R M Pfeiffer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women
    Alexander M Strasak
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Int J Cancer 123:1902-6. 2008
  2. ncbi Combining assays for estimating prevalence of human herpesvirus 8 infection using multivariate mixture models
    Ruth M Pfeiffer
    Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892 7244, USA
    Biostatistics 9:137-51. 2008
  3. ncbi Absolute risk prediction of second primary thyroid cancer among 5-year survivors of childhood cancer
    Stephanie A Kovalchik
    National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    J Clin Oncol 31:119-27. 2013
  4. ncbi Sufficient dimension reduction for longitudinally measured predictors
    Ruth M Pfeiffer
    Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892 7244, USA
    Stat Med 31:2414-27. 2012
  5. ncbi HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study
    Mercy Guech-Ongey
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, Bethesda, Maryland, USA
    Infect Agent Cancer 5:21. 2010
  6. ncbi Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Breast Cancer Res 13:R42. 2011
  7. ncbi Cis sequence effects on gene expression
    Andrew W Bergen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
    BMC Genomics 8:296. 2007
  8. ncbi Performance of high-throughput DNA quantification methods
    Kashif A Haque
    Core Genotyping Facility, SAIC Frederick, Inc, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biotechnol 3:20. 2003
  9. ncbi Two criteria for evaluating risk prediction models
    R M Pfeiffer
    Biostatistics Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA
    Biometrics 67:1057-65. 2011
  10. ncbi Geographic heterogeneity of prevalence of the human herpesvirus 8 in sub-Saharan Africa: clues about etiology
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Ann Epidemiol 20:958-63. 2010

Detail Information

Publications93

  1. ncbi Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women
    Alexander M Strasak
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Int J Cancer 123:1902-6. 2008
    ..006). Our study is the first to demonstrate in a large population-based cohort that high GGT levels significantly increased cancer risk in women...
  2. ncbi Combining assays for estimating prevalence of human herpesvirus 8 infection using multivariate mixture models
    Ruth M Pfeiffer
    Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892 7244, USA
    Biostatistics 9:137-51. 2008
    ..We assess model performance in simulations and present results from applying various parameterizations of the model to the Ugandan study...
  3. ncbi Absolute risk prediction of second primary thyroid cancer among 5-year survivors of childhood cancer
    Stephanie A Kovalchik
    National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    J Clin Oncol 31:119-27. 2013
    ..We developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors...
  4. ncbi Sufficient dimension reduction for longitudinally measured predictors
    Ruth M Pfeiffer
    Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892 7244, USA
    Stat Med 31:2414-27. 2012
    ....
  5. ncbi HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study
    Mercy Guech-Ongey
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, Bethesda, Maryland, USA
    Infect Agent Cancer 5:21. 2010
    ..Larger population-based studies are needed to estimate the magnitude and direction of association of HLA with KSHV shedding and viral control...
  6. ncbi Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Breast Cancer Res 13:R42. 2011
    ..Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study...
  7. ncbi Cis sequence effects on gene expression
    Andrew W Bergen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
    BMC Genomics 8:296. 2007
    ....
  8. ncbi Performance of high-throughput DNA quantification methods
    Kashif A Haque
    Core Genotyping Facility, SAIC Frederick, Inc, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biotechnol 3:20. 2003
    ..The effects of manual and robotic laboratory sample handling procedures on the estimates of DNA concentration were assessed using variance components analyses...
  9. ncbi Two criteria for evaluating risk prediction models
    R M Pfeiffer
    Biostatistics Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA
    Biometrics 67:1057-65. 2011
    ..We develop new methods, based on influence functions, for inference for a single risk model, and also for comparing the PCFs and PNFs of two risk models, both of which were evaluated in the same validation data...
  10. ncbi Geographic heterogeneity of prevalence of the human herpesvirus 8 in sub-Saharan Africa: clues about etiology
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Ann Epidemiol 20:958-63. 2010
    ..We assessed HHV-8 seropositivity in several African countries with heterogeneous environments and varying KS incidence using a unified approach...
  11. ncbi On a supplemented case-control design
    Ruth M Pfeiffer
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8030, Bethesda, Maryland 20892 7244, USA
    Biometrics 61:584-90. 2005
    ....
  12. ncbi Effect of changing breast cancer incidence rates on the calibration of the Gail model
    Sara J Schonfeld
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Clin Oncol 28:2411-7. 2010
    ..Motivated by changes in breast cancer incidence during the 1990s, we evaluated the model's calibration in two recent cohorts...
  13. ncbi A case-cohort design for assessing covariate effects in longitudinal studies
    Ruth M Pfeiffer
    Biostatistics Branch, National Cancer Institute, DCEG, EPS 8030, Bethesda, Maryland 20892 7244, USA
    Biometrics 61:982-91. 2005
    ..As an illustration we apply the design to data from an ongoing study of childhood asthma...
  14. ncbi Timing of births and endometrial cancer risk in Swedish women
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd EPS RM 8030, Bethesda, MD 20892 7244, USA
    Cancer Causes Control 20:1441-9. 2009
    ..0001) for women with > or =25 years since a last birth compared to women having given birth within 4 years. Our findings support that clearance of initiated cells during delivery may be important in endometrial carcinogenesis...
  15. ncbi A model free approach to combining biomarkers
    Ruth M Pfeiffer
    Biostatistics Branch, National Cancer Institute, 6120 Executive Blvd, EPS 8030, Bethesda, MD 20892, USA
    Biom J 50:558-70. 2008
    ..An asymptotic chi-squared test for assessing individual biomarker contribution to the diagnostic score is also derived...
  16. ncbi On combining family and case-control studies
    Ruth M Pfeiffer
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892 7244, USA
    Genet Epidemiol 32:638-46. 2008
    ..The models are compared in simulations. Data from a case-control and a family study from north-eastern Italy on melanoma and a low-risk melanoma-susceptibility gene, MC1R, are used to illustrate the approaches...
  17. ncbi Methods for testing familial aggregation of diseases in population-based samples: application to Hodgkin lymphoma in Swedish registry data
    R M Pfeiffer
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Bethesda, MD, 20892 7244, USA
    Ann Hum Genet 68:498-508. 2004
    ..We compare these methods in analysis of familial aggregation of HL and also present simulations to compare survival analyses with analyses of binary outcome data...
  18. ncbi Robustness of inference on measured covariates to misspecification of genetic random effects in family studies
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7244, USA
    Genet Epidemiol 24:14-23. 2003
    ..The model is applied to data from a family study on nasopharyngeal carcinoma in Taiwan...
  19. ncbi Sample size calculations for population- and family-based case-control association studies on marker genotypes
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7244, USA
    Genet Epidemiol 25:136-48. 2003
    ..The large sample-size requirements represent a formidable challenge to studies of this type...
  20. ncbi A model to estimate risk of infection with human herpesvirus 8 associated with transfusion from cross-sectional data
    Ruth M Pfeiffer
    Biostatistics Branch, National Cancer Institute, Bethesda, Maryland 20892 7244, USA
    Biometrics 60:249-56. 2004
    ..The parameters are estimated via maximum likelihood. Finally, we present results from applying various parameterizations of the model to the Ugandan study...
  21. ncbi Efficiency of DNA pooling to estimate joint allele frequencies and measure linkage disequilibrium
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8030, Bethesda, MD 20892 7244, USA
    Genet Epidemiol 22:94-102. 2002
    ..Our methods allow for imperfect assay sensitivity and specificity. The expected savings in numbers of assays required when pooling is utilized compared to individual testing are quantified...
  22. ncbi Two approaches to mutation detection based on functional data
    Ruth M Pfeiffer
    National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892 7244, USA
    Stat Med 21:3447-64. 2002
    ..We apply both methods to data on the breast cancer susceptibility gene BRCA1 and test the performance of the methods on independent samples...
  23. ncbi The effect of a low-fat, high fiber, fruit and vegetable intervention on rectal mucosal proliferation
    Ruth Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, The National Institutes of Health, Bethesda, Maryland 20892 7244, USA
    Cancer 98:1161-8. 2003
    ..The basic hypothesis underlying these investigations is that specific dietary components may reduce or increase the rate of cell proliferation, which, in turn, may reduce or increase neoplastic changes in the large bowel...
  24. ncbi Spectrum of cancer risk late after AIDS onset in the United States
    Edgar P Simard
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076, Rockville, MD 20892, USA
    Arch Intern Med 170:1337-45. 2010
    ..We conducted this study to assess long-term cancer risk among persons with AIDS relative to the general population and the impact of HAART on cancer incidence...
  25. ncbi Survival patterns among lymphoma patients with a family history of lymphoma
    Lesley A Anderson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Clin Oncol 26:4958-65. 2008
    ..Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings...
  26. ncbi CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China
    M Patricia Madigan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Int J Cancer 107:271-5. 2003
    ..Large population-based studies are needed to clarify whether CYP17 plays a role in prostate cancer risk and whether genotype effects vary in different racial/ethnic and other subgroups...
  27. ncbi Prediction error estimation: a comparison of resampling methods
    Annette M Molinaro
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD 20852, USA
    Bioinformatics 21:3301-7. 2005
    ..With a focus on prediction assessment, we compare several methods for estimating the 'true' prediction error of a prediction model in the presence of feature selection...
  28. ncbi Prevalence of SEN viruses among injection drug users in the San Francisco Bay area
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    J Infect Dis 188:13-8. 2003
    ..05; 95% CI, 2.62-18.95). SENV strains are common among San Francisco Bay area IDUs, and prevalence varies demographically within this group...
  29. ncbi Probability that a two-stage genome-wide association study will detect a disease-associated snp and implications for multistage designs
    M H Gail
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7244, US
    Ann Hum Genet 72:812-20. 2008
    ..g. pi(sample)<or= 0.25) should be avoided, and that additional genotyping in earlier studies with small first stages will yield previously unselected disease-associated SNPs...
  30. ncbi Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis
    M C Camargo
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Br J Cancer 105:38-43. 2011
    ..This study aimed to identify additional determinants of EBV positivity and their joint effects...
  31. ncbi Age-related crossover in breast cancer incidence rates between black and white ethnic groups
    William F Anderson
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 100:1804-14. 2008
    ..This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact...
  32. ncbi Reproducibility and correlations of multiplex cytokine levels in asymptomatic persons
    Hui Lee Wong
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, Room 7073, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 17:3450-6. 2008
    ..Grossly elevated blood levels characterize certain diseases; variations within physiologic ranges could also have significance. We therefore evaluated the performance characteristics of a multiplex cytokine immunoassay...
  33. ncbi Tuberculosis and subsequent risk of lung cancer in Xuanwei, China
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 124:1183-7. 2009
    ..The increased lung cancer risk, persisting years after a tuberculosis diagnosis, could reflect the effects of chronic pulmonary inflammation and scarring arising from tuberculosis...
  34. ncbi Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:5412-7. 2009
    ..In the present study, an asymptomatic MGUS stage consistently preceded MM. Novel molecular markers are needed to better predict progression to MM in patients with MGUS...
  35. ncbi A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer
    Claire S Zhu
    Division of Cancer Prevention, National Cancer Institute, National Institute of Health, Bethesda, MD 20892 7346, USA
    Cancer Prev Res (Phila) 4:375-83. 2011
    ..Thus, biomarker panels discovered in diagnostic samples may not validate in prediagnostic samples; utilizing prediagnostic samples for discovery may be helpful in developing validated early detection panels...
  36. ncbi A novel wavelet-based thresholding method for the pre-processing of mass spectrometry data that accounts for heterogeneous noise
    Deukwoo Kwon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Proteomics 8:3019-29. 2008
    ..We study our method on real and simulated mass spectrometry data and show that it improves on performances of peak detection methods...
  37. ncbi Seroprevalence and risk factors for human herpesvirus 8 infection, rural Egypt
    Sam M Mbulaiteye
    National Cancer Institute, Bethesda, MD, USA
    Emerg Infect Dis 14:586-91. 2008
    ..1, 95% CI 0.3-16.4), but marginal for women (OR 1.5, 95% CI 1.0-2.5). Our findings suggest salivary and possible nosocomial HHV-8 transmission in rural Egypt...
  38. ncbi Colorectal cancer risk prediction tool for white men and women without known susceptibility
    Andrew N Freedman
    Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, EPN 4005 MSC 7344, Bethesda, MD 20892 7344, USA
    J Clin Oncol 27:686-93. 2009
    ....
  39. ncbi Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
    ..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
  40. ncbi Common variation in genes related to innate immunity and risk of adult glioma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1651-8. 2009
    ..We have identified a promising set of innate immunity-related genetic regions for further investigation...
  41. ncbi Cancer burden in the HIV-infected population in the United States
    Meredith S Shiels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    J Natl Cancer Inst 103:753-62. 2011
    ..We estimated the annual number of cancers in the HIV-infected population, both with and without AIDS, in the United States...
  42. ncbi Survival patterns in patients with Hodgkin's lymphoma with a pre-existing hospital discharge diagnosis of autoimmune disease
    Ola Landgren
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Oncol 28:5081-7. 2010
    ..Autoimmune diseases (AIs) are associated with elevated risk for Hodgkin's lymphoma (HL); however, information on the interplay of AIs and HL on survival is sparse...
  43. ncbi Age at cancer diagnosis among persons with AIDS in the United States
    Meredith S Shiels
    National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA
    Ann Intern Med 153:452-60. 2010
    ..Studies have reported young ages at cancer diagnosis in HIV-infected persons and have suggested that HIV accelerates carcinogenesis. However, these comparisons did not account for differences in population age structures...
  44. ncbi Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007
    Meredith S Shiels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7059, Rockville, MD 20892, USA
    JAMA 305:1450-9. 2011
    ....
  45. ncbi Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women
    Ola Landgren
    Center for Cancer Research and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:1056-9. 2010
    ..Our findings support the hypothesis that obesity is etiologically linked to myelomagenesis. The 2-fold excess of MGUS among blacks compared with whites of similar socioeconomic status supports a role for susceptibility genes in MGUS...
  46. ncbi Immunologic and virologic predictors of AIDS-related non-hodgkin lymphoma in the highly active antiretroviral therapy era
    Eric A Engels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, 6120 Executive Boulevard, EPS 7076 Rockville, MD 20892
    J Acquir Immune Defic Syndr 54:78-84. 2010
    ..The association with high-level viremia could reflect detrimental effects on immune function related to incompletely effective HAART or direct effects on B cells...
  47. ncbi A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma
    Todd M Gibson
    Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA
    Cancer Causes Control 21:1061-9. 2010
    ..We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a prospective study of Finnish male smokers aged 50-69 at baseline...
  48. ncbi Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts
    Li Jiao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 21:1305-14. 2010
    ..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes...
  49. ncbi Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD, USA
    Fam Cancer 9:625-33. 2010
    ..These genetic variants may, at least partially, exert their effects through nevi and tanning ability...
  50. ncbi Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations
    Xiaohong Rose Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD 20852, USA
    Int J Cancer 125:2912-7. 2009
    ..Our findings support the hypothesis that common genetic polymorphisms in DNA repair, apoptosis and immune response pathways may modify the risk of CMM in CMM-prone families with or without CDKN2A mutations...
  51. ncbi Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, USA
    Lancet Oncol 9:359-66. 2008
    ..DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer...
  52. ncbi Human herpesvirus 8 infection within families in rural Tanzania
    Sam M Mbulaiteye
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    J Infect Dis 187:1780-5. 2003
    ..2; 95% CI, 1.9-9.4). Our data are consistent with the occurrence of HHV-8 transmission within families, from mothers and other relatives to children via nonsexual routes and between spouses via sexual routes...
  53. ncbi Risk of second non-hematological malignancies among 376,825 breast cancer survivors
    Linda Morris Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, MSC 7244, Bethesda, MD 20892 7244, USA
    Breast Cancer Res Treat 106:439-51. 2007
    ....
  54. ncbi Cancer risk prediction models: a workshop on development, evaluation, and application
    Andrew N Freedman
    Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
    J Natl Cancer Inst 97:715-23. 2005
    ....
  55. ncbi Elevated risk of lung cancer among people with AIDS
    Anil K Chaturvedi
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7072, Rockville, MD 20852, USA
    AIDS 21:207-13. 2007
    ..Lung cancer risk was compared between PWA and the general population and its relationship with immunosuppression was assessed. The likelihood that excess risk is explained by a high prevalence of smoking was also investigated...
  56. ncbi Comparison of age distribution patterns for different histopathologic types of breast carcinoma
    William F Anderson
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS, Room 8036, 6120 Executive Boulevard, Bethesda, MD 20892 7244, USA
    Cancer Epidemiol Biomarkers Prev 15:1899-905. 2006
    ..More recent studies, however, have shown distinct age incidence patterns for female breast cancer when stratified by estrogen receptor (ER) expression and/or histopathologic subtypes, suggesting etiologic heterogeneity...
  57. ncbi Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 98:1321-30. 2006
    ..In contrast, there are limited data on risk of Hodgkin lymphoma following autoimmune diseases and almost no data addressing whether there is a familial association between the conditions...
  58. ncbi MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 97:998-1007. 2005
    ..We examined MC1R and ASIP genotypes in relation to phenotypic characteristics, sporadic and familial melanoma risk, and melanoma thickness as an indicator of disease progression in a Mediterranean population...
  59. ncbi Methods for etiologic and early marker investigations in the PLCO trial
    Richard B Hayes
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
    Mutat Res 592:147-54. 2005
    ..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial...
  60. ncbi Trends in cancer risk among people with AIDS in the United States 1980-2002
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    AIDS 20:1645-54. 2006
    ..People with AIDS have heightened cancer risk from immunosuppression. HAART has been available since 1996 and has reduced AIDS-related mortality, but there are few large-scale studies on cancer trends...
  61. ncbi MC1R germline variants confer risk for BRAF-mutant melanoma
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Science 313:521-2. 2006
    ..In this tumor subtype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanomas with BRAF mutations...
  62. ncbi Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7084, MSC 7234 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:873-5. 2006
    ..001)...
  63. ncbi No evidence for anticipation in lymphoproliferative tumors in population-based samples
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Room 511, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1245-50. 2005
    ..This is the first study to consider the changes of incidence over time as a source of bias when evaluating anticipation in lymphoproliferative cancers...
  64. ncbi Early- and late-onset breast cancer types among women in the United States and Japan
    Rayna K Matsuno
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 8105, Rockville, MD 20852 7244, USA
    Cancer Epidemiol Biomarkers Prev 16:1437-42. 2007
    ....
  65. ncbi Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Cancer Res 67:10608-17. 2007
    ....
  66. ncbi Probability of detecting disease-associated single nucleotide polymorphisms in case-control genome-wide association studies
    Mitchell H Gail
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8032, Bethesda, MD 20892 7244, USA
    Biostatistics 9:201-15. 2008
    ..A large initial CCGWAS is desirable if genetic effects are small or if the cost of a follow-up study is large...
  67. ncbi Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
    Int J Cancer 105:546-51. 2003
    ..The peak in late adulthood deserves further study. Variation in incidence by race suggests a role for genetic factors. Our study did not demonstrate broadly increased risk for malignancies following thymoma...
  68. ncbi Risk of second malignant neoplasms among lymphoma patients with a family history of cancer
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 120:1099-102. 2007
    ..99, 95% CI: 0.73-5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders...
  69. ncbi Familial aggregation of Hodgkin lymphoma and related tumors
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Cancer 100:1902-8. 2004
    ..However, the spectrum of malignancies associated with common genetic etiology and the effects of gender and age on familial risk have not been established...
  70. ncbi Shifting breast cancer trends in the United States
    William F Anderson
    Biostatistics Branch, Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892 7244, USA
    J Clin Oncol 25:3923-9. 2007
    ..United States breast cancer incidence rates declined during the years 1999 to 2003, and then reached a plateau. These recent trends are impressive and may indicate an end to decades of increasing incidence...
  71. ncbi Detection of kaposi sarcoma-associated herpesvirus DNA in saliva and buffy-coat samples from children with sickle cell disease in Uganda
    Sam M Mbulaiteye
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
    J Infect Dis 190:1382-6. 2004
    ..Detection was associated with K8.1 seropositivity, younger age, and high household density, indicating the importance of in-household person-to-person transmission, likely via saliva...
  72. ncbi Identifying individuals at high risk of melanoma: a practical predictor of absolute risk
    Thomas R Fears
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Oncol 24:3590-6. 2006
    ..We developed a model to estimate the 5-year absolute risk of melanoma to efficiently identify individuals at increased risk of melanoma for potential interventions...
  73. ncbi Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies
    Kelly L Bolton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 19:992-9. 2010
    ..We assessed agreement between automated and pathologist scores of a diverse set of immunohistochemical assays done on breast cancer tissue microarrays (TMA)...
  74. ncbi Human herpesvirus 8 infection and transfusion history in children with sickle-cell disease in Uganda
    Sam M Mbulaiteye
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 95:1330-5. 2003
    ..We studied the association between HHV-8 seropositivity and transfusion history among children with sickle-cell disease in Uganda, where HHV-8 infection is common in blood donors...
  75. ncbi Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bldg EPS Room 7110, Bethesda, MD 20892 7236, USA
    Mayo Clin Proc 82:1468-73. 2007
    ....
  76. ncbi Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver
    T R O'Brien
    Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Genes Immun 12:428-33. 2011
    ..We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV...
  77. ncbi Prolactin serum levels and breast cancer: relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland
    J M Faupel-Badger
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, 6120 Executive Blvd EPS, Suite 150E, MSC 7105, Bethesda, MD 20892, USA
    Br J Cancer 103:1097-102. 2010
    ....
  78. ncbi Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: a population-based case-control study
    S M Gadalla
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 100:817-21. 2009
    ..49, 95% CI=0.26-0.93) among women with SLE. These findings suggest that systemic inflammation may affect breast epithelial neoplasia...
  79. ncbi Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 104:1850-4. 2004
    ..We conclude that the familial component of CLL is shared with other lymphoproliferative malignances, suggesting common genetic pathways. However, because clinically diagnosed CLL is uncommon, absolute excess risk to relatives is small...
  80. ncbi Autoimmune disease in individuals and close family members and susceptibility to non-Hodgkin's lymphoma
    Lene Mellemkjaer
    Danish Cancer Society, Copenhagen, Denmark
    Arthritis Rheum 58:657-66. 2008
    ..This study was initiated to evaluate the risks of NHL associated with a personal or family history of a wide range of autoimmune diseases...
  81. ncbi Graphical methods for class prediction using dimension reduction techniques on DNA microarray data
    Efstathia Bura
    Department of Statistics, The George Washington University, 2201 G Street NW, Washington, DC 20052, USA
    Bioinformatics 19:1252-8. 2003
    ..RESULTS: The methods are applied to cDNA microarray data on BRCA1 and BRCA2 mutation carriers as well as sporadic tumors from Hedenfalk et al. (2001). All samples are correctly classified...
  82. ncbi MC1R variants increase risk of melanomas harboring BRAF mutations
    Maria Concetta Fargnoli
    Department of Dermatology, University of L Aquila, L Aquila, Italy
    J Invest Dermatol 128:2485-90. 2008
    ..This study confirms that the known MC1R-melanoma risk association is confined to subjects whose melanomas harbor BRAF mutations...
  83. ncbi Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Prostate 67:1487-97. 2007
    ..Significant differences in AMACR allele frequencies have been reported for hereditary prostate cancer (HPC), but the relevance of AMACR in the context of its substrates have not been studied...
  84. ncbi Racial differences in breast cancer trends in the United States (2000-2004)
    Ruth M Pfeiffer
    J Natl Cancer Inst 100:751-2. 2008
  85. ncbi Workshop on imaging science development for cancer prevention and preemption
    Gary J Kelloff
    NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
    Cancer Biomark 3:1-33. 2007
    ..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer...
  86. ncbi Water, socioeconomic factors, and human herpesvirus 8 infection in Ugandan children and their mothers
    Sam M Mbulaiteye
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
    J Acquir Immune Defic Syndr 38:474-9. 2005
    ..Human herpesvirus 8 (HHV-8) infection is common in sub-Saharan Africa, but its distribution is uneven. Transmission occurs during childhood within families by unclear routes...
  87. ncbi On criteria for evaluating models of absolute risk
    Mitchell H Gail
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, EPS 8032, Bethesda, MD 20892 7244, USA
    Biostatistics 6:227-39. 2005
    ..These examples indicate that the usefulness of a general criterion such as concordance depends on the application, and that using specific loss functions can lead to more appropriate assessments...
  88. ncbi HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    AIDS 21:225-9. 2007
    ..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission...
  89. ncbi Survival after cancer diagnosis in persons with AIDS
    Robert J Biggar
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20852, USA
    J Acquir Immune Defic Syndr 39:293-9. 2005
    ..Clinicians should be encouraged by the improving prognosis and be diligent about detecting and treating cancer in PWA...
  90. ncbi Transmission of Kaposi sarcoma-associated herpesvirus between mothers and children in a South African population
    Babatyi I Malope
    Cancer Epidemiology Research Group, National Health Laboratory Services, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 44:351-5. 2007
    ..To assess whether Kaposi sarcoma-associated herpesvirus (KSHV) with or without HIV coinfection in South African mothers is associated with higher KSHV seropositivity in their children...
  91. ncbi Evaluation of apolipoprotein A1 and posttranslationally modified forms of transthyretin as biomarkers for ovarian cancer detection in an independent study population
    Lee E Moore
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS 8118, Bethesda, MD 20852 7240, USA
    Cancer Epidemiol Biomarkers Prev 15:1641-6. 2006
    ..A previous study by Zhang et al. reported identification and validation of three biomarkers using proteomic profiling that together improved early-stage ovarian cancer detection...
  92. ncbi Measurement of urine pH for epidemiological studies on bladder cancer
    Juan Alguacil
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Eur J Epidemiol 22:91-8. 2007
    ....
  93. ncbi With or without a gold standard
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Epidemiology 16:595-7. 2005