C P Ponting

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins
    C P Ponting
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA
    J Mol Med (Berl) 77:695-8. 1999
  2. ncbi request reprint Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer
    C P Ponting
    National Center for Biotechnology Information National Library of Medicine, National Institutes of Health, Bldg 38A, Bethesda, MD, 20894, USA
    J Mol Biol 289:729-45. 1999
  3. pmc SMART: identification and annotation of domains from signalling and extracellular protein sequences
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, The Old Observatory, South Parks Road, Oxford OX1 3RH, UK
    Nucleic Acids Res 27:229-32. 1999
  4. ncbi request reprint Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Genome Res 11:1996-2008. 2001
  5. ncbi request reprint Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex
    S E Newey
    Department of Human Anatomy and Genetics, University of Oxford, UK
    Curr Biol 10:1295-8. 2000
  6. pmc A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 5:914-22. 1996
  7. ncbi request reprint Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex
    K Talbot
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Hum Mol Genet 7:2149-56. 1998
  8. ncbi request reprint IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices
    A A Schaffer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Bioinformatics 15:1000-11. 1999
  9. ncbi request reprint Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
    J Mol Biol 302:1041-7. 2000
  10. ncbi request reprint Genome cartography through domain annotation
    C P Ponting
    MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX13QX, UK
    Genome Biol 2:Comment 2006. 2001

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins
    C P Ponting
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA
    J Mol Med (Berl) 77:695-8. 1999
    ..These findings indicate "cross-talk" interactions between signalling pathways involving Ras and Rap and pathways involving Rho, Rac and G alpha GTPases...
  2. ncbi request reprint Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer
    C P Ponting
    National Center for Biotechnology Information National Library of Medicine, National Institutes of Health, Bldg 38A, Bethesda, MD, 20894, USA
    J Mol Biol 289:729-45. 1999
    ..A number of transfers of signalling domains from eukaryotes to bacteria were confidently identified, in contrast to only a single case of apparent transfer from eukaryotes to archaea...
  3. pmc SMART: identification and annotation of domains from signalling and extracellular protein sequences
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, The Old Observatory, South Parks Road, Oxford OX1 3RH, UK
    Nucleic Acids Res 27:229-32. 1999
    ..In addition, each domain is annotated extensively with respect to cellular localisation, species distribution, functional class, tertiary structure and functionally important residues...
  4. ncbi request reprint Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Genome Res 11:1996-2008. 2001
    ..These findings demonstrate how completely sequenced genomes can be exploited to further understand the relationships between molecular structure, function, and evolution...
  5. ncbi request reprint Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex
    S E Newey
    Department of Human Anatomy and Genetics, University of Oxford, UK
    Curr Biol 10:1295-8. 2000
    ..This is likely to have important consequences for the recruitment of specific signalling molecules to the DPC and ultimately for its function...
  6. pmc A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 5:914-22. 1996
    ..It is suggested that, for each of these enzymes, conserved histidine, lysine, aspartic acid, and/or asparagine residues may be involved in a two-step ping pong mechanism involving an enzyme-substrate intermediate...
  7. ncbi request reprint Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex
    K Talbot
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Hum Mol Genet 7:2149-56. 1998
    ..In addition to a possible role for this protein as a pro-apoptotic factor, SMN and its related protein share significant similarities in sequence and cellular function...
  8. ncbi request reprint IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices
    A A Schaffer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Bioinformatics 15:1000-11. 1999
    ..One popular program for constructing a PSSM and comparing it with a database of sequences is Position-Specific Iterated BLAST (PSI-BLAST)...
  9. ncbi request reprint Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
    J Mol Biol 302:1041-7. 2000
    ..The combined analysis of structure and sequence databases for detecting significant similarities is suggested as a highly sensitive approach to determining the common ancestry of extremely divergent homologues...
  10. ncbi request reprint Genome cartography through domain annotation
    C P Ponting
    MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX13QX, UK
    Genome Biol 2:Comment 2006. 2001
    ..To account for the great diversity of domain contexts and an unexpected paucity of ortholog conservation, we must categorize the coding regions of completely sequenced genomes into domain families, as well as protein families...
  11. ncbi request reprint JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta
    P M Clissold
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK
    Trends Biochem Sci 26:7-9. 2001
    ..JmjC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling...
  12. ncbi request reprint Issues in predicting protein function from sequence
    C P Ponting
    Department of Human Anatomy and Genetics, University of Oxford, UK
    Brief Bioinform 2:19-29. 2001
    ..Pitfalls in database searching methods arising from amino acid compositional bias and database size effects are also discussed...
  13. pmc Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochem J 351:527-35. 2000
    ..This finding hints at the mechanism by which Ire1p may sense extended unfolded proteins at the expense of compact folded molecules...
  14. ncbi request reprint Syncoilin, a novel member of the intermediate filament superfamily that interacts with alpha-dystrobrevin in skeletal muscle
    S E Newey
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
    J Biol Chem 276:6645-55. 2001
    ....
  15. ncbi request reprint CHROMA: consensus-based colouring of multiple alignments for publication
    L Goodstadt
    MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Bioinformatics 17:845-6. 2001
    ..Both the executables and source code for CHROMA running under Windows and Linux (portable command-line only) are freely available at http://www.lg.ndirect.co.uk/chroma. Software enquiries should be directed to CHROMA@lg.ndirect.co.uk...
  16. ncbi request reprint Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene
    J D Vargas
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Mech Dev 117:289-92. 2002
    ..The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development...
  17. ncbi request reprint Phospholipase Czeta, the trigger of egg activation in mammals, is present in a non-mammalian species
    K Coward
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Reproduction 130:157-63. 2005
    ..Our findings suggest that PLCzeta may have a universal role in triggering egg activation in vertebrates...
  18. ncbi request reprint PDZ domains: targeting signalling molecules to sub-membranous sites
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, UK
    Bioessays 19:469-79. 1997
    ..Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand-binding and the structural bases for sequence conservation among diverse PDZ domains...
  19. ncbi request reprint Porcine natural-killer-enhancing factor-B: oligomerisation and identification as a calpain substrate in vitro
    E Schroder
    Department of Biochemistry, University of Oxford, UK
    Biochim Biophys Acta 1383:279-91. 1998
    ....
  20. ncbi request reprint Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases
    J D Vargas
    Department of Human Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, UK
    Biochim Biophys Acta 1651:116-23. 2003
    ..Moreover, we demonstrate the presence of mouse sdr2 in the choroid plexus and in the ependymal cells lining the four ventricles, through in situ hybridization analysis...
  21. pmc Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, United Kingdom
    Protein Sci 5:162-6. 1996
    ..Twenty-two previously unrecognized C2 domain sequences are presented, which include a single copy in the mammalian poreforming proteins, perforin...
  22. ncbi request reprint A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration
    R D Emes
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Hum Mol Genet 10:2813-20. 2001
    ..Uncharacterized LisH motif-containing proteins represent candidates for other diseases associated with aberrant microtubule dynamics and defects of cell migration, nucleokinesis or chromosome segregation...
  23. ncbi request reprint Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?
    C P Ponting
    MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Hum Mol Genet 10:1853-8. 2001
    ..The hypothesis that aberrant ferric reductase activities are involved in the progression of neurodegenerative diseases should open up new avenues of research, and possibly therapy, for these devastating diseases...
  24. ncbi request reprint Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism?
    K Talbot
    University of Oxford, Department of Biochemistry, UK
    Hum Mol Genet 6:497-500. 1997
    ..We have identified apparent orthologues of SMN in Caenorhabditis elegans and Schizosaccharomyces pombe. These sequences retain the highly conserved Y-G motif and provide additional support for a role of SMN in mRNA metabolism...
  25. pmc Evidence for PDZ domains in bacteria, yeast, and plants
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 6:464-8. 1997
    ..The known affinity of Escherichia coli tsp for C-terminal polypeptides is proposed to be mediated by its PDZ-like domain, in a similar manner to the binding of C-terminal polypeptides by animal PDZ domains...
  26. pmc Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, United Kingdom
    Protein Sci 5:2353-7. 1996
    ....
  27. ncbi request reprint Sequence variation and disease in the wake of the draft human genome
    L Goodstadt
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Hum Mol Genet 10:2209-14. 2001
    ..Ultimately, the success of genome sequencing and functional genomics will be measured not by the quantity and accuracy of raw data generated, but how rapidly they can be harnessed to span the divide between genotype and phenotype...
  28. pmc SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, Old Observatory, United Kingdom
    Protein Sci 4:1928-30. 1995
    ..Its appearance in byr2 and STE11, which are MEK kinases, and in proteins containing pleckstrain homology, src homology 3, and discs-large homologous region domains, suggests possible participation in signal transduction pathways...
  29. ncbi request reprint Plagiarized bacterial genes in the human book of life
    C P Ponting
    MRC Functional Genetics Unit, Dept of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK OX1 3QX
    Trends Genet 17:235-7. 2001
    ..So how did the human 'book of life' evolve to be a chimaera, part animal and part bacterium? And what was the probable evolutionary impact of such gene plagiarism?..
  30. pmc P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 6:459-63. 1997
    ..Conservation of Asp-19 and Asp-83 among these homologues suggests a re-evaluation of the roles of these residues in Ca(2+)-binding and/or catalysis...
  31. ncbi request reprint Tudor domains in proteins that interact with RNA
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, UK OX1 3RH
    Trends Biochem Sci 22:51-2. 1997
  32. ncbi request reprint beta-propeller repeats and a PDZ domain in the tricorn protease: predicted self-compartmentalisation and C-terminal polypeptide-binding strategies of substrate selection
    C P Ponting
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    FEMS Microbiol Lett 179:447-51. 1999
    ..acidophilum proteasome, whereas the beta-propeller domains serve to exclude large substrates from the tricorn protease active site in a similar manner to that previously indicated for prolyl oligopeptidase...