Robert M Post

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
  2. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
  3. doi request reprint Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Int Clin Psychopharmacol 26:96-106. 2011
  4. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
  5. doi request reprint Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
  6. ncbi request reprint Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
  7. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
  8. ncbi request reprint Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controls
    Robert T Dunn
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 140:181-98. 2005
  9. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
  10. ncbi request reprint Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Pharmacol Biochem Behav 74:565-71. 2003

Collaborators

Detail Information

Publications82

  1. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  2. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  3. doi request reprint Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Int Clin Psychopharmacol 26:96-106. 2011
    ....
  4. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  5. doi request reprint Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
    ..The long-term impact of prior antidepressant exposure on the subsequent course of bipolar illness remains controversial...
  6. ncbi request reprint Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
    ..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood...
  7. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  8. ncbi request reprint Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controls
    Robert T Dunn
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 140:181-98. 2005
    ....
  9. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  10. ncbi request reprint Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Pharmacol Biochem Behav 74:565-71. 2003
    ..These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored...
  11. doi request reprint Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, 5415 West Cedar Lane Suite 201B, Bethesda, MD 20814, USA
    J Affect Disord 147:288-94. 2013
    ....
  12. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  13. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  14. ncbi request reprint Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: II. Effects of prefrontal cortex rTMS
    Andrew M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892 1430, USA
    Biol Psychiatry 54:826-32. 2003
    ..We examined intensity-related changes in brain activity with positron emission tomography (PET) in normal volunteers during rTMS delivered to the left PFC...
  15. pmc Interregional cerebral metabolic associativity during a continuous performance task (Part I): healthy adults
    Mark W Willis
    Uniformed Services University of the Health Sciences, PHS, HHS, Bethesda, MD, USA
    Psychiatry Res 164:16-29. 2008
    ..These analytical data may help to confirm known functional and neuroanatomical relationships, elucidate others as yet unreported, and serve as a basis for comparison to patients with psychiatric illness...
  16. ncbi request reprint Convergences in course of illness and treatments of the epilepsies and recurrent affective disorders
    Robert M Post
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD, USA
    Clin EEG Neurosci 35:14-24. 2004
    ..Caveats in the use of this model and convergences and divergences in its predictive validity for seizures and affective disorders are noted...
  17. ncbi request reprint Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression
    Robert T Dunn
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1272, USA
    Biol Psychiatry 51:387-99. 2002
    ..Then, comparing unipolars and bipolars, these symptom clusters were examined for interrelationships, and for relationships to regional cerebral metabolism for glucose measured by positron emission tomography...
  18. ncbi request reprint Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders
    Gabriela V Obrocea
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
    Biol Psychiatry 51:253-60. 2002
    ..The objective of the current study was to examine possible clinical predictors of positive response to lamotrigine or gabapentin monotherapy in treatment-refractory affectively ill patients...
  19. ncbi request reprint Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: I. Effects of primary motor cortex rTMS
    Andrew M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892 1430, USA
    Biol Psychiatry 54:818-25. 2003
    ..We combined the administration of varying intensities of 1-Hz rTMS of the motor cortex with simultaneous positron emission tomography (PET) to delineate local and distant effects on brain activity...
  20. ncbi request reprint Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder
    Guo Qiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Neuropsychopharmacol 7:143-53. 2004
    ..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored...
  21. doi request reprint Earliest symptoms discriminating juvenile-onset bipolar illness from ADHD
    David A Luckenbaugh
    Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Bipolar Disord 11:441-51. 2009
    ....
  22. ncbi request reprint A potential cholinergic mechanism of procaine's limbic activation
    Brenda E Benson
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1272, USA
    Neuropsychopharmacology 29:1239-50. 2004
    ..v. procaine's emotional and sensory effects in man. These findings are consistent with other evidence of cholinergic modulation of mood and emotion...
  23. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  24. ncbi request reprint Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteers
    Timothy A Kimbrell
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 115:101-13. 2002
    ..While these results are in the predicted direction, further studies using other designs and higher intensities and frequencies of rTMS are indicated to better describe the local and distant changes induced by rTMS...
  25. ncbi request reprint Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children
    Emily L Fergus
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    J Affect Disord 77:71-8. 2003
    ..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community...
  26. doi request reprint Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation
    Robert M Post
    MD, Head, Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Br J Psychiatry 202:172-6. 2013
    ..Bipolar disorder has a high co-occurrence with substance use disorders, but the pathophysiological mechanisms have not been adequately explored...
  27. pmc Repetitive TMS combined with exposure therapy for PTSD: a preliminary study
    Elizabeth A Osuch
    Biological Psychiatry Branch, National Institute of Mental Health, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD, United States
    J Anxiety Disord 23:54-9. 2009
    ..Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD...
  28. ncbi request reprint Unique design issues in clinical trials of patients with bipolar affective disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Psychiatr Res 37:61-73. 2003
    ..Acceptance of a wider variety of clinical trial designs may help facilitate the funding and accelerate the acquisition of new data on treatment of bipolar illness...
  29. doi request reprint Antidepressant Efficacy of High and Low Frequency rTMS at 110% of Motor Threshold versus Sham Stimulation over Left Prefrontal Cortex
    Andrew M Speer
    Laboratory of Brain and Cognition, 4804 Montgomery Avenue, Bethesda, MD 20814, USA
    Brain Stimul 7:36-41. 2014
    ....
  30. ncbi request reprint Neurobiology of bipolar illness: implications for future study and therapeutics
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892 1272, USA
    Ann Clin Psychiatry 15:85-94. 2003
    ..Further examination of the pathophysiology and neurobiology of bipolar illness should lead to both more effective treatments and, potentially, secondary and even primary episode prevention...
  31. doi request reprint Mechanisms of illness progression in the recurrent affective disorders
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Neurotox Res 18:256-71. 2010
    ....
  32. ncbi request reprint The health care crisis of childhood-onset bipolar illness: some recommendations for its amelioration
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Psychiatry 67:115-25. 2006
    ..To describe new data on the incidence and impact of childhood- and adolescent-onset bipolar illness and make recommendations to help accelerate the acquisition of knowledge in this area...
  33. ncbi request reprint The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neurosci Lett 329:253-6. 2002
    ..The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored...
  34. ncbi request reprint The impact of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    J Clin Psychiatry 66:5-10. 2005
    ..Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder...
  35. doi request reprint Interregional cerebral metabolic associativity during a continuous performance task (Part II) : differential alterations in bipolar and unipolar disorders
    Brenda E Benson
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, United States
    Psychiatry Res 164:30-47. 2008
    ....
  36. ncbi request reprint Bipolar depression: the role of atypical antipsychotics
    Robert M Post
    Expert Rev Neurother 4:S27-33. 2004
    ..The receptor-binding profile of these agents supports a role in the treatment of depressive symptoms and clinical data are beginning to emerge of their efficacy in both the acute and maintenance setting...
  37. ncbi request reprint Course of bipolar illness after history of childhood trauma
    Gabriele S Leverich
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Lancet 367:1040-2. 2006
  38. ncbi request reprint Psychological complexity: barriers to its integration into the neurobiology of major psychiatric disorders
    Robert M Post
    National Institute of Mental Health BPB, Bethesda, MD 20892 1272, USA
    Dev Psychopathol 14:635-51. 2002
    ..This paper endorses renewed effort toward the multidisciplinary team approach under the leadership of a physician-scientist in order to better integrate many fields of study critical to ameliorating the effects of psychiatric illness...
  39. ncbi request reprint Parental attitudes towards early intervention in children at high risk for affective disorders
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Affect Disord 70:117-24. 2002
    ....
  40. ncbi request reprint Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic database
    Robert M Post
    Biological Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Department of Health and Human Services, 10 Center Drive MSC 1272, Bldg 10, Room 3S239, Bethesda, MD 20892 1272, USA
    Expert Opin Pharmacother 6:531-46. 2005
    ....
  41. ncbi request reprint Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorder
    Kirk D Denicoff
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Depress Anxiety 15:1-9. 2002
    ....
  42. ncbi request reprint Antithyroid antibody-linked symptoms in borderline personality disorder
    Thomas D Geracioti
    Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, MD, USA
    Endocrine 21:153-8. 2003
    ..It will be of interest to determine the prevalence, pathophysiologic mechanisms, and treatment implications of this putative autoimmune- BPD link...
  43. pmc Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disorders
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    CNS Neurosci Ther 17:649-60. 2011
    ..Careful longitudinal monitoring of episode occurrence is essential to understanding tolerance development in the affective disorder and its treatment...
  44. ncbi request reprint Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Schizophr Res 58:21-30. 2002
    ..28, P < 0.05, n = 60) and in the PMI controlled subgroup (r = 0.43, P < 0.01, n = 38). Our data provide evidence of reduced cNOS activity in the postmortem brains of patients with schizophrenia and depression...
  45. ncbi request reprint Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, NIH Building 10, Bethesda, MD 20892 1272, USA
    Epilepsy Res 50:203-19. 2002
    ..Given these recognized limitations of non-homologous models, kindling may still provide insights into the longitudinal course, progression, and treatment of some neuropsychiatric syndromes that can then be directly tested in the clinic...
  46. ncbi request reprint Age, sex and laterality effects on cerebral glucose metabolism in healthy adults
    Mark W Willis
    Biological Psychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 114:23-37. 2002
    ..These findings contribute toward a convergence in the literature, and the regression models of CMRglc vs. age serve as a normative database to which patients may be compared...
  47. ncbi request reprint Maternal deprivation increases cell death in the infant rat brain
    Li Xin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Brain Res Dev Brain Res 133:1-11. 2002
    ....
  48. doi request reprint Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  49. doi request reprint Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  50. ncbi request reprint The effectiveness of carbamazepine in unipolar depression: a double-blind, randomized, placebo-controlled study
    Zhang Jin Zhang
    Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi an, Shannxi 710032, China
    J Affect Disord 109:91-7. 2008
    ..Based on the results of our present and previous studies, we suggest that CBZ might be considered an alternative in the management of certain conditions in major depressive disorder...
  51. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  52. ncbi request reprint Newer prophylactic agents for bipolar disorder and their influence on suicidality
    Christoph Born
    Psychiatrische Klinik der LMU, Munchen
    Arch Suicide Res 9:301-6. 2005
    ..Confounding variables in more intensive care of these patients participating in a naturalistic study may blur small differences and contribute to a generally favorable outcome...
  53. ncbi request reprint Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  54. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  55. ncbi request reprint Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, U S A
    Epilepsia 44:1487-93. 2003
    ..The present study was designed to determine whether cross-tolerance occurs between levetiracetam (LEV) and carbamazepine (CBZ) in amygdala-kindled rats...
  56. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  57. ncbi request reprint Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  58. ncbi request reprint New designs for studies of the prophylaxis of bipolar disorder
    Robert M Post
    J Clin Psychopharmacol 22:1-3. 2002
  59. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  60. ncbi request reprint Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  61. ncbi request reprint High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure
    Ralph W Kupka
    Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
    Biol Psychiatry 51:305-11. 2002
    ..We assessed the prevalence of thyroperoxidase antibodies (TPO-Abs) and thyroid failure in outpatients with bipolar disorder compared with two control groups...
  62. ncbi request reprint Regional cerebral glucose utilization in patients with a range of severities of unipolar depression
    Tim A Kimbrell
    North Little Rock VA Medical Center TAKi, North Little Rock, Arkansas, USA
    Biol Psychiatry 51:237-52. 2002
    ....
  63. ncbi request reprint Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena
    Robert M Post
    Penn State College of Medicine, 3502 Turner Lane, Chevy Chase, MD 20815, USA
    Neurosci Biobehav Rev 31:858-73. 2007
    ....
  64. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  65. ncbi request reprint Atypical antipsychotics in bipolar depression: potential mechanisms of action
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
    J Clin Psychiatry 66:40-8. 2005
    ..Further studies should be conducted to examine these hypotheses...
  66. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  67. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  68. ncbi request reprint Bupropion and venlafaxine responders differ in pretreatment regional cerebral metabolism in unipolar depression
    John T Little
    Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 57:220-8. 2005
    ..Pretreatment functional brain imaging was examined for never-hospitalized outpatients with unipolar depression compared with control subjects in a crossover treatment trial involving bupropion or venlafaxine monotherapy...
  69. ncbi request reprint Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004
  70. ncbi request reprint Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD
    Robert M Post
    J Clin Psychiatry 65:898-902. 2004
  71. ncbi request reprint Low cerebrospinal fluid glutamate and glycine in refractory affective disorder
    Mark A Frye
    Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
    Biol Psychiatry 61:162-6. 2007
    ..Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness...
  72. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  73. ncbi request reprint Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agenda
    Daniel F Connor
    Department of Psychiatry MC1410, University of Connecticut Health Center, Farmington 06030 1410, USA
    J Clin Psychiatry 67:808-20. 2006
    ..To propose a research agenda for disorders of aggression in child and adolescent psychiatry...
  74. ncbi request reprint The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials
    Richard H Weisler
    University of North Carolina at Chapel Hill, NC, USA
    CNS Spectr 11:788-99. 2006
    ..This article provides an overview of data on the use of AEDs in bipolar disorder, including acute mania and depression, prophylaxis, and rapid cycling...
  75. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  76. ncbi request reprint New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  77. ncbi request reprint Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practice
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Drugs 21:47-71. 2007
    ..More precise clinical and biological predictors and correlates of individual clinical responsiveness to carbamazepine and other mood stabilisers are eagerly awaited...
  78. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  79. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  80. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  81. ncbi request reprint Treatment of rapid-cycling bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    CNS Spectr 9:1-11. 2004
  82. ncbi request reprint Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
    Biol Psychiatry 63:125-30. 2008
    ..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated...