M C Poirier

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Chemical-induced DNA damage and human cancer risk
    Miriam C Poirier
    Carcinogen DNA Interactions Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Discov Med 14:283-8. 2012
  2. ncbi request reprint Carcinogen macromolecular adducts and their measurement
    M C Poirier
    Carcinogen DNA Interactions Section, LCCTP, Division of Basic Sciences, NCI, NIH, Building 37, Room 2A05, 37 Convent Drive, MSC 4255, Bethesda, MD 20892, USA
    Carcinogenesis 21:353-9. 2000
  3. ncbi request reprint The genotoxicity of tamoxifen: extent and consequences, Kona, Hawaii, January 23, 2003
    Miriam C Poirier
    Center for Cancer Research, National Cancer Institute, 37 Convent Drive MSC 4255, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Mutagenesis 18:395-9. 2003
  4. ncbi request reprint Chemical-induced DNA damage and human cancer risk
    Miriam C Poirier
    Carcinogen DNA Interactions Section, LCCTP, Building 37 Room 4032, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, Maryland 20892 4255, USA
    Nat Rev Cancer 4:630-7. 2004
  5. ncbi request reprint Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers
    Miriam C Poirier
    Carcinogen DNA Interactions Section, National Cancer Institute, National Institutes of Health, Building 37, Room 4032, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    J Acquir Immune Defic Syndr 33:175-83. 2003
  6. ncbi request reprint Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs
    Miriam C Poirier
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Toxicol Appl Pharmacol 199:151-61. 2004
  7. ncbi request reprint Incorporation of 3'-azido-3'-deoxythymidine (AZT) into fetal DNA and fetal tissue distribution of drug after infusion of pregnant late-term rhesus macaques with a human-equivalent AZT dose
    M C Poirier
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 22:477-83. 1999
  8. ncbi request reprint Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    AIDS Res Hum Retroviruses 16:635-44. 2000
  9. ncbi request reprint Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria
    E L Ewings
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 24:100-5. 2000
  10. ncbi request reprint Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys
    O A Olivero
    Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892 4255, USA
    J Natl Cancer Inst 89:1602-8. 1997

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Chemical-induced DNA damage and human cancer risk
    Miriam C Poirier
    Carcinogen DNA Interactions Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Discov Med 14:283-8. 2012
    ..Taken together the data suggest that a reduction in human DNA adduct level is likely to produce a reduction in human cancer risk...
  2. ncbi request reprint Carcinogen macromolecular adducts and their measurement
    M C Poirier
    Carcinogen DNA Interactions Section, LCCTP, Division of Basic Sciences, NCI, NIH, Building 37, Room 2A05, 37 Convent Drive, MSC 4255, Bethesda, MD 20892, USA
    Carcinogenesis 21:353-9. 2000
    ....
  3. ncbi request reprint The genotoxicity of tamoxifen: extent and consequences, Kona, Hawaii, January 23, 2003
    Miriam C Poirier
    Center for Cancer Research, National Cancer Institute, 37 Convent Drive MSC 4255, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Mutagenesis 18:395-9. 2003
    ....
  4. ncbi request reprint Chemical-induced DNA damage and human cancer risk
    Miriam C Poirier
    Carcinogen DNA Interactions Section, LCCTP, Building 37 Room 4032, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, Maryland 20892 4255, USA
    Nat Rev Cancer 4:630-7. 2004
  5. ncbi request reprint Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers
    Miriam C Poirier
    Carcinogen DNA Interactions Section, National Cancer Institute, National Institutes of Health, Building 37, Room 4032, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    J Acquir Immune Defic Syndr 33:175-83. 2003
    ..The study shows that children of HIV+ mothers are at risk for mitochondrial damage that is further increased in infants of mothers receiving AZT during pregnancy...
  6. ncbi request reprint Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs
    Miriam C Poirier
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Toxicol Appl Pharmacol 199:151-61. 2004
    ....
  7. ncbi request reprint Incorporation of 3'-azido-3'-deoxythymidine (AZT) into fetal DNA and fetal tissue distribution of drug after infusion of pregnant late-term rhesus macaques with a human-equivalent AZT dose
    M C Poirier
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 22:477-83. 1999
    ..Data imply that the human fetus may also be subject to incorporation of AZT into DNA even after short-term AZT infusion to the mother just before delivery...
  8. ncbi request reprint Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    AIDS Res Hum Retroviruses 16:635-44. 2000
    ..Furthermore, a dose-dependent depletion of mitochondrial DNA levels was observed in both tissues. The data demonstrate that transplacental AZT exposure causes cardiac and skeletal muscle mitochondrial myopathy in the patas monkey fetus...
  9. ncbi request reprint Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria
    E L Ewings
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 24:100-5. 2000
    ..Thus, in fetal patas monkeys given a human equivalent daily dose of AZT during the last half of pregnancy, mitochondria in the fetal cerebrum appear to sustain moderate damage, while the fetal cerebellum mitochondria were not effected...
  10. ncbi request reprint Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys
    O A Olivero
    Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892 4255, USA
    J Natl Cancer Inst 89:1602-8. 1997
    ..In this study, we assessed the transplacental tumorigenic and genotoxic effects of AZT in the offspring of CD-1 mice and Erythrocebus patas monkeys given AZT orally during pregnancy...
  11. ncbi request reprint Transplacental cisplatin exposure induces persistent fetal mitochondrial and genomic DNA damage in patas monkeys
    A J Giurgiovich
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Reprod Toxicol 11:95-100. 1997
    ..The study demonstrates significant fetal genotoxicity in g-DNA and mt-DNA of patas monkeys exposed to cisplatin in utero, suggesting that similarly exposed human fetuses may also sustain drug-induced DNA damage...
  12. ncbi request reprint DNA adducts in human and patas monkey maternal and fetal tissues induced by platinum drug chemotherapy
    H Shamkhani
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892
    Reprod Toxicol 8:207-16. 1994
    ..Thus, cisplatin does cross the placenta in the patas monkey. These observations imply that the human fetus, for which the total maternal dose was approximately 5.4 mg platinum drug/kg body weight, may also have sustained some DNA damage...
  13. ncbi request reprint Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 4255, USA
    Ann N Y Acad Sci 918:269-81. 2000
    ..It is therefore possible that the placenta, which is a readily accessible tissue, might be an indicator of potential mitochondrial toxicity in human pregnancies involving nucleoside analog drug exposure...
  14. ncbi request reprint 3'-azido-3'-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZT
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Mutat Res 428:41-7. 1999
    ....
  15. ncbi request reprint Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice
    B A Diwan
    Division of Basic Sciences, SAIC Frederick, Inc, Frederick, Maryland, 21702 1201, USA
    Toxicol Appl Pharmacol 161:82-99. 1999
    ..The results confirm that AZT is a moderately effective perinatal carcinogen in mice, targeting several tissue types...
  16. ncbi request reprint Preferential formation and decreased removal of cisplatin-DNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNA
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA
    Mutat Res 391:79-86. 1997
    ..The final results demonstrated that both, higher initial binding and lack of removal of cisplatin-DNA adducts appear to contribute to the preferential cisplatin-mtDNA binding observed in CHO cells...
  17. ncbi request reprint Chromosome site-specific immunohistochemical detection of DNA adducts in N-acetoxy-2-acetylaminofluorene--exposed Chinese hamster ovary cells
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892
    Mol Carcinog 3:37-43. 1990
    ..Thus, the stage of cell cycle in which adducts are induced is an important factor in the specific location of the highest concentrations of this type of DNA lesion...
  18. ncbi request reprint Chronic stavudine exposure induces hepatic mitochondrial toxicity in adult Erythrocebus patas monkeys
    M Gerschenson
    Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    J Hum Virol 4:335-42. 2001
    ....
  19. ncbi request reprint Cisplatin-DNA adduct determination in the hepatic albumin gene as compared to whole genomic DNA
    Z Zhang
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Chem Res Toxicol 10:971-7. 1997
    ..85 kb fragment. The data demonstrate that this 1.85 kb region containing expressed regions of the albumin gene has undergone both less adduction and more rapid adduct removal, as compared to the MH1C1 genome as a whole...
  20. ncbi request reprint Plasma drug levels compared with DNA incorporation of 3'-azido-3'-deoxythymidine (AZT) in adult cynomolgus (Macaca fascicularis) monkeys
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
    Exp Biol Med (Maywood) 226:446-9. 2001
    ..In addition, AZT-DNA levels in monkey organs were similar to or lower than values observed in peripheral leukocytes of adult AIDS patients...
  21. ncbi request reprint Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifen
    R L Divi
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Carcinogenesis 22:1693-9. 2001
    ..In addition, unlike the normal surrounding liver, preneoplastic GST-p-positive foci have virtually no TAM-DNA adducts...
  22. pmc Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity
    A Dutra
    Cytogenetics and Microscopy Core, National Human Genome Research Institute, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Cytogenet Genome Res 128:105-10. 2010
    ..It has been hypothesized that NBs occur as a result of expulsion of amplified DNA from the main nucleus; however, this data demonstrates that NBs may contain any chromosome, suggesting that NBs do not consist of just amplified DNA...
  23. ncbi request reprint Biomonitoring of United States Army soldiers serving in Kuwait in 1991
    M C Poirier
    Carcinogen DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    Cancer Epidemiol Biomarkers Prev 7:545-51. 1998
    ..Overall, the data suggest that this group of soldiers was not exposed to elevated levels of PAHs while deployed in Kuwait...
  24. pmc Human DNA adduct measurements: state of the art
    M C Poirier
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892, USA
    Environ Health Perspect 104:883-93. 1996
    ..The studies presented here may serve as useful prototypes for exploration of other toxicological end points...
  25. pmc DNA adducts as exposure biomarkers and indicators of cancer risk
    M C Poirier
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Environ Health Perspect 105:907-12. 1997
    ....
  26. ncbi request reprint Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, China
    M J Roth
    The Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Cancer Lett 156:73-81. 2000
    ..These results are consistent with the notion that exposure to environmental carcinogens that are detoxified by GSTM1, such as polycyclic aromatic hydrocarbons, may contribute to the etiology of esophageal cancer in Linxian...
  27. ncbi request reprint Localization of DNA adducts induced by N-acetoxy-N-2-acetylaminofluorene in Chinese hamster ovary cells using electron microscopy and colloidal gold
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892
    Genes Chromosomes Cancer 2:130-6. 1990
    ..15-26 in the surrounding cytoplasm. Treated cells incubated with normal rabbit serum or specific adduct-absorbed serum showed 19-34 particles for all cellular compartments...
  28. ncbi request reprint Aromatic amine DNA adduct formation in chronically-exposed mice: considerations for human comparison
    M C Poirier
    National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Mutat Res 376:177-84. 1997
    ....
  29. ncbi request reprint Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetuses
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
    Reprod Toxicol 15:525-31. 2001
    ..Therefore, cisplatin-induced mitochondrial toxicity in maternal rat kidney is severe, while damage to mitochondria in fetal kidney and liver, occurring as a result of the transplacental drug exposure, appears to be mild...
  30. ncbi request reprint Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC
    Patricia A Escobar
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Environ Mol Mutagen 48:330-43. 2007
    ..Overall, the mutagenic effects found in mother-child pairs receiving AZT-based treatments justify their surveillance for long-term genotoxic consequences...
  31. ncbi request reprint Special issue on health risks of perinatal exposure to nucleoside reverse transcriptase inhibitors
    Vernon E Walker
    Lovelace Respiratory Research Institute, 2425 Ridgecrost Drive SE, Albuquerque, NM 87108, USA
    Environ Mol Mutagen 48:159-65. 2007
  32. ncbi request reprint Plasma and cellular markers of 3'-azido-3'-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs
    Quanxin Meng
    Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Environ Mol Mutagen 48:307-21. 2007
    ..While these data support the continued use of AZT-based therapies during pregnancy, infants receiving prepartum AZT should be monitored long-term for adverse health effects...
  33. ncbi request reprint Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Division of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 28:1426-9. 2007
    ..8 (95% CI, 1.2-6.5; P(trend) = 0.048) for risk of colorectal adenoma. These data support a link between PAH exposure and colorectal adenoma...
  34. ncbi request reprint Cisplatin-DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatin
    Hilde E van Gijssel
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, CCR, National Cancer Institute, National Institutes of Health, Building 37 Room 4032, Bethesda, MD 20892 4255, USA
    Mutagenesis 22:49-54. 2007
    ....
  35. ncbi request reprint Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine
    Rao L Divi
    Carcinogen DNA Interactions Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Environ Mol Mutagen 48:179-89. 2007
    ....
  36. ncbi request reprint Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations
    Salina M Torres
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Environ Mol Mutagen 48:224-38. 2007
    ..These results suggest that the mutagenicity by these nucleoside analogs is driven by cumulative dose, and raises the question of whether AZT-3TC has greater mutagenic effects than AZT alone in perinatally exposed children...
  37. ncbi request reprint Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of age
    Rao L Divi
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892 4255, USA
    Toxicol Sci 99:203-13. 2007
    ....
  38. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry study
    M Margaret Pratt
    Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Mutat Res 624:114-23. 2007
    ..Therefore, PAH-DNA adduct formation as measured by this methodology did not appear related to the increased risk of cervical precancer and cancer among carcinogenic HPV-infected smokers...
  39. ncbi request reprint Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis
    Rao L Divi
    Carcinogen DNA Interactions Section, LCBG, CCR, National Cancer Institute, Bldg 37 Rm 4032 NIH, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Toxicol Appl Pharmacol 226:206-11. 2008
    ..This study shows similar metabolism and pharmacokinetics for oral administration of AZT/3TC in the adult patas monkey, other primate species and humans. The data validate the use of the patas monkey for studies of NRTI toxicity...
  40. pmc Human inter-individual variability in metabolism and genotoxic response to zidovudine
    Ofelia A Olivero
    Carcinogen DNA Interactions Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Toxicol Appl Pharmacol 228:158-64. 2008
    ..These data suggest that variability in AZT-DNA incorporation may be modulated by inter-individual differences in the rate of induction of TK1 in response to AZT exposure...
  41. pmc The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo
    Lauren A Courter
    Department of Environmental and Molecular Toxicology, Oregon State University, Agricultural and Life Sciences 1007, Corvallis, OR 97331, USA
    Cancer Lett 265:135-47. 2008
    ..Therefore we validate microarray data as a source to uncover transcriptional signatures that may provide insights into molecular pathways affected following exposure to environmental complex mixtures such as diesel exhaust particulates...
  42. ncbi request reprint Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity
    Rao L Divi
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Environ Mol Mutagen 48:201-9. 2007
    ..The study demonstrates that transplacental NRTI exposures induce similar mitochondrial damage in cord blood and umbilical cords taken from retroviral-uninfected monkey infants and from human infants born to HIV-1-infected women...
  43. ncbi request reprint Transcriptional signatures of normal human mammary epithelial cells in response to benzo[a]pyrene exposure: a comparison of three microarray platforms
    Maureen R Gwinn
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    OMICS 9:334-50. 2005
    ..Also, microarray variability needs to be taken into consideration, not only in the data analysis but also in specific probe selection for each array type...
  44. ncbi request reprint Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology
    Brinda Mahadevan
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
    Mol Carcinog 45:118-25. 2006
    ..Overall the data suggest the utility of antisense technology in the redirection of TAM metabolism thereby lowering TAM genotoxicity in rat liver...
  45. ncbi request reprint Semiquantitation of polycyclic aromatic hydrocarbon-DNA adducts in human esophagus by immunohistochemistry and the automated cellular imaging system
    Hilde E van Gijssel
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1622-9. 2002
    ..These results appear to support the hypothesis that high PAH exposure levels may be etiologically associated with the development of esophageal cancer in Linxian...
  46. ncbi request reprint Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring
    Rao L Divi
    National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Carcinogenesis 23:2043-9. 2002
    ..95). Coded duplicate DNA samples from 15 individuals were assayed four times gave an inter-assay CV of 13.8%...
  47. ncbi request reprint Identification of tamoxifen-DNA adducts in monkeys treated with tamoxifen
    Shinya Shibutani
    Laboratory of Chemical Biology, Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    Cancer Res 63:4402-6. 2003
    ..No TAM-DNA adducts were detected in the kidneys or in any tissues obtained from the unexposed monkey. Our results suggest that women receiving TAM may form genotoxic damage in many organs, including the reproductive organs...
  48. ncbi request reprint Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 days
    Laura J Schild
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    Cancer Res 63:5999-6003. 2003
    ..2-0.4 adducts/10(8) nucleotides). This study indicates that cynomolgus monkeys are capable of metabolizing TAM to genotoxic intermediates that form TAM-DNA adducts in multiple tissues...
  49. ncbi request reprint Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine
    Mariana Gerschenson
    Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    AIDS Res Hum Retroviruses 20:91-100. 2004
    ..Overall, the data indicate that significant mitochondrial damage was observed at birth in monkey fetuses exposed in utero to AZT plus 3TC in a human-equivalent dosing protocol...
  50. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts determined by semiquantitative immunohistochemistry in human esophageal biopsies taken in 1985
    Hilde E van Gijssel
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NIH, 37 Convent Dr, MSC 4255, Bethesda, MD 20892 4255, USA
    Mutat Res 547:55-62. 2004
    ....
  51. ncbi request reprint Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir
    Rao L Divi
    CDI Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    AIDS 18:1013-21. 2004
    ..In this pilot study we examined mitochondrial integrity in HIV-1-uninfected infants born to HIV-1-infected women receiving Combivir during pregnancy...
  52. ncbi request reprint Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in utero to 3'-azido-3'-deoxythymidine
    Dale M Walker
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Cardiovasc Toxicol 4:133-53. 2004
    ....
  53. ncbi request reprint Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods
    Laura J Schild
    Carcinogen DNA Interactions Section, National Cancer Institute, Building 37, Room 4032 NIH, 37 Convent Drive MSC 4255, Bethesda, MD 20892 4255, USA
    Mutagenesis 20:115-24. 2005
    ..The study demonstrated a remarkably good agreement for TAM-DNA adduct measurements among the diverse methods employed...
  54. ncbi request reprint Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells
    Ofelia A Olivero
    Carcinogen DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Mutagenesis 20:139-46. 2005
    ..Overall, the study demonstrates that AZT, but not 3TC, causes an arrest of cells in S phase with a consistent alteration in the expression of several cell cycle genes...
  55. ncbi request reprint Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene
    Channa Keshava
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Cancer Lett 221:213-24. 2005
    ..Overall the data suggest that BPDE-DNA adduct levels in normal human breast tissue may be modulated by multiple factors that include, but are not exclusive to, CYP1A1 and CYP1B1 inducibility and the presence or absence of GSTM1...
  56. ncbi request reprint Cardiac mitochondrial compromise in 1-yr-old Erythrocebus patas monkeys perinatally-exposed to nucleoside reverse transcriptase inhibitors
    Rao L Divi
    Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Cardiovasc Toxicol 5:333-46. 2005
    ....
  57. ncbi request reprint Transplacental genotoxicity of combined antiretroviral nucleoside analogue therapy in Erythrocebus patas monkeys
    Ofelia A Olivero
    Carcinogen DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Acquir Immune Defic Syndr 29:323-9. 2002
    ..Overall, these studies demonstrate that monkey fetuses exposed in utero to the combination ZDV plus 3TC sustain a higher level of drug-DNA incorporation and show evidence of more telomere damage than monkey fetuses exposed to ZDV alone...
  58. ncbi request reprint DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and non-smoking lung cancer patients: correlations between tissues and detection by 32P-postlabelling and immunoassay
    Erika Gyorffy
    National Institute of Environmental Health, Jozsef Fodor National Center for Public Health, Budapest, H 1097 Hungary
    Carcinogenesis 25:1201-9. 2004
    ..27, P = 0.054). However, with normal lung DNA samples, values obtained by the two assays did not correlate...
  59. ncbi request reprint High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts
    Frederick A Beland
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 18:1306-15. 2005
    ..The results further suggest that dG-BPDE may contribute only a small fraction of the total DNA adducts detected by other DNA adduct methodologies in individuals exposed to PAHs...