M Margaret Pratt

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome
    M Margaret Pratt
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97339, USA
    Carcinogenesis 28:611-24. 2007
  2. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry study
    M Margaret Pratt
    Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Mutat Res 624:114-23. 2007
  3. pmc Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days
    Kaarthik John
    Carcinogen DNA Interactions Section, LCBG, CCR, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Carcinogenesis 33:2236-41. 2012
  4. pmc Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic
    M Margaret Pratt
    Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Environ Mol Mutagen 52:58-68. 2011
  5. pmc Polycyclic aromatic hydrocarbon (PAH) exposure and DNA adduct semi-quantitation in archived human tissues
    M Margaret Pratt
    Carcinogen DNA Interactions Section, National Cancer Institute, Bldg 37, Rm 4032 NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Int J Environ Res Public Health 8:2675-91. 2011
  6. pmc Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study
    Tammie J McQuistan
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 50:341-52. 2012
  7. pmc Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon-DNA adduct levels in human prostate
    Kaarthik John
    Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Prostate 69:505-19. 2009

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome
    M Margaret Pratt
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97339, USA
    Carcinogenesis 28:611-24. 2007
    ....
  2. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry study
    M Margaret Pratt
    Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Mutat Res 624:114-23. 2007
    ..Therefore, PAH-DNA adduct formation as measured by this methodology did not appear related to the increased risk of cervical precancer and cancer among carcinogenic HPV-infected smokers...
  3. pmc Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days
    Kaarthik John
    Carcinogen DNA Interactions Section, LCBG, CCR, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Carcinogenesis 33:2236-41. 2012
    ..Therefore, the addition of CHL to a BP-containing diet showed a lack of consistent chemoprotective effect, indicating that oral CHL administration may not reduce PAH-DNA adduct levels consistently in human organs...
  4. pmc Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic
    M Margaret Pratt
    Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Environ Mol Mutagen 52:58-68. 2011
    ..In addition, PAH-DNA adducts were present at high concentrations in the CT cells and ST knots of the chorionic villi...
  5. pmc Polycyclic aromatic hydrocarbon (PAH) exposure and DNA adduct semi-quantitation in archived human tissues
    M Margaret Pratt
    Carcinogen DNA Interactions Section, National Cancer Institute, Bldg 37, Rm 4032 NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Int J Environ Res Public Health 8:2675-91. 2011
    ..This semi-quantative method for PAH-DNA adduct measurement could potentially see widespread use in molecular epidemiology studies...
  6. pmc Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study
    Tammie J McQuistan
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 50:341-52. 2012
    ..This finding questions the human relevance of chemoprevention studies carried out at high carcinogen doses that are not proven to lie within a linear, or at least monotonic, endpoint dose-response range...
  7. pmc Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon-DNA adduct levels in human prostate
    Kaarthik John
    Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Prostate 69:505-19. 2009
    ..The human prostate consists of the peripheral zone (PZ), transition zone (TZ), and central zone (CZ); CaP occurs most often in the PZ...