Paul F Pinsky

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Applying the National Lung Screening Trial eligibility criteria to the US population: what percent of the population and of incident lung cancers would be covered?
    Paul F Pinsky
    Detection Branch, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, Maryland, 20892, USA
    J Med Screen 19:154-6. 2012
  2. ncbi request reprint Reported family history of cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 157:792-9. 2003
  3. ncbi request reprint Predictors of advanced proximal neoplasia in persons with abnormal screening flexible sigmoidoscopy
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7346, USA
    Clin Gastroenterol Hepatol 1:103-10. 2003
  4. ncbi request reprint An early- and late-stage convolution model for disease natural history
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, Maryland 20892, USA
    Biometrics 60:191-8. 2004
  5. doi request reprint Assessing contamination and compliance in the prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Clin Trials 7:303-11. 2010
  6. ncbi request reprint Prostate biopsy following a positive screen in the prostate, lung, colorectal and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Urol 173:746-50; discussion 750-1. 2005
  7. doi request reprint The prostate, lung, colorectal, and ovarian cancer screening trial and its associated research resource
    Claire S Zhu
    Affiliations of authors Early Detection Research Group, Division of Cancer Prevention CSZ, PFP, BSK, PCP, CDB and Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute MPP, and Office of Disease Prevention, National Institutes of Health, Bethesda, MD JKG
    J Natl Cancer Inst 105:1684-93. 2013
  8. ncbi request reprint Variability in flexible sigmoidoscopy performance among examiners in a screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 3:792-7. 2005
  9. ncbi request reprint Prostate-specific antigen velocity and prostate cancer gleason grade and stage
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 109:1689-95. 2007
  10. pmc Utilization and yield of surveillance colonoscopy in the continued follow-up study of the polyp prevention trial
    Adeyinka O Laiyemo
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Gastroenterol Hepatol 7:562-7; quiz 497. 2009

Collaborators

Detail Information

Publications37

  1. doi request reprint Applying the National Lung Screening Trial eligibility criteria to the US population: what percent of the population and of incident lung cancers would be covered?
    Paul F Pinsky
    Detection Branch, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, Maryland, 20892, USA
    J Med Screen 19:154-6. 2012
    ....
  2. ncbi request reprint Reported family history of cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 157:792-9. 2003
    ..7. Liver, bone, stomach, and brain cancer had greater-than-average reported:expected ratios, while lymphoma, bladder cancer, melanoma, and testicular cancer had lower-than-average ratios...
  3. ncbi request reprint Predictors of advanced proximal neoplasia in persons with abnormal screening flexible sigmoidoscopy
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7346, USA
    Clin Gastroenterol Hepatol 1:103-10. 2003
    ..The relationship between distal and proximal colonic findings is uncertain. Thus, there is no consensus on which findings on screening flexible sigmoidoscopy should trigger colonoscopy...
  4. ncbi request reprint An early- and late-stage convolution model for disease natural history
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, Maryland 20892, USA
    Biometrics 60:191-8. 2004
    ..As an example, we fit the model to data from the Mayo Lung Cancer Screening trial...
  5. doi request reprint Assessing contamination and compliance in the prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Clin Trials 7:303-11. 2010
    ..An issue of concern was the substantial level of 'contamination', or use of PSA and DRE in control arm men...
  6. ncbi request reprint Prostate biopsy following a positive screen in the prostate, lung, colorectal and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Urol 173:746-50; discussion 750-1. 2005
    ..Followup of positive screens in PLCO is done by subject personal physicians and it is outside of trial control. We describe the pattern of prostate biopsy in men with positive screens in PLCO...
  7. doi request reprint The prostate, lung, colorectal, and ovarian cancer screening trial and its associated research resource
    Claire S Zhu
    Affiliations of authors Early Detection Research Group, Division of Cancer Prevention CSZ, PFP, BSK, PCP, CDB and Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute MPP, and Office of Disease Prevention, National Institutes of Health, Bethesda, MD JKG
    J Natl Cancer Inst 105:1684-93. 2013
    ..The overall cost of PLCO was $454 million over 20 years, adjusted to 2011 dollars, with approximately $37 million for the collection, processing, and storage of biospecimens, including blood samples, buccal cells, and pathology tissues...
  8. ncbi request reprint Variability in flexible sigmoidoscopy performance among examiners in a screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 3:792-7. 2005
    ..In 2 European trials, wide variability across examiners in FSG performance was noted. We report on the performance of examiners in the US randomized trial: the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
  9. ncbi request reprint Prostate-specific antigen velocity and prostate cancer gleason grade and stage
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 109:1689-95. 2007
    ..The authors evaluated the relation between PSAV, biopsy Gleason score, and pathologic stage in men who were enrolled in a prostate cancer screening trial...
  10. pmc Utilization and yield of surveillance colonoscopy in the continued follow-up study of the polyp prevention trial
    Adeyinka O Laiyemo
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Gastroenterol Hepatol 7:562-7; quiz 497. 2009
    ..We examined the use and yield of surveillance colonoscopy among participants in the Polyp Prevention Trial (PPT) after the 4-year dietary intervention trial ended...
  11. ncbi request reprint Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer
    John K Gohagan
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, MD 20892, USA
    Lung Cancer 47:9-15. 2005
    ..A total of 16 stage III-IV cancers were observed in the LDCT arm versus nine in the CXR arm. The LSS has established the feasibility of a RCT comparing annual spiral CT to chest X-ray for lung cancer screening...
  12. pmc Prostate cancer specific survival in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
    Cancer Epidemiol 36:e401-6. 2012
    ..The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized screening trial demonstrated no mortality effect of screening. Here we analyze prostate cancer specific survival in PLCO and its relation to screening...
  13. ncbi request reprint Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    BJU Int 99:775-9. 2007
    ..To determine patterns of repeat prostate biopsy in a cohort of men undergoing prostate cancer screening who have a negative initial biopsy...
  14. doi request reprint The yield of surveillance colonoscopy by adenoma history and time to examination
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 7:86-92. 2009
    ..Surveillance colonoscopy is recommended for subjects with a history of adenomas but there is limited information on the yield of surveillance...
  15. ncbi request reprint Enrollment of racial and ethnic minorities in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Med Assoc 100:291-8. 2008
    ..Here, we report the experience of enrolling ethnic minorities in a large cancer screening trial...
  16. doi request reprint Potential effect of the risk of ovarian cancer algorithm (ROCA) on the mortality outcome of the Prostate, Lung, Colorectal and Ovarian (PLCO) trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 132:2127-33. 2013
    ..95 (95% CI: 0.74-1.23), respectively. Having utilized ROCA in PLCO would not have led to a significant mortality benefit of screening. However, ROCA could still show a significant effect in other screening trials, including UKCTOCS...
  17. pmc Projecting prostate cancer mortality in the PCPT and REDUCE chemoprevention trials
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer 119:593-601. 2013
    ..The authors attempted to estimate the effect of these drugs on prostate cancer mortality to be able to better evaluate the cost-benefit tradeoff...
  18. ncbi request reprint Abnormalities on chest radiograph reported in subjects in a cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Chest 130:688-93. 2006
    ..There is little literature either on the prevalence in the general population of various abnormalities seen on CXRs or on the risks associated with these abnormalities...
  19. pmc Lung cancer risk following detection of pulmonary scarring by chest radiography in the prostate, lung, colorectal, and ovarian cancer screening trial
    Ying Ying Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076, Rockville, MD 20892, USA
    Arch Intern Med 168:2326-32; discussion 2332. 2008
    ..However, the nature of the relationship between pulmonary scarring and lung cancer remains uncertain. Our objective was to test whether localized pulmonary scarring is associated with increased lung cancer risk...
  20. pmc Factors associated with inadequate colorectal cancer screening with flexible sigmoidoscopy
    Adeyinka O Laiyemo
    Division of Gastroenterology, Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA
    Cancer Epidemiol 36:395-9. 2012
    ....
  21. ncbi request reprint Diagnostic procedures after a positive spiral computed tomography lung carcinoma screen
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer 103:157-63. 2005
    ....
  22. ncbi request reprint Prostate volume and prostate-specific antigen levels in men enrolled in a large screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethedsa, Maryland, USA
    Urology 68:352-6. 2006
    ..Here we examine the relationship between prostate volume and PSA level in a large, geographically diverse sample of men undergoing prostate cancer screening...
  23. pmc National lung screening trial: variability in nodule detection rates in chest CT studies
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Radiology 268:865-73. 2013
    ....
  24. ncbi request reprint Racial and ethnic differences in lung cancer incidence: how much is explained by differences in smoking patterns? (United States)
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Causes Control 17:1017-24. 2006
    ..Lung cancer rates vary considerably among U.S. racial/ethnic groups. We quantitatively analyzed the extent to which these differences can be attributed to differential patterns of smoking...
  25. ncbi request reprint Meat, meat cooking methods and preservation, and risk for colorectal adenoma
    Rashmi Sinha
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:8034-41. 2005
    ..04; 95% CI, 0.90-1.19). Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma...
  26. doi request reprint ROC curves for low-dose CT in the National Lung Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute
    J Med Screen 20:165-8. 2013
    ..4% could be achieved while only lowering sensitivity to 86.9%. Radiologists using LDCT have good predictive ability; the optimal operating point for sensitivity and specificity remains to be determined. ..
  27. doi request reprint Enriched designs for assessing discriminatory performance--analysis of bias and variance
    Paul F Pinsky
    Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiologic Health, Food and Drug Administration, Silver Spring, MD, USA
    Stat Med 31:501-15. 2012
    ..These principles are illustrated with a simulation study motivated by the Digital Mammographic Imaging Screening Trial study, a trial of digital versus screen film mammography...
  28. pmc A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer
    Claire S Zhu
    Division of Cancer Prevention, National Cancer Institute, National Institute of Health, Bethesda, MD 20892 7346, USA
    Cancer Prev Res (Phila) 4:375-83. 2011
    ..Thus, biomarker panels discovered in diagnostic samples may not validate in prediagnostic samples; utilizing prediagnostic samples for discovery may be helpful in developing validated early detection panels...
  29. pmc One year recurrence of aberrant crypt foci
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 3:839-43. 2010
    ..After removal of ACF at baseline, ACF counts 1 year later were only slightly reduced and were significantly correlated with the baseline ACF count. The results of this study do not support a role for ACF in clinical practice...
  30. pmc Building multi-marker algorithms for disease prediction-the role of correlations among markers
    Paul F Pinsky
    Early Detection Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852, USA
    Biomark Insights 6:83-93. 2011
    ..Thus, univariate analyses alone may not be the best approach in choosing which markers to combine in a predictive panel of markers; patterns of statistical correlation should be considered in ranking top-performing biomarkers...
  31. ncbi request reprint Yield of advanced adenoma and cancer based on polyp size detected at screening flexible sigmoidoscopy
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvani 15213 2582, USA
    Gastroenterology 131:1683-9. 2006
    ..To examine the yield at colonoscopy when a given size lesion is observed, we assessed the yield of advanced adenoma and cancer at colonoscopy based on the size of the abnormality detected at flexible sigmoidoscopy (FSG)...
  32. ncbi request reprint Results of repeat sigmoidoscopy 3 years after a negative examination
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    JAMA 290:41-8. 2003
    ..The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain...
  33. ncbi request reprint Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial
    Joel L Weissfeld
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Natl Cancer Inst 97:989-97. 2005
    ..Here we report findings from the baseline screening flexible sigmoidoscopy examination...
  34. ncbi request reprint Prostate Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trial
    Gerald L Andriole
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Natl Cancer Inst 97:433-8. 2005
    ..We describe the population enrolled in the PLCO trial, their baseline PSA and DRE screening results, and diagnostic follow-up results during the first year of follow-up...
  35. ncbi request reprint Prostate specific antigen changes as related to the initial prostate specific antigen: data from the prostate, lung, colorectal and ovarian cancer screening trial
    E David Crawford
    Department of Urologic Oncology, University of Colorado Health Sciences Center, Denver, Colorado, Washington, DC, USA
    J Urol 175:1286-90; discussion 1290. 2006
    ..A large fraction of screened men have low (less than 2 ng/ml) initial PSA. The yield over time of positive PSA screens (ie more than 4 ng/ml) in these men has not been well characterized in large cohorts in the United States...
  36. doi request reprint Claims of sex-gene interactions
    Paul F Pinsky
    JAMA 298:2741-2; author reply 2742. 2007
  37. ncbi request reprint Results of a randomized controlled trail of prostate cancer screening
    Paul F Pinsky
    Prostate 61:371. 2004