Affiliation: National Institutes of Health
Fabozzi G, Pegu A, Koup R, Petrovas C. Bispecific antibodies: Potential immunotherapies for HIV treatment. Methods. 2018;: pubmed publisher
..Inclusion of novel HIV neutralizing Abs with high potency and breadth as components of bsAbs could represent alternative strategies for virus elimination by harnessing the adaptive immune response in vivo. ..
Moysi E, Petrovas C, Koup R. The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses. Retrovirology. 2018;15:54 pubmed publisher
..Finally, we consider future directions for the study of Tfh and offer perspective on factors that could be modulated to enhance Tfh function in the context of prophylactic vaccination. ..
Moysi E, Estes J, Petrovas C. Novel Imaging Methods for Analysis of Tissue Resident Cells in HIV/SIV. Curr HIV/AIDS Rep. 2016;13:38-43 pubmed publisher
..We also present some perspective on the future of the technology development. ..
Petrovas C, Ferrando Martinez S, Gerner M, Casazza J, Pegu A, Deléage C, et al
. Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies. Sci Transl Med. 2017;9: pubmed publisher
..Our results indicate that CD8 T cells with potent cytolytic activity are recruited to GCs during HIV infection and, if appropriately redirected to kill HIV-infected cells, could be an effective component of an HIV cure strategy. ..
Petrovas C, Chaon B, Ambrozak D, Price D, Melenhorst J, Hill B, et al
. Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection. J Immunol. 2009;183:1120-32 pubmed publisher
..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection. ..
Petrovas C, Yamamoto T, Gerner M, Boswell K, Wloka K, Smith E, et al
. CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest. 2012;122:3281-94 pubmed publisher
..Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins. ..
Dimopoulos Y, Moysi E, Petrovas C. The Lymph Node in HIV Pathogenesis. Curr HIV/AIDS Rep. 2017;14:133-140 pubmed publisher
..A better understanding of the biology of immune cells in HIV-infected lymph nodes is a prerequisite to attaining the ultimate goal of complete viral eradication. ..
Amodio D, Cotugno N, Macchiarulo G, Rocca S, Dimopoulos Y, Castrucci M, et al
. Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination. J Immunol. 2018;200:538-550 pubmed publisher