Research Topics
Genomes and Genes
| R S PetraliaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neuronsJinhyun Kim
Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 54:933-47. 2007..These results present an additional mechanism for synaptic integration and plasticity through the activity-dependent regulation of Kv4.2 channel surface expression...
AP180 and CALM in the developing hippocampus: expression at the nascent synapse and localization to trafficking organellesRonald S Petralia
Laboratory of Neurochemistry, NIDCD NIH, Bethesda, Maryland 20892, USA
J Comp Neurol 504:314-27. 2007..Our observations link AP180 and CALM to multiple vesicular organelles and raise the possibility that these proteins may play additional roles in developing neurons...- Distribution of extrasynaptic NMDA receptors on neuronsRonald S Petralia
Advanced Imaging Core, NIDCD NIH, 50 South Drive 50 4142, Bethesda, MD 20892 8027, USA
ScientificWorldJournal 2012:267120. 2012..In some cases, activation of extrasynaptic NMDA receptors may have a negative influence on the neuron, leading to cell damage and death, as may occur in some major diseases of the nervous system... - Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1Wei Wang
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Pain 7:11. 2011..PICK1 appears to be required for peripheral nerve injury-induced neuropathic pain development and to be a potential biochemical target for treating this disorder... - NMDA receptors and PSD-95 are found in attachment plaques in cerebellar granular layer glomeruliRonald S Petralia
Laboratory of Neurochemistry, 50 4142, NIDCD NIH, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
Eur J Neurosci 15:583-7. 2002..The presence of NMDA receptors in attachment plaques suggests that these receptors mediate changes in the adhesive properties of these plaques, similar to this function in synapses... - Internalization at glutamatergic synapses during developmentRonald S Petralia
Laboratory of Neuroscience, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
Eur J Neurosci 18:3207-17. 2003..Also, caveolin might be prevalent at excitatory synapses, although it is not known whether it is involved in receptor internalization, receptor stabilization, or some other function... - Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nucleiRonald S Petralia
Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
Eur J Neurosci 19:2017-29. 2004.... - Organization of NMDA receptors at extrasynaptic locationsR S Petralia
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders National Institutes of Health NIDCD NIH, Bethesda, MD, USA
Neuroscience 167:68-87. 2010..These associations may facilitate unique functions for extrasynaptic NMDA receptors... - Ontogeny of postsynaptic density proteins at glutamatergic synapsesRonald S Petralia
Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
Mol Cell Neurosci 29:436-52. 2005..Development was marked by substantial decreases in NR2B and SAP102 and increases in NR2A, PSD-95, AMPA receptors, and CaMKII. Other components showed more moderate changes... - Glutamate receptor targeting in the postsynaptic spine involves mechanisms that are independent of myosin VaR S Petralia
Laboratory of Neurochemistry, NIDCD NIH, 36 5D08, 36 CONVENT DR MSC 4162, Bethesda MD 20892 4162, USA
Eur J Neurosci 13:1722-32. 2001..Other possible mechanisms include diffusion along the extrasynaptic membrane and delivery via other motors running along the spine's actin cytoskeleton... - Variations in the tangential distribution of postsynaptic glutamate receptors in Purkinje cell parallel and climbing fiber synapses during developmentR S Petralia
NIDCD NIH, Laboratory of Neurochemistry, Bethesda, MD 20892, USA
Neuropharmacology 37:1321-34. 1998.... - A developmental change in NMDA receptor-associated proteins at hippocampal synapsesN Sans
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 20:1260-71. 2000..These studies suggest that there is a preference for complexes of NR2A/PSD-93/95 and NR2B/SAP-102. These results indicate that individual receptor-associated proteins may have specific functions that are critical to synapse development... - Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathwayN Sans
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
J Neurosci 21:7506-16. 2001..We also show that internalization of GluR1, as triggered by NMDAR activation, does not require SAP97. These results implicate GluR1-SAP97 interactions in mechanisms underlying AMPA receptor targeting... - Glutamate receptor subunit 2-selective antibody shows a differential distribution of calcium-impermeable AMPA receptors among populations of neuronsR S Petralia
Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892 4162, USA
J Comp Neurol 385:456-76. 1997..Both ultrastructural and immunofluorescence data showed that calcium-impermeable AMPA receptors are widespread in dendrite arborizations... - Ocsyn, a novel syntaxin-interacting protein enriched in the subapical region of inner hair cellsS Safieddine
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892, USA
Mol Cell Neurosci 20:343-53. 2002..Here we report the cloning of a novel syntaxin-binding protein that is concentrated in a previously uncharacterized organelle at the apex of inner hair cells... - Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleusR S Petralia
Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892, USA
J Comp Neurol 372:356-83. 1996.... - A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR1 alpha metabotropic glutamate receptorsR S Petralia
Laboratory of Neurochemistry, NIDCD NIH, Bethesda, MD 20892 4162, USA
J Chem Neuroanat 13:77-93. 1997.... - Distribution of members of the PSD-95 family of MAGUK proteins at the synaptic region of inner and outer hair cells of the guinea pig cochleaC Davies
Section on Structural Cell Biology, NIDCD, NIH, Bethesda, Maryland, USA
Synapse 40:258-68. 2001..In addition, PSD-93 and PSD-95 are found in postsynaptic afferent terminals on inner hair cells, while postsynaptic afferent terminals on outer hair cells have PSD-93... - Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapsesK W Roche
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 19:3926-34. 1999.... - Homer 1b regulates the trafficking of group I metabotropic glutamate receptorsK W Roche
Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 274:25953-7. 1999..Because H1b is found in dendritic spines of neurons, local retention of metabotropic receptors within dendritic ER provides a potential mechanism for regulating synapse-specific expression of group I metabotropic glutamate receptors... - mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expressionNathalie Sans
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
Nat Cell Biol 7:1179-90. 2005..mPins changes the number and morphology of dendritic spines and these effects depend on its Galphai interaction domain, thus implicating G-protein signalling in the regulation of postsynaptic structure and trafficking of GluRs... - A neuronal role for SNAP-23 in postsynaptic glutamate receptor traffickingYoung Ho Suh
Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
Nat Neurosci 13:338-43. 2010..SNAP-23 is therefore important for the functional regulation of postsynaptic glutamate receptors... - A novel family of adhesion-like molecules that interacts with the NMDA receptorChang Yu Wang
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
J Neurosci 26:2174-83. 2006..After transfection of heterologous cells with NR1 and NR2 cDNAs, through coimmunoprecipitation analyses, we find that SALM1 also interacts with the NMDA receptor NR1 subunit through its extracellular or TM1 domains... - Early events in the trafficking of N-methyl-D-aspartate (NMDA) receptorsR J Wenthold
Laboratory of Neurochemistry, NIDCD, NIH, Building 50, Room 4140, Bethesda, MD 20892, USA
Biochem Soc Trans 31:885-8. 2003.... - Glutamate receptor subunits in the nucleus of the tractus solitarius and other regions of the medulla oblongata in the catR Ambalavanar
Voice and Speech Section, NIDCD, NIH, Bethesda, Maryland 20892 1416, USA
J Comp Neurol 402:75-92. 1998..This finding suggests that neurons in these structures are designed to respond differently to excitatory input... - The role of the PDZ protein GIPC in regulating NMDA receptor traffickingZhaohong Yi
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:11663-75. 2007..Our results suggest that GIPC may be preferentially associated with extrasynaptic NMDA receptors and may play a role in the organization and trafficking of this population of receptors... - Identification of a novel SNAP25 interacting protein (SIP30)Ho Ki Lee
Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 81:1338-47. 2002..Although SIP30 does not directly interact with syntaxin based on pull-down assays, syntaxin does co-immunoprecipitate with SIP30 suggesting that syntaxin is indirectly associated with SIP30, perhaps through SNAP25... - Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopyPamela J Yao
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
J Comp Neurol 494:368-79. 2006..Our results suggest a dual role for epsin1 and HIP1 in the synapse: as broadly required factors for promoting clathrin assembly and as adaptors for specific endocytic pathways... - Trafficking of NMDA receptorsRobert J Wenthold
Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892, USA
Annu Rev Pharmacol Toxicol 43:335-58. 2003..This review addresses recent advances in our understanding of NMDAR trafficking and its synaptic delivery and maintenance... - Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber CA3 pyramid synapsesMichelle T W Ho
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:11651-62. 2007..Together, these findings indicate that the transient participation of CP-AMPARs at young MF-PYR synapses dictates the developmental window to observe DiLTD... - Synaptic distribution of the endocytic accessory proteins AP180 and CALMPamela J Yao
Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
J Comp Neurol 481:58-69. 2005..We propose that both AP180 and CALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways... - Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunitNathalie Sans
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
J Neurosci 23:9367-73. 2003..Therefore, GluR1 may have a greater preference for GluR2 than it does for GluR3... - NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complexNathalie Sans
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
Nat Cell Biol 5:520-30. 2003..Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking... - SAP102 is a highly mobile MAGUK in spinesChan Ying Zheng
Laboratories of Neurochemistry and Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:4757-66. 2010..These differences and the compensatory properties of the MAGUKs point out an unrecognized versatility of the MAGUKs in their function in synaptic organization and plasticity... - Vesicle targeting in hair cellsRobert J Wenthold
Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD 20892, USA
Audiol Neurootol 7:45-8. 2002..Our results are consistent with ocsyn playing a role in vesicle trafficking to the apical membrane of the hair cell... - Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodiesR J Wenthold
Laboratory of Neurochemistry, National Institute of Deafness and Communication Disease, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 269:1332-9. 1994..Interestingly, GluR1 and GluR2, subunits of the AMPA receptor, also co-immunoprecipitated with GluR6 in cells co-transfected with GluR6 and GluR1 or GluR2 cD-NAs. Such complexes appear to be present to a limited extent in the brain... - Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampusDetlef Vullhorst
Section on Molecular Neurobiology, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892 3714, USA
J Neurosci 29:12255-64. 2009.... - The SALM family of adhesion-like molecules forms heteromeric and homomeric complexesGail K Seabold
Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD 20892 8027, USA
J Biol Chem 283:8395-405. 2008..Co-culture experiments using HeLa cells and rat hippocampal neurons expressing the SALMs showed that SALM4 is recruited to points of contact between the cells. In neurons, these points of contact were seen in both axons and dendrites... - Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizuresMangala M Soundarapandian
Biomedical Science Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA
J Neurochem 103:1982-8. 2007..1/SUR1 channels enhances glutamate release at CA3 synapses. Hence, expression of functional Kir6.1/SUR1 channels inhibits seizure responses and possibly acts via limiting excitatory glutamate release... - Actinfilin, a brain-specific actin-binding protein in postsynaptic densityYing Chen
Department of Physiology, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
J Biol Chem 277:30495-501. 2002..The results showed the postsynaptic density distribution of actinfilin. Together, these results indicate that actinfilin may be a key player in the actin-based neuronal function... - mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACERichard W Cho
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 57:858-71. 2008..These observations suggest that cleaved NPR functions to "capture" AMPAR for endocytosis and reveal a bifunctional role of NPs in both synapse strengthening and weakening... - Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor traffickingShoaib Chowdhury
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 52:445-59. 2006..These findings reveal a novel molecular pathway that is regulated by Arc/Arg3.1 and likely contributes to late-phase synaptic plasticity and memory consolidation... - Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticityDesheng Xu
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 39:513-28. 2003..This mechanism appears to contribute to both activity-independent and activity-dependent excitatory synaptogenesis... - Distribution of kainate receptor subunits at hippocampal mossy fiber synapsesMelanie Darstein
Molecular Neurobiology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 23:8013-9. 2003.... - Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1Sang Jeong Kim
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland 21205, USA
Nature 426:285-91. 2003..Furthermore, co-expression of mGluR1 and TRPC1 in a heterologous system reconstituted a mGluR1-evoked conductance that closely resembles the slow EPSC in Purkinje cells... 
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteinsSusumu Tomita
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 161:805-16. 2003..These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system...- Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memoryHey Kyoung Lee
Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Cell 112:631-43. 2003..The phosphomutant mice show deficits in LTD and LTP and have memory defects in spatial learning tasks. These results demonstrate that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories... - AMPA receptor subunit expression in chick vestibular nucleus neuronsAnastas Popratiloff
Department of Anatomy and Cell Biology, and Neuroscience Program, George Washington University Medical Center, Washington DC 20037, USA
J Neurosci Res 76:662-77. 2004..In summary, these results indicate that GluR3 and GluR4 are the major AMPA receptor subunits involved in excitatory synaptic transmission in principal cells during the perinatal period... - Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densitiesOlga Ganeshina
Department of Cell and Molecular Biology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Comp Neurol 468:86-95. 2004.... - Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1Chong Hyun Kim
Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Nat Neurosci 8:985-7. 2005..This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity... - TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticityNathalie Rouach
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
Nat Neurosci 8:1525-33. 2005.... - Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 proteinYuan Xiang Tao
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosci 23:6703-12. 2003..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain... - Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neuronsIttai Bushlin
Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 28:10257-71. 2008..Additionally, CALM-deficient neurons show disrupted secretory transport. Our data demonstrate previously unknown functions for AP180 and CALM in intracellular trafficking that are essential in the growth of neurons... - Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2Jeffrey R Gingrich
Brain and Behaviour Program, Hospital for Sick Children, Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1X8
Proc Natl Acad Sci U S A 101:6237-42. 2004....