R E Pratley

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians
    R E Pratley
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 101:1757-64. 1998
  2. ncbi request reprint Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 48:2197-203. 1999
  3. ncbi request reprint Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Hypertension 36:531-7. 2000
  4. ncbi request reprint Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:414-7. 2001
  5. ncbi request reprint Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 24:89-94. 2001
  6. ncbi request reprint Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 23:779-85. 2000
  7. ncbi request reprint Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes
    J F Gautier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 50:1828-33. 2001
  8. ncbi request reprint A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 49:2094-101. 2000
  9. ncbi request reprint Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms
    X Yang
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:111-3. 2001
  10. ncbi request reprint Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans?
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Metabolism 50:223-30. 2001

Detail Information

Publications32

  1. pmc An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians
    R E Pratley
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 101:1757-64. 1998
    ..None of the linkages exceeded a LOD score of 3.6 (a 5% probability of occurring in a genome-wide scan). These findings must, therefore, be considered tentative until extended in this population or replicated in others...
  2. ncbi request reprint Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 48:2197-203. 1999
    ..More severe metabolic abnormalities are present in Pima Indians with combined IFG and IGT...
  3. ncbi request reprint Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Hypertension 36:531-7. 2000
    ..The lack of an increase in SNS activity with increasing adiposity and insulinemia in Pima Indians may contribute to the low prevalence of hypertension in this population...
  4. ncbi request reprint Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:414-7. 2001
    ....
  5. ncbi request reprint Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 24:89-94. 2001
    ..We therefore assessed the predictive effect of insulin resistance and insulin secretory dysfunction separately for the progression from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and from IGT to diabetes...
  6. ncbi request reprint Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 23:779-85. 2000
    ..We hypothesized that an elevated C3 concentration might be linked to insulin resistance and/or hyperinsulinemia, abnormalities commonly observed in association with the above conditions...
  7. ncbi request reprint Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes
    J F Gautier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 50:1828-33. 2001
    ..1,255 [1,045-1,505] pmol/l, P < 0.02). Thus, insulin secretion is lower in normal glucose tolerant offspring of people with early onset type 2 diabetes. This impairment may be worsened by exposure to a diabetic environment in utero...
  8. ncbi request reprint A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 49:2094-101. 2000
    ..Whether amelioration of basal insulin hypersecretion will prevent diabetes remains to be elucidated...
  9. ncbi request reprint Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms
    X Yang
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:111-3. 2001
    ..The expression levels of the major isoforms, calpain-10a and -10f, were positively correlated with the total calpain-10 mRNA levels, indicating a cumulative effect...
  10. ncbi request reprint Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans?
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Metabolism 50:223-30. 2001
    ....
  11. ncbi request reprint Relationship between birth weight and body composition, energy metabolism, and sympathetic nervous system activity later in life
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 8:559-65. 2000
    ..Programming of metabolic, endocrine, and/or autonomic pathways during intrauterine development has been proposed to explain this association...
  12. ncbi request reprint Fasting and postprandial plasma concentrations of acylation-stimulation protein (ASP) in lean and obese Pima Indians compared to Caucasians
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Obes Res 7:444-52. 1999
    ..We tested whether fasting and post-prandial plasma ASP concentrations are increased in Pima Indians, a population with a very high prevalence of obesity, but a remarkably low prevalence of dyslipidemia...
  13. pmc Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic pima indians are related To glycogen synthase fractional activity in cultured myoblasts
    D M Mott
    Clinical Diabetes and Nutrition Section, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 101:2251-6. 1998
    ..Abnormal regulation of glycogen synthase phosphorylation state may be an intrinsic defect in skeletal muscle associated with obesity and insulin resistance...
  14. ncbi request reprint Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA
    J Clin Endocrinol Metab 83:2993-6. 1998
    ..These variants in DBP were associated with differences in oral glucose tolerance in nondiabetic Pima Indians...
  15. pmc The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 104:787-94. 1999
    ..Thus, defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes. Intervention to prevent diabetes should target both abnormalities...
  16. ncbi request reprint Metabolic factors contributing to increased resting metabolic rate and decreased insulin-induced thermogenesis during the development of type 2 diabetes
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 48:1607-14. 1999
    ....
  17. pmc Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
    P A Tataranni
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Phoenix, AZ 85016, USA
    Proc Natl Acad Sci U S A 96:4569-74. 1999
    ..Although exploratory, the present study provides a foundation for investigating the human brain regions and cognitive operations that respond to nutritional stimuli...
  18. ncbi request reprint Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 85:1087-94. 2000
    ..The metabolic responses to weight changes are highly variable among individuals, however...
  19. ncbi request reprint Identification of differentially expressed genes in skeletal muscle of non-diabetic insulin-resistant and insulin-sensitive Pima Indians by differential display PCR
    Y H Lee
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetologia 46:1567-75. 2003
    ..We carried out muscle gene expression profiling to identify differentially expressed genes associated with insulin resistance...
  20. ncbi request reprint Effects of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insulin-resistant Pima Indians
    R E Pratley
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA Richard
    J Clin Endocrinol Metab 81:4418-21. 1996
    ..Plasma leptin concentrations did not change in response to insulin in either the insulin-sensitive or insulin-resistant subjects. These results suggest that insulin does not acutely regulate plasma leptin concentrations in humans...
  21. ncbi request reprint Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 86:1930-5. 2001
    ....
  22. ncbi request reprint Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabet Med 21:1090-5. 2004
    ....
  23. ncbi request reprint The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus
    R E Pratley
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetologia 44:929-45. 2001
    ..Strategies that enhance early insulin secretion improve glucose tolerance and represent a novel and more physiologic approach to improving glycaemic control in patients with Type II diabetes mellitus...
  24. ncbi request reprint Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, Arizona 85016, USA
    Mol Genet Metab 72:231-8. 2001
    ..c. abd. AS can be attributed to familial factors and that genetic variation in LMNA might not only underlie rare cases of FPLD, but may also contribute to variation in adipocyte size in the general population...
  25. ncbi request reprint Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: lessons learned from the Pima Indians
    R E Pratley
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA
    Proc Nutr Soc 57:175-81. 1998
    ....
  26. pmc A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85016, USA
    J Clin Invest 106:R69-73. 2000
    ..A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons...
  27. ncbi request reprint Genomic structure and promoter analysis of the human obese gene
    D W Gong
    Molecular and Cellular Endocrinology Branch and Phoenix Epidemiology and Clinical Research Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:3971-4. 1996
    ..A 3-kb 5'-flanking region of the gene was cloned and transient transfection assay with luciferase reporter confirmed the promoter activity in differentiated F442-A adipocytes. Potential regulatory elements are discussed in this report...
  28. ncbi request reprint Effect of satiation on brain activity in obese and lean women
    J F Gautier
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:676-84. 2001
    ..It also lends additional support to the hypothesis that the paralimbic areas participate in a central orexigenic network modulated by the prefrontal cortex through feedback loops...
  29. ncbi request reprint Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians
    X Yang
    Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetologia 45:1584-93. 2002
    ..This approach also complemented the ongoing genomic linkage analyses to identify genes linked to insulin resistance and diabetes in Pima Indians...
  30. ncbi request reprint Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    M Maffei
    Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021, USA
    Nat Med 1:1155-61. 1995
    ..Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans...
  31. ncbi request reprint The independent and combined effects of weight loss and aerobic exercise on blood pressure and oral glucose tolerance in older men
    D R Dengel
    Department of Internal Medicine, University of Michigan, and Department of Veterans Affairs Medical Center, Ann Arbor 48105, USA
    Am J Hypertens 11:1405-12. 1998
    ..However, combining the two interventions does not result in any further improvement in BP...
  32. ncbi request reprint Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    R E Pratley
    University of Vermont College of Medicine, Burlington, VT 05401, USA
    Horm Metab Res 38:423-8. 2006
    ..Concomitant improvements in beta-cell function were also observed. Subjects with higher baseline HbA1c levels showed greater response...