Constantinos Petrovas

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007
  2. pmc CD4 T follicular helper cell dynamics during SIV infection
    Constantinos Petrovas
    Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    J Clin Invest 122:3281-94. 2012
  3. pmc Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
  4. pmc High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:9836-44. 2013
  5. pmc Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection
    Takuya Yamamoto
    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
    J Virol 86:5877-84. 2012
  6. pmc HIV integration and T cell death: additional commentary
    Arik Cooper
    Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bldg, 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, MD 20892 3005, USA
    Retrovirology 10:150. 2013
  7. pmc PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2281-92. 2006
  8. pmc Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
    Takuya Yamamoto
    National Institutes of Health, Bethesda, MD, USA
    Blood 117:4805-15. 2011
  9. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
  10. pmc Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010

Collaborators

Detail Information

Publications18

  1. pmc SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007
    ..Manipulation of the interaction of PD-1 with its ligands could thus potentially restore the CD8+ T-cell responses in SIV infection...
  2. pmc CD4 T follicular helper cell dynamics during SIV infection
    Constantinos Petrovas
    Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    J Clin Invest 122:3281-94. 2012
    ..Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins...
  3. pmc Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
    ..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection...
  4. pmc High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:9836-44. 2013
    ..Our data suggest that the persistence of PD-1(high) SIV-specific CD8 T cells in chronic infection is maintained in vivo by a mechanism involving high production coupled with a high disappearance rate. ..
  5. pmc Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection
    Takuya Yamamoto
    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
    J Virol 86:5877-84. 2012
    ..The ability to elicit such virus-specific EM CD8(+) T cells might contribute substantially to an efficacious HIV/AIDS vaccine, even after breakthrough infection...
  6. pmc HIV integration and T cell death: additional commentary
    Arik Cooper
    Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bldg, 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, MD 20892 3005, USA
    Retrovirology 10:150. 2013
    ..Nature 498:376-379, 2013). They have raised several hypothetical points that we further clarify here...
  7. pmc PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2281-92. 2006
    ....
  8. pmc Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
    Takuya Yamamoto
    National Institutes of Health, Bethesda, MD, USA
    Blood 117:4805-15. 2011
    ..Thus, multiple coinhibitory receptors can affect the development of HIV-specific CD8(+) T-cell responses and, by extension, represent potential targets for new immune-based interventions in HIV-infected persons...
  9. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
    ..These data provide the first direct evidence that immune activation drives viral replication, and suggest caution in the use of therapeutic approaches for HIV infection in vivo that increase CD4(+) T cell proliferation...
  10. pmc Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010
    ....
  11. pmc Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression
    Matthew J Johnson
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    Vaccine 32:717-24. 2014
    ..This may be a possible mechanism that results in reduced immunogenicity of rAd28 and rAd35-based vectors. ..
  12. pmc Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Blood 114:1553-62. 2009
    ..Thus, minor viral and host genetic polymorphisms can dramatically alter the immunologic and virologic outcome of an epitope-specific CD8 T-cell response...
  13. ncbi request reprint HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration
    Arik Cooper
    Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3005, USA
    Nature 498:376-9. 2013
    ....
  14. pmc Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity
    Matthew J Johnson
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:6109-18. 2012
    ..Taken together, our results demonstrate that rAd-induced IFN-α production has multiple effects on T cell immunogenicity, the understanding of which should be considered in the design of rAd vaccine vectors...
  15. pmc Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection
    Kristin L Boswell
    Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
    PLoS Pathog 10:e1003853. 2014
    ..Overall, our data identify a heterogeneous population of circulating CD4 T cells that provides in vitro help to B cells, and challenges the origin of these cells as memory TFH cells. ..
  16. pmc Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
    Athanassios Vassilopoulos
    Genetics of Development, Disease Branch, National Institute of Diabetes, Digestive, Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Int J Biol Sci 4:133-42. 2008
    ..These data provide evidence that breast cancer stem cells originate from normal stem cells and advance our understanding of BRCA1-associated tumorigenesis with possible implications for future cancer treatment...
  17. pmc Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes
    Jung S Byun
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:19286-91. 2009
    ....
  18. ncbi request reprint T follicular helper cells and HIV/SIV-specific antibody responses
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
    Curr Opin HIV AIDS 9:235-41. 2014
    ....