Susan K Pierce


Affiliation: National Institutes of Health
Country: USA


  1. Akkaya M, Akkaya B, Miozzo P, Rawat M, Pena M, Sheehan P, et al. B Cells Produce Type 1 IFNs in Response to the TLR9 Agonist CpG-A Conjugated to Cationic Lipids. J Immunol. 2017;199:931-940 pubmed publisher
    ..These findings fill an important gap in our understanding of the B cell response to CpGs, with implications for the use of CpG-A and CpG-B as immunomodulators. ..
  2. Kwak K, Quizon N, Sohn H, Saniee A, Manzella Lapeira J, Holla P, et al. Intrinsic properties of human germinal center B cells set antigen affinity thresholds. Sci Immunol. 2018;3: pubmed publisher
    ..The pod-like structures also mediated affinity-dependent antigen internalization by unconventional pathways distinct from those of naïve B cells. Thus, intrinsic properties of human GC B cells set thresholds for affinity selection. ..
  3. Akkaya M, Traba J, Roesler A, Miozzo P, Akkaya B, Theall B, et al. Second signals rescue B cells from activation-induced mitochondrial dysfunction and death. Nat Immunol. 2018;19:871-884 pubmed publisher
    ..Thus, BCR signaling seems to activate a metabolic program that imposes a limited time frame during which B cells either receive a second signal and survive or are eliminated. ..
  4. Pierce S. Understanding B cell activation: from single molecule tracking, through Tolls, to stalking memory in malaria. Immunol Res. 2009;43:85-97 pubmed publisher
  5. Pierce S, Liu W. Encoding immunological memory in the initiation of B-cell receptor signaling. Cold Spring Harb Symp Quant Biol. 2013;78:231-7 pubmed publisher
    ..These findings underscore an interesting parallel in the mechanisms at play in encoding immunological memory and memory in the nervous system. ..
  6. Wang J, Sohn H, Sun G, Milner J, Pierce S. The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly. Sci Signal. 2014;7:ra89 pubmed publisher
    ..Thus, the cSH2 domain functions not only to inhibit the active site of PLC-γ2 but also to directly or indirectly stabilize the early BCR signaling complex. ..
  7. Gordon E, Hart G, Tran T, Waisberg M, Akkaya M, Skinner J, et al. Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria. MBio. 2015;6:e00725 pubmed publisher
    ..Here we report results that open a new avenue for the development of highly selective adjunctive therapies for cerebral malaria by targeting pathways that regulate host and parasite metabolism. ..
  8. Pierce S, Miller L. World Malaria Day 2009: what malaria knows about the immune system that immunologists still do not. J Immunol. 2009;182:5171-7 pubmed publisher
    ..A close second is the antigenic targets in malaria and how to overcome the enormous polymorphism of these targets. Meeting these challenges represents a call to arms of basic immunologists to advance our knowledge of malaria immunity. ..
  9. Hart G, Akkaya M, Chida A, Wei C, Jenks S, Tipton C, et al. The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa. J Immunol. 2016;197:3841-3849 pubmed
    ..Determining the origin and function of 9G4+ B cells and 9G4+ IgG in malaria may contribute to a better understanding of the varied roles of autoreactivity in infectious diseases. ..

More Information


  1. Lee J, Sengupta P, Brzostowski J, Lippincott Schwartz J, Pierce S. The nanoscale spatial organization of B-cell receptors on immunoglobulin M- and G-expressing human B-cells. Mol Biol Cell. 2017;28:511-523 pubmed publisher
  2. Akkaya M, Akkaya B, Kim A, Miozzo P, Sohn H, Pena M, et al. Toll-like receptor 9 antagonizes antibody affinity maturation. Nat Immunol. 2018;19:255-266 pubmed publisher
    ..Thus, TLR9 signaling might enhance antibody titers at the expense of the ability of B cells to engage in germinal-center events that are highly dependent on B cells' capture and presentation of antigen. ..
  3. Crompton P, Pierce S. PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria. Immunity. 2016;45:231-3 pubmed publisher
    ..In this issue of Immunity, Karunarathne et al. (2016) show that dendritic cells help CD4(+) T helper 1 cell immunity against malaria through PD-L2's competition with PD-L1. ..
  4. Portugal S, Obeng Adjei N, Moir S, Crompton P, Pierce S. Atypical memory B cells in human chronic infectious diseases: An interim report. Cell Immunol. 2017;321:18-25 pubmed publisher
    ..We also comment on the possible relationship of human aMBCs and T-bet+, CD11c+ age/autoimmune-associated B cells, also a topic of this review volume. ..