A G Pletnev

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4
    A G Pletnev
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:1746-51. 1998
  2. ncbi Chimeric Langat/Dengue viruses protect mice from heterologous challenge with the highly virulent strains of tick-borne encephalitis virus
    A G Pletnev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 274:26-31. 2000
  3. ncbi Infectious cDNA clone of attenuated Langat tick-borne flavivirus (strain E5) and a 3' deletion mutant constructed from it exhibit decreased neuroinvasiveness in immunodeficient mice
    A G Pletnev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Virology 282:288-300. 2001
  4. ncbi Tick-borne Langat/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: evaluation in rhesus monkeys and in mosquitoes
    A G Pletnev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 75:8259-67. 2001
  5. ncbi Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice
    A G Pletnev
    Molecular Viral Biology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:4956-63. 1993
  6. ncbi Infection with Langat Flavivirus or expression of the envelope protein induces apoptotic cell death
    G G Prikhod'ko
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 286:328-35. 2001
  7. ncbi Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence
    M S Campbell
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Virology 269:225-37. 2000

Collaborators

Detail Information

Publications7

  1. ncbi Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4
    A G Pletnev
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:1746-51. 1998
    ..p. challenge with LGT TP21. The implications of these observations for development of a live attenuated TBEV vaccine are discussed...
  2. ncbi Chimeric Langat/Dengue viruses protect mice from heterologous challenge with the highly virulent strains of tick-borne encephalitis virus
    A G Pletnev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 274:26-31. 2000
    ..The adapted chimeras remained completely attenuated for SCID mice and, significantly, provided protection in immunocompetent mice against tick-borne encephalitis virus, the most virulent of the tick-borne flaviviruses...
  3. ncbi Infectious cDNA clone of attenuated Langat tick-borne flavivirus (strain E5) and a 3' deletion mutant constructed from it exhibit decreased neuroinvasiveness in immunodeficient mice
    A G Pletnev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Virology 282:288-300. 2001
    ....
  4. ncbi Tick-borne Langat/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: evaluation in rhesus monkeys and in mosquitoes
    A G Pletnev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 75:8259-67. 2001
    ....
  5. ncbi Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice
    A G Pletnev
    Molecular Viral Biology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:4956-63. 1993
    ..Following parenteral inoculation, these attenuated mutants induced complete resistance in mice to fatal encephalitis caused by the highly neurovirulent vME...
  6. ncbi Infection with Langat Flavivirus or expression of the envelope protein induces apoptotic cell death
    G G Prikhod'ko
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 286:328-35. 2001
    ..These observations indicate that infection of cells with LGT virus or expression of LGT virus E protein induces apoptosis through a caspase-3-like protease pathway...
  7. ncbi Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence
    M S Campbell
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Virology 269:225-37. 2000
    ..Manipulation of these clones should facilitate elucidation of LGT virulence...