R M Post

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Schizophr Res 58:21-30. 2002
  2. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
  3. ncbi request reprint Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic database
    Robert M Post
    Biological Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Department of Health and Human Services, 10 Center Drive MSC 1272, Bldg 10, Room 3S239, Bethesda, MD 20892 1272, USA
    Expert Opin Pharmacother 6:531-46. 2005
  4. ncbi request reprint The impact of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    J Clin Psychiatry 66:5-10. 2005
  5. ncbi request reprint Comparative pharmacology of bipolar disorder and schizophrenia
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1272, USA
    Schizophr Res 39:153-8; discussion 163. 1999
  6. ncbi request reprint Neurobiology of seizures and behavioral abnormalities
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1272, USA
    Epilepsia 45:5-14. 2004
  7. ncbi request reprint Bipolar depression: the role of atypical antipsychotics
    Robert M Post
    Expert Rev Neurother 4:S27-33. 2004
  8. ncbi request reprint The health care crisis of childhood-onset bipolar illness: some recommendations for its amelioration
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Psychiatry 67:115-25. 2006
  9. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
  10. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Schizophr Res 58:21-30. 2002
    ..28, P < 0.05, n = 60) and in the PMI controlled subgroup (r = 0.43, P < 0.01, n = 38). Our data provide evidence of reduced cNOS activity in the postmortem brains of patients with schizophrenia and depression...
  2. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  3. ncbi request reprint Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic database
    Robert M Post
    Biological Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Department of Health and Human Services, 10 Center Drive MSC 1272, Bldg 10, Room 3S239, Bethesda, MD 20892 1272, USA
    Expert Opin Pharmacother 6:531-46. 2005
    ....
  4. ncbi request reprint The impact of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    J Clin Psychiatry 66:5-10. 2005
    ..Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder...
  5. ncbi request reprint Comparative pharmacology of bipolar disorder and schizophrenia
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1272, USA
    Schizophr Res 39:153-8; discussion 163. 1999
    ....
  6. ncbi request reprint Neurobiology of seizures and behavioral abnormalities
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1272, USA
    Epilepsia 45:5-14. 2004
    ....
  7. ncbi request reprint Bipolar depression: the role of atypical antipsychotics
    Robert M Post
    Expert Rev Neurother 4:S27-33. 2004
    ..The receptor-binding profile of these agents supports a role in the treatment of depressive symptoms and clinical data are beginning to emerge of their efficacy in both the acute and maintenance setting...
  8. ncbi request reprint The health care crisis of childhood-onset bipolar illness: some recommendations for its amelioration
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Psychiatry 67:115-25. 2006
    ..To describe new data on the incidence and impact of childhood- and adolescent-onset bipolar illness and make recommendations to help accelerate the acquisition of knowledge in this area...
  9. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  10. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  11. ncbi request reprint Convergences in course of illness and treatments of the epilepsies and recurrent affective disorders
    Robert M Post
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD, USA
    Clin EEG Neurosci 35:14-24. 2004
    ..Caveats in the use of this model and convergences and divergences in its predictive validity for seizures and affective disorders are noted...
  12. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  13. ncbi request reprint Unique design issues in clinical trials of patients with bipolar affective disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Psychiatr Res 37:61-73. 2003
    ..Acceptance of a wider variety of clinical trial designs may help facilitate the funding and accelerate the acquisition of new data on treatment of bipolar illness...
  14. ncbi request reprint The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients
    T Suppes
    The Stanley Foundation Bipolar Network, 5430 Grosvenor Lane, Suite 200, Bethesda, MD 20814, USA
    J Affect Disord 67:45-59. 2001
    ..This report describes the demographics and course of illness characteristics of this study population...
  15. ncbi request reprint The Stanley Foundation Bipolar Network. I. Rationale and methods
    R M Post
    National Institute of Mental Health, Bethesda, Maryland, USA
    Br J Psychiatry Suppl 41:s169-76. 2001
    ..CONCLUSIONS: Well-characterised patients are followed in a detailed continuous longitudinal fashion in both opportunistic case series and double-blind, randomised controlled trials with reliable and validated measures...
  16. ncbi request reprint The Stanley Foundation Bipolar Treatment Outcome Network. I. Longitudinal methodology
    G S Leverich
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1272, USA
    J Affect Disord 67:33-44. 2001
    ..This article describes the rationale for the Network, its guiding principles, methods, and study design to systematically assess the highly variable course of bipolar illness and its response to current and future treatments...
  17. ncbi request reprint Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics
    M A Frye
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD, USA
    J Affect Disord 48:91-104. 1998
    ..The foregoing agents and future drugs with atypical neuroleptic properties should come to play an increasingly important role, compared to the older classical neuroleptics, in the acute and long term management of bipolar disorder...
  18. ncbi request reprint Gabapentin does not alter single-dose lithium pharmacokinetics
    M A Frye
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Clin Psychopharmacol 18:461-4. 1998
    ....
  19. ncbi request reprint Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers
    R M Post
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892-1272, USA
    Bipolar Disord 3:259-65. 2001
    ..Individual data on each drug will be assessed in the next phase of the study after more subjects are recruited and the blind is broken...
  20. ncbi request reprint Kindling: separate vs. shared mechanisms in affective disorders and epilepsy
    S R Weiss
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropsychobiology 38:167-80. 1998
    ..It is hoped that some of the lessons from the kindling model will provide useful and novel insights into aspects of treatment and mechanisms of psychiatric and neurologic illnesses...
  21. ncbi request reprint Understanding emotional prosody activates right hemisphere regions
    M S George
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Neurol 53:665-70. 1996
    ..The brain regions involved in recognition of emotional prosody in healthy subjects is less clear...
  22. pmc Opposite effects of high and low frequency rTMS on mood in depressed patients: relationship to baseline cerebral activity on PET
    A M Speer
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland, United States
    J Affect Disord 115:386-94. 2009
    ..Optimal parameters of rTMS for antidepressant efficacy in general, or within patients, have not been adequately delineated...
  23. ncbi request reprint Increased parental history of bipolar disorder in the United States: association with early age of onset
    R M Post
    Bipolar Collaborative Network, Bethesda, MD, USA Department of Psychiatry and Behavioral Sciences, George Washington University, Washington, D C, USA
    Acta Psychiatr Scand 129:375-82. 2014
    ..We explored the impact of parental loading for affective illness on onset and other characteristics of BP disorder...
  24. ncbi request reprint Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus
    M A Smith
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain Res 745:248-56. 1997
    ..These results suggest that CRF may contribute to the development of amygdala kindling. However, the compensatory induction of CRF-BP may serve to limit the excitatory effects of CRF in the dentate gyrus...
  25. ncbi request reprint Relationship between prior course of illness and neuropsychological functioning in patients with bipolar disorder
    K D Denicoff
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Affect Disord 56:67-73. 1999
    ..This study investigated the relationship between prior course of illness and neuropsychological deficits in relatively high functioning outpatients with bipolar disorder...
  26. ncbi request reprint Lack of adverse cognitive effects of 1 Hz and 20 Hz repetitive transcranial magnetic stimulation at 100% of motor threshold over left prefrontal cortex in depression
    A M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J ECT 17:259-63. 2001
    ..This study assesses the cognitive performance of depressed patients receiving high or low frequency rTMS for 10 days...
  27. ncbi request reprint Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial
    M S George
    Biological Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 154:1752-6. 1997
    ..Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design...
  28. ncbi request reprint Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders
    Gabriela V Obrocea
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
    Biol Psychiatry 51:253-60. 2002
    ..The objective of the current study was to examine possible clinical predictors of positive response to lamotrigine or gabapentin monotherapy in treatment-refractory affectively ill patients...
  29. ncbi request reprint More pernicious course of bipolar disorder in the United States than in many European countries: Implications for policy and treatment
    R M Post
    Bipolar Collaborative Network, 5415 W Cedar Ln, Suite 201 B, Bethesda, MD 20814, United States Psychiatry and Behavioral Sciences, George Washington University, Washington, D C, United States Electronic address
    J Affect Disord 160:27-33. 2014
    ..There is some controversy but growing evidence that childhood onset bipolar disorder may be more prevalent and run a more difficult course in the United States than some European countries...
  30. ncbi request reprint Relationship between prior course of illness and neuroanatomic structures in bipolar disorder: a preliminary study
    S O Ali
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Neuropsychiatry Neuropsychol Behav Neurol 14:227-32. 2001
    ..CONCLUSIONS: Additional studies are needed to both replicate and further examine the association of prior course of illness and larger hippocampal and ventricular volumes in bipolar disorder...
  31. ncbi request reprint Effect of cocaine, lidocaine kindling and carbamazepine on batrachotoxin-induced phosphoinositide hydrolysis in rat brain slices
    R L Margolis
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
    Brain Res 614:185-90. 1993
    ..Neither in vitro nor in vivo carbamazepine altered the effect of cocaine on BTX-induced PI hydrolysis. These results demonstrate that local anesthetic kindling does not alter PI hydrolysis coupled to Na channel or IBO activation...
  32. ncbi request reprint Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop)
    M S George
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Neuropsychiatry Clin Neurosci 9:55-63. 1997
    ..This study supports theories of blunted limbic and paralimbic activation and abnormal cingulate activity in depression and adds to the growing knowledge of the functional neuroanatomy of depression...
  33. ncbi request reprint Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline
    R M Post
    Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland, USA
    Br J Psychiatry 189:124-31. 2006
    ..Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression...
  34. ncbi request reprint Apoptosis of hippocampal neurons after amygdala kindled seizures
    L X Zhang
    Biological Psychiatric Branch, NIMH, Bldg 10 Rm 3N212, Bethesda, MD 20982, USA
    Brain Res Mol Brain Res 55:198-208. 1998
    ....
  35. ncbi request reprint Autoradiographic analysis of serotonin receptors and transporter in kindled rat brain
    M Clark
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
    Neurosci Lett 161:21-6. 1993
    ..Alterations in 5-HT receptors and the 5-HT transporter may endogenously modulate kindled seizures. Additionally, autoradiography of adenosine A1 receptors revealed no change for these receptors in any brain region...
  36. ncbi request reprint Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study
    B D Greenberg
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
    Am J Psychiatry 154:867-9. 1997
    ..Prefrontal mechanisms are implicated in obsessive-compulsive disorder. The authors investigated whether prefrontal repetitive transcranial magnetic stimulation influenced obsessive-compulsive disorder symptoms...
  37. ncbi request reprint Elevated concentration of N-CAM VASE isoforms in schizophrenia
    M P Vawter
    Cellular Neurobiology Branch, NIDA IRP, Baltimore, MD 21224, USA
    J Psychiatr Res 34:25-34. 2000
    ..These results provide further evidence of an abnormality of N-CAM protein in chronic schizophrenia and suggest differences between schizophrenia and affective disorders in regulation of N-CAM...
  38. ncbi request reprint Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizures
    G Xing
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 47:251-61. 1997
    ..kindled seizures. In addition, as r-nurr1 is prominently expressed in the specific brain sites associated with memory acquisition and consolidation, it may play a role in memory processing...
  39. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  40. ncbi request reprint Age, sex and laterality effects on cerebral glucose metabolism in healthy adults
    Mark W Willis
    Biological Psychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 114:23-37. 2002
    ..These findings contribute toward a convergence in the literature, and the regression models of CMRglc vs. age serve as a normative database to which patients may be compared...
  41. ncbi request reprint Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
    ..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood...
  42. ncbi request reprint Course of bipolar illness after history of childhood trauma
    Gabriele S Leverich
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Lancet 367:1040-2. 2006
  43. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  44. ncbi request reprint Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controls
    Robert T Dunn
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 140:181-98. 2005
    ....
  45. ncbi request reprint Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorder
    Kirk D Denicoff
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Depress Anxiety 15:1-9. 2002
    ....
  46. ncbi request reprint Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder
    Guo Qiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Neuropsychopharmacol 7:143-53. 2004
    ..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored...
  47. ncbi request reprint A potential cholinergic mechanism of procaine's limbic activation
    Brenda E Benson
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1272, USA
    Neuropsychopharmacology 29:1239-50. 2004
    ..v. procaine's emotional and sensory effects in man. These findings are consistent with other evidence of cholinergic modulation of mood and emotion...
  48. ncbi request reprint Treatment of rapid-cycling bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    CNS Spectr 9:1-11. 2004
  49. doi request reprint Interregional cerebral metabolic associativity during a continuous performance task (Part II) : differential alterations in bipolar and unipolar disorders
    Brenda E Benson
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, United States
    Psychiatry Res 164:30-47. 2008
    ....
  50. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  51. ncbi request reprint The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neurosci Lett 329:253-6. 2002
    ..The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored...
  52. ncbi request reprint Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression
    Robert T Dunn
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1272, USA
    Biol Psychiatry 51:387-99. 2002
    ..Then, comparing unipolars and bipolars, these symptom clusters were examined for interrelationships, and for relationships to regional cerebral metabolism for glucose measured by positron emission tomography...
  53. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  54. ncbi request reprint Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disorders
    P Hauser
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
    Arch Neurol 46:696-9. 1989
    ..High-dose benzodiazepine therapy and a history of viral encephalitis may be risk factors for withdrawal delirium...
  55. ncbi request reprint Effects of thyroid alterations and carbamazepine on cortical beta-adrenergic receptors in the rat
    R T Joffe
    Biological Psychiatry Branch, NIMH, Bethesda, Maryland
    Neuropharmacology 27:171-4. 1988
    ....
  56. ncbi request reprint Input-specific LTP and depotentiation in the basolateral amygdala
    V Aroniadou-Anderjaska
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Neuroreport 12:635-40. 2001
    ..These synapse-specific, reversible changes in synaptic strength in the basolateral nucleus of the amygdala may be important to amygdala's role in emotional memory...
  57. ncbi request reprint Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders
    M F M Braga
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland, MD 20814, USA
    Neuropharmacology 42:522-9. 2002
    ..The modulation of inhibitory synaptic transmission may be an important mechanism underlying the psychotropic effects of LTG...
  58. ncbi request reprint Post-dexamethasone cortisol correlates with severity of depression before and during carbamazepine treatment in women but not men
    E A Osuch
    Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Acta Psychiatr Scand 104:397-401. 2001
    ..CONCLUSION: The pathophysiological implications of this selective positive relationship between severity of depression and post-DST cortisol in women, but not men, should be explored further...
  59. doi request reprint Earliest symptoms discriminating juvenile-onset bipolar illness from ADHD
    David A Luckenbaugh
    Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Bipolar Disord 11:441-51. 2009
    ....
  60. ncbi request reprint Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Pharmacol Biochem Behav 74:565-71. 2003
    ..These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored...
  61. ncbi request reprint Developmental vulnerabilities to the onset and course of bipolar disorder
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892-1272, USA
    Dev Psychopathol 13:581-98. 2001
    ....
  62. ncbi request reprint Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena
    Robert M Post
    Penn State College of Medicine, 3502 Turner Lane, Chevy Chase, MD 20815, USA
    Neurosci Biobehav Rev 31:858-73. 2007
    ....
  63. ncbi request reprint Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: II. Effects of prefrontal cortex rTMS
    Andrew M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892 1430, USA
    Biol Psychiatry 54:826-32. 2003
    ..We examined intensity-related changes in brain activity with positron emission tomography (PET) in normal volunteers during rTMS delivered to the left PFC...
  64. ncbi request reprint Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practice
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Drugs 21:47-71. 2007
    ..More precise clinical and biological predictors and correlates of individual clinical responsiveness to carbamazepine and other mood stabilisers are eagerly awaited...
  65. ncbi request reprint Specific amygdaloid nuclei are involved in suppression or propagation of epileptiform activity during transition stage between oral automatisms and generalized clonic seizures
    M Sitcoske O'Shea
    Biological Psychiatry Branch, National Institutes of Mental Health, Bethesda, MD 0892, USA
    Brain Res 873:1-17. 2000
    ..A neuroanatomical model of Am-induced seizure propagation is proposed suggesting that the Claust-Ins-PRh play a pivotal role during the transition between oral automatisms and generalized clonic convulsions...
  66. pmc Interregional cerebral metabolic associativity during a continuous performance task (Part I): healthy adults
    Mark W Willis
    Uniformed Services University of the Health Sciences, PHS, HHS, Bethesda, MD, USA
    Psychiatry Res 164:16-29. 2008
    ..These analytical data may help to confirm known functional and neuroanatomical relationships, elucidate others as yet unreported, and serve as a basis for comparison to patients with psychiatric illness...
  67. ncbi request reprint Psychological complexity: barriers to its integration into the neurobiology of major psychiatric disorders
    Robert M Post
    National Institute of Mental Health BPB, Bethesda, MD 20892 1272, USA
    Dev Psychopathol 14:635-51. 2002
    ..This paper endorses renewed effort toward the multidisciplinary team approach under the leadership of a physician-scientist in order to better integrate many fields of study critical to ameliorating the effects of psychiatric illness...
  68. ncbi request reprint Neurobiology of bipolar illness: implications for future study and therapeutics
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892 1272, USA
    Ann Clin Psychiatry 15:85-94. 2003
    ..Further examination of the pathophysiology and neurobiology of bipolar illness should lead to both more effective treatments and, potentially, secondary and even primary episode prevention...
  69. ncbi request reprint Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: I. Effects of primary motor cortex rTMS
    Andrew M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892 1430, USA
    Biol Psychiatry 54:818-25. 2003
    ..We combined the administration of varying intensities of 1-Hz rTMS of the motor cortex with simultaneous positron emission tomography (PET) to delineate local and distant effects on brain activity...
  70. ncbi request reprint Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteers
    Timothy A Kimbrell
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 115:101-13. 2002
    ..While these results are in the predicted direction, further studies using other designs and higher intensities and frequencies of rTMS are indicated to better describe the local and distant changes induced by rTMS...
  71. ncbi request reprint Antithyroid antibody-linked symptoms in borderline personality disorder
    Thomas D Geracioti
    Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, MD, USA
    Endocrine 21:153-8. 2003
    ..It will be of interest to determine the prevalence, pathophysiologic mechanisms, and treatment implications of this putative autoimmune- BPD link...
  72. ncbi request reprint Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, NIH Building 10, Bethesda, MD 20892 1272, USA
    Epilepsy Res 50:203-19. 2002
    ..Given these recognized limitations of non-homologous models, kindling may still provide insights into the longitudinal course, progression, and treatment of some neuropsychiatric syndromes that can then be directly tested in the clinic...
  73. ncbi request reprint Treatment of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Spectr 8:1-10; quiz 11. 2003
    ..Other adjuncts for treatment-refractory patients include monoamine oxidase inhibitors and electroconvulsive therapy...
  74. ncbi request reprint Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children
    Emily L Fergus
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    J Affect Disord 77:71-8. 2003
    ..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community...
  75. pmc Repetitive TMS combined with exposure therapy for PTSD: a preliminary study
    Elizabeth A Osuch
    Biological Psychiatry Branch, National Institute of Mental Health, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD, United States
    J Anxiety Disord 23:54-9. 2009
    ..Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD...
  76. ncbi request reprint Maternal deprivation increases cell death in the infant rat brain
    Li Xin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Brain Res Dev Brain Res 133:1-11. 2002
    ....
  77. ncbi request reprint Parental attitudes towards early intervention in children at high risk for affective disorders
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Affect Disord 70:117-24. 2002
    ....
  78. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  79. ncbi request reprint Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  80. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  81. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  82. ncbi request reprint Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
    Biol Psychiatry 63:125-30. 2008
    ..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated...
  83. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  84. doi request reprint Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  85. doi request reprint Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  86. ncbi request reprint The effectiveness of carbamazepine in unipolar depression: a double-blind, randomized, placebo-controlled study
    Zhang Jin Zhang
    Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi an, Shannxi 710032, China
    J Affect Disord 109:91-7. 2008
    ..Based on the results of our present and previous studies, we suggest that CBZ might be considered an alternative in the management of certain conditions in major depressive disorder...
  87. ncbi request reprint High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure
    Ralph W Kupka
    Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
    Biol Psychiatry 51:305-11. 2002
    ..We assessed the prevalence of thyroperoxidase antibodies (TPO-Abs) and thyroid failure in outpatients with bipolar disorder compared with two control groups...
  88. ncbi request reprint Regional cerebral glucose utilization in patients with a range of severities of unipolar depression
    Tim A Kimbrell
    North Little Rock VA Medical Center TAKi, North Little Rock, Arkansas, USA
    Biol Psychiatry 51:237-52. 2002
    ....
  89. ncbi request reprint New designs for studies of the prophylaxis of bipolar disorder
    Robert M Post
    J Clin Psychopharmacol 22:1-3. 2002
  90. ncbi request reprint Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  91. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  92. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  93. ncbi request reprint Bupropion and venlafaxine responders differ in pretreatment regional cerebral metabolism in unipolar depression
    John T Little
    Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 57:220-8. 2005
    ..Pretreatment functional brain imaging was examined for never-hospitalized outpatients with unipolar depression compared with control subjects in a crossover treatment trial involving bupropion or venlafaxine monotherapy...
  94. ncbi request reprint Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD
    Robert M Post
    J Clin Psychiatry 65:898-902. 2004
  95. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  96. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  97. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  98. ncbi request reprint Newer prophylactic agents for bipolar disorder and their influence on suicidality
    Christoph Born
    Psychiatrische Klinik der LMU, Munchen
    Arch Suicide Res 9:301-6. 2005
    ..Confounding variables in more intensive care of these patients participating in a naturalistic study may blur small differences and contribute to a generally favorable outcome...
  99. ncbi request reprint Atypical antipsychotics in bipolar depression: potential mechanisms of action
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
    J Clin Psychiatry 66:40-8. 2005
    ..Further studies should be conducted to examine these hypotheses...
  100. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  101. ncbi request reprint Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, U S A
    Epilepsia 44:1487-93. 2003
    ..The present study was designed to determine whether cross-tolerance occurs between levetiracetam (LEV) and carbamazepine (CBZ) in amygdala-kindled rats...