Research Topics
| Paul F PinskySummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Applying the National Lung Screening Trial eligibility criteria to the US population: what percent of the population and of incident lung cancers would be covered?Paul F Pinsky
6130 Executive Blvd, EPN 3064, Bethesda, MD, 20892, USA
J Med Screen 19:154-6. 2012....
Reported family history of cancer in the prostate, lung, colorectal, and ovarian cancer screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
Am J Epidemiol 157:792-9. 2003..7. Liver, bone, stomach, and brain cancer had greater-than-average reported:expected ratios, while lymphoma, bladder cancer, melanoma, and testicular cancer had lower-than-average ratios...- Predictors of advanced proximal neoplasia in persons with abnormal screening flexible sigmoidoscopyPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7346, USA
Clin Gastroenterol Hepatol 1:103-10. 2003..The relationship between distal and proximal colonic findings is uncertain. Thus, there is no consensus on which findings on screening flexible sigmoidoscopy should trigger colonoscopy... - An early- and late-stage convolution model for disease natural historyPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, Maryland 20892, USA
Biometrics 60:191-8. 2004..As an example, we fit the model to data from the Mayo Lung Cancer Screening trial... - Assessing contamination and compliance in the prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening TrialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Clin Trials 7:303-11. 2010..An issue of concern was the substantial level of 'contamination', or use of PSA and DRE in control arm men... - Prostate biopsy following a positive screen in the prostate, lung, colorectal and ovarian cancer screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Urol 173:746-50; discussion 750-1. 2005..Followup of positive screens in PLCO is done by subject personal physicians and it is outside of trial control. We describe the pattern of prostate biopsy in men with positive screens in PLCO... - Variability in flexible sigmoidoscopy performance among examiners in a screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Clin Gastroenterol Hepatol 3:792-7. 2005..In 2 European trials, wide variability across examiners in FSG performance was noted. We report on the performance of examiners in the US randomized trial: the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial... - Prostate-specific antigen velocity and prostate cancer gleason grade and stagePaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer 109:1689-95. 2007..The authors evaluated the relation between PSAV, biopsy Gleason score, and pathologic stage in men who were enrolled in a prostate cancer screening trial... - Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancerJohn K Gohagan
Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, MD 20892, USA
Lung Cancer 47:9-15. 2005..A total of 16 stage III-IV cancers were observed in the LDCT arm versus nine in the CXR arm. The LSS has established the feasibility of a RCT comparing annual spiral CT to chest X-ray for lung cancer screening... 
Utilization and yield of surveillance colonoscopy in the continued follow-up study of the polyp prevention trialAdeyinka O Laiyemo
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA
Clin Gastroenterol Hepatol 7:562-7; quiz 497. 2009..We examined the use and yield of surveillance colonoscopy among participants in the Polyp Prevention Trial (PPT) after the 4-year dietary intervention trial ended...- The yield of surveillance colonoscopy by adenoma history and time to examinationPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA
Clin Gastroenterol Hepatol 7:86-92. 2009..Surveillance colonoscopy is recommended for subjects with a history of adenomas but there is limited information on the yield of surveillance... - Enrollment of racial and ethnic minorities in the Prostate, Lung, Colorectal and Ovarian Cancer Screening TrialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Med Assoc 100:291-8. 2008..Here, we report the experience of enrolling ethnic minorities in a large cancer screening trial... - Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
BJU Int 99:775-9. 2007..To determine patterns of repeat prostate biopsy in a cohort of men undergoing prostate cancer screening who have a negative initial biopsy... - Abnormalities on chest radiograph reported in subjects in a cancer screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Chest 130:688-93. 2006..There is little literature either on the prevalence in the general population of various abnormalities seen on CXRs or on the risks associated with these abnormalities... - Lung cancer risk following detection of pulmonary scarring by chest radiography in the prostate, lung, colorectal, and ovarian cancer screening trialYing Ying Yu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076, Rockville, MD 20892, USA
Arch Intern Med 168:2326-32; discussion 2332. 2008..However, the nature of the relationship between pulmonary scarring and lung cancer remains uncertain. Our objective was to test whether localized pulmonary scarring is associated with increased lung cancer risk... - Factors associated with inadequate colorectal cancer screening with flexible sigmoidoscopyAdeyinka O Laiyemo
Division of Gastroenterology, Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA
Cancer Epidemiol 36:395-9. 2012.... - Prostate volume and prostate-specific antigen levels in men enrolled in a large screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethedsa, Maryland, USA
Urology 68:352-6. 2006..Here we examine the relationship between prostate volume and PSA level in a large, geographically diverse sample of men undergoing prostate cancer screening... - Diagnostic procedures after a positive spiral computed tomography lung carcinoma screenPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Cancer 103:157-63. 2005.... - Projecting prostate cancer mortality in the PCPT and REDUCE chemoprevention trialsPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland
Cancer 119:593-601. 2013..Cancer 2013. © 2012 American Cancer Society... - Prostate cancer specific survival in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening TrialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
Cancer Epidemiol 36:e401-6. 2012..The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized screening trial demonstrated no mortality effect of screening. Here we analyze prostate cancer specific survival in PLCO and its relation to screening... - Meat, meat cooking methods and preservation, and risk for colorectal adenomaRashmi Sinha
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 65:8034-41. 2005..04; 95% CI, 0.90-1.19). Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma... - Racial and ethnic differences in lung cancer incidence: how much is explained by differences in smoking patterns? (United States)Paul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
Cancer Causes Control 17:1017-24. 2006..Lung cancer rates vary considerably among U.S. racial/ethnic groups. We quantitatively analyzed the extent to which these differences can be attributed to differential patterns of smoking... - Potential effect of the risk of ovarian cancer algorithm (ROCA) on the mortality outcome of the Prostate, Lung, Colorectal and Ovarian (PLCO) trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD
Int J Cancer 132:2127-33. 2013..95 (95% CI: 0.74-1.23), respectively. Having utilized ROCA in PLCO would not have led to a significant mortality benefit of screening. However, ROCA could still show a significant effect in other screening trials, including UKCTOCS... - Enriched designs for assessing discriminatory performance--analysis of bias and variancePaul F Pinsky
Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiologic Health, Food and Drug Administration, Silver Spring, MD, USA
Stat Med 31:501-15. 2012..These principles are illustrated with a simulation study motivated by the Digital Mammographic Imaging Screening Trial study, a trial of digital versus screen film mammography... - A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancerClaire S Zhu
Division of Cancer Prevention, National Cancer Institute, National Institute of Health, Bethesda, MD 20892 7346, USA
Cancer Prev Res (Phila) 4:375-83. 2011..Thus, biomarker panels discovered in diagnostic samples may not validate in prediagnostic samples; utilizing prediagnostic samples for discovery may be helpful in developing validated early detection panels... - Building multi-marker algorithms for disease prediction-the role of correlations among markersPaul F Pinsky
Early Detection Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852, USA
Biomark Insights 6:83-93. 2011..Thus, univariate analyses alone may not be the best approach in choosing which markers to combine in a predictive panel of markers; patterns of statistical correlation should be considered in ranking top-performing biomarkers... - One year recurrence of aberrant crypt fociPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
Cancer Prev Res (Phila) 3:839-43. 2010..After removal of ACF at baseline, ACF counts 1 year later were only slightly reduced and were significantly correlated with the baseline ACF count. The results of this study do not support a role for ACF in clinical practice... - Prostate specific antigen changes as related to the initial prostate specific antigen: data from the prostate, lung, colorectal and ovarian cancer screening trialE David Crawford
Department of Urologic Oncology, University of Colorado Health Sciences Center, Denver, Colorado, Washington, DC, USA
J Urol 175:1286-90; discussion 1290. 2006..A large fraction of screened men have low (less than 2 ng/ml) initial PSA. The yield over time of positive PSA screens (ie more than 4 ng/ml) in these men has not been well characterized in large cohorts in the United States... - Prostate Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trialGerald L Andriole
Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Natl Cancer Inst 97:433-8. 2005..We describe the population enrolled in the PLCO trial, their baseline PSA and DRE screening results, and diagnostic follow-up results during the first year of follow-up... - Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trialJoel L Weissfeld
University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
J Natl Cancer Inst 97:989-97. 2005..Here we report findings from the baseline screening flexible sigmoidoscopy examination... - Results of repeat sigmoidoscopy 3 years after a negative examinationRobert E Schoen
Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
JAMA 290:41-8. 2003..The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain... - Yield of advanced adenoma and cancer based on polyp size detected at screening flexible sigmoidoscopyRobert E Schoen
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvani 15213 2582, USA
Gastroenterology 131:1683-9. 2006..To examine the yield at colonoscopy when a given size lesion is observed, we assessed the yield of advanced adenoma and cancer at colonoscopy based on the size of the abnormality detected at flexible sigmoidoscopy (FSG)... - Results of a randomized controlled trail of prostate cancer screeningPaul F Pinsky
Prostate 61:371. 2004 - Claims of sex-gene interactionsPaul F Pinsky
JAMA 298:2741-2; author reply 2742. 2007