D S Pine

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint A developmental examination of gender differences in brain engagement during evaluation of threat
    Erin B McClure
    Section on Development and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1047-55. 2004
  2. pmc Stimulus-reinforcement-based decision making and anxiety: impairment in generalized anxiety disorder (GAD) but not in generalized social phobia (GSP)
    J DeVido
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Psychol Med 39:1153-61. 2009
  3. pmc Association between level of emotional intelligence and severity of anxiety in generalized social phobia
    Madeline Jacobs
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD, United States
    J Anxiety Disord 22:1487-95. 2008
  4. pmc Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder
    Christian Grillon
    NIMH MAP, 15K North Dr, Bldg 15k, Rm 113, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 165:898-904. 2008
  5. pmc Modulation of emotion by cognition and cognition by emotion
    K S Blair
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Neuroimage 35:430-40. 2007
  6. ncbi request reprint Treating children and adolescents with selective serotonin reuptake inhibitors: how long is appropriate?
    Daniel S Pine
    National Institute of Mental Health, Intramural Research Program, Bethesda, Maryland 20892 1381, USA
    J Child Adolesc Psychopharmacol 12:189-203. 2002
  7. ncbi request reprint Face-emotion processing in offspring at risk for panic disorder
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20817 2670, USA
    J Am Acad Child Adolesc Psychiatry 44:664-72. 2005
  8. pmc Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety
    Daniel S Pine
    Mood and Anxiety Disorders Program, Intramural Research Program, The National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 34:213-28. 2009
  9. ncbi request reprint Integrating research on developmental psychopathology and neuroscience in the study of adolescence: introduction to part II
    Daniel S Pine
    NIMH Building 15 K, Room 110, MSC 2670, Bethesda, MD 20817 2670, USA
    Ann N Y Acad Sci 1021:61-3. 2004
  10. ncbi request reprint Stress responsivity and HPA axis activity in juveniles: results from a home-based CO2 inhalation study
    Thomas A Terleph
    NIMH, NIH, Bldg 15 K, Rm 110, MSC 2670, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 163:738-40. 2006

Collaborators

Detail Information

Publications100

  1. ncbi request reprint A developmental examination of gender differences in brain engagement during evaluation of threat
    Erin B McClure
    Section on Development and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1047-55. 2004
    ..Recent theoretical models suggest that developmental changes in brain functioning play important roles in the emergence of such gender differences...
  2. pmc Stimulus-reinforcement-based decision making and anxiety: impairment in generalized anxiety disorder (GAD) but not in generalized social phobia (GSP)
    J DeVido
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Psychol Med 39:1153-61. 2009
    ..In this study, we examined stimulus-reinforcement-based decision making in GSP and GAD...
  3. pmc Association between level of emotional intelligence and severity of anxiety in generalized social phobia
    Madeline Jacobs
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD, United States
    J Anxiety Disord 22:1487-95. 2008
    ..These results suggest that EI may index emotional processing systems that mitigate the impact of systems causally implicated in GSP...
  4. pmc Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder
    Christian Grillon
    NIMH MAP, 15K North Dr, Bldg 15k, Rm 113, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 165:898-904. 2008
    ..The authors tested the hypothesis that elevated anxious reactivity, specifically toward unpredictable aversive events, is a psychophysiological correlate of panic disorder...
  5. pmc Modulation of emotion by cognition and cognition by emotion
    K S Blair
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Neuroimage 35:430-40. 2007
    ..NeuroImage, 29 (3), 721-733] and negative connectivity with bilateral amygdala. These data suggest that processes involved in emotional regulation are recruited during task performance in the context of emotional distractors...
  6. ncbi request reprint Treating children and adolescents with selective serotonin reuptake inhibitors: how long is appropriate?
    Daniel S Pine
    National Institute of Mental Health, Intramural Research Program, Bethesda, Maryland 20892 1381, USA
    J Child Adolesc Psychopharmacol 12:189-203. 2002
    ..Third, SSRI treatment should be reinitiated in children who exhibit signs of relapse during this medication-free trial...
  7. ncbi request reprint Face-emotion processing in offspring at risk for panic disorder
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20817 2670, USA
    J Am Acad Child Adolesc Psychiatry 44:664-72. 2005
    ..This study tested the hypotheses that offspring of parents with PD and offspring with anxiety disorders display relatively greater sensitivity and attention allocation to fear provocation...
  8. pmc Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety
    Daniel S Pine
    Mood and Anxiety Disorders Program, Intramural Research Program, The National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 34:213-28. 2009
    ..This summary ends by describing potential novel treatments, illustrating the manner in which basic neuroscience informs therapeutics...
  9. ncbi request reprint Integrating research on developmental psychopathology and neuroscience in the study of adolescence: introduction to part II
    Daniel S Pine
    NIMH Building 15 K, Room 110, MSC 2670, Bethesda, MD 20817 2670, USA
    Ann N Y Acad Sci 1021:61-3. 2004
    ..From the basic science perspective they call attention to the sequence of events that culminates in a fully mature central nervous system...
  10. ncbi request reprint Stress responsivity and HPA axis activity in juveniles: results from a home-based CO2 inhalation study
    Thomas A Terleph
    NIMH, NIH, Bldg 15 K, Rm 110, MSC 2670, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 163:738-40. 2006
    ..The current home-based study tested the hypothesis that parental panic disorder and offspring response to CO(2) are associated with elevated cortisol levels in juvenile offspring...
  11. ncbi request reprint Face-memory and emotion: associations with major depression in children and adolescents
    Daniel S Pine
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
    J Child Psychol Psychiatry 45:1199-208. 2004
    ..The study also examines the relationship between parental MDD and memory performance in offspring...
  12. ncbi request reprint Response to 5% carbon dioxide in children and adolescents: relationship to panic disorder in parents and anxiety disorders in subjects
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20817, USA
    Arch Gen Psychiatry 62:73-80. 2005
    ..Exaggerated responses to CO(2) inhalation have been reported in adults with PD and their unaffected adult relatives, as well as in clinic-referred children with anxiety disorders...
  13. ncbi request reprint Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramurral Research Program, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 162:291-6. 2005
    ..They tested the hypothesis that attention bias to threatening facial photographs is associated with maltreatment and PTSD...
  14. ncbi request reprint Trauma, proximity, and developmental psychopathology: the effects of war and terrorism on children
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Neuropsychopharmacology 30:1781-92. 2005
    ..Third, data are reviewed from studies in developmental psychobiology. These data are designed to illustrate the mechanisms through which children exhibit unique effects in the wake of traumatic circumstances...
  15. ncbi request reprint Research review: a neuroscience framework for pediatric anxiety disorders
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    J Child Psychol Psychiatry 48:631-48. 2007
    ..Research using threat-exposure paradigms might most directly integrate basic and clinical perspectives on pediatric anxiety...
  16. pmc Imaging-genetics applications in child psychiatry
    Daniel S Pine
    National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 49:772-82. 2010
    ..To place imaging-genetics research in the context of child psychiatry...
  17. ncbi request reprint Cortical brain regions engaged by masked emotional faces in adolescents and adults: an fMRI study
    D S Pine
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Emotion 1:137-47. 2001
    ..Adolescents and adults differed in the degree to which posterior hemisphere brain areas were engaged by viewing masked facial displays of emotion...
  18. ncbi request reprint Affective neuroscience and the development of social anxiety disorder
    D S Pine
    Section on Development and Affective Neuroscience, Intramural Research Program and Program on Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, Maryland, USA
    Psychiatr Clin North Am 24:689-705. 2001
    ..Recent studies in affective neuroscience suggest potential avenues for answering these questions. As reviewed in the current article, fMRI studies of face processing provide examples of such potentially informative research directions...
  19. ncbi request reprint A primer on brain imaging in developmental psychopathology: what is it good for?
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD 20817 2670, USA
    J Child Psychol Psychiatry 47:983-6. 2006
    ..Brain-imaging research offers a unique opportunity to constrain theories of pathophysiology based on understandings of brain function. This effect promises to open avenues for novel treatments...
  20. ncbi request reprint Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
    ..However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues...
  21. pmc Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation
    Geoff Rau
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1289, USA
    J Child Adolesc Psychopharmacol 18:185-96. 2008
    ..Therefore, we hypothesized that SMD, but not BD, youths would be impaired on a decision-making task that has identified reward- and punishment-processing deficits in individuals with psychopathy...
  22. doi request reprint Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders
    Abigail A Marsh
    Mood and Anxiety Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:712-20. 2008
    ..Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of pediatric callous-unemotional traits and ADHD...
  23. doi request reprint Proton magnetic resonance spectroscopy in youth with severe mood dysregulation
    Daniel P Dickstein
    Unit on Bipolar Spectrum Disorders, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD, USA
    Psychiatry Res 163:30-9. 2008
    ....
  24. ncbi request reprint Clinical correlates of episodicity in juvenile mania
    Robinder K Bhangoo
    The Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 13:507-14. 2003
    ..We hypothesized that the episodic group would be more likely to have a history of psychosis and a parental history of BPD, whereas the chronic group would be more likely to have conduct disorder...
  25. doi request reprint Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder
    Jennifer C Britton
    Mood and Anxiety Disorders Program at the National Institute of Mental Health in Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 49:944-53. 2010
    ..In this study, we tested hypotheses regarding group differences in the behavioral and neural correlates of cognitive flexibility in a pediatric OCD and a healthy comparison (HC) sample...
  26. ncbi request reprint Methods for developmental studies of fear conditioning circuitry
    D S Pine
    National Institute of Mental Health, Bethesda, Maryland 20892-0135, USA
    Biol Psychiatry 50:225-8. 2001
    ..Given that prior studies relate air-puff conditioning to risk for anxiety in children, these methods may provide an avenue for directly studying the developmental neurobiology of fear conditioning...
  27. pmc Neural substrates of choice selection in adults and adolescents: development of the ventrolateral prefrontal and anterior cingulate cortices
    Neir Eshel
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Neuropsychologia 45:1270-9. 2007
    ..Consistent with predictions, these results suggest that adolescents engage prefrontal regulatory structures to a lesser extent than adults when making risky economic choices...
  28. pmc Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders
    Karina Blair
    Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:1193-202. 2008
    ..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder...
  29. ncbi request reprint Performance on a virtual reality spatial memory navigation task in depressed patients
    Neda F Gould
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, NIMH, Mark O Hatfield Clinical Research Center, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 164:516-9. 2007
    ..Findings on spatial memory in depression have been inconsistent. A navigation task based on virtual reality may provide a more sensitive and consistent measure of the hippocampal-related spatial memory deficits associated with depression...
  30. ncbi request reprint Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study
    Roxann Roberson-Nay
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
    Biol Psychiatry 60:966-73. 2006
    ..This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing...
  31. ncbi request reprint Fear conditioning in virtual reality contexts: a new tool for the study of anxiety
    Johanna M Baas
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1056-60. 2004
    ..A virtual environment might prove to be the ideal tool for innovative experimental paradigms to study explicitly cued fear and contextual anxiety in humans...
  32. ncbi request reprint Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder
    Tristan Gorrindo
    Mood and Anxiety Program, National Institute of Mental Health, Bldg 10, Rm 4N 208, 10 Center Dr MSC 1255, Bethesda, MD 20892 1255, USA
    Am J Psychiatry 162:1975-7. 2005
    ....
  33. doi request reprint Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder
    K S Blair
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Psychol Med 43:85-95. 2013
    ....
  34. ncbi request reprint Biased emotional attention in post-traumatic stress disorder: a help as well as a hindrance?
    M Vythilingam
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Psychol Med 37:1445-55. 2007
    ..We investigated these possibilities both with respect to threatening and positive stimuli among traumatized individuals with and without PTSD...
  35. pmc Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndrome
    Francoise S Maheu
    National Institute of Mental Health, Bethesda, MD, 20892 2670, USA
    Dev Psychopathol 20:1177-89. 2008
    ....
  36. ncbi request reprint Neuropsychological performance in pediatric bipolar disorder
    Daniel P Dickstein
    National Institute of Mental Health Mood and Anxiety Disorders Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1255, USA
    Biol Psychiatry 55:32-9. 2004
    ..We sought to examine whether neuropsychological function in children with bipolar disorder resembles that in adults with the illness and to extend our knowledge about cognitive function in pediatric bipolar disorder...
  37. ncbi request reprint Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion
    Abigail A Marsh
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 189:387-94. 2006
    ..Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed...
  38. ncbi request reprint Emotion recognition deficits in pediatric anxiety disorders: implications for amygdala research
    Josh Easter
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    J Child Adolesc Psychopharmacol 15:563-70. 2005
    ..This study examines the relationship between face-emotion recognition and anxiety in a sample of children and adolescents participating in a brain-imaging study of amygdala structure and function...
  39. ncbi request reprint Cognitive control under contingencies in anxious and depressed adolescents: an antisaccade task
    Sandra Jazbec
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Psychiatry 58:632-9. 2005
    ..Antisaccade paradigms are particularly well suited for this endeavor because they provide exquisite behavioral measures of modulation of response errors...
  40. pmc The impact of processing load on emotion
    D G V Mitchell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Neuroimage 34:1299-309. 2007
    ..Together, the data suggest that the processing of task-irrelevant emotional information, like neutral information, is subject to the effects of processing load and is under top-down control...
  41. ncbi request reprint Brain development and the onset of mood disorders
    Daniel S Pine
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 1381, USA
    Semin Clin Neuropsychiatry 7:223-33. 2002
    ..This is a US government work. There are no restrictions on its use...
  42. pmc Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty
    Sven C Mueller
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 19:41-50. 2009
    ..In contrast, no significant activation of the amygdala was found. These data are consistent with previous studies of the effects of sex hormones on brain function and support the role of testosterone on emotional development...
  43. pmc Animal models of suicide-trait-related behaviors
    Oz Malkesman
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 30:165-73. 2009
    ..Modeling these relevant traits in animals can help to clarify the impact of SSRIs on these traits, suggesting avenues for reducing suicide risk in this vulnerable population...
  44. ncbi request reprint Adolescent life events as predictors of adult depression
    Daniel S Pine
    National Institute of Mental Health, Intramural Research Program, Building 10, Room 4N 222, Bethesda, MD 20892 1381, USA
    J Affect Disord 68:49-57. 2002
    ..While studies have begun to examine this issue in adolescents, few studies rely upon prospective epidemiological designs to document relationships between adolescent life events and adult major depression...
  45. ncbi request reprint Adolescent fears as predictors of depression
    D S Pine
    National Institute of Mental Health (NIMH, Intramural Research Program, Program on Mood and Anxiety Disorders, DSP, Bethesda, Maryland 20892-1381, USA
    Biol Psychiatry 50:721-4. 2001
    ..CONCLUSIONS: Relatively high levels of fear in adolescence represent a risk factor for later episodes of major depression...
  46. doi request reprint Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder
    Melissa A Brotman
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 165:385-9. 2008
    ....
  47. pmc Fear conditioning in adolescents with anxiety disorders: results from a novel experimental paradigm
    Jennifer Y F Lau
    Mood and Anxiety Disorders Program, National Institute of Mental Health National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 47:94-102. 2008
    ..Adult data suggest that anxiety disorders involve elevated fear but intact differential conditioning. We used a novel paradigm to assess fear conditioning in pediatric anxiety patients...
  48. pmc Elevated fear conditioning to socially relevant unconditioned stimuli in social anxiety disorder
    Shmuel Lissek
    NIMH, NIH, 15K North Dr, Rm 200, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 165:124-32. 2008
    ..This study represents the first effort to assess the conditioning correlates of social anxiety disorder within an ecologically enhanced paradigm...
  49. pmc Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder
    Melissa A Brotman
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 167:61-9. 2010
    ..The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths...
  50. doi request reprint Elucidating risk mechanisms of gene-environment interactions on pediatric anxiety: integrating findings from neuroscience
    Jennifer Y F Lau
    Mood and Anxiety Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Eur Arch Psychiatry Clin Neurosci 258:97-106. 2008
    ..Exploring these relationships during development is crucial, given that these early life processes may potentially shape longer-term patterns of emotional behavior, and therefore life-long trajectories of anxiety...
  51. pmc Normative data on development of neural and behavioral mechanisms underlying attention orienting toward social-emotional stimuli: an exploratory study
    Kara M Lindstrom
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Bethesda, MD 20892 2670, USA
    Brain Res 1292:61-70. 2009
    ..Implications for future work on developmental changes in attention-emotion processing are discussed...
  52. pmc Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety
    Amanda E Guyer
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Dr, Room 208, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 65:1303-12. 2008
    ..Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening...
  53. pmc Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevance
    Shmuel Lissek
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Intramural Research Program, NIH, DHHS, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Behav Res Ther 46:678-87. 2008
    ..The current paradigm represents an updated and efficacious tool with which to study fear generalization--a central, yet understudied conditioning-correlate of pathologic anxiety...
  54. pmc Perturbed reward processing in pediatric bipolar disorder: an antisaccade study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, 15K North Drive, Bethesda, MD 20814, USA
    J Psychopharmacol 24:1779-84. 2010
    ..By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder...
  55. pmc Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
    Neuropsychologia 48:3037-44. 2010
    ..incorrect "change" responses recruited the inferior prefrontal cortex (BA 44/46) more strongly in ES subjects than controls. These data suggest impaired cognitive control in youth who experienced ES...
  56. pmc The influence of context valence in the neural coding of monetary outcomes
    Michael G Hardin
    Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892 2670, USA
    Neuroimage 48:249-57. 2009
    ..The results of this work provide evidence of complex valence-based regional dissociations that are influenced by contextual factors...
  57. pmc Contextual fear conditioning in humans: cortical-hippocampal and amygdala contributions
    Ruben P Alvarez
    Mood and Anxiety Disorders Program, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:6211-9. 2008
    ..These results provide evidence that similar brain mechanisms may underlie contextual fear conditioning across species...
  58. pmc Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 66:47-53. 2009
    ..This study tested the hypothesis that elevated anxious reactivity, specifically for unpredictable aversive events, is a psychophysiological correlate of PTSD...
  59. pmc What does distractibility in ADHD reveal about mechanisms for top-down attentional control?
    Stacia R Friedman-Hill
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Cognition 115:93-103. 2010
    ....
  60. pmc Impaired spatial navigation in pediatric anxiety
    Sven C Mueller
    MAP, NIMH, NIH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 50:1227-34. 2009
    ..Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders...
  61. pmc Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differences
    Michael G Hardin
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:446-54. 2007
    ....
  62. pmc Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Proc Natl Acad Sci U S A 103:8900-5. 2006
    ..Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability...
  63. ncbi request reprint Chronic versus episodic irritability in youth: a community-based, longitudinal study of clinical and diagnostic associations
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 16:456-66. 2006
    ..In psychiatric nosology, a distinction is made between chronic and episodic irritability. This study examines the validity of this distinction...
  64. ncbi request reprint The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasks
    Elizabeth C Finger
    Mood and Anxiety Disorders Program, Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 32:206-15. 2007
    ..Furthermore, they demonstrate behavioral differences in responses to punishing stimuli between long allele homozygotes and short allele carriers when serotonin levels are acutely reduced...
  65. ncbi request reprint Choice selection and reward anticipation: an fMRI study
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuropsychologia 42:1585-97. 2004
    ....
  66. ncbi request reprint Irritability in pediatric mania and other childhood psychopathology
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Room 4N 208, MSC 1255, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1008:201-18. 2003
    ..Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly...
  67. ncbi request reprint Classical fear conditioning in the anxiety disorders: a meta-analysis
    Shmuel Lissek
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
    Behav Res Ther 43:1391-424. 2005
    ....
  68. ncbi request reprint Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuroimage 25:1279-91. 2005
    ..These developmental differences, if replicated, may have important implications for the development of early-onset disorders of emotion and motivation...
  69. ncbi request reprint Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder
    Ellen Leibenluft
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Health and Human Services, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 164:52-60. 2007
    ..They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder (ADHD) versus those with bipolar disorder without ADHD...
  70. ncbi request reprint A developmental and neurobiological approach to early trauma research
    Christopher S Monk
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Semin Clin Neuropsychiatry 7:137-46. 2002
    ..This approach will help clarify how early traumatic events have the capacity to lead to psychopathology or a healthy outcome...
  71. ncbi request reprint Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI study
    Eric E Nelson
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 1381, USA
    J Child Psychol Psychiatry 44:1015-24. 2003
    ..Prior studies document strong interactions between emotional and mnemonic processes. These interactions have been shown to vary across development and psychopathology, particularly mood and anxiety disorders...
  72. ncbi request reprint A neuroimaging method for the study of threat in adolescents
    Christopher S Monk
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Dev Psychobiol 43:359-66. 2003
    ..Those who reported increased fear showed right amygdala activation during the threat condition and left amygdala activation in the safe condition. These procedures offer a promising tool for studying youth with anxiety disorders...
  73. ncbi request reprint The development of psychopathy
    R J R Blair
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Heath, Department of Health and Human Services, Bethesda, MD, USA
    J Child Psychol Psychiatry 47:262-76. 2006
    ..These impairments disrupt the impact of standard socialization techniques and increase the risk for frustration-induced reactive aggression respectively...
  74. pmc Early childhood temperament predicts substance use in young adults
    A Lahat
    Department of Human Development, University of Maryland, College Park, MD 20742, USA
    Transl Psychiatry 2:e157. 2012
    ..These longitudinal data delineate one developmental pathway involving early biology and brain mechanisms for substance use in young adulthood...
  75. pmc Early androgen exposure modulates spatial cognition in congenital adrenal hyperplasia (CAH)
    S C Mueller
    MAP, NIMH, NIH, 15K North Drive, Bethesda, MD 20892, United States
    Psychoneuroendocrinology 33:973-80. 2008
    ..Such finding suggests a pivotal role of hormonal function on brain development in humans, mirroring results from the animal literature...
  76. ncbi request reprint Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorder
    Daniel P Dickstein
    National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 10 Center Drive MSC 1255, Building 10 Room 4N208, Bethesda MD 20892 1255, USA
    Biol Psychiatry 58:517-24. 2005
    ..To move beyond diagnosis toward unique pathophysiology, we evaluated both ADHD and BPD children for neurologic examination abnormalities (NEAs) in comparison with normal control (NC) children...
  77. ncbi request reprint Polishing the windows of the mind
    Cameron S Carter
    Am J Psychiatry 163:761-3. 2006
  78. ncbi request reprint The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle
    Christian Grillon
    Mood and Anxiety Disorder Program, National Institutes of Mental Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:760-6. 2006
    ..The present study tested the hypothesis that alprazolam would reduce the sustained startle potentiation to contextual threats but not the startle potentiation to a threat cue...
  79. ncbi request reprint Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder
    Christopher S Monk
    Department of Psychology, University of Michigan, 2000 East Hall, 530 Church St, Ann Arbor, MI 48109, USA
    Am J Psychiatry 163:1091-7. 2006
    ....
  80. ncbi request reprint Salivary cortisol concentrations before and after carbon-dioxide inhalations in children
    Jeremy D Coplan
    Department of Psychiatry, SUNY Downstate, Brooklyn, NY, USA
    Biol Psychiatry 51:326-33. 2002
    ..If confirmed, this would relate hypothalamic-pituitary adrenal axis activation in juveniles, as in adults, and response to a well-studied respiratory procedure...
  81. ncbi request reprint The strong situation: a potential impediment to studying the psychobiology and pharmacology of anxiety disorders
    Shmuel Lissek
    DHHS, NIH, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Biol Psychol 72:265-70. 2006
    ....
  82. ncbi request reprint Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation
    Michael P Milham
    Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biol Psychiatry 57:961-6. 2005
    ..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies...
  83. ncbi request reprint Incidence of social anxiety disorder and the consistent risk for secondary depression in the first three decades of life
    Katja Beesdo
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Germany
    Arch Gen Psychiatry 64:903-12. 2007
    ....
  84. ncbi request reprint The social re-orientation of adolescence: a neuroscience perspective on the process and its relation to psychopathology
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Psychol Med 35:163-74. 2005
    ..While such changes in social behavior have been well documented in the literature, relatively few neurophysiological explanations for these behavioral changes have been presented...
  85. ncbi request reprint Memory deficits in children with and at risk for anxiety disorders
    Roma A Vasa
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21211, USA
    Depress Anxiety 24:85-94. 2007
    ..These findings are relevant to understanding the phenomenology of childhood anxiety disorders and may provide insights into the neural circuits underlying these disorders...
  86. ncbi request reprint Effects of a psychosocial family-based preventive intervention on cortisol response to a social challenge in preschoolers at high risk for antisocial behavior
    Laurie Miller Brotman
    NYU Child Study Center, New York University School of Medicine, 215 Lexington Avenue, New York, NY 10016, USA
    Arch Gen Psychiatry 64:1172-9. 2007
    ..Although studies in rodents implicate early-life social experience in cortisol regulation, no studies with humans have examined the effects of an experimentally manipulated early-life social experience on cortisol regulation...
  87. ncbi request reprint Does major depressive disorder in parents predict specific fears and phobias in offspring?
    Matthew G Biel
    Department of Child and Adolescent Psychiatry, NYU Child Study Center, NYU School of Medicine, New York University, New York, USA
    Depress Anxiety 25:379-82. 2008
    ..Elevated rates of specific fears in offspring of parents with MDD+anxiety disorder may be a function of more severe parental psychopathology, increased genetic loading, or unmeasured environmental influences...
  88. ncbi request reprint Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression
    Christopher S Monk
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Psychiatry 165:90-8. 2008
    ..This study compares amygdala and nucleus accumbens activation in children and adolescents at high and low risk for major depression under varying attentional and emotional conditions...
  89. ncbi request reprint Editorial: Answering questions in developmental science: separating the wheat from the chaff
    Daniel S Pine
    J Child Psychol Psychiatry 48:1157-9. 2007
  90. pmc Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder
    Carrie L Masten
    Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095, USA
    Child Abuse Negl 32:139-53. 2008
    ..However, research has provided little evidence indicating how high rates of PTSD might relate to maltreated children's processing of emotions...
  91. pmc Attention alters neural responses to evocative faces in behaviorally inhibited adolescents
    Koraly Perez-Edgar
    Department of Psychology, George Mason University, USA
    Neuroimage 35:1538-46. 2007
    ..These patterns of reactivity may help sustain early temperamental biases over time and contribute to the observed relation between BI and anxiety...
  92. ncbi request reprint Responses to conflict and cooperation in adolescents with anxiety and mood disorders
    Erin B McClure
    Department of Psychology, Georgia State University, P O Box 5010, Atlanta, GA 30302 5010, USA
    J Abnorm Child Psychol 35:567-77. 2007
    ..These findings offer a first step toward elucidating the mechanisms underlying social impairment in youth with internalizing disorders...
  93. doi request reprint Agoraphobia and panic. Prospective-longitudinal relations suggest a rethinking of diagnostic concepts
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Psychother Psychosom 77:147-57. 2008
    ..The aim of the current study is to prospectively examine the 10-year natural course of PA, PD and AG in the first three decades of life, their stability and their reciprocal transitions...
  94. ncbi request reprint Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disorders
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:819-21. 2007
    ..Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness...
  95. doi request reprint Attentional bias for emotional faces in children with generalized anxiety disorder
    Allison M Waters
    School of Psychology, Griffith University, Queensland, Australia
    J Am Acad Child Adolesc Psychiatry 47:435-42. 2008
    ..To examine attentional bias for angry and happy faces in 7- to 12-year-old children with generalized anxiety disorder (GAD; n = 23) and nonanxious controls (n = 25)...
  96. ncbi request reprint Onset of spontaneous panic attacks: a prospective study of risk factors
    William Coryell
    University of Iowa Carver College of Medicine, Department of Psychiatry, 2 205 MEB, Iowa City, IA 52242, USA
    Psychosom Med 68:754-7. 2006
    ..An association of those features with a subsequent onset of panic attacks would compose additional evidence that they are trait markers for panic disorder...
  97. ncbi request reprint fMRI predictors of treatment outcome in pediatric anxiety disorders
    Erin B McClure
    Department of Psychology, Georgia State University, P O Box 5010, Atlanta, GA 30302 5010, USA
    Psychopharmacology (Berl) 191:97-105. 2007
    ..Interest has emerged in this phenomenon as a possible biological marker for individuals who are likely to benefit from tailored treatment approaches...
  98. pmc Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder
    Christopher S Monk
    Department of Psychology, University of Michigan, 530 Church St, Ann Arbor, MI 48109 1043, USA
    Arch Gen Psychiatry 65:568-76. 2008
    ..Disturbed interactions between these structures may underlie pediatric anxiety. To date, no study has selectively examined responses to briefly presented threats in GAD or in pediatric anxiety...
  99. ncbi request reprint An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making
    Amy L Krain
    NYU Child Study Center, NYU School of Medicine, New York, NY 10016, USA
    J Child Psychol Psychiatry 47:1023-30. 2006
    ..The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits...
  100. ncbi request reprint A functional magnetic resonance imaging investigation of uncertainty in adolescents with anxiety disorders
    Amy L Krain
    New York University Child Study Center, New York University School of Medicine, New York, NY 10016, USA
    Biol Psychiatry 63:563-8. 2008
    ..As such, the present study examines the relationship between IU and neural responses to uncertainty in anxious adolescents...