Daniel S Pine

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Investigating the genetic and environmental bases of biases in threat recognition and avoidance in children with anxiety problems
    Jennifer Y F Lau
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Biol Mood Anxiety Disord 2:12. 2012
  2. pmc Autism spectrum disorder scale scores in pediatric mood and anxiety disorders
    Daniel S Pine
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 47:652-61. 2008
  3. ncbi request reprint Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
  4. ncbi request reprint Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
    Bipolar Disord 9:810-9. 2007
  5. pmc Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation
    Geoff Rau
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1289, USA
    J Child Adolesc Psychopharmacol 18:185-96. 2008
  6. ncbi request reprint Deficits in social cognition and response flexibility in pediatric bipolar disorder
    Erin B McClure
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, Room 102, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 162:1644-51. 2005
  7. doi request reprint Disrupted expected value and prediction error signaling in youths with disruptive behavior disorders during a passive avoidance task
    Stuart F White
    National Institute of Mental Health, Bethesda, MD, USA
    Am J Psychiatry 170:315-23. 2013
  8. pmc Neural activation during encoding of emotional faces in pediatric bipolar disorder
    Daniel P Dickstein
    Division of Intramural Research Program, National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, Bethesda, MD 20892 2670, USA
    Bipolar Disord 9:679-92. 2007
  9. pmc Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety
    Amanda E Guyer
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Dr, Room 208, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 65:1303-12. 2008
  10. ncbi request reprint Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Section on Development and Affective Neuroscience, NIMH Mood and Anxiety Program, Bethesda, MD 20892, USA
    Am J Psychiatry 164:309-17. 2007

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. pmc Investigating the genetic and environmental bases of biases in threat recognition and avoidance in children with anxiety problems
    Jennifer Y F Lau
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Biol Mood Anxiety Disord 2:12. 2012
    ..abstract:..
  2. pmc Autism spectrum disorder scale scores in pediatric mood and anxiety disorders
    Daniel S Pine
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 47:652-61. 2008
    ..To compare scores on autism spectrum disorder (ASD) symptom scales in healthy youths and youths with mood or anxiety disorders...
  3. ncbi request reprint Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
    ..However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues...
  4. ncbi request reprint Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
    Bipolar Disord 9:810-9. 2007
    ..The present study was undertaken to determine if neuronal responses differed between BD and control subjects on a simple motor response flexibility task...
  5. pmc Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation
    Geoff Rau
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1289, USA
    J Child Adolesc Psychopharmacol 18:185-96. 2008
    ..Therefore, we hypothesized that SMD, but not BD, youths would be impaired on a decision-making task that has identified reward- and punishment-processing deficits in individuals with psychopathy...
  6. ncbi request reprint Deficits in social cognition and response flexibility in pediatric bipolar disorder
    Erin B McClure
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, Room 102, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 162:1644-51. 2005
    ..The purpose of this study was to test the hypothesis that youths with bipolar disorder would perform more poorly than matched healthy comparison subjects on measures of social cognition, motor inhibition, and response flexibility...
  7. doi request reprint Disrupted expected value and prediction error signaling in youths with disruptive behavior disorders during a passive avoidance task
    Stuart F White
    National Institute of Mental Health, Bethesda, MD, USA
    Am J Psychiatry 170:315-23. 2013
    ..This partly reflects previous failures to differentiate responses during decision making and feedback processing and to take advantage of computational model-based functional MRI (fMRI)...
  8. pmc Neural activation during encoding of emotional faces in pediatric bipolar disorder
    Daniel P Dickstein
    Division of Intramural Research Program, National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, Bethesda, MD 20892 2670, USA
    Bipolar Disord 9:679-92. 2007
    ..To begin to address these limitations, the current study tests the hypothesis that pediatric BD (PBD) subjects exhibit altered neural activation during encoding of emotional faces compared to typically developing controls...
  9. pmc Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety
    Amanda E Guyer
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Dr, Room 208, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 65:1303-12. 2008
    ..Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening...
  10. ncbi request reprint Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Section on Development and Affective Neuroscience, NIMH Mood and Anxiety Program, Bethesda, MD 20892, USA
    Am J Psychiatry 164:309-17. 2007
    ..e., a history of at least one manic or hypomanic episode with euphoric mood) as well as those with no diagnosis (i.e., healthy comparison children)...
  11. pmc Neural response to self- and other referential praise and criticism in generalized social phobia
    Karina Blair
    Mood and Anxiety Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 65:1176-84. 2008
    ..However, studies have not examined the neural response in GSP to another equally important class of social stimuli, the communication of praise or criticism...
  12. doi request reprint Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders
    Abigail A Marsh
    Mood and Anxiety Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:712-20. 2008
    ..Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of pediatric callous-unemotional traits and ADHD...
  13. doi request reprint Reduced amygdala response in youths with disruptive behavior disorders and psychopathic traits: decreased emotional response versus increased top-down attention to nonemotional features
    Stuart F White
    National Institute of Mental Health, Bethesda, MD, USA
    Am J Psychiatry 169:750-8. 2012
    ..However, there has been disagreement as to whether this dysfunction reflects a primary emotional deficit or is secondary to atypical attentional control. The authors examined the validity of the contrasting predictions...
  14. doi request reprint Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder
    Melissa A Brotman
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 165:385-9. 2008
    ....
  15. pmc A developmental examination of amygdala response to facial expressions
    Amanda E Guyer
    National Institutes of Health NIH, Bethesda, MD 20892 2670, USA
    J Cogn Neurosci 20:1565-82. 2008
    ....
  16. ncbi request reprint Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder
    Ellen Leibenluft
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Health and Human Services, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 164:52-60. 2007
    ..They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder (ADHD) versus those with bipolar disorder without ADHD...
  17. pmc Normative data on development of neural and behavioral mechanisms underlying attention orienting toward social-emotional stimuli: an exploratory study
    Kara M Lindstrom
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Bethesda, MD 20892 2670, USA
    Brain Res 1292:61-70. 2009
    ..Implications for future work on developmental changes in attention-emotion processing are discussed...
  18. ncbi request reprint Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study
    Roxann Roberson-Nay
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
    Biol Psychiatry 60:966-73. 2006
    ..This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing...
  19. pmc Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder
    Melissa A Brotman
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 167:61-9. 2010
    ..The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths...
  20. pmc Neural recruitment during failed motor inhibition differentiates youths with bipolar disorder and severe mood dysregulation
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
    Biol Psychol 89:148-55. 2012
    ..Exploratory analyses indicate that, in BD youths, reduced activation in the right ACC may be independent of comorbid ADHD. These findings highlight neural distinctions between the phenotypically related BD and SMD populations...
  21. doi request reprint Proton magnetic resonance spectroscopy in youth with severe mood dysregulation
    Daniel P Dickstein
    Unit on Bipolar Spectrum Disorders, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD, USA
    Psychiatry Res 163:30-9. 2008
    ....
  22. pmc Probing the neural correlates of anticipated peer evaluation in adolescence
    Amanda E Guyer
    National Institute of Mental Health, 15K North Drive, Room 208, Bethesda, MD 20892 2670, USA
    Child Dev 80:1000-15. 2009
    ..Relating these neural response patterns to changes in adolescent social-cognition enriches theories of adolescent social development through enhanced neurobiological understanding of social behavior...
  23. pmc Association between level of emotional intelligence and severity of anxiety in generalized social phobia
    Madeline Jacobs
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD, United States
    J Anxiety Disord 22:1487-95. 2008
    ..These results suggest that EI may index emotional processing systems that mitigate the impact of systems causally implicated in GSP...
  24. ncbi request reprint Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disorders
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:819-21. 2007
    ..Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness...
  25. pmc Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892 2670, MD, USA
    J Child Psychol Psychiatry 49:88-96. 2008
    ....
  26. ncbi request reprint Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humans
    Christopher S Monk
    National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 56:607-10. 2004
    ..Examination of plasticity of attention bias with individuals at risk for anxiety disorders may reveal how threatening stimuli come to be categorized differently in this population over time...
  27. pmc Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging
    Nancy E Adleman
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Psychiatry Res 212:161-3. 2013
    ..Fusiform activation abnormalities in BD were correlated with mania severity and may therefore represent a trait and state BD biomarker...
  28. pmc Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Prog Neuropsychopharmacol Biol Psychiatry 38:127-33. 2012
    ..This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD...
  29. pmc Attention bias of anxious youth during extended exposure of emotional face pairs: an eye-tracking study
    Tomer Shechner
    Section on Developmental Affective Neuroscience, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Depress Anxiety 30:14-21. 2013
    ..Using eye-tracking methodology, the current study measured attention biases in anxious and nonanxious youth, using unrestricted free viewing of angry, happy, and neutral faces...
  30. doi request reprint Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    J Child Psychol Psychiatry 53:262-70. 2012
    ..Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations...
  31. pmc A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder
    Judah D Weathers
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:633-41. 2012
    ..The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers...
  32. pmc Incentive effect on inhibitory control in adolescents with early-life stress: an antisaccade study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
    Child Abuse Negl 36:217-25. 2012
    ..Findings revealed deficits in both reward processing and inhibitory control in ES youths. However, no work has yet examined whether incentives can improve automatic response or inhibitory control in ES youths...
  33. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  34. pmc Elevated fear conditioning to socially relevant unconditioned stimuli in social anxiety disorder
    Shmuel Lissek
    NIMH, NIH, 15K North Dr, Rm 200, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 165:124-32. 2008
    ..This study represents the first effort to assess the conditioning correlates of social anxiety disorder within an ecologically enhanced paradigm...
  35. pmc Training-associated changes and stability of attention bias in youth: Implications for Attention Bias Modification Treatment for pediatric anxiety
    Jennifer C Britton
    Section on Development and Affective Neuroscience, National Institute of Mental Health NIMH, 9000 Rockville Pike, Building 15K, Bethesda, MD 20892, USA
    Dev Cogn Neurosci 4:52-64. 2013
    ..Together, these two studies investigate the ways in which attention-bias stability may impact future work on ABMT...
  36. pmc Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder
    Karina S Blair
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 72:476-82. 2012
    ..Here we compare the neural correlates of EER and TAC in GSP, GAD, and GSP/GAD...
  37. pmc Neural correlates of cognitive flexibility in children at risk for bipolar disorder
    Pilyoung Kim
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    J Psychiatr Res 46:22-30. 2012
    ..Youth with bipolar disorder (BD) show behavioral and neural deficits in cognitive flexibility; however, whether such deficits exist among youths at risk for BD has not been explored...
  38. pmc Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits
    Abigail A Marsh
    Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA
    Psychiatry Res 194:279-86. 2011
    ..These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population...
  39. ncbi request reprint Reduction of trace but not delay eyeblink conditioning in panic disorder
    Christian Grillon
    NIMH Mood and Anxiety Disorders Program, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 164:283-9. 2007
    ..The present study examined trace eyeblink conditioning in order to test the hypothesis that individuals with panic disorder are impaired in associative learning tasks that depend on declarative memory...
  40. ncbi request reprint Cognitive flexibility in phenotypes of pediatric bipolar disorder
    Daniel P Dickstein
    National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670 Building 15K Room 204, Bethesda MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 46:341-55. 2007
    ..6 +/- 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression)...
  41. ncbi request reprint Striatal functional alteration in adolescents characterized by early childhood behavioral inhibition
    Amanda E Guyer
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    J Neurosci 26:6399-405. 2006
    ....
  42. pmc Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder
    Christian Grillon
    NIMH MAP, 15K North Dr, Bldg 15k, Rm 113, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 165:898-904. 2008
    ..The authors tested the hypothesis that elevated anxious reactivity, specifically toward unpredictable aversive events, is a psychophysiological correlate of panic disorder...
  43. ncbi request reprint The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle
    Christian Grillon
    Mood and Anxiety Disorder Program, National Institutes of Mental Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:760-6. 2006
    ..The present study tested the hypothesis that alprazolam would reduce the sustained startle potentiation to contextual threats but not the startle potentiation to a threat cue...
  44. pmc Overgeneralization of conditioned fear as a pathogenic marker of panic disorder
    Shmuel Lissek
    Mood and Anxiety Disorders Program, NIMH Intramural Research Program, Bethesda, MD, USA
    Am J Psychiatry 167:47-55. 2010
    ..The authors conducted a laboratory-based assessment of this potential correlate of panic disorder by testing the degree to which panic patients and healthy subjects manifest generalization of conditioned fear...
  45. pmc Neural substrates of choice selection in adults and adolescents: development of the ventrolateral prefrontal and anterior cingulate cortices
    Neir Eshel
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Neuropsychologia 45:1270-9. 2007
    ..Consistent with predictions, these results suggest that adolescents engage prefrontal regulatory structures to a lesser extent than adults when making risky economic choices...
  46. pmc Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiers
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD, 20892, USA
    Psychiatry Res 172:75-7. 2009
    ..Findings in this group of resilient individuals revealed unique patterns of activation during expectation of reward in the subgenual prefrontal cortex and nucleus accumbens area, regions pivotal to reward processes...
  47. pmc Risk for bipolar disorder is associated with face-processing deficits across emotions
    Melissa A Brotman
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 47:1455-61. 2008
    ..It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest...
  48. ncbi request reprint Comorbid anxiety in phenotypes of pediatric bipolar disorder
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1255, USA
    J Child Adolesc Psychopharmacol 15:534-48. 2005
    ..Adult BPD studies suggest comorbid anxiety disorders are common and impact treatment outcome. We explored the association of comorbid anxiety with two phenotypes of pediatric BPD...
  49. pmc The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala 'aversive amplification' circuit
    Oliver J Robinson
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuroimage 78:217-23. 2013
    ..These findings thus provide a promising explanation for the role of serotonin and serotonergic medications in the neurocircuitry of negative affective bias...
  50. doi request reprint Effect of mother's dominance rank on offspring temperament in infant rhesus monkeys (Macaca mulatta)
    Benjamin Suarez-Jimenez
    DIRP Non Human Primate Core, National Institute of Mental Health, Bethesda, Maryland, USA
    Am J Primatol 75:65-73. 2013
    ..These results also suggest future human-based studies of a similar relationship may be warranted, although social dominance is clearly more complex in human than macaque societies...
  51. doi request reprint Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits
    Stuart F White
    Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Dev Psychopathol 24:1105-16. 2012
    ..The results are discussed with reference to current models of DBD + PT and possible treatment innovations...
  52. pmc The influence of emotional stimuli on attention orienting and inhibitory control in pediatric anxiety
    Sven C Mueller
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 53:856-63. 2012
    ....
  53. pmc Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorder
    Aviva K Olsavsky
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, Maryland, USA
    J Am Acad Child Adolesc Psychiatry 51:294-303. 2012
    ..e., those with a first-degree BD relative) will demonstrate amygdala hyperactivation when viewing fearful and happy faces. The at-risk youth were unaffected, in that they had no history of mood disorder...
  54. pmc The pathology of social phobia is independent of developmental changes in face processing
    Karina S Blair
    Mood and Anxiety Program, National Institute of Mental Health, USA
    Am J Psychiatry 168:1202-9. 2011
    ..The authors examined neural responses to facial expressions in adults and adolescents with social phobia to determine whether the neural correlates of adult social phobia during face processing also manifest in adolescent social phobia...
  55. pmc Development of anxiety: the role of threat appraisal and fear learning
    Jennifer C Britton
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Depress Anxiety 28:5-17. 2011
    ..This novel paradigm can be used to investigate key questions relevant to prognosis and treatment. Depression and Anxiety, 2011.© 2010 Wiley-Liss, Inc...
  56. ncbi request reprint Specificity of facial expression labeling deficits in childhood psychopathology
    Amanda E Guyer
    Mood and Anxiety Program MAP, National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
    J Child Psychol Psychiatry 48:863-71. 2007
    ..We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation...
  57. pmc Fear conditioning in adolescents with anxiety disorders: results from a novel experimental paradigm
    Jennifer Y F Lau
    Mood and Anxiety Disorders Program, National Institute of Mental Health National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 47:94-102. 2008
    ..Adult data suggest that anxiety disorders involve elevated fear but intact differential conditioning. We used a novel paradigm to assess fear conditioning in pediatric anxiety patients...
  58. pmc Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
    Neuropsychologia 48:3037-44. 2010
    ..incorrect "change" responses recruited the inferior prefrontal cortex (BA 44/46) more strongly in ES subjects than controls. These data suggest impaired cognitive control in youth who experienced ES...
  59. ncbi request reprint A developmental examination of gender differences in brain engagement during evaluation of threat
    Erin B McClure
    Section on Development and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1047-55. 2004
    ..Recent theoretical models suggest that developmental changes in brain functioning play important roles in the emergence of such gender differences...
  60. ncbi request reprint Autism spectrum traits in children with mood and anxiety disorders
    Kenneth E Towbin
    Mood and Anxiety Program, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 15:452-64. 2005
    ..These results demonstrate a need to develop valid and reliable instruments to screen for ASDs in children presenting outside of ASD clinics...
  61. ncbi request reprint Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion
    Abigail A Marsh
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 189:387-94. 2006
    ..Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed...
  62. pmc Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning
    Elizabeth C Finger
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 65:586-94. 2008
    ....
  63. ncbi request reprint Stress responsivity and HPA axis activity in juveniles: results from a home-based CO2 inhalation study
    Thomas A Terleph
    NIMH, NIH, Bldg 15 K, Rm 110, MSC 2670, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 163:738-40. 2006
    ..The current home-based study tested the hypothesis that parental panic disorder and offspring response to CO(2) are associated with elevated cortisol levels in juvenile offspring...
  64. pmc Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder
    Shmuel Lissek
    Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, NIH, DHHS, MD 20892 2670, USA
    Behav Res Ther 47:111-8. 2009
    ..Such results link PD to impaired discrimination learning, reflecting elevated fear responding to learned safety cues...
  65. ncbi request reprint Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramurral Research Program, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 162:291-6. 2005
    ..They tested the hypothesis that attention bias to threatening facial photographs is associated with maltreatment and PTSD...
  66. ncbi request reprint Emotion recognition deficits in pediatric anxiety disorders: implications for amygdala research
    Josh Easter
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    J Child Adolesc Psychopharmacol 15:563-70. 2005
    ..This study examines the relationship between face-emotion recognition and anxiety in a sample of children and adolescents participating in a brain-imaging study of amygdala structure and function...
  67. pmc Steroid abnormalities and the developing brain: declarative memory for emotionally arousing and neutral material in children with congenital adrenal hyperplasia
    Francoise S Maheu
    Mood and Anxiety Disorders Program, Emotional Development and Affective Neuroscience Section, National Institute of Mental Health, 15K North Drive, Room 300 C, Bethesda, MD 20892 2670, USA
    Psychoneuroendocrinology 33:238-45. 2008
    ..Such memory impairments may result from abnormal brain organization and function following hormonal dysfunction during critical periods of development...
  68. pmc Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 66:47-53. 2009
    ..This study tested the hypothesis that elevated anxious reactivity, specifically for unpredictable aversive events, is a psychophysiological correlate of PTSD...
  69. doi request reprint Elucidating risk mechanisms of gene-environment interactions on pediatric anxiety: integrating findings from neuroscience
    Jennifer Y F Lau
    Mood and Anxiety Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Eur Arch Psychiatry Clin Neurosci 258:97-106. 2008
    ..Exploring these relationships during development is crucial, given that these early life processes may potentially shape longer-term patterns of emotional behavior, and therefore life-long trajectories of anxiety...
  70. pmc Adult outcomes of youth irritability: a 20-year prospective community-based study
    Argyris Stringaris
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, Mood and Anxiety Program, NIMH Bldg 15K, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 166:1048-54. 2009
    ..This study examines the extent to which youth irritability is related to adult psychiatric outcomes by testing the hypothesis that it predicts depressive and generalized anxiety disorders...
  71. ncbi request reprint Face-emotion processing in offspring at risk for panic disorder
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20817 2670, USA
    J Am Acad Child Adolesc Psychiatry 44:664-72. 2005
    ..This study tested the hypotheses that offspring of parents with PD and offspring with anxiety disorders display relatively greater sensitivity and attention allocation to fear provocation...
  72. ncbi request reprint Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:991-7. 2006
    ..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
  73. pmc Attention orientation in parents exposed to the 9/11 terrorist attacks and their children
    Kara M Lindstrom
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatry Res 187:261-6. 2011
    ..Larger, prospective studies might examine relationships within families among traumatic exposures, psychopathology, and information-processing functions...
  74. pmc Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipation
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    J Clin Psychiatry 72:942-8. 2011
    ..Our aim was to isolate the specific components of public speaking that trigger fear in vulnerable individuals and best discriminate between SAD and healthy individuals...
  75. pmc Altered neural function in pediatric bipolar disorder during reversal learning
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Bipolar Disord 12:707-19. 2010
    ..Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls...
  76. pmc Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 69:549-55. 2011
    ..The current study examines these effects, as instantiated with short- and long-duration threats...
  77. pmc Atypical modulation of medial prefrontal cortex to self-referential comments in generalized social phobia
    Karina S Blair
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Psychiatry Res 193:38-45. 2011
    ..We believe that these data reflect a reorganization of self-referential reasoning in the disorder with a self-concept perhaps atypically related to the view of others...
  78. pmc Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety
    Daniel S Pine
    Mood and Anxiety Disorders Program, Intramural Research Program, The National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 34:213-28. 2009
    ..This summary ends by describing potential novel treatments, illustrating the manner in which basic neuroscience informs therapeutics...
  79. ncbi request reprint A neuroimaging method for the study of threat in adolescents
    Christopher S Monk
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Dev Psychobiol 43:359-66. 2003
    ..Those who reported increased fear showed right amygdala activation during the threat condition and left amygdala activation in the safe condition. These procedures offer a promising tool for studying youth with anxiety disorders...
  80. pmc Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differences
    Michael G Hardin
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:446-54. 2007
    ....
  81. ncbi request reprint Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuroimage 25:1279-91. 2005
    ..These developmental differences, if replicated, may have important implications for the development of early-onset disorders of emotion and motivation...
  82. pmc Perturbed reward processing in pediatric bipolar disorder: an antisaccade study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, 15K North Drive, Bethesda, MD 20814, USA
    J Psychopharmacol 24:1779-84. 2010
    ..By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder...
  83. ncbi request reprint Clinical correlates of episodicity in juvenile mania
    Robinder K Bhangoo
    The Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 13:507-14. 2003
    ..We hypothesized that the episodic group would be more likely to have a history of psychosis and a parental history of BPD, whereas the chronic group would be more likely to have conduct disorder...
  84. pmc Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders
    Karina Blair
    Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:1193-202. 2008
    ..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder...
  85. ncbi request reprint Performance on a virtual reality spatial memory navigation task in depressed patients
    Neda F Gould
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, NIMH, Mark O Hatfield Clinical Research Center, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 164:516-9. 2007
    ..Findings on spatial memory in depression have been inconsistent. A navigation task based on virtual reality may provide a more sensitive and consistent measure of the hippocampal-related spatial memory deficits associated with depression...
  86. ncbi request reprint Fear conditioning in virtual reality contexts: a new tool for the study of anxiety
    Johanna M Baas
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1056-60. 2004
    ..A virtual environment might prove to be the ideal tool for innovative experimental paradigms to study explicitly cued fear and contextual anxiety in humans...
  87. ncbi request reprint Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder
    Tristan Gorrindo
    Mood and Anxiety Program, National Institute of Mental Health, Bldg 10, Rm 4N 208, 10 Center Dr MSC 1255, Bethesda, MD 20892 1255, USA
    Am J Psychiatry 162:1975-7. 2005
    ....
  88. pmc Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndrome
    Francoise S Maheu
    National Institute of Mental Health, Bethesda, MD, 20892 2670, USA
    Dev Psychopathol 20:1177-89. 2008
    ....
  89. ncbi request reprint Neuropsychological performance in pediatric bipolar disorder
    Daniel P Dickstein
    National Institute of Mental Health Mood and Anxiety Disorders Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1255, USA
    Biol Psychiatry 55:32-9. 2004
    ..We sought to examine whether neuropsychological function in children with bipolar disorder resembles that in adults with the illness and to extend our knowledge about cognitive function in pediatric bipolar disorder...
  90. ncbi request reprint Cognitive control under contingencies in anxious and depressed adolescents: an antisaccade task
    Sandra Jazbec
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Psychiatry 58:632-9. 2005
    ..Antisaccade paradigms are particularly well suited for this endeavor because they provide exquisite behavioral measures of modulation of response errors...
  91. pmc Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty
    Sven C Mueller
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 19:41-50. 2009
    ..In contrast, no significant activation of the amygdala was found. These data are consistent with previous studies of the effects of sex hormones on brain function and support the role of testosterone on emotional development...
  92. ncbi request reprint Adolescent life events as predictors of adult depression
    Daniel S Pine
    National Institute of Mental Health, Intramural Research Program, Building 10, Room 4N 222, Bethesda, MD 20892 1381, USA
    J Affect Disord 68:49-57. 2002
    ..While studies have begun to examine this issue in adolescents, few studies rely upon prospective epidemiological designs to document relationships between adolescent life events and adult major depression...
  93. pmc Animal models of suicide-trait-related behaviors
    Oz Malkesman
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 30:165-73. 2009
    ..Modeling these relevant traits in animals can help to clarify the impact of SSRIs on these traits, suggesting avenues for reducing suicide risk in this vulnerable population...
  94. ncbi request reprint Brain development and the onset of mood disorders
    Daniel S Pine
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 1381, USA
    Semin Clin Neuropsychiatry 7:223-33. 2002
    ..This is a US government work. There are no restrictions on its use...
  95. pmc Cortisol and DHEA-S are associated with startle potentiation during aversive conditioning in humans
    Christian Grillon
    NIMH NIH DHHS, Mood and Anxiety Disorder Program, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychopharmacology (Berl) 186:434-41. 2006
    ....
  96. ncbi request reprint Integrating research on developmental psychopathology and neuroscience in the study of adolescence: introduction to part II
    Daniel S Pine
    NIMH Building 15 K, Room 110, MSC 2670, Bethesda, MD 20817 2670, USA
    Ann N Y Acad Sci 1021:61-3. 2004
    ..From the basic science perspective they call attention to the sequence of events that culminates in a fully mature central nervous system...
  97. ncbi request reprint Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI study
    Eric E Nelson
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 1381, USA
    J Child Psychol Psychiatry 44:1015-24. 2003
    ..Prior studies document strong interactions between emotional and mnemonic processes. These interactions have been shown to vary across development and psychopathology, particularly mood and anxiety disorders...
  98. pmc What does distractibility in ADHD reveal about mechanisms for top-down attentional control?
    Stacia R Friedman-Hill
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Cognition 115:93-103. 2010
    ....
  99. ncbi request reprint The strong situation: a potential impediment to studying the psychobiology and pharmacology of anxiety disorders
    Shmuel Lissek
    DHHS, NIH, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Biol Psychol 72:265-70. 2006
    ....
  100. pmc Imaging-genetics applications in child psychiatry
    Daniel S Pine
    National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 49:772-82. 2010
    ..To place imaging-genetics research in the context of child psychiatry...
  101. pmc Impaired spatial navigation in pediatric anxiety
    Sven C Mueller
    MAP, NIMH, NIH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 50:1227-34. 2009
    ..Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders...