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| M C PoirierSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Chemical-induced DNA damage and human cancer riskMiriam C Poirier
Carcinogen DNA Interactions Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Discov Med 14:283-8. 2012..Taken together the data suggest that a reduction in human DNA adduct level is likely to produce a reduction in human cancer risk...- Carcinogen macromolecular adducts and their measurementM C Poirier
Carcinogen DNA Interactions Section, LCCTP, Division of Basic Sciences, NCI, NIH, Building 37, Room 2A05, 37 Convent Drive, MSC 4255, Bethesda, MD 20892, USA
Carcinogenesis 21:353-9. 2000.... - The genotoxicity of tamoxifen: extent and consequences, Kona, Hawaii, January 23, 2003Miriam C Poirier
Center for Cancer Research, National Cancer Institute, 37 Convent Drive MSC 4255, National Institutes of Health, Bethesda, MD 20892 4255, USA
Mutagenesis 18:395-9. 2003.... - Chemical-induced DNA damage and human cancer riskMiriam C Poirier
Carcinogen-DNA Interactions Section, LCCTP, Building 37 Room 4032, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC-4255, Bethesda, Maryland 20892-4255, USA
Nat Rev Cancer 4:630-7. 2004 - Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothersMiriam C Poirier
Carcinogen DNA Interactions Section, National Cancer Institute, National Institutes of Health, Building 37, Room 4032, 37 Convent Drive, Bethesda, MD 20892 4255, USA
J Acquir Immune Defic Syndr 33:175-83. 2003..The study shows that children of HIV+ mothers are at risk for mitochondrial damage that is further increased in infants of mothers receiving AZT during pregnancy... - Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugsMiriam C Poirier
Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
Toxicol Appl Pharmacol 199:151-61. 2004.... - Incorporation of 3'-azido-3'-deoxythymidine (AZT) into fetal DNA and fetal tissue distribution of drug after infusion of pregnant late-term rhesus macaques with a human-equivalent AZT doseM C Poirier
Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
J Acquir Immune Defic Syndr 22:477-83. 1999..Data imply that the human fetus may also be subject to incorporation of AZT into DNA even after short-term AZT infusion to the mother just before delivery... - Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidineM Gerschenson
Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
AIDS Res Hum Retroviruses 16:635-44. 2000..Furthermore, a dose-dependent depletion of mitochondrial DNA levels was observed in both tissues. The data demonstrate that transplacental AZT exposure causes cardiac and skeletal muscle mitochondrial myopathy in the patas monkey fetus... - Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondriaE L Ewings
Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
J Acquir Immune Defic Syndr 24:100-5. 2000..Thus, in fetal patas monkeys given a human equivalent daily dose of AZT during the last half of pregnancy, mitochondria in the fetal cerebrum appear to sustain moderate damage, while the fetal cerebellum mitochondria were not effected... - Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeysO A Olivero
Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892 4255, USA
J Natl Cancer Inst 89:1602-8. 1997..In this study, we assessed the transplacental tumorigenic and genotoxic effects of AZT in the offspring of CD-1 mice and Erythrocebus patas monkeys given AZT orally during pregnancy... - Transplacental cisplatin exposure induces persistent fetal mitochondrial and genomic DNA damage in patas monkeysA J Giurgiovich
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
Reprod Toxicol 11:95-100. 1997..The study demonstrates significant fetal genotoxicity in g-DNA and mt-DNA of patas monkeys exposed to cisplatin in utero, suggesting that similarly exposed human fetuses may also sustain drug-induced DNA damage... - DNA adducts in human and patas monkey maternal and fetal tissues induced by platinum drug chemotherapyH Shamkhani
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892
Reprod Toxicol 8:207-16. 1994..Thus, cisplatin does cross the placenta in the patas monkey. These observations imply that the human fetus, for which the total maternal dose was approximately 5.4 mg platinum drug/kg body weight, may also have sustained some DNA damage... - Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposureM Gerschenson
Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 4255, USA
Ann N Y Acad Sci 918:269-81. 2000..It is therefore possible that the placenta, which is a readily accessible tissue, might be an indicator of potential mitochondrial toxicity in human pregnancies involving nucleoside analog drug exposure... - 3'-azido-3'-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZTO A Olivero
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
Mutat Res 428:41-7. 1999.... - Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in miceB A Diwan
Division of Basic Sciences, SAIC Frederick, Inc, Frederick, Maryland, 21702 1201, USA
Toxicol Appl Pharmacol 161:82-99. 1999..The results confirm that AZT is a moderately effective perinatal carcinogen in mice, targeting several tissue types... - Preferential formation and decreased removal of cisplatin-DNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNAO A Olivero
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA
Mutat Res 391:79-86. 1997..The final results demonstrated that both, higher initial binding and lack of removal of cisplatin-DNA adducts appear to contribute to the preferential cisplatin-mtDNA binding observed in CHO cells... - Chromosome site-specific immunohistochemical detection of DNA adducts in N-acetoxy-2-acetylaminofluorene--exposed Chinese hamster ovary cellsO A Olivero
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892
Mol Carcinog 3:37-43. 1990..Thus, the stage of cell cycle in which adducts are induced is an important factor in the specific location of the highest concentrations of this type of DNA lesion... - Chronic stavudine exposure induces hepatic mitochondrial toxicity in adult Erythrocebus patas monkeysM Gerschenson
Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
J Hum Virol 4:335-42. 2001.... - Cisplatin-DNA adduct determination in the hepatic albumin gene as compared to whole genomic DNAZ Zhang
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
Chem Res Toxicol 10:971-7. 1997..85 kb fragment. The data demonstrate that this 1.85 kb region containing expressed regions of the albumin gene has undergone both less adduction and more rapid adduct removal, as compared to the MH1C1 genome as a whole... - Plasma drug levels compared with DNA incorporation of 3'-azido-3'-deoxythymidine (AZT) in adult cynomolgus (Macaca fascicularis) monkeysO A Olivero
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
Exp Biol Med (Maywood) 226:446-9. 2001..In addition, AZT-DNA levels in monkey organs were similar to or lower than values observed in peripheral leukocytes of adult AIDS patients... - Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifenR L Divi
National Cancer Institute, NIH, Bethesda, MD 20892, USA
Carcinogenesis 22:1693-9. 2001..In addition, unlike the normal surrounding liver, preneoplastic GST-p-positive foci have virtually no TAM-DNA adducts... 
Nuclear bud formation: a novel manifestation of Zidovudine genotoxicityA Dutra
Cytogenetics and Microscopy Core, National Human Genome Research Institute, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
Cytogenet Genome Res 128:105-10. 2010..It has been hypothesized that NBs occur as a result of expulsion of amplified DNA from the main nucleus; however, this data demonstrates that NBs may contain any chromosome, suggesting that NBs do not consist of just amplified DNA...- Biomonitoring of United States Army soldiers serving in Kuwait in 1991M C Poirier
Carcinogen DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
Cancer Epidemiol Biomarkers Prev 7:545-51. 1998..Overall, the data suggest that this group of soldiers was not exposed to elevated levels of PAHs while deployed in Kuwait... - Human DNA adduct measurements: state of the artM C Poirier
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892, USA
Environ Health Perspect 104:883-93. 1996..The studies presented here may serve as useful prototypes for exploration of other toxicological end points... - Aromatic amine DNA adduct formation in chronically-exposed mice: considerations for human comparisonM C Poirier
National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
Mutat Res 376:177-84. 1997.... - Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, ChinaM J Roth
The Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute NIH, Bethesda, MD 20892, USA
Cancer Lett 156:73-81. 2000..These results are consistent with the notion that exposure to environmental carcinogens that are detoxified by GSTM1, such as polycyclic aromatic hydrocarbons, may contribute to the etiology of esophageal cancer in Linxian... - Localization of DNA adducts induced by N-acetoxy-N-2-acetylaminofluorene in Chinese hamster ovary cells using electron microscopy and colloidal goldO A Olivero
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892
Genes Chromosomes Cancer 2:130-6. 1990..15-26 in the surrounding cytoplasm. Treated cells incubated with normal rabbit serum or specific adduct-absorbed serum showed 19-34 particles for all cellular compartments... - DNA adducts as exposure biomarkers and indicators of cancer riskM C Poirier
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
Environ Health Perspect 105:907-12. 1997.... - Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetusesM Gerschenson
Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
Reprod Toxicol 15:525-31. 2001..Therefore, cisplatin-induced mitochondrial toxicity in maternal rat kidney is severe, while damage to mitochondria in fetal kidney and liver, occurring as a result of the transplacental drug exposure, appears to be mild... - Special issue on health risks of perinatal exposure to nucleoside reverse transcriptase inhibitorsVernon E Walker
Lovelace Respiratory Research Institute, 2425 Ridgecrost Drive SE, Albuquerque, NM 87108, USA
Environ Mol Mutagen 48:159-65. 2007 - Plasma and cellular markers of 3'-azido-3'-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIsQuanxin Meng
Wadsworth Center, New York State Department of Health, Albany, New York, USA
Environ Mol Mutagen 48:307-21. 2007..While these data support the continued use of AZT-based therapies during pregnancy, infants receiving prepartum AZT should be monitored long-term for adverse health effects... - Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenomaMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Division of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 28:1426-9. 2007..8 (95% CI, 1.2-6.5; P(trend) = 0.048) for risk of colorectal adenoma. These data support a link between PAH exposure and colorectal adenoma... - Cisplatin-DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatinHilde E van Gijssel
Laboratory of Cellular Carcinogenesis and Tumor Promotion, CCR, National Cancer Institute, National Institutes of Health, Building 37 Room 4032, Bethesda, MD 20892 4255, USA
Mutagenesis 22:49-54. 2007.... - Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to ZidovudineRao L Divi
Carcinogen DNA Interactions Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Environ Mol Mutagen 48:179-89. 2007.... - Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicityRao L Divi
Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
Environ Mol Mutagen 48:201-9. 2007..The study demonstrates that transplacental NRTI exposures induce similar mitochondrial damage in cord blood and umbilical cords taken from retroviral-uninfected monkey infants and from human infants born to HIV-1-infected women... - Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TCPatricia A Escobar
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Environ Mol Mutagen 48:330-43. 2007..Overall, the mutagenic effects found in mother-child pairs receiving AZT-based treatments justify their surveillance for long-term genotoxic consequences... - Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinationsSalina M Torres
Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
Environ Mol Mutagen 48:224-38. 2007..These results suggest that the mutagenicity by these nucleoside analogs is driven by cumulative dose, and raises the question of whether AZT-3TC has greater mutagenic effects than AZT alone in perinatally exposed children... - Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of ageRao L Divi
Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892 4255, USA
Toxicol Sci 99:203-13. 2007.... - Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry studyM Margaret Pratt
Carcinogen DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
Mutat Res 624:114-23. 2007..Therefore, PAH-DNA adduct formation as measured by this methodology did not appear related to the increased risk of cervical precancer and cancer among carcinogenic HPV-infected smokers... - Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysisRao L Divi
Carcinogen DNA Interactions Section, LCBG, CCR, National Cancer Institute, Bldg 37 Rm 4032 NIH, 37 Convent Drive, Bethesda, MD 20892 4255, USA
Toxicol Appl Pharmacol 226:206-11. 2008..This study shows similar metabolism and pharmacokinetics for oral administration of AZT/3TC in the adult patas monkey, other primate species and humans. The data validate the use of the patas monkey for studies of NRTI toxicity... - Human inter-individual variability in metabolism and genotoxic response to zidovudineOfelia A Olivero
Carcinogen DNA Interactions Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892 4255, USA
Toxicol Appl Pharmacol 228:158-64. 2008..These data suggest that variability in AZT-DNA incorporation may be modulated by inter-individual differences in the rate of induction of TK1 in response to AZT exposure... - The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivoLauren A Courter
Department of Environmental and Molecular Toxicology, Oregon State University, Agricultural and Life Sciences 1007, Corvallis, OR 97331, USA
Cancer Lett 265:135-47. 2008..Therefore we validate microarray data as a source to uncover transcriptional signatures that may provide insights into molecular pathways affected following exposure to environmental complex mixtures such as diesel exhaust particulates... - Transcriptional signatures of normal human mammary epithelial cells in response to benzo[a]pyrene exposure: a comparison of three microarray platformsMaureen R Gwinn
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
OMICS 9:334-50. 2005..Also, microarray variability needs to be taken into consideration, not only in the data analysis but also in specific probe selection for each array type... - Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technologyBrinda Mahadevan
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
Mol Carcinog 45:118-25. 2006..Overall the data suggest the utility of antisense technology in the redirection of TAM metabolism thereby lowering TAM genotoxicity in rat liver... - Semiquantitation of polycyclic aromatic hydrocarbon-DNA adducts in human esophagus by immunohistochemistry and the automated cellular imaging systemHilde E van Gijssel
Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 11:1622-9. 2002..These results appear to support the hypothesis that high PAH exposure levels may be etiologically associated with the development of esophageal cancer in Linxian... - Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoringRao L Divi
National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
Carcinogenesis 23:2043-9. 2002..95). Coded duplicate DNA samples from 15 individuals were assayed four times gave an inter-assay CV of 13.8%... - Identification of tamoxifen-DNA adducts in monkeys treated with tamoxifenShinya Shibutani
Laboratory of Chemical Biology, Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
Cancer Res 63:4402-6. 2003..No TAM-DNA adducts were detected in the kidneys or in any tissues obtained from the unexposed monkey. Our results suggest that women receiving TAM may form genotoxic damage in many organs, including the reproductive organs... - Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 daysLaura J Schild
Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA
Cancer Res 63:5999-6003. 2003..2-0.4 adducts/10(8) nucleotides). This study indicates that cynomolgus monkeys are capable of metabolizing TAM to genotoxic intermediates that form TAM-DNA adducts in multiple tissues... - Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudineMariana Gerschenson
Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, USA
AIDS Res Hum Retroviruses 20:91-100. 2004..Overall, the data indicate that significant mitochondrial damage was observed at birth in monkey fetuses exposed in utero to AZT plus 3TC in a human-equivalent dosing protocol... - Polycyclic aromatic hydrocarbon-DNA adducts determined by semiquantitative immunohistochemistry in human esophageal biopsies taken in 1985Hilde E van Gijssel
Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NIH, 37 Convent Dr, MSC-4255, Bethesda, MD 20892-4255, USA
Mutat Res 547:55-62. 2004.... - Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to CombivirRao L Divi
CDI Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
AIDS 18:1013-21. 2004..006) and cord blood (P = 0.003) from drug-exposed infants. CONCLUSIONS: A cohort of HIV-1-uninfected Combivir-exposed infants with no clinical symptoms showed morphological and molecular evidence of mitochondrial damage... - Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in utero to 3'-azido-3'-deoxythymidineDale M Walker
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Cardiovasc Toxicol 4:133-53. 2004.... - Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methodsLaura J Schild
Carcinogen-DNA Interactions Section, National Cancer Institute, Building 37, Room 4032 NIH, 37 Convent Drive MSC-4255, Bethesda, MD 20892-4255, USA
Mutagenesis 20:115-24. 2005..The study demonstrated a remarkably good agreement for TAM-DNA adduct measurements among the diverse methods employed... - Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cellsOfelia A Olivero
Carcinogen DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
Mutagenesis 20:139-46. 2005..Overall, the study demonstrates that AZT, but not 3TC, causes an arrest of cells in S phase with a consistent alteration in the expression of several cell cycle genes... - Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyreneChanna Keshava
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
Cancer Lett 221:213-24. 2005..Overall the data suggest that BPDE-DNA adduct levels in normal human breast tissue may be modulated by multiple factors that include, but are not exclusive to, CYP1A1 and CYP1B1 inducibility and the presence or absence of GSTM1... - Cardiac mitochondrial compromise in 1-yr-old Erythrocebus patas monkeys perinatally-exposed to nucleoside reverse transcriptase inhibitorsRao L Divi
Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, MD 20892 4255, USA
Cardiovasc Toxicol 5:333-46. 2005.... - Transplacental genotoxicity of combined antiretroviral nucleoside analogue therapy in Erythrocebus patas monkeysOfelia A Olivero
Carcinogen DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Acquir Immune Defic Syndr 29:323-9. 2002..Overall, these studies demonstrate that monkey fetuses exposed in utero to the combination ZDV plus 3TC sustain a higher level of drug-DNA incorporation and show evidence of more telomere damage than monkey fetuses exposed to ZDV alone... - DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and non-smoking lung cancer patients: correlations between tissues and detection by 32P-postlabelling and immunoassayErika Gyorffy
National Institute of Environmental Health, Jozsef Fodor National Center for Public Health, Budapest, H-1097 Hungary
Carcinogenesis 25:1201-9. 2004..27, P = 0.054). However, with normal lung DNA samples, values obtained by the two assays did not correlate... - High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adductsFrederick A Beland
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Chem Res Toxicol 18:1306-15. 2005..The results further suggest that dG-BPDE may contribute only a small fraction of the total DNA adducts detected by other DNA adduct methodologies in individuals exposed to PAHs...