Research Topics
| Robert M PostSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar NetworkRobert M Post
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:396-406. 2003..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and GermanyRobert M Post
Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
Int Clin Psychopharmacol 26:96-106. 2011....- Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizersGabriele S Leverich
Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
Am J Psychiatry 163:232-9. 2006..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression... - Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorderRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Clin Psychiatry 66:370-4. 2005..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness... - Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatientsRobert M Post
Bipolar Collaborative Network, Bethesda, Maryland, USA
J Clin Psychiatry 73:924-30. 2012..The long-term impact of prior antidepressant exposure on the subsequent course of bipolar illness remains controversial... - An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)Robert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:310-9. 2003..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed... - Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthoodRobert M Post
Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
J Clin Psychiatry 71:864-72. 2010..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood... - Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controlsRobert T Dunn
Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
Psychiatry Res 140:181-98. 2005.... - Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizuresZhang Jin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Pharmacol Biochem Behav 74:565-71. 2003..These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored... - Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar NetworkGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Clin Psychiatry 64:506-15. 2003..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder... - Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: II. Effects of prefrontal cortex rTMSAndrew M Speer
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892-1430, USA
Biol Psychiatry 54:826-32. 2003.... - Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart methodRobert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
J Clin Psychiatry 64:680-90; quiz 738-9. 2003..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated... - The poor prognosis of childhood-onset bipolar disorderGabriele S Leverich
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Pediatr 150:485-90. 2007..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness... - Convergences in course of illness and treatments of the epilepsies and recurrent affective disordersRobert M Post
Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD, USA
Clin EEG Neurosci 35:14-24. 2004..Caveats in the use of this model and convergences and divergences in its predictive validity for seizures and affective disorders are noted... - Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depressionRobert T Dunn
Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892-1272, USA
Biol Psychiatry 51:387-99. 2002..Thus, different depressive symptom clusters may have different neural substrates in unipolars, but clusters and their substrates are convergent in bipolars... 
Interregional cerebral metabolic associativity during a continuous performance task (Part I): healthy adultsMark W Willis
Uniformed Services University of the Health Sciences, PHS, HHS, Bethesda, MD, USA
Psychiatry Res 164:16-29. 2008..These analytical data may help to confirm known functional and neuroanatomical relationships, elucidate others as yet unreported, and serve as a basis for comparison to patients with psychiatric illness...- Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disordersGabriela V Obrocea
National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
Biol Psychiatry 51:253-60. 2002..These preliminary data in a treatment refractory subgroup may help in the further definition of the range of clinical utility of these widely used anticonvulsants... - Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteersTimothy A Kimbrell
Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
Psychiatry Res 115:101-13. 2002..While these results are in the predicted direction, further studies using other designs and higher intensities and frequencies of rTMS are indicated to better describe the local and distant changes induced by rTMS... - Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: I. Effects of primary motor cortex rTMSAndrew M Speer
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892-1430, USA
Biol Psychiatry 54:818-25. 2003..CONCLUSIONS: This study demonstrates that 1-Hz rTMS delivered to the primary motor cortex (M1) produces intensity-dependent increases in brain activity locally and has associated effects in distant sites with known connections to M1... - Early physical and sexual abuse associated with an adverse course of bipolar illnessGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892-1272, USA
Biol Psychiatry 51:288-97. 2002.... - Earliest symptoms discriminating juvenile-onset bipolar illness from ADHDDavid A Luckenbaugh
Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
Bipolar Disord 11:441-51. 2009.... - A potential cholinergic mechanism of procaine's limbic activationBrenda E Benson
Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1272, USA
Neuropsychopharmacology 29:1239-50. 2004..v. procaine's emotional and sensory effects in man. These findings are consistent with other evidence of cholinergic modulation of mood and emotion... - Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorderGuo Qiang Xing
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Int J Neuropsychopharmacol 7:143-53. 2004..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored... - Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar childrenEmily L Fergus
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
J Affect Disord 77:71-8. 2003..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community... - Unique design issues in clinical trials of patients with bipolar affective disorderRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
J Psychiatr Res 37:61-73. 2003..Acceptance of a wider variety of clinical trial designs may help facilitate the funding and accelerate the acquisition of new data on treatment of bipolar illness... - Repetitive TMS combined with exposure therapy for PTSD: a preliminary studyElizabeth A Osuch
Biological Psychiatry Branch, National Institute of Mental Health, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD, United States
J Anxiety Disord 23:54-9. 2009..Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD... - Mechanisms of illness progression in the recurrent affective disordersRobert M Post
Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
Neurotox Res 18:256-71. 2010.... - The health care crisis of childhood-onset bipolar illness: some recommendations for its ameliorationRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
J Clin Psychiatry 67:115-25. 2006..To describe new data on the incidence and impact of childhood- and adolescent-onset bipolar illness and make recommendations to help accelerate the acquisition of knowledge in this area... - Neurobiology of bipolar illness: implications for future study and therapeuticsRobert M Post
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892-1272, USA
Ann Clin Psychiatry 15:85-94. 2003..Further examination of the pathophysiology and neurobiology of bipolar illness should lead to both more effective treatments and, potentially, secondary and even primary episode prevention... - The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled ratsZhang Jin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Neurosci Lett 329:253-6. 2002..The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored... - The impact of bipolar depressionRobert M Post
Bipolar Collaborative Network, Chevy Chase, MD, USA
J Clin Psychiatry 66:5-10. 2005..Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder... - Bipolar depression: the role of atypical antipsychoticsRobert M Post
Expert Rev Neurother 4:S27-33. 2004..The receptor-binding profile of these agents supports a role in the treatment of depressive symptoms and clinical data are beginning to emerge of their efficacy in both the acute and maintenance setting... - Interregional cerebral metabolic associativity during a continuous performance task (Part II) : differential alterations in bipolar and unipolar disordersBrenda E Benson
Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, United States
Psychiatry Res 164:30-47. 2008.... - Course of bipolar illness after history of childhood traumaGabriele S Leverich
Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
Lancet 367:1040-2. 2006 - Psychological complexity: barriers to its integration into the neurobiology of major psychiatric disordersRobert M Post
National Institute of Mental Health/BPB, Bethesda, MD 20892-1272, USA
Dev Psychopathol 14:635-51. 2002..This paper endorses renewed effort toward the multidisciplinary team approach under the leadership of a physician-scientist in order to better integrate many fields of study critical to ameliorating the effects of psychiatric illness... - Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic databaseRobert M Post
Biological Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Department of Health and Human Services, 10 Center Drive MSC 1272, Bldg 10, Room 3S239, Bethesda, MD 20892 1272, USA
Expert Opin Pharmacother 6:531-46. 2005.... - Parental attitudes towards early intervention in children at high risk for affective disordersRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bldg. 10, Rm. 3S239, 10 Center Drive, MSC-1272, Bethesda, MD 20892-1272, USA
J Affect Disord 70:117-24. 2002.... - Antithyroid antibody-linked symptoms in borderline personality disorderThomas D Geracioti
Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, MD, USA
Endocrine 21:153-8. 2003..It will be of interest to determine the prevalence, pathophysiologic mechanisms, and treatment implications of this putative autoimmune- BPD link... - Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorderKirk D Denicoff
Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Depress Anxiety 15:1-9. 2002.... - Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?Robert M Post
Biological Psychiatry Branch, National Institute of Mental Health, NIH Building 10, Bethesda, MD 20892 1272, USA
Epilepsy Res 50:203-19. 2002..Given these recognized limitations of non-homologous models, kindling may still provide insights into the longitudinal course, progression, and treatment of some neuropsychiatric syndromes that can then be directly tested in the clinic... - Age, sex and laterality effects on cerebral glucose metabolism in healthy adultsMark W Willis
Biological Psychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
Psychiatry Res 114:23-37. 2002..These findings contribute toward a convergence in the literature, and the regression models of CMRglc vs. age serve as a normative database to which patients may be compared... - Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depressionGuoqiang Xing
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
Schizophr Res 58:21-30. 2002..28, P < 0.05, n = 60) and in the PMI controlled subgroup (r = 0.43, P < 0.01, n = 38). Our data provide evidence of reduced cNOS activity in the postmortem brains of patients with schizophrenia and depression... - Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disordersRobert M Post
Department of Psychiatry, George Washington University, Washington, DC, USA
CNS Neurosci Ther 17:649-60. 2011..Careful longitudinal monitoring of episode occurrence is essential to understanding tolerance development in the affective disorder and its treatment... - Maternal deprivation increases cell death in the infant rat brainLi Xin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Brain Res Dev Brain Res 133:1-11. 2002.... - The effectiveness of carbamazepine in unipolar depression: a double-blind, randomized, placebo-controlled studyZhang Jin Zhang
Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi an, Shannxi 710032, China
J Affect Disord 109:91-7. 2008..Based on the results of our present and previous studies, we suggest that CBZ might be considered an alternative in the management of certain conditions in major depressive disorder... - Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholismEric Levander
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
J Affect Disord 101:211-7. 2007..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)... - Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment NetworkTrisha Suppes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
Int Clin Psychopharmacol 22:376-81. 2007..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted... - Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorderJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
Biol Psychiatry 63:125-30. 2008..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated... - A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disordersSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Bipolar Disord 9:426-34. 2007..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD... - Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomenaRobert M Post
Penn State College of Medicine, 3502 Turner Lane, Chevy Chase, MD 20815, USA
Neurosci Biobehav Rev 31:858-73. 2007.... - A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depressionMark A Frye
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
Am J Psychiatry 164:1242-9. 2007..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue... - Are bipolar mood symptoms affected by the phase of the menstrual cycle?Geetha Shivakumar
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
J Womens Health (Larchmt) 17:473-8. 2008..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue... - High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposureRalph W Kupka
Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
Biol Psychiatry 51:305-11. 2002..These variables appear to be independent risk factors for the development of hypothyroidism, especially in women with bipolar disorder... - Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorderRalph W Kupka
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bipolar Disord 9:531-5. 2007..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder... - New designs for studies of the prophylaxis of bipolar disorderRobert M Post
J Clin Psychopharmacol 22:1-3. 2002 - Incidence of childhood-onset bipolar illness in the USA and EuropeRobert M Post
Department of Psychiatry, George Washington University, Washington, DC, USA
Br J Psychiatry 192:150-1. 2008..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration... - Regional cerebral glucose utilization in patients with a range of severities of unipolar depressionTim A Kimbrell
North Little Rock VA Medical Center (TAKi, North Little Rock, Arkansas, USA
Biol Psychiatry 51:237-52. 2002..CONCLUSIONS: Areas of frontal, cingulate, insula, and temporal cortex appear hypometabolic in association with different components of the severity and course of illness in treatment-resistant unipolar depression... - Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trialSusan L McElroy
Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
J Affect Disord 101:275-81. 2007..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole... - Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practiceRobert M Post
Bipolar Collaborative Network, Chevy Chase, Maryland, USA
CNS Drugs 21:47-71. 2007..More precise clinical and biological predictors and correlates of individual clinical responsiveness to carbamazepine and other mood stabilisers are eagerly awaited... - Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizuresZhang Jin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, U S A
Epilepsia 44:1487-93. 2003..The present study was designed to determine whether cross-tolerance occurs between levetiracetam (LEV) and carbamazepine (CBZ) in amygdala-kindled rats... - Tiagabine in treatment refractory bipolar disorder: a clinical case seriesTrisha Suppes
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Bipolar Disord 4:283-9. 2002..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments... - Bupropion and venlafaxine responders differ in pretreatment regional cerebral metabolism in unipolar depressionJohn T Little
Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Biol Psychiatry 57:220-8. 2005.... - Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to actionDennis S Charney
Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA
Biol Psychiatry 56:703-13. 2004 - Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHDRobert M Post
J Clin Psychiatry 65:898-902. 2004 - Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar NetworkWillem A Nolen
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Am J Psychiatry 161:1447-54. 2004..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder... - Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorderMark A Frye
Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
Am J Psychiatry 160:883-9. 2003..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study... - Treatment of rapid-cycling bipolar disorderRobert M Post
Bipolar Collaborative Network, Chevy Chase, MD, USA
CNS Spectr 9:1-11. 2004 - Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatientsRalph W Kupka
Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
Am J Psychiatry 162:1273-80. 2005..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective... - Newer prophylactic agents for bipolar disorder and their influence on suicidalityChristoph Born
Psychiatrische Klinik der LMU,
Arch Suicide Res 9:301-6. 2005..Confounding variables in more intensive care of these patients participating in a naturalistic study may blur small differences and contribute to a generally favorable outcome... - Atypical antipsychotics in bipolar depression: potential mechanisms of actionLakshmi N Yatham
Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
J Clin Psychiatry 66:40-8. 2005..Further studies should be conducted to examine these hypotheses... - New findings from the Bipolar Collaborative Network: clinical implications for therapeuticsRobert M Post
Penn State College of Medicine, Hershey, PA, USA
Curr Psychiatry Rep 8:489-97. 2006..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss... - Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite studyLori L Altshuler
Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
J Clin Psychiatry 67:1551-60. 2006..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder... - The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trialsRichard H Weisler
University of North Carolina at Chapel Hill, NC, USA
CNS Spectr 11:788-99. 2006..This article provides an overview of data on the use of AEDs in bipolar disorder, including acute mania and depression, prophylaxis, and rapid cycling... - Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agendaDaniel F Connor
Department of Psychiatry MC1410, University of Connecticut Health Center, Farmington 06030 1410, USA
J Clin Psychiatry 67:808-20. 2006..To propose a research agenda for disorders of aggression in child and adolescent psychiatry... - Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorderPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
Biol Psychiatry 60:1020-2. 2006..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder... - Low cerebrospinal fluid glutamate and glycine in refractory affective disorderMark A Frye
Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
Biol Psychiatry 61:162-6. 2007..Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness... - Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trialSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Clin Psychiatry 66:617-24. 2005..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002... - Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenonTrisha Suppes
Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
Arch Gen Psychiatry 62:1089-96. 2005..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved... - Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illnessPaul E Keck
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA
Compr Psychiatry 44:263-9. 2003..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...