Barbora Piknova

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay
    Barbora Piknova
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Mol Biol 704:39-56. 2011
  2. pmc The role of nitrite in neurovascular coupling
    Barbora Piknova
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Brain Res 1407:62-8. 2011
  3. pmc Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin
    Steven B Solomon
    Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Free Radic Biol Med 53:2229-39. 2012
  4. pmc Effect of storage on levels of nitric oxide metabolites in platelet preparations
    Ji Won Park
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Transfusion 53:637-44. 2013
  5. pmc In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines
    Dong Wang
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Division of Pulmonary, Allergy and Critical Care Medicine and the Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Physics and the Translational Science Center, Wake Forest University, Winston Salem, North Carolina Anesthesia and Critical Care Medicine Department, West China Hospital of Sichuan University, Cheng Du, China Critical Care Medicine Department, Hospital Universitario de Getafe, Getafe, Madrid, Spain
    Transfusion 53:3149-63. 2013
  6. pmc The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies
    Barbora Piknova
    National Institutes of Health, NIH, NIDDK, Molecular Medicine Branch, Bethesda, MD 20892, USA
    Nitric Oxide 20:88-94. 2009
  7. pmc A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes
    Krittapoom Akrawinthawong
    Molecular Medicine Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Department of Biochemistry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    PLoS ONE 9:e92435. 2014
  8. pmc Effect of blood nitrite and nitrate levels on murine platelet function
    Ji Won Park
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e55699. 2013
  9. pmc Acute erythropoietin cardioprotection is mediated by endothelial response
    Ruifeng Teng
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1822, USA
    Basic Res Cardiol 106:343-54. 2011
  10. doi request reprint Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes
    Nathawut Sibmooh
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 47:2989-96. 2008

Collaborators

  • Daniel B Kim-Shapiro
  • Mark T Gladwin
  • Charles Natanson
  • John W Calvert
  • Dong Wang
  • Masayuki Yamamoto
  • Junhui Sun
  • Alan N Schechter
  • Ji Won Park
  • Nathawut Sibmooh
  • Krittapoom Akrawinthawong
  • Steven B Solomon
  • Ruifeng Teng
  • Suthat Fucharoen
  • Shalini Seetharaman
  • James Kurtz
  • Paul L Huang
  • Constance T Noguchi
  • Stephen J Wagner
  • Daniel Sweeney
  • Steven J Kern
  • Landon Bellavia
  • Gabriela A Ferreyra
  • Christine C Helms
  • Nicolaas J H Raat
  • Linda C McPhail
  • S Bruce King
  • Andreas Perlegas
  • David J Lefer
  • Constance Tom Noguchi
  • Kevin Martinez
  • Norio Suzuki
  • Fabiola Rizzatti

Detail Information

Publications10

  1. pmc Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay
    Barbora Piknova
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Mol Biol 704:39-56. 2011
    ..We also explain how to preserve the original physiological nitrite concentration in nitrite-hostile environments, such as an excess of hemoglobin in blood...
  2. pmc The role of nitrite in neurovascular coupling
    Barbora Piknova
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Brain Res 1407:62-8. 2011
    ..These results suggest that nitrite can be efficiently converted into NO and utilized to support normal cerebrovascular physiology...
  3. pmc Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin
    Steven B Solomon
    Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Free Radic Biol Med 53:2229-39. 2012
    ..Increases in metHb in the red blood cell, the potential of AS for neurotoxicity, and hypotension would need to be carefully monitored in a clinical trial. ..
  4. pmc Effect of storage on levels of nitric oxide metabolites in platelet preparations
    Ji Won Park
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Transfusion 53:637-44. 2013
    ..We also tested whether the material of PLT storage containers affects nitrite content since many plastic materials are known to contain and release nitrite...
  5. pmc In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines
    Dong Wang
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Division of Pulmonary, Allergy and Critical Care Medicine and the Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Physics and the Translational Science Center, Wake Forest University, Winston Salem, North Carolina Anesthesia and Critical Care Medicine Department, West China Hospital of Sichuan University, Cheng Du, China Critical Care Medicine Department, Hospital Universitario de Getafe, Getafe, Madrid, Spain
    Transfusion 53:3149-63. 2013
    ..To clarify this, we tested the vascular effect and fate of oxyHb or metHb infusions...
  6. pmc The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies
    Barbora Piknova
    National Institutes of Health, NIH, NIDDK, Molecular Medicine Branch, Bethesda, MD 20892, USA
    Nitric Oxide 20:88-94. 2009
    ..Our findings suggest that pharmacological doses of nitrite are unlikely to cause free radical or ferrylhemoglobin formation in plasma originating from the reaction of nitrite with cell-free oxyhemoglobin in vivo...
  7. pmc A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes
    Krittapoom Akrawinthawong
    Molecular Medicine Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Department of Biochemistry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    PLoS ONE 9:e92435. 2014
    ..We believe that our flow cytometric assays offer a possibility to identify the individual molecular process involved in these effects. ..
  8. pmc Effect of blood nitrite and nitrate levels on murine platelet function
    Ji Won Park
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e55699. 2013
    ..Our study suggests that endogenous levels of nitrite and nitrate may be used as a biomarker for predicting platelet function and that dietary manipulation may affect thrombotic processes...
  9. pmc Acute erythropoietin cardioprotection is mediated by endothelial response
    Ruifeng Teng
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1822, USA
    Basic Res Cardiol 106:343-54. 2011
    ..The immediate response of coronary artery endothelial cells to Epo stimulation by NO production may be a critical mechanism underlying this Epo cardioprotection...
  10. doi request reprint Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes
    Nathawut Sibmooh
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 47:2989-96. 2008
    ..These data provide a physiologically robust mechanism for erythrocytic transport of NO bioactivity allowing for hormone-like properties...