Research Topics
Species | R M PostSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depressionGuoqiang Xing
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
Schizophr Res 58:21-30. 2002..28, P < 0.05, n = 60) and in the PMI controlled subgroup (r = 0.43, P < 0.01, n = 38). Our data provide evidence of reduced cNOS activity in the postmortem brains of patients with schizophrenia and depression...- Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar NetworkGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Clin Psychiatry 64:506-15. 2003..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder... - Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic databaseRobert M Post
Biological Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Department of Health and Human Services, 10 Center Drive MSC 1272, Bldg 10, Room 3S239, Bethesda, MD 20892 1272, USA
Expert Opin Pharmacother 6:531-46. 2005.... - Comparative pharmacology of bipolar disorder and schizophreniaR M Post
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1272, USA
Schizophr Res 39:153-8; discussion 163. 1999.... - Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorderRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Clin Psychiatry 66:370-4. 2005..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness... - An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)Robert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:310-9. 2003..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed... - Neurobiology of seizures and behavioral abnormalitiesR M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1272, USA
Epilepsia 45:5-14. 2004.... - The health care crisis of childhood-onset bipolar illness: some recommendations for its ameliorationRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
J Clin Psychiatry 67:115-25. 2006..To describe new data on the incidence and impact of childhood- and adolescent-onset bipolar illness and make recommendations to help accelerate the acquisition of knowledge in this area... - Convergences in course of illness and treatments of the epilepsies and recurrent affective disordersRobert M Post
Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD, USA
Clin EEG Neurosci 35:14-24. 2004..Caveats in the use of this model and convergences and divergences in its predictive validity for seizures and affective disorders are noted... - Bipolar depression: the role of atypical antipsychoticsRobert M Post
Expert Rev Neurother 4:S27-33. 2004..The receptor-binding profile of these agents supports a role in the treatment of depressive symptoms and clinical data are beginning to emerge of their efficacy in both the acute and maintenance setting... - Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart methodRobert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
J Clin Psychiatry 64:680-90; quiz 738-9. 2003..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated... - Unique design issues in clinical trials of patients with bipolar affective disorderRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
J Psychiatr Res 37:61-73. 2003..Acceptance of a wider variety of clinical trial designs may help facilitate the funding and accelerate the acquisition of new data on treatment of bipolar illness... - The impact of bipolar depressionRobert M Post
Bipolar Collaborative Network, Chevy Chase, MD, USA
J Clin Psychiatry 66:5-10. 2005..Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder... - The Stanley Foundation Bipolar Network. I. Rationale and methodsR M Post
National Institute of Mental Health, Bethesda, Maryland, USA
Br J Psychiatry Suppl 41:s169-76. 2001..CONCLUSIONS: Well-characterised patients are followed in a detailed continuous longitudinal fashion in both opportunistic case series and double-blind, randomised controlled trials with reliable and validated measures... - The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patientsT Suppes
The Stanley Foundation Bipolar Network, 5430 Grosvenor Lane, Suite 200, Bethesda, MD 20814, USA
J Affect Disord 67:45-59. 2001..This report describes the demographics and course of illness characteristics of this study population... - The Stanley Foundation Bipolar Treatment Outcome Network. I. Longitudinal methodologyG S Leverich
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1272, USA
J Affect Disord 67:33-44. 2001..This article describes the rationale for the Network, its guiding principles, methods, and study design to systematically assess the highly variable course of bipolar illness and its response to current and future treatments... - Clozapine in bipolar disorder: treatment implications for other atypical antipsychoticsM A Frye
National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD, USA
J Affect Disord 48:91-104. 1998..The foregoing agents and future drugs with atypical neuroleptic properties should come to play an increasingly important role, compared to the older classical neuroleptics, in the acute and long term management of bipolar disorder... - Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizersR M Post
Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892-1272, USA
Bipolar Disord 3:259-65. 2001..Individual data on each drug will be assessed in the next phase of the study after more subjects are recruited and the blind is broken... - Gabapentin does not alter single-dose lithium pharmacokineticsM A Frye
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Clin Psychopharmacol 18:461-4. 1998.... - Understanding emotional prosody activates right hemisphere regionsM S George
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Neurol 53:665-70. 1996..The brain regions involved in recognition of emotional prosody in healthy subjects is less clear... - Kindling: separate vs. shared mechanisms in affective disorders and epilepsyS R Weiss
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuropsychobiology 38:167-80. 1998..It is hoped that some of the lessons from the kindling model will provide useful and novel insights into aspects of treatment and mechanisms of psychiatric and neurologic illnesses... 
Opposite effects of high and low frequency rTMS on mood in depressed patients: relationship to baseline cerebral activity on PETA M Speer
Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland, United States
J Affect Disord 115:386-94. 2009..Optimal parameters of rTMS for antidepressant efficacy in general, or within patients, have not been adequately delineated...- Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilusM A Smith
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Brain Res 745:248-56. 1997..These results suggest that CRF may contribute to the development of amygdala kindling. However, the compensatory induction of CRF-BP may serve to limit the excitatory effects of CRF in the dentate gyrus... - Lack of adverse cognitive effects of 1 Hz and 20 Hz repetitive transcranial magnetic stimulation at 100% of motor threshold over left prefrontal cortex in depressionA M Speer
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J ECT 17:259-63. 2001..This study assesses the cognitive performance of depressed patients receiving high or low frequency rTMS for 10 days... - Relationship between prior course of illness and neuropsychological functioning in patients with bipolar disorderK D Denicoff
Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
J Affect Disord 56:67-73. 1999..This study investigated the relationship between prior course of illness and neuropsychological deficits in relatively high functioning outpatients with bipolar disorder... - Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trialM S George
Biological Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
Am J Psychiatry 154:1752-6. 1997..Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design... - Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disordersGabriela V Obrocea
National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
Biol Psychiatry 51:253-60. 2002..These preliminary data in a treatment refractory subgroup may help in the further definition of the range of clinical utility of these widely used anticonvulsants... - Relationship between prior course of illness and neuroanatomic structures in bipolar disorder: a preliminary studyS O Ali
Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Neuropsychiatry Neuropsychol Behav Neurol 14:227-32. 2001..CONCLUSIONS: Additional studies are needed to both replicate and further examine the association of prior course of illness and larger hippocampal and ventricular volumes in bipolar disorder... - Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertralineR M Post
Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland, USA
Br J Psychiatry 189:124-31. 2006..Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression... - Effect of cocaine, lidocaine kindling and carbamazepine on batrachotoxin-induced phosphoinositide hydrolysis in rat brain slicesR L Margolis
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
Brain Res 614:185-90. 1993..Neither in vitro nor in vivo carbamazepine altered the effect of cocaine on BTX-induced PI hydrolysis. These results demonstrate that local anesthetic kindling does not alter PI hydrolysis coupled to Na channel or IBO activation... - Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop)M S George
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
J Neuropsychiatry Clin Neurosci 9:55-63. 1997..This study supports theories of blunted limbic and paralimbic activation and abnormal cingulate activity in depression and adds to the growing knowledge of the functional neuroanatomy of depression... - Apoptosis of hippocampal neurons after amygdala kindled seizuresL X Zhang
Biological Psychiatric Branch, NIMH, Bldg 10 Rm 3N212, Bethesda, MD 20982, USA
Brain Res Mol Brain Res 55:198-208. 1998.... - Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary studyB D Greenberg
Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
Am J Psychiatry 154:867-9. 1997..Prefrontal mechanisms are implicated in obsessive-compulsive disorder. The authors investigated whether prefrontal repetitive transcranial magnetic stimulation influenced obsessive-compulsive disorder symptoms... - Autoradiographic analysis of serotonin receptors and transporter in kindled rat brainM Clark
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
Neurosci Lett 161:21-6. 1993..Alterations in 5-HT receptors and the 5-HT transporter may endogenously modulate kindled seizures. Additionally, autoradiography of adenosine A1 receptors revealed no change for these receptors in any brain region... - Elevated concentration of N-CAM VASE isoforms in schizophreniaM P Vawter
Cellular Neurobiology Branch, NIDA IRP, Baltimore, MD 21224, USA
J Psychiatr Res 34:25-34. 2000..These results provide further evidence of an abnormality of N-CAM protein in chronic schizophrenia and suggest differences between schizophrenia and affective disorders in regulation of N-CAM... - Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizuresG Xing
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Brain Res Mol Brain Res 47:251-61. 1997..kindled seizures. In addition, as r-nurr1 is prominently expressed in the specific brain sites associated with memory acquisition and consolidation, it may play a role in memory processing... - Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorderGuo Qiang Xing
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Int J Neuropsychopharmacol 7:143-53. 2004..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored... - A potential cholinergic mechanism of procaine's limbic activationBrenda E Benson
Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1272, USA
Neuropsychopharmacology 29:1239-50. 2004..v. procaine's emotional and sensory effects in man. These findings are consistent with other evidence of cholinergic modulation of mood and emotion... - Treatment of rapid-cycling bipolar disorderRobert M Post
Bipolar Collaborative Network, Chevy Chase, MD, USA
CNS Spectr 9:1-11. 2004 - A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar NetworkRobert M Post
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:396-406. 2003..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations... - Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorderKirk D Denicoff
Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Depress Anxiety 15:1-9. 2002.... - Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizersGabriele S Leverich
Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
Am J Psychiatry 163:232-9. 2006..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression... - Age, sex and laterality effects on cerebral glucose metabolism in healthy adultsMark W Willis
Biological Psychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
Psychiatry Res 114:23-37. 2002..These findings contribute toward a convergence in the literature, and the regression models of CMRglc vs. age serve as a normative database to which patients may be compared... - Course of bipolar illness after history of childhood traumaGabriele S Leverich
Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
Lancet 367:1040-2. 2006 - The poor prognosis of childhood-onset bipolar disorderGabriele S Leverich
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Pediatr 150:485-90. 2007..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness... - Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depressionRobert T Dunn
Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892-1272, USA
Biol Psychiatry 51:387-99. 2002..Thus, different depressive symptom clusters may have different neural substrates in unipolars, but clusters and their substrates are convergent in bipolars... 
Interregional cerebral metabolic associativity during a continuous performance task (Part II) : differential alterations in bipolar and unipolar disordersBrenda E Benson
Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, United States
Psychiatry Res 164:30-47. 2008....- Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controlsRobert T Dunn
Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
Psychiatry Res 140:181-98. 2005.... - Early physical and sexual abuse associated with an adverse course of bipolar illnessGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892-1272, USA
Biol Psychiatry 51:288-97. 2002.... - Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthoodRobert M Post
Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
J Clin Psychiatry 71:864-72. 2010..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood... - The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled ratsZhang Jin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Neurosci Lett 329:253-6. 2002..The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored... - Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disordersP Hauser
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
Arch Neurol 46:696-9. 1989..High-dose benzodiazepine therapy and a history of viral encephalitis may be risk factors for withdrawal delirium... - Post-dexamethasone cortisol correlates with severity of depression before and during carbamazepine treatment in women but not menE A Osuch
Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Acta Psychiatr Scand 104:397-401. 2001..CONCLUSION: The pathophysiological implications of this selective positive relationship between severity of depression and post-DST cortisol in women, but not men, should be explored further... - Effects of thyroid alterations and carbamazepine on cortical beta-adrenergic receptors in the ratR T Joffe
Biological Psychiatry Branch, NIMH, Bethesda, Maryland
Neuropharmacology 27:171-4. 1988.... - Input-specific LTP and depotentiation in the basolateral amygdalaV Aroniadou-Anderjaska
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Neuroreport 12:635-40. 2001..These synapse-specific, reversible changes in synaptic strength in the basolateral nucleus of the amygdala may be important to amygdala's role in emotional memory... - Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disordersM F M Braga
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland, MD 20814, USA
Neuropharmacology 42:522-9. 2002..The modulation of inhibitory synaptic transmission may be an important mechanism underlying the psychotropic effects of LTG... - Earliest symptoms discriminating juvenile-onset bipolar illness from ADHDDavid A Luckenbaugh
Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
Bipolar Disord 11:441-51. 2009.... - Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizuresZhang Jin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Pharmacol Biochem Behav 74:565-71. 2003..These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored... - Developmental vulnerabilities to the onset and course of bipolar disorderR M Post
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892-1272, USA
Dev Psychopathol 13:581-98. 2001.... - Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: II. Effects of prefrontal cortex rTMSAndrew M Speer
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892-1430, USA
Biol Psychiatry 54:826-32. 2003.... - Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomenaRobert M Post
Penn State College of Medicine, 3502 Turner Lane, Chevy Chase, MD 20815, USA
Neurosci Biobehav Rev 31:858-73. 2007.... - Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practiceRobert M Post
Bipolar Collaborative Network, Chevy Chase, Maryland, USA
CNS Drugs 21:47-71. 2007..More precise clinical and biological predictors and correlates of individual clinical responsiveness to carbamazepine and other mood stabilisers are eagerly awaited... - Specific amygdaloid nuclei are involved in suppression or propagation of epileptiform activity during transition stage between oral automatisms and generalized clonic seizuresM Sitcoske O'Shea
Biological Psychiatry Branch, National Institutes of Mental Health, Bethesda, MD 0892, USA
Brain Res 873:1-17. 2000..A neuroanatomical model of Am-induced seizure propagation is proposed suggesting that the Claust-Ins-PRh play a pivotal role during the transition between oral automatisms and generalized clonic convulsions... - Psychological complexity: barriers to its integration into the neurobiology of major psychiatric disordersRobert M Post
National Institute of Mental Health/BPB, Bethesda, MD 20892-1272, USA
Dev Psychopathol 14:635-51. 2002..This paper endorses renewed effort toward the multidisciplinary team approach under the leadership of a physician-scientist in order to better integrate many fields of study critical to ameliorating the effects of psychiatric illness... - Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteersTimothy A Kimbrell
Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
Psychiatry Res 115:101-13. 2002..While these results are in the predicted direction, further studies using other designs and higher intensities and frequencies of rTMS are indicated to better describe the local and distant changes induced by rTMS... - Interregional cerebral metabolic associativity during a continuous performance task (Part I): healthy adultsMark W Willis
Uniformed Services University of the Health Sciences, PHS, HHS, Bethesda, MD, USA
Psychiatry Res 164:16-29. 2008..These analytical data may help to confirm known functional and neuroanatomical relationships, elucidate others as yet unreported, and serve as a basis for comparison to patients with psychiatric illness... - Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: I. Effects of primary motor cortex rTMSAndrew M Speer
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892-1430, USA
Biol Psychiatry 54:818-25. 2003..CONCLUSIONS: This study demonstrates that 1-Hz rTMS delivered to the primary motor cortex (M1) produces intensity-dependent increases in brain activity locally and has associated effects in distant sites with known connections to M1... - Treatment of bipolar depressionRobert M Post
Bipolar Collaborative Network, Chevy Chase, Maryland, USA
CNS Spectr 8:1-10; quiz 11. 2003..Other adjuncts for treatment-refractory patients include monoamine oxidase inhibitors and electroconvulsive therapy... - Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?Robert M Post
Biological Psychiatry Branch, National Institute of Mental Health, NIH Building 10, Bethesda, MD 20892 1272, USA
Epilepsy Res 50:203-19. 2002..Given these recognized limitations of non-homologous models, kindling may still provide insights into the longitudinal course, progression, and treatment of some neuropsychiatric syndromes that can then be directly tested in the clinic... - Antithyroid antibody-linked symptoms in borderline personality disorderThomas D Geracioti
Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, MD, USA
Endocrine 21:153-8. 2003..It will be of interest to determine the prevalence, pathophysiologic mechanisms, and treatment implications of this putative autoimmune- BPD link... - Neurobiology of bipolar illness: implications for future study and therapeuticsRobert M Post
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892-1272, USA
Ann Clin Psychiatry 15:85-94. 2003..Further examination of the pathophysiology and neurobiology of bipolar illness should lead to both more effective treatments and, potentially, secondary and even primary episode prevention... - Parental attitudes towards early intervention in children at high risk for affective disordersRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bldg. 10, Rm. 3S239, 10 Center Drive, MSC-1272, Bethesda, MD 20892-1272, USA
J Affect Disord 70:117-24. 2002.... - Repetitive TMS combined with exposure therapy for PTSD: a preliminary studyElizabeth A Osuch
Biological Psychiatry Branch, National Institute of Mental Health, Clinical Center Nursing Department, National Institutes of Health, Bethesda, MD, United States
J Anxiety Disord 23:54-9. 2009..Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD... - Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar childrenEmily L Fergus
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
J Affect Disord 77:71-8. 2003..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community... - Maternal deprivation increases cell death in the infant rat brainLi Xin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Brain Res Dev Brain Res 133:1-11. 2002.... - Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholismEric Levander
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
J Affect Disord 101:211-7. 2007..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)... - Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorderJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
Biol Psychiatry 63:125-30. 2008..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated... - Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trialSusan L McElroy
Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
J Affect Disord 101:275-81. 2007..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole... - A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depressionMark A Frye
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
Am J Psychiatry 164:1242-9. 2007..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue... - Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorderRalph W Kupka
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bipolar Disord 9:531-5. 2007..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder... - Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment NetworkTrisha Suppes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
Int Clin Psychopharmacol 22:376-81. 2007..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted... - The effectiveness of carbamazepine in unipolar depression: a double-blind, randomized, placebo-controlled studyZhang Jin Zhang
Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi an, Shannxi 710032, China
J Affect Disord 109:91-7. 2008..Based on the results of our present and previous studies, we suggest that CBZ might be considered an alternative in the management of certain conditions in major depressive disorder... - Incidence of childhood-onset bipolar illness in the USA and EuropeRobert M Post
Department of Psychiatry, George Washington University, Washington, DC, USA
Br J Psychiatry 192:150-1. 2008..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration... - Are bipolar mood symptoms affected by the phase of the menstrual cycle?Geetha Shivakumar
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
J Womens Health (Larchmt) 17:473-8. 2008..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue... - A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disordersSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Bipolar Disord 9:426-34. 2007..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD... - New findings from the Bipolar Collaborative Network: clinical implications for therapeuticsRobert M Post
Penn State College of Medicine, Hershey, PA, USA
Curr Psychiatry Rep 8:489-97. 2006..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss... - Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite studyLori L Altshuler
Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
J Clin Psychiatry 67:1551-60. 2006..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder... - The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trialsRichard H Weisler
University of North Carolina at Chapel Hill, NC, USA
CNS Spectr 11:788-99. 2006..This article provides an overview of data on the use of AEDs in bipolar disorder, including acute mania and depression, prophylaxis, and rapid cycling... - Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trialSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Clin Psychiatry 66:617-24. 2005..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002... - Bupropion and venlafaxine responders differ in pretreatment regional cerebral metabolism in unipolar depressionJohn T Little
Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Biol Psychiatry 57:220-8. 2005.... - Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to actionDennis S Charney
Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA
Biol Psychiatry 56:703-13. 2004 - Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHDRobert M Post
J Clin Psychiatry 65:898-902. 2004 - Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar NetworkWillem A Nolen
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Am J Psychiatry 161:1447-54. 2004..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder... - Tiagabine in treatment refractory bipolar disorder: a clinical case seriesTrisha Suppes
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Bipolar Disord 4:283-9. 2002..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments... - Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorderMark A Frye
Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
Am J Psychiatry 160:883-9. 2003..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study... - Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizuresZhang Jin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, U S A
Epilepsia 44:1487-93. 2003..The present study was designed to determine whether cross-tolerance occurs between levetiracetam (LEV) and carbamazepine (CBZ) in amygdala-kindled rats... - Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatientsRalph W Kupka
Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
Am J Psychiatry 162:1273-80. 2005..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective... - Newer prophylactic agents for bipolar disorder and their influence on suicidalityChristoph Born
Psychiatrische Klinik der LMU,
Arch Suicide Res 9:301-6. 2005..Confounding variables in more intensive care of these patients participating in a naturalistic study may blur small differences and contribute to a generally favorable outcome... - Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agendaDaniel F Connor
Department of Psychiatry MC1410, University of Connecticut Health Center, Farmington 06030 1410, USA
J Clin Psychiatry 67:808-20. 2006..To propose a research agenda for disorders of aggression in child and adolescent psychiatry... - Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorderPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
Biol Psychiatry 60:1020-2. 2006..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder... - Low cerebrospinal fluid glutamate and glycine in refractory affective disorderMark A Frye
Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
Biol Psychiatry 61:162-6. 2007..Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness...