P F Pinsky

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Estimation and prediction for cancer screening models using deconvolution and smoothing
    P F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biometrics 57:389-95. 2001
  2. pmc Building multi-marker algorithms for disease prediction-the role of correlations among markers
    Paul F Pinsky
    Early Detection Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852, USA
    Biomark Insights 6:83-93. 2011
  3. pmc National lung screening trial: variability in nodule detection rates in chest CT studies
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Radiology 268:865-73. 2013
  4. pmc Projecting prostate cancer mortality in the PCPT and REDUCE chemoprevention trials
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer 119:593-601. 2013
  5. ncbi request reprint Potential effect of the risk of ovarian cancer algorithm (ROCA) on the mortality outcome of the Prostate, Lung, Colorectal and Ovarian (PLCO) trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 132:2127-33. 2013
  6. pmc Prostate cancer specific survival in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
    Cancer Epidemiol 36:e401-6. 2012
  7. doi request reprint Enriched designs for assessing discriminatory performance--analysis of bias and variance
    Paul F Pinsky
    Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiologic Health, Food and Drug Administration, Silver Spring, MD, USA
    Stat Med 31:501-15. 2012
  8. ncbi request reprint Racial and ethnic differences in lung cancer incidence: how much is explained by differences in smoking patterns? (United States)
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Causes Control 17:1017-24. 2006
  9. ncbi request reprint Abnormalities on chest radiograph reported in subjects in a cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Chest 130:688-93. 2006
  10. ncbi request reprint Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    BJU Int 99:775-9. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Estimation and prediction for cancer screening models using deconvolution and smoothing
    P F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biometrics 57:389-95. 2001
    ..This, along with the realistic preclinical incidence function described above, results in more accurate estimates of sojourn time and lead time and allows for estimation of quantities related to overdiagnosis, which we define here...
  2. pmc Building multi-marker algorithms for disease prediction-the role of correlations among markers
    Paul F Pinsky
    Early Detection Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852, USA
    Biomark Insights 6:83-93. 2011
    ..Thus, univariate analyses alone may not be the best approach in choosing which markers to combine in a predictive panel of markers; patterns of statistical correlation should be considered in ranking top-performing biomarkers...
  3. pmc National lung screening trial: variability in nodule detection rates in chest CT studies
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Radiology 268:865-73. 2013
    ....
  4. pmc Projecting prostate cancer mortality in the PCPT and REDUCE chemoprevention trials
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer 119:593-601. 2013
    ..The authors attempted to estimate the effect of these drugs on prostate cancer mortality to be able to better evaluate the cost-benefit tradeoff...
  5. ncbi request reprint Potential effect of the risk of ovarian cancer algorithm (ROCA) on the mortality outcome of the Prostate, Lung, Colorectal and Ovarian (PLCO) trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 132:2127-33. 2013
    ..95 (95% CI: 0.74-1.23), respectively. Having utilized ROCA in PLCO would not have led to a significant mortality benefit of screening. However, ROCA could still show a significant effect in other screening trials, including UKCTOCS...
  6. pmc Prostate cancer specific survival in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
    Cancer Epidemiol 36:e401-6. 2012
    ..The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized screening trial demonstrated no mortality effect of screening. Here we analyze prostate cancer specific survival in PLCO and its relation to screening...
  7. doi request reprint Enriched designs for assessing discriminatory performance--analysis of bias and variance
    Paul F Pinsky
    Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiologic Health, Food and Drug Administration, Silver Spring, MD, USA
    Stat Med 31:501-15. 2012
    ..These principles are illustrated with a simulation study motivated by the Digital Mammographic Imaging Screening Trial study, a trial of digital versus screen film mammography...
  8. ncbi request reprint Racial and ethnic differences in lung cancer incidence: how much is explained by differences in smoking patterns? (United States)
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Causes Control 17:1017-24. 2006
    ..Lung cancer rates vary considerably among U.S. racial/ethnic groups. We quantitatively analyzed the extent to which these differences can be attributed to differential patterns of smoking...
  9. ncbi request reprint Abnormalities on chest radiograph reported in subjects in a cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Chest 130:688-93. 2006
    ..There is little literature either on the prevalence in the general population of various abnormalities seen on CXRs or on the risks associated with these abnormalities...
  10. ncbi request reprint Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    BJU Int 99:775-9. 2007
    ..To determine patterns of repeat prostate biopsy in a cohort of men undergoing prostate cancer screening who have a negative initial biopsy...
  11. ncbi request reprint Prostate-specific antigen velocity and prostate cancer gleason grade and stage
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 109:1689-95. 2007
    ..The authors evaluated the relation between PSAV, biopsy Gleason score, and pathologic stage in men who were enrolled in a prostate cancer screening trial...
  12. ncbi request reprint Enrollment of racial and ethnic minorities in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Med Assoc 100:291-8. 2008
    ..Here, we report the experience of enrolling ethnic minorities in a large cancer screening trial...
  13. doi request reprint The yield of surveillance colonoscopy by adenoma history and time to examination
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 7:86-92. 2009
    ..Surveillance colonoscopy is recommended for subjects with a history of adenomas but there is limited information on the yield of surveillance...
  14. doi request reprint Estimating rates of true high-grade disease in the prostate cancer prevention trial
    Paul Pinsky
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, EPN 3064, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 1:182-6. 2008
    ..Results from RP show that misclassification rates on biopsy were higher in the placebo arm and that the rate of true high-grade disease may have been lower in the finasteride arm...
  15. pmc One year recurrence of aberrant crypt foci
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 3:839-43. 2010
    ..After removal of ACF at baseline, ACF counts 1 year later were only slightly reduced and were significantly correlated with the baseline ACF count. The results of this study do not support a role for ACF in clinical practice...
  16. ncbi request reprint Prostate volume and prostate-specific antigen levels in men enrolled in a large screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethedsa, Maryland, USA
    Urology 68:352-6. 2006
    ..Here we examine the relationship between prostate volume and PSA level in a large, geographically diverse sample of men undergoing prostate cancer screening...
  17. ncbi request reprint Variability in flexible sigmoidoscopy performance among examiners in a screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 3:792-7. 2005
    ..In 2 European trials, wide variability across examiners in FSG performance was noted. We report on the performance of examiners in the US randomized trial: the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
  18. ncbi request reprint Diagnostic procedures after a positive spiral computed tomography lung carcinoma screen
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer 103:157-63. 2005
    ....
  19. ncbi request reprint Evidence of a healthy volunteer effect in the prostate, lung, colorectal, and ovarian cancer screening trial
    P F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Am J Epidemiol 165:874-81. 2007
    ..Standardized incidence ratios for all cancer were 84 in women and 73 in men, with a large range of standardized incidence ratios observed for specific cancers...
  20. ncbi request reprint Methods for etiologic and early marker investigations in the PLCO trial
    Richard B Hayes
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
    Mutat Res 592:147-54. 2005
    ..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial...
  21. ncbi request reprint GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma
    Lee E Moore
    National Cancer Institute, 6120 Executive Boulevard, EPS 7034, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 14:1823-7. 2005
    ..These findings only became apparent using a newly developed assay able to distinguish heterozygous from wild-type individuals. Our data provide evidence that phenotypic differences between these two groups exist...
  22. ncbi request reprint Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, EPS 3024, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:546-52. 2004
    ..We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer...
  23. pmc Transparency and reproducibility in data analysis: the Prostate Cancer Prevention Trial
    Stuart G Baker
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Bethesda, MD 20892 7354, USA
    Biostatistics 11:413-8. 2010
    ..With such an important result at stake, a transparent analysis was important...
  24. ncbi request reprint Results of repeat sigmoidoscopy 3 years after a negative examination
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    JAMA 290:41-8. 2003
    ..The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain...
  25. ncbi request reprint Reported family history of cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 157:792-9. 2003
    ..7. Liver, bone, stomach, and brain cancer had greater-than-average reported:expected ratios, while lymphoma, bladder cancer, melanoma, and testicular cancer had lower-than-average ratios...
  26. ncbi request reprint An early- and late-stage convolution model for disease natural history
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, Maryland 20892, USA
    Biometrics 60:191-8. 2004
    ..As an example, we fit the model to data from the Mayo Lung Cancer Screening trial...
  27. ncbi request reprint Predictors of advanced proximal neoplasia in persons with abnormal screening flexible sigmoidoscopy
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7346, USA
    Clin Gastroenterol Hepatol 1:103-10. 2003
    ..The relationship between distal and proximal colonic findings is uncertain. Thus, there is no consensus on which findings on screening flexible sigmoidoscopy should trigger colonoscopy...
  28. ncbi request reprint Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer
    John K Gohagan
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, EPN 3064, Bethesda, MD 20892, USA
    Lung Cancer 47:9-15. 2005
    ..A total of 16 stage III-IV cancers were observed in the LDCT arm versus nine in the CXR arm. The LSS has established the feasibility of a RCT comparing annual spiral CT to chest X-ray for lung cancer screening...
  29. ncbi request reprint Prostate biopsy following a positive screen in the prostate, lung, colorectal and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Urol 173:746-50; discussion 750-1. 2005
    ..Followup of positive screens in PLCO is done by subject personal physicians and it is outside of trial control. We describe the pattern of prostate biopsy in men with positive screens in PLCO...
  30. ncbi request reprint Prostate Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trial
    Gerald L Andriole
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Natl Cancer Inst 97:433-8. 2005
    ..We describe the population enrolled in the PLCO trial, their baseline PSA and DRE screening results, and diagnostic follow-up results during the first year of follow-up...
  31. ncbi request reprint Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial
    Joel L Weissfeld
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Natl Cancer Inst 97:989-97. 2005
    ..Here we report findings from the baseline screening flexible sigmoidoscopy examination...
  32. ncbi request reprint Yield of advanced adenoma and cancer based on polyp size detected at screening flexible sigmoidoscopy
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvani 15213 2582, USA
    Gastroenterology 131:1683-9. 2006
    ..To examine the yield at colonoscopy when a given size lesion is observed, we assessed the yield of advanced adenoma and cancer at colonoscopy based on the size of the abnormality detected at flexible sigmoidoscopy (FSG)...
  33. ncbi request reprint Meat, meat cooking methods and preservation, and risk for colorectal adenoma
    Rashmi Sinha
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:8034-41. 2005
    ..04; 95% CI, 0.90-1.19). Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma...
  34. ncbi request reprint Prostate specific antigen changes as related to the initial prostate specific antigen: data from the prostate, lung, colorectal and ovarian cancer screening trial
    E David Crawford
    Department of Urologic Oncology, University of Colorado Health Sciences Center, Denver, Colorado, Washington, DC, USA
    J Urol 175:1286-90; discussion 1290. 2006
    ..A large fraction of screened men have low (less than 2 ng/ml) initial PSA. The yield over time of positive PSA screens (ie more than 4 ng/ml) in these men has not been well characterized in large cohorts in the United States...
  35. ncbi request reprint Results of a randomized controlled trail of prostate cancer screening
    Paul F Pinsky
    Prostate 61:371. 2004
  36. doi request reprint Claims of sex-gene interactions
    Paul F Pinsky
    JAMA 298:2741-2; author reply 2742. 2007