Research Topics
Genomes and GenesSpecies | Daniel S PineSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Autism spectrum disorder scale scores in pediatric mood and anxiety disordersDaniel S Pine
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
J Am Acad Child Adolesc Psychiatry 47:652-61. 2008..To compare scores on autism spectrum disorder (ASD) symptom scales in healthy youths and youths with mood or anxiety disorders...
Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorderErin B McClure
Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:97-106. 2007..However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues...- Deficits in social cognition and response flexibility in pediatric bipolar disorderErin B McClure
Mood and Anxiety Disorders Program, NIMH, 15K North Dr, Room 102, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 162:1644-51. 2005..The purpose of this study was to test the hypothesis that youths with bipolar disorder would perform more poorly than matched healthy comparison subjects on measures of social cognition, motor inhibition, and response flexibility... - Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulationGeoff Rau
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1289, USA
J Child Adolesc Psychopharmacol 18:185-96. 2008..Therefore, we hypothesized that SMD, but not BD, youths would be impaired on a decision-making task that has identified reward- and punishment-processing deficits in individuals with psychopathy... - Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI studyEric E Nelson
Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
Bipolar Disord 9:810-9. 2007..The present study was undertaken to determine if neuronal responses differed between BD and control subjects on a simple motor response flexibility task... - Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxietyAmanda E Guyer
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Dr, Room 208, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 65:1303-12. 2008..Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening... - Neural response to self- and other referential praise and criticism in generalized social phobiaKarina Blair
Mood and Anxiety Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Arch Gen Psychiatry 65:1176-84. 2008..However, studies have not examined the neural response in GSP to another equally important class of social stimuli, the communication of praise or criticism... 
Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disordersAbigail A Marsh
Mood and Anxiety Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 165:712-20. 2008..Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of pediatric callous-unemotional traits and ADHD...- Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulationBrendan A Rich
Pediatrics and Developmental Neuropsychiatry Branch, Section on Development and Affective Neuroscience, NIMH Mood and Anxiety Program, Bethesda, MD 20892, USA
Am J Psychiatry 164:309-17. 2007..e., a history of at least one manic or hypomanic episode with euphoric mood) as well as those with no diagnosis (i.e., healthy comparison children)... - Neural activation during encoding of emotional faces in pediatric bipolar disorderDaniel P Dickstein
Division of Intramural Research Program, National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, Bethesda, MD 20892 2670, USA
Bipolar Disord 9:679-92. 2007..To begin to address these limitations, the current study tests the hypothesis that pediatric BD (PBD) subjects exhibit altered neural activation during encoding of emotional faces compared to typically developing controls... - Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorderMelissa A Brotman
Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Psychiatry 167:61-9. 2010..The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths... - A developmental examination of amygdala response to facial expressionsAmanda E Guyer
National Institutes of Health NIH, Bethesda, MD 20892 2670, USA
J Cogn Neurosci 20:1565-82. 2008.... - Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorderEllen Leibenluft
Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Health and Human Services, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
Am J Psychiatry 164:52-60. 2007..They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder (ADHD) versus those with bipolar disorder without ADHD... - Facial emotion labeling deficits in children and adolescents at risk for bipolar disorderMelissa A Brotman
Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
Am J Psychiatry 165:385-9. 2008.... - Normative data on development of neural and behavioral mechanisms underlying attention orienting toward social-emotional stimuli: an exploratory studyKara M Lindstrom
Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Bethesda, MD 20892 2670, USA
Brain Res 1292:61-70. 2009..Implications for future work on developmental changes in attention-emotion processing are discussed... - Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI studyRoxann Roberson-Nay
Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
Biol Psychiatry 60:966-73. 2006..This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing... - Neural recruitment during failed motor inhibition differentiates youths with bipolar disorder and severe mood dysregulationChristen M Deveney
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
Biol Psychol 89:148-55. 2012..Exploratory analyses indicate that, in BD youths, reduced activation in the right ACC may be independent of comorbid ADHD. These findings highlight neural distinctions between the phenotypically related BD and SMD populations... - Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humansChristopher S Monk
National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 56:607-10. 2004..Examination of plasticity of attention bias with individuals at risk for anxiety disorders may reveal how threatening stimuli come to be categorized differently in this population over time... - Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuitBrendan A Rich
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892 2670, MD, USA
J Child Psychol Psychiatry 49:88-96. 2008.... - Association between level of emotional intelligence and severity of anxiety in generalized social phobiaMadeline Jacobs
Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD, United States
J Anxiety Disord 22:1487-95. 2008..These results suggest that EI may index emotional processing systems that mitigate the impact of systems causally implicated in GSP... - Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disordersMelissa A Brotman
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Biol Psychiatry 61:819-21. 2007..Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness... - Probing the neural correlates of anticipated peer evaluation in adolescenceAmanda E Guyer
National Institute of Mental Health, 15K North Drive, Room 208, Bethesda, MD 20892 2670, USA
Child Dev 80:1000-15. 2009..Relating these neural response patterns to changes in adolescent social-cognition enriches theories of adolescent social development through enhanced neurobiological understanding of social behavior... - Proton magnetic resonance spectroscopy in youth with severe mood dysregulationDaniel P Dickstein
Unit on Bipolar Spectrum Disorders, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD, USA
Psychiatry Res 163:30-9. 2008.... - Affective prosody labeling in youths with bipolar disorder or severe mood dysregulationChristen M Deveney
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
J Child Psychol Psychiatry 53:262-70. 2012..Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations... - Incentive effect on inhibitory control in adolescents with early-life stress: an antisaccade studySven C Mueller
Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
Child Abuse Negl 36:217-25. 2012..Findings revealed deficits in both reward processing and inhibitory control in ES youths. However, no work has yet examined whether incentives can improve automatic response or inhibitory control in ES youths... - A developmental study of the neural circuitry mediating motor inhibition in bipolar disorderJudah D Weathers
Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, MD, USA
Am J Psychiatry 169:633-41. 2012..The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers... - Elevated fear conditioning to socially relevant unconditioned stimuli in social anxiety disorderShmuel Lissek
NIMH, NIH, 15K North Dr, Rm 200, Bethesda, MD 20892 2670, USA
Am J Psychiatry 165:124-32. 2008..This study represents the first effort to assess the conditioning correlates of social anxiety disorder within an ecologically enhanced paradigm... - Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulationMelissa A Brotman
Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Psychiatry 164:1238-41. 2007..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation... - Neural correlates of cognitive flexibility in children at risk for bipolar disorderPilyoung Kim
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
J Psychiatr Res 46:22-30. 2012..Youth with bipolar disorder (BD) show behavioral and neural deficits in cognitive flexibility; however, whether such deficits exist among youths at risk for BD has not been explored... - Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traitsAbigail A Marsh
Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA
Psychiatry Res 194:279-86. 2011..These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population... - Comorbid anxiety in phenotypes of pediatric bipolar disorderDaniel P Dickstein
Mood and Anxiety Disorders Program, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1255, USA
J Child Adolesc Psychopharmacol 15:534-48. 2005..Adult BPD studies suggest comorbid anxiety disorders are common and impact treatment outcome. We explored the association of comorbid anxiety with two phenotypes of pediatric BPD... - Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorderChristian Grillon
NIMH MAP, 15K North Dr, Bldg 15k, Rm 113, MSC 2670, Bethesda, MD 20892 2670, USA
Am J Psychiatry 165:898-904. 2008..The authors tested the hypothesis that elevated anxious reactivity, specifically toward unpredictable aversive events, is a psychophysiological correlate of panic disorder... - Overgeneralization of conditioned fear as a pathogenic marker of panic disorderShmuel Lissek
Mood and Anxiety Disorders Program, NIMH Intramural Research Program, Bethesda, MD, USA
Am J Psychiatry 167:47-55. 2010..The authors conducted a laboratory-based assessment of this potential correlate of panic disorder by testing the degree to which panic patients and healthy subjects manifest generalization of conditioned fear... - Cognitive flexibility in phenotypes of pediatric bipolar disorderDaniel P Dickstein
National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670 Building 15K Room 204, Bethesda MD 20892 2670, USA
J Am Acad Child Adolesc Psychiatry 46:341-55. 2007..6 +/- 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression)... - Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiersMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD, 20892, USA
Psychiatry Res 172:75-7. 2009..Findings in this group of resilient individuals revealed unique patterns of activation during expectation of reward in the subgenual prefrontal cortex and nucleus accumbens area, regions pivotal to reward processes... - Striatal functional alteration in adolescents characterized by early childhood behavioral inhibitionAmanda E Guyer
Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
J Neurosci 26:6399-405. 2006.... - The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startleChristian Grillon
Mood and Anxiety Disorder Program, National Institutes of Mental Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 60:760-6. 2006..The present study tested the hypothesis that alprazolam would reduce the sustained startle potentiation to contextual threats but not the startle potentiation to a threat cue... - Risk for bipolar disorder is associated with face-processing deficits across emotionsMelissa A Brotman
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Am Acad Child Adolesc Psychiatry 47:1455-61. 2008..It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest... - Neural substrates of choice selection in adults and adolescents: development of the ventrolateral prefrontal and anterior cingulate corticesNeir Eshel
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
Neuropsychologia 45:1270-9. 2007..Consistent with predictions, these results suggest that adolescents engage prefrontal regulatory structures to a lesser extent than adults when making risky economic choices... - Reduction of trace but not delay eyeblink conditioning in panic disorderChristian Grillon
NIMH Mood and Anxiety Disorders Program, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 164:283-9. 2007..The present study examined trace eyeblink conditioning in order to test the hypothesis that individuals with panic disorder are impaired in associative learning tasks that depend on declarative memory... - Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traitsStuart F White
Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Dev Psychopathol 24:1105-16. 2012..The results are discussed with reference to current models of DBD + PT and possible treatment innovations... - The influence of emotional stimuli on attention orienting and inhibitory control in pediatric anxietySven C Mueller
Section of Developmental and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 53:856-63. 2012.... - Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorderAviva K Olsavsky
Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, Maryland, USA
J Am Acad Child Adolesc Psychiatry 51:294-303. 2012..e., those with a first-degree BD relative) will demonstrate amygdala hyperactivation when viewing fearful and happy faces. The at-risk youth were unaffected, in that they had no history of mood disorder... - The pathology of social phobia is independent of developmental changes in face processingKarina S Blair
Mood and Anxiety Program, National Institute of Mental Health, USA
Am J Psychiatry 168:1202-9. 2011..The authors examined neural responses to facial expressions in adults and adolescents with social phobia to determine whether the neural correlates of adult social phobia during face processing also manifest in adolescent social phobia... - Specificity of facial expression labeling deficits in childhood psychopathologyAmanda E Guyer
Mood and Anxiety Program MAP, National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
J Child Psychol Psychiatry 48:863-71. 2007..We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation... - Fear conditioning in adolescents with anxiety disorders: results from a novel experimental paradigmJennifer Y F Lau
Mood and Anxiety Disorders Program, National Institute of Mental Health National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
J Am Acad Child Adolesc Psychiatry 47:94-102. 2008..Adult data suggest that anxiety disorders involve elevated fear but intact differential conditioning. We used a novel paradigm to assess fear conditioning in pediatric anxiety patients... - Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletionAbigail A Marsh
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 189:387-94. 2006..Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed... - Autism spectrum traits in children with mood and anxiety disordersKenneth E Towbin
Mood and Anxiety Program, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Child Adolesc Psychopharmacol 15:452-64. 2005..These results demonstrate a need to develop valid and reliable instruments to screen for ASDs in children presenting outside of ASD clinics... - Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learningElizabeth C Finger
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Arch Gen Psychiatry 65:586-94. 2008.... - Stress responsivity and HPA axis activity in juveniles: results from a home-based CO2 inhalation studyThomas A Terleph
NIMH, NIH, Bldg 15 K, Rm 110, MSC 2670, Bethesda, MD 20817 2670, USA
Am J Psychiatry 163:738-40. 2006..The current home-based study tested the hypothesis that parental panic disorder and offspring response to CO(2) are associated with elevated cortisol levels in juvenile offspring... - Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI studySven C Mueller
Section of Developmental and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
Neuropsychologia 48:3037-44. 2010..incorrect "change" responses recruited the inferior prefrontal cortex (BA 44/46) more strongly in ES subjects than controls. These data suggest impaired cognitive control in youth who experienced ES... - Development of anxiety: the role of threat appraisal and fear learningJennifer C Britton
Mood and Anxiety Disorders Program, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Depress Anxiety 28:5-17. 2011..This novel paradigm can be used to investigate key questions relevant to prognosis and treatment. Depression and Anxiety, 2011.© 2010 Wiley-Liss, Inc... - A developmental examination of gender differences in brain engagement during evaluation of threatErin B McClure
Section on Development and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 55:1047-55. 2004..CONCLUSIONS: These findings suggest that there are gender differences in patterns of neural responses to emotional faces that are not fully apparent until adulthood... - Attention orientation in parents exposed to the 9/11 terrorist attacks and their childrenKara M Lindstrom
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Psychiatry Res 187:261-6. 2011..Larger, prospective studies might examine relationships within families among traumatic exposures, psychopathology, and information-processing functions... - Steroid abnormalities and the developing brain: declarative memory for emotionally arousing and neutral material in children with congenital adrenal hyperplasiaFrancoise S Maheu
Mood and Anxiety Disorders Program, Emotional Development and Affective Neuroscience Section, National Institute of Mental Health, 15K North Drive, Room 300 C, Bethesda, MD 20892 2670, USA
Psychoneuroendocrinology 33:238-45. 2008..Such memory impairments may result from abnormal brain organization and function following hormonal dysfunction during critical periods of development... - Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in childrenMelissa A Brotman
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 60:991-7. 2006..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample... - Altered neural function in pediatric bipolar disorder during reversal learningDaniel P Dickstein
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Bipolar Disord 12:707-19. 2010..Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls... - Adult outcomes of youth irritability: a 20-year prospective community-based studyArgyris Stringaris
Section on Bipolar Spectrum Disorders, Emotion and Development Branch, Mood and Anxiety Program, NIMH Bldg 15K, MSC 2670, Bethesda, MD 20892 2670, USA
Am J Psychiatry 166:1048-54. 2009..This study examines the extent to which youth irritability is related to adult psychiatric outcomes by testing the hypothesis that it predicts depressive and generalized anxiety disorders... - Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle studyChristian Grillon
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 69:549-55. 2011..The current study examines these effects, as instantiated with short- and long-duration threats... - Atypical modulation of medial prefrontal cortex to self-referential comments in generalized social phobiaKarina S Blair
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Psychiatry Res 193:38-45. 2011..We believe that these data reflect a reorganization of self-referential reasoning in the disorder with a self-concept perhaps atypically related to the view of others... - Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorderChristian Grillon
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 66:47-53. 2009..This study tested the hypothesis that elevated anxious reactivity, specifically for unpredictable aversive events, is a psychophysiological correlate of PTSD... - Elucidating risk mechanisms of gene-environment interactions on pediatric anxiety: integrating findings from neuroscienceJennifer Y F Lau
Mood and Anxiety Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Eur Arch Psychiatry Clin Neurosci 258:97-106. 2008..Exploring these relationships during development is crucial, given that these early life processes may potentially shape longer-term patterns of emotional behavior, and therefore life-long trajectories of anxiety... - Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipationBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
J Clin Psychiatry 72:942-8. 2011..Our aim was to isolate the specific components of public speaking that trigger fear in vulnerable individuals and best discriminate between SAD and healthy individuals... - Emotion recognition deficits in pediatric anxiety disorders: implications for amygdala researchJosh Easter
Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892-2670, USA
J Child Adolesc Psychopharmacol 15:563-70. 2005..CONCLUSION: As this study was conducted in a sample undergoing a neuroimaging investigation of amygdala integrity, future analyses will examine associations among amygdala function, clinical anxiety, and face-recognition abilities... - Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathologyDaniel S Pine
Section on Development and Affective Neuroscience, National Institute of Mental Health Intramurral Research Program, Bethesda, MD 20817 2670, USA
Am J Psychiatry 162:291-6. 2005..They tested the hypothesis that attention bias to threatening facial photographs is associated with maltreatment and PTSD... - Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorderShmuel Lissek
Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, NIH, DHHS, MD 20892 2670, USA
Behav Res Ther 47:111-8. 2009..Such results link PD to impaired discrimination learning, reflecting elevated fear responding to learned safety cues... - Face-emotion processing in offspring at risk for panic disorderDaniel S Pine
Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20817 2670, USA
J Am Acad Child Adolesc Psychiatry 44:664-72. 2005..This study tested the hypotheses that offspring of parents with PD and offspring with anxiety disorders display relatively greater sensitivity and attention allocation to fear provocation... - Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescentsMonique Ernst
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
Neuroimage 25:1279-91. 2005..These developmental differences, if replicated, may have important implications for the development of early-onset disorders of emotion and motivation... - Perturbed reward processing in pediatric bipolar disorder: an antisaccade studySven C Mueller
Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, 15K North Drive, Bethesda, MD 20814, USA
J Psychopharmacol 24:1779-84. 2010..By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder... - A neuroimaging method for the study of threat in adolescentsChristopher S Monk
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Dev Psychobiol 43:359-66. 2003..Those who reported increased fear showed right amygdala activation during the threat condition and left amygdala activation in the safe condition. These procedures offer a promising tool for studying youth with anxiety disorders... - Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differencesMichael G Hardin
Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 48:446-54. 2007.... - Challenges in developing novel treatments for childhood disorders: lessons from research on anxietyDaniel S Pine
Mood and Anxiety Disorders Program, Intramural Research Program, The National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Neuropsychopharmacology 34:213-28. 2009..This summary ends by describing potential novel treatments, illustrating the manner in which basic neuroscience informs therapeutics... - Clinical correlates of episodicity in juvenile maniaRobinder K Bhangoo
The Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
J Child Adolesc Psychopharmacol 13:507-14. 2003..The latter hypothesis should be tested in a sample where relatives are interviewed directly... - Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disordersKarina Blair
Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 165:1193-202. 2008..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder... - Performance on a virtual reality spatial memory navigation task in depressed patientsNeda F Gould
Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, NIMH, Mark O Hatfield Clinical Research Center, 10 Center Dr, Bethesda, MD 20892, USA
Am J Psychiatry 164:516-9. 2007..Findings on spatial memory in depression have been inconsistent. A navigation task based on virtual reality may provide a more sensitive and consistent measure of the hippocampal-related spatial memory deficits associated with depression... - Fear conditioning in virtual reality contexts: a new tool for the study of anxietyJohanna M Baas
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 55:1056-60. 2004..CONCLUSIONS: These results support the future use of virtual reality to design new conditioning experiments to study both fear and anxiety... - Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorderTristan Gorrindo
Mood and Anxiety Program, National Institute of Mental Health, Bldg. 10, Rm. 4N-208, 10 Center Dr.-MSC 1255, Bethesda, MD 20892-1255, USA
Am J Psychiatry 162:1975-7. 2005..CONCLUSIONS: Children with bipolar disorder may have a reversal learning deficit... - Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndromeFrancoise S Maheu
National Institute of Mental Health, Bethesda, MD, 20892 2670, USA
Dev Psychopathol 20:1177-89. 2008.... - Cognitive control under contingencies in anxious and depressed adolescents: an antisaccade taskSandra Jazbec
Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Biol Psychiatry 58:632-9. 2005..Furthermore, neural mechanisms can now be examined by using this task paired with functional neuroimaging... - Neuropsychological performance in pediatric bipolar disorderDaniel P Dickstein
National Institute of Mental Health Mood and Anxiety Disorders Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1255, USA
Biol Psychiatry 55:32-9. 2004..Our work suggests altered ventrolateral prefrontal cortex function, especially when linked to other lesion and neuroimaging studies... - Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious pubertySven C Mueller
Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
J Child Adolesc Psychopharmacol 19:41-50. 2009..In contrast, no significant activation of the amygdala was found. These data are consistent with previous studies of the effects of sex hormones on brain function and support the role of testosterone on emotional development... - Adolescent life events as predictors of adult depressionDaniel S Pine
National Institute of Mental Health, Intramural Research Program, Building 10, Room 4N-222, Bethesda, MD 20892-1381, USA
J Affect Disord 68:49-57. 2002..However, this association with generalized anxiety disorder was limited to females. CONCLUSIONS: Life events in adolescence predict risk for major depression during early adulthood... - Animal models of suicide-trait-related behaviorsOz Malkesman
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Trends Pharmacol Sci 30:165-73. 2009..Modeling these relevant traits in animals can help to clarify the impact of SSRIs on these traits, suggesting avenues for reducing suicide risk in this vulnerable population... - Brain development and the onset of mood disordersDaniel S Pine
Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892-1381, USA
Semin Clin Neuropsychiatry 7:223-33. 2002..This is a US government work. There are no restrictions on its use... - Classical fear conditioning in the anxiety disorders: a meta-analysisShmuel Lissek
Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
Behav Res Ther 43:1391-424. 2005.... - The influence of context valence in the neural coding of monetary outcomesMichael G Hardin
Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892 2670, USA
Neuroimage 48:249-57. 2009..The results of this work provide evidence of complex valence-based regional dissociations that are influenced by contextual factors... - Impaired spatial navigation in pediatric anxietySven C Mueller
MAP, NIMH, NIH, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 50:1227-34. 2009..Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders... - Trauma in children and adolescents: risk and treatment of psychiatric sequelaeDaniel S Pine
Intramural Research Program, National Institute of Mental Health, 15K North Drive, Room 110 MSC 2670, Bethesda, MD 20892-1670, USA
Biol Psychiatry 51:519-31. 2002.... - A developmental and neurobiological approach to early trauma researchChristopher S Monk
Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Semin Clin Neuropsychiatry 7:137-46. 2002..This approach will help clarify how early traumatic events have the capacity to lead to psychopathology or a healthy outcome... - Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI studyEric E Nelson
Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 1381, USA
J Child Psychol Psychiatry 44:1015-24. 2003..Prior studies document strong interactions between emotional and mnemonic processes. These interactions have been shown to vary across development and psychopathology, particularly mood and anxiety disorders... - Irritability in pediatric mania and other childhood psychopathologyEllen Leibenluft
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Room 4N 208, MSC 1255, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1008:201-18. 2003..Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly... - Integrating research on developmental psychopathology and neuroscience in the study of adolescence: introduction to part IIDaniel S Pine
NIMH Building 15 K, Room 110, MSC 2670, Bethesda, MD 20817 2670, USA
Ann N Y Acad Sci 1021:61-3. 2004..From the basic science perspective they call attention to the sequence of events that culminates in a fully mature central nervous system... - What does distractibility in ADHD reveal about mechanisms for top-down attentional control?Stacia R Friedman-Hill
Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Cognition 115:93-103. 2010.... - Response to 5% carbon dioxide in children and adolescents: relationship to panic disorder in parents and anxiety disorders in subjectsDaniel S Pine
Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20817, USA
Arch Gen Psychiatry 62:73-80. 2005..Exaggerated responses to CO(2) inhalation have been reported in adults with PD and their unaffected adult relatives, as well as in clinic-referred children with anxiety disorders... - The social re-orientation of adolescence: a neuroscience perspective on the process and its relation to psychopathologyEric E Nelson
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Psychol Med 35:163-74. 2005..While such changes in social behavior have been well documented in the literature, relatively few neurophysiological explanations for these behavioral changes have been presented... - Imaging-genetics applications in child psychiatryDaniel S Pine
National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
J Am Acad Child Adolesc Psychiatry 49:772-82. 2010..To place imaging-genetics research in the context of child psychiatry... - Cortisol and DHEA-S are associated with startle potentiation during aversive conditioning in humansChristian Grillon
NIMH NIH DHHS, Mood and Anxiety Disorder Program, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
Psychopharmacology (Berl) 186:434-41. 2006.... - Chronic versus episodic irritability in youth: a community-based, longitudinal study of clinical and diagnostic associationsEllen Leibenluft
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
J Child Adolesc Psychopharmacol 16:456-66. 2006..In psychiatric nosology, a distinction is made between chronic and episodic irritability. This study examines the validity of this distinction... - The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasksElizabeth C Finger
Mood and Anxiety Disorders Program, Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 32:206-15. 2007..Furthermore, they demonstrate behavioral differences in responses to punishing stimuli between long allele homozygotes and short allele carriers when serotonin levels are acutely reduced... - Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorderBrendan A Rich
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 2670, USA
Proc Natl Acad Sci U S A 103:8900-5. 2006..Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability... - Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevanceShmuel Lissek
Mood and Anxiety Disorders Program, National Institute of Mental Health, Intramural Research Program, NIH, DHHS, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
Behav Res Ther 46:678-87. 2008..The current paradigm represents an updated and efficacious tool with which to study fear generalization--a central, yet understudied conditioning-correlate of pathologic anxiety...