behav 17:73-82. 2003..Posttreatment, there were signs of additive benefits, significant in 3- versus 12-month contrasts. Former CBT participants were also more likely to acknowledge cocaine use and its effects and to report employment... - The reinstatement model and relapse prevention: a clinical perspectiveDavid H Epstein
NIDA IRP Treatment Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 168:31-41. 2003..This commentary assesses the degree to which the reinstatement model is homologous to the human experience of relapse... - Do noncontingent vouchers increase drug use?Jennifer R Schroeder
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Exp Clin Psychopharmacol 11:195-201. 2003..05, 95% confidence interval: 1.01-1.09). Overall, results do not indicate a causal relationship between noncontingent voucher receipt and increased drug use... - QT interval increased after single dose of lofexidineJohn Schmittner
National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
BMJ 329:1075. 2004 - Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependenceIvan D Montoya
Division of Treatment Research and Development and Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Clin Pharmacol Ther 75:34-48. 2004..CONCLUSIONS: A sublingual buprenorphine solution at 16 mg daily is well tolerated and effective in reducing concomitant opiate and cocaine use. The therapeutic effect on cocaine use appears independent of that on opiate use... - A laboratory study of hydromorphone and cyclazocine on smoking behavior in residential polydrug usersWallace B Pickworth
National Institute on Drug Abuse NIDA, Intramural Research Program, Clinical Pharmacology and Therapeutics Branch, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Pharmacol Biochem Behav 77:711-5. 2004..4 mg) reduced exhaled carbon monoxide (CO) boost, a measure of smoke exposure. Further studies of the effects of kappa opioid agonists on smoking behavior may lead to a better understanding of the role of opiates in smoking behavior... - Effects of high-dose intravenous buprenorphine in experienced opioid abusersAnnie Umbricht
National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
J Clin Psychopharmacol 24:479-87. 2004..v. dose. Buprenorphine appears to have a ceiling for cardiorespiratory and subjective effects and a high safety margin even when taken by the i.v. route... - Gender differences in indices of opioid dependency and medical comorbidity in a population of hospitalized HIV-infected African-AmericansSusan J Boyd
NIDA/IRP, Baltimore, MD, USA
Am J Addict 13:281-91. 2004..These gender differences in opioid dependency and medical comorbidity may indicate a need for alternative treatment approaches for men and women... - Influence of psychotherapy attendance on buprenorphine treatment outcomeIvan D Montoya
Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
J Subst Abuse Treat 28:247-54. 2005..02). These results suggest that psychotherapy can improve the outcome of buprenorphine maintenance treatment for patients with dual (cocaine and opioid) dependence... - Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detectionMaria Esther Rodriguez Rosas
Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA
J Chromatogr B Analyt Technol Biomed Life Sci 796:355-70. 2003..0%) and accuracy (CVs<4.0%) were obtained. These findings demonstrate the accuracy and precision of the method used to successfully analyze saliva obtained from patients enrolled in a methadone-maintenance program... - Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detectionMaria Esther Rodriguez-Rosas
Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA
J Chromatogr A 1073:237-48. 2005..S.D. for the intra- and inter-day precision of the method were < 5.3% and the R.S.D. for accuracy was < 5.0%. The method was used to analyze plasma samples obtained from patients enrolled in a Met-maintenance program... - Open-label pilot study of bupropion plus bromocriptine for treatment of cocaine dependenceIvan D Montoya
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Am J Drug Alcohol Abuse 28:189-96. 2002..There were no significant differences in outcome between groups. These results suggest that the combination of bupropion and bromocriptine is safe in cocaine addicts, but provide ambiguous evidence of its efficacy...