R S Petralia

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons
    Jinhyun Kim
    Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 54:933-47. 2007
  2. ncbi request reprint AP180 and CALM in the developing hippocampus: expression at the nascent synapse and localization to trafficking organelles
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, Bethesda, Maryland 20892, USA
    J Comp Neurol 504:314-27. 2007
  3. ncbi request reprint Communication breakdown: the impact of ageing on synapse structure
    Ronald S Petralia
    Advanced Imaging Core, NIDCD NIH, Bethesda, MD 20892, United States Electronic address
    Ageing Res Rev 14:31-42. 2014
  4. pmc Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti
    Katherine B Szarama
    Section on Developmental Neuroscience, Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    BMC Dev Biol 13:6. 2013
  5. pmc Distribution of extrasynaptic NMDA receptors on neurons
    Ronald S Petralia
    Advanced Imaging Core, NIDCD NIH, 50 South Drive 50 4142, Bethesda, MD 20892 8027, USA
    ScientificWorldJournal 2012:267120. 2012
  6. pmc Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1
    Wei Wang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 7:11. 2011
  7. ncbi request reprint NMDA receptors and PSD-95 are found in attachment plaques in cerebellar granular layer glomeruli
    Ronald S Petralia
    Laboratory of Neurochemistry, 50 4142, NIDCD NIH, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 15:583-7. 2002
  8. ncbi request reprint Internalization at glutamatergic synapses during development
    Ronald S Petralia
    Laboratory of Neuroscience, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 18:3207-17. 2003
  9. ncbi request reprint Glutamate receptor targeting in the postsynaptic spine involves mechanisms that are independent of myosin Va
    R S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 36 5D08, 36 CONVENT DR MSC 4162, Bethesda MD 20892 4162, USA
    Eur J Neurosci 13:1722-32. 2001
  10. pmc Organization of NMDA receptors at extrasynaptic locations
    R S Petralia
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders National Institutes of Health NIDCD NIH, Bethesda, MD, USA
    Neuroscience 167:68-87. 2010

Collaborators

Detail Information

Publications56

  1. pmc Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons
    Jinhyun Kim
    Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 54:933-47. 2007
    ..These results present an additional mechanism for synaptic integration and plasticity through the activity-dependent regulation of Kv4.2 channel surface expression...
  2. ncbi request reprint AP180 and CALM in the developing hippocampus: expression at the nascent synapse and localization to trafficking organelles
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, Bethesda, Maryland 20892, USA
    J Comp Neurol 504:314-27. 2007
    ..Our observations link AP180 and CALM to multiple vesicular organelles and raise the possibility that these proteins may play additional roles in developing neurons...
  3. ncbi request reprint Communication breakdown: the impact of ageing on synapse structure
    Ronald S Petralia
    Advanced Imaging Core, NIDCD NIH, Bethesda, MD 20892, United States Electronic address
    Ageing Res Rev 14:31-42. 2014
    ..The morphological characteristics of aged synapses could shed light on the underlying molecular changes and their functional consequences. ..
  4. pmc Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti
    Katherine B Szarama
    Section on Developmental Neuroscience, Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    BMC Dev Biol 13:6. 2013
    ..The mammalian cochlea is an intriguing system to examine these mechanisms, as cellular structure plays a key role in tissue development, and thyroid hormone is required for the maturation of the cochlea in the first postnatal week...
  5. pmc Distribution of extrasynaptic NMDA receptors on neurons
    Ronald S Petralia
    Advanced Imaging Core, NIDCD NIH, 50 South Drive 50 4142, Bethesda, MD 20892 8027, USA
    ScientificWorldJournal 2012:267120. 2012
    ..In some cases, activation of extrasynaptic NMDA receptors may have a negative influence on the neuron, leading to cell damage and death, as may occur in some major diseases of the nervous system...
  6. pmc Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1
    Wei Wang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 7:11. 2011
    ..PICK1 appears to be required for peripheral nerve injury-induced neuropathic pain development and to be a potential biochemical target for treating this disorder...
  7. ncbi request reprint NMDA receptors and PSD-95 are found in attachment plaques in cerebellar granular layer glomeruli
    Ronald S Petralia
    Laboratory of Neurochemistry, 50 4142, NIDCD NIH, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 15:583-7. 2002
    ..The presence of NMDA receptors in attachment plaques suggests that these receptors mediate changes in the adhesive properties of these plaques, similar to this function in synapses...
  8. ncbi request reprint Internalization at glutamatergic synapses during development
    Ronald S Petralia
    Laboratory of Neuroscience, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 18:3207-17. 2003
    ..Also, caveolin might be prevalent at excitatory synapses, although it is not known whether it is involved in receptor internalization, receptor stabilization, or some other function...
  9. ncbi request reprint Glutamate receptor targeting in the postsynaptic spine involves mechanisms that are independent of myosin Va
    R S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 36 5D08, 36 CONVENT DR MSC 4162, Bethesda MD 20892 4162, USA
    Eur J Neurosci 13:1722-32. 2001
    ..Other possible mechanisms include diffusion along the extrasynaptic membrane and delivery via other motors running along the spine's actin cytoskeleton...
  10. pmc Organization of NMDA receptors at extrasynaptic locations
    R S Petralia
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders National Institutes of Health NIDCD NIH, Bethesda, MD, USA
    Neuroscience 167:68-87. 2010
    ..These associations may facilitate unique functions for extrasynaptic NMDA receptors...
  11. pmc Ontogeny of postsynaptic density proteins at glutamatergic synapses
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Mol Cell Neurosci 29:436-52. 2005
    ..Development was marked by substantial decreases in NR2B and SAP102 and increases in NR2A, PSD-95, AMPA receptors, and CaMKII. Other components showed more moderate changes...
  12. ncbi request reprint Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 19:2017-29. 2004
    ....
  13. ncbi request reprint Variations in the tangential distribution of postsynaptic glutamate receptors in Purkinje cell parallel and climbing fiber synapses during development
    R S Petralia
    NIDCD NIH, Laboratory of Neurochemistry, Bethesda, MD 20892, USA
    Neuropharmacology 37:1321-34. 1998
    ....
  14. ncbi request reprint A developmental change in NMDA receptor-associated proteins at hippocampal synapses
    N Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 20:1260-71. 2000
    ..These studies suggest that there is a preference for complexes of NR2A/PSD-93/95 and NR2B/SAP-102. These results indicate that individual receptor-associated proteins may have specific functions that are critical to synapse development...
  15. ncbi request reprint Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway
    N Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 21:7506-16. 2001
    ..We also show that internalization of GluR1, as triggered by NMDAR activation, does not require SAP97. These results implicate GluR1-SAP97 interactions in mechanisms underlying AMPA receptor targeting...
  16. ncbi request reprint Glutamate receptor subunit 2-selective antibody shows a differential distribution of calcium-impermeable AMPA receptors among populations of neurons
    R S Petralia
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892 4162, USA
    J Comp Neurol 385:456-76. 1997
    ..Both ultrastructural and immunofluorescence data showed that calcium-impermeable AMPA receptors are widespread in dendrite arborizations...
  17. ncbi request reprint Ocsyn, a novel syntaxin-interacting protein enriched in the subapical region of inner hair cells
    S Safieddine
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892, USA
    Mol Cell Neurosci 20:343-53. 2002
    ..Here we report the cloning of a novel syntaxin-binding protein that is concentrated in a previously uncharacterized organelle at the apex of inner hair cells...
  18. ncbi request reprint A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR1 alpha metabotropic glutamate receptors
    R S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, Bethesda, MD 20892 4162, USA
    J Chem Neuroanat 13:77-93. 1997
    ....
  19. ncbi request reprint Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus
    R S Petralia
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892, USA
    J Comp Neurol 372:356-83. 1996
    ....
  20. ncbi request reprint Distribution of members of the PSD-95 family of MAGUK proteins at the synaptic region of inner and outer hair cells of the guinea pig cochlea
    C Davies
    Section on Structural Cell Biology, NIDCD, NIH, Bethesda, Maryland, USA
    Synapse 40:258-68. 2001
    ..In addition, PSD-93 and PSD-95 are found in postsynaptic afferent terminals on inner hair cells, while postsynaptic afferent terminals on outer hair cells have PSD-93...
  21. ncbi request reprint Homer 1b regulates the trafficking of group I metabotropic glutamate receptors
    K W Roche
    Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:25953-7. 1999
    ..Because H1b is found in dendritic spines of neurons, local retention of metabotropic receptors within dendritic ER provides a potential mechanism for regulating synapse-specific expression of group I metabotropic glutamate receptors...
  22. ncbi request reprint Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses
    K W Roche
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 19:3926-34. 1999
    ....
  23. pmc A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking
    Young Ho Suh
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Nat Neurosci 13:338-43. 2010
    ..SNAP-23 is therefore important for the functional regulation of postsynaptic glutamate receptors...
  24. ncbi request reprint A novel family of adhesion-like molecules that interacts with the NMDA receptor
    Chang Yu Wang
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 26:2174-83. 2006
    ..After transfection of heterologous cells with NR1 and NR2 cDNAs, through coimmunoprecipitation analyses, we find that SALM1 also interacts with the NMDA receptor NR1 subunit through its extracellular or TM1 domains...
  25. ncbi request reprint mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
    Nat Cell Biol 7:1179-90. 2005
    ..mPins changes the number and morphology of dendritic spines and these effects depend on its Galphai interaction domain, thus implicating G-protein signalling in the regulation of postsynaptic structure and trafficking of GluRs...
  26. ncbi request reprint Early events in the trafficking of N-methyl-D-aspartate (NMDA) receptors
    R J Wenthold
    Laboratory of Neurochemistry, NIDCD, NIH, Building 50, Room 4140, Bethesda, MD 20892, USA
    Biochem Soc Trans 31:885-8. 2003
    ....
  27. ncbi request reprint Glutamate receptor subunits in the nucleus of the tractus solitarius and other regions of the medulla oblongata in the cat
    R Ambalavanar
    Voice and Speech Section, NIDCD, NIH, Bethesda, Maryland 20892 1416, USA
    J Comp Neurol 402:75-92. 1998
    ..This finding suggests that neurons in these structures are designed to respond differently to excitatory input...
  28. ncbi request reprint The role of the PDZ protein GIPC in regulating NMDA receptor trafficking
    Zhaohong Yi
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:11663-75. 2007
    ..Our results suggest that GIPC may be preferentially associated with extrasynaptic NMDA receptors and may play a role in the organization and trafficking of this population of receptors...
  29. ncbi request reprint Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 23:9367-73. 2003
    ..Therefore, GluR1 may have a greater preference for GluR2 than it does for GluR3...
  30. ncbi request reprint NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
    Nat Cell Biol 5:520-30. 2003
    ..Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking...
  31. ncbi request reprint Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber CA3 pyramid synapses
    Michelle T W Ho
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:11651-62. 2007
    ..Together, these findings indicate that the transient participation of CP-AMPARs at young MF-PYR synapses dictates the developmental window to observe DiLTD...
  32. ncbi request reprint Trafficking of NMDA receptors
    Robert J Wenthold
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892, USA
    Annu Rev Pharmacol Toxicol 43:335-58. 2003
    ..This review addresses recent advances in our understanding of NMDAR trafficking and its synaptic delivery and maintenance...
  33. ncbi request reprint Identification of a novel SNAP25 interacting protein (SIP30)
    Ho Ki Lee
    Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 81:1338-47. 2002
    ..Although SIP30 does not directly interact with syntaxin based on pull-down assays, syntaxin does co-immunoprecipitate with SIP30 suggesting that syntaxin is indirectly associated with SIP30, perhaps through SNAP25...
  34. pmc SAP102 is a highly mobile MAGUK in spines
    Chan Ying Zheng
    Laboratories of Neurochemistry and Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:4757-66. 2010
    ..These differences and the compensatory properties of the MAGUKs point out an unrecognized versatility of the MAGUKs in their function in synaptic organization and plasticity...
  35. ncbi request reprint Vesicle targeting in hair cells
    Robert J Wenthold
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD 20892, USA
    Audiol Neurootol 7:45-8. 2002
    ..Our results are consistent with ocsyn playing a role in vesicle trafficking to the apical membrane of the hair cell...
  36. ncbi request reprint Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Comp Neurol 494:368-79. 2006
    ..Our results suggest a dual role for epsin1 and HIP1 in the synapse: as broadly required factors for promoting clathrin assembly and as adaptors for specific endocytic pathways...
  37. ncbi request reprint Synaptic distribution of the endocytic accessory proteins AP180 and CALM
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Comp Neurol 481:58-69. 2005
    ..We propose that both AP180 and CALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways...
  38. ncbi request reprint Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies
    R J Wenthold
    Laboratory of Neurochemistry, National Institute of Deafness and Communication Disease, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:1332-9. 1994
    ..Interestingly, GluR1 and GluR2, subunits of the AMPA receptor, also co-immunoprecipitated with GluR6 in cells co-transfected with GluR6 and GluR1 or GluR2 cD-NAs. Such complexes appear to be present to a limited extent in the brain...
  39. pmc Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus
    Detlef Vullhorst
    Section on Molecular Neurobiology, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892 3714, USA
    J Neurosci 29:12255-64. 2009
    ....
  40. pmc The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes
    Gail K Seabold
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, MD 20892 8027, USA
    J Biol Chem 283:8395-405. 2008
    ..Co-culture experiments using HeLa cells and rat hippocampal neurons expressing the SALMs showed that SALM4 is recruited to points of contact between the cells. In neurons, these points of contact were seen in both axons and dendrites...
  41. ncbi request reprint Distribution of kainate receptor subunits at hippocampal mossy fiber synapses
    Melanie Darstein
    Molecular Neurobiology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:8013-9. 2003
    ....
  42. ncbi request reprint Actinfilin, a brain-specific actin-binding protein in postsynaptic density
    Ying Chen
    Department of Physiology, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 277:30495-501. 2002
    ..The results showed the postsynaptic density distribution of actinfilin. Together, these results indicate that actinfilin may be a key player in the actin-based neuronal function...
  43. ncbi request reprint Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities
    Olga Ganeshina
    Department of Cell and Molecular Biology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Comp Neurol 468:86-95. 2004
    ....
  44. ncbi request reprint Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1
    Sang Jeong Kim
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland 21205, USA
    Nature 426:285-91. 2003
    ..Furthermore, co-expression of mGluR1 and TRPC1 in a heterologous system reconstituted a mGluR1-evoked conductance that closely resembles the slow EPSC in Purkinje cells...
  45. pmc Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons
    Ittai Bushlin
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 28:10257-71. 2008
    ..Additionally, CALM-deficient neurons show disrupted secretory transport. Our data demonstrate previously unknown functions for AP180 and CALM in intracellular trafficking that are essential in the growth of neurons...
  46. ncbi request reprint Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity
    Desheng Xu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 39:513-28. 2003
    ..This mechanism appears to contribute to both activity-independent and activity-dependent excitatory synaptogenesis...
  47. pmc mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE
    Richard W Cho
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 57:858-71. 2008
    ..These observations suggest that cleaved NPR functions to "capture" AMPAR for endocytosis and reveal a bifunctional role of NPs in both synapse strengthening and weakening...
  48. ncbi request reprint AMPA receptor subunit expression in chick vestibular nucleus neurons
    Anastas Popratiloff
    Department of Anatomy and Cell Biology, and Neuroscience Program, George Washington University Medical Center, Washington DC 20037, USA
    J Neurosci Res 76:662-77. 2004
    ..In summary, these results indicate that GluR3 and GluR4 are the major AMPA receptor subunits involved in excitatory synaptic transmission in principal cells during the perinatal period...
  49. ncbi request reprint Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures
    Mangala M Soundarapandian
    Biomedical Science Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA
    J Neurochem 103:1982-8. 2007
    ..1/SUR1 channels enhances glutamate release at CA3 synapses. Hence, expression of functional Kir6.1/SUR1 channels inhibits seizure responses and possibly acts via limiting excitatory glutamate release...
  50. ncbi request reprint Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory
    Hey Kyoung Lee
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Cell 112:631-43. 2003
    ..The phosphomutant mice show deficits in LTD and LTP and have memory defects in spatial learning tasks. These results demonstrate that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories...
  51. ncbi request reprint Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:6703-12. 2003
    ..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain...
  52. pmc Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
    Shoaib Chowdhury
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:445-59. 2006
    ..These findings reveal a novel molecular pathway that is regulated by Arc/Arg3.1 and likely contributes to late-phase synaptic plasticity and memory consolidation...
  53. ncbi request reprint Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
    Chong Hyun Kim
    Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nat Neurosci 8:985-7. 2005
    ..This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity...
  54. ncbi request reprint TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
    Nathalie Rouach
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 8:1525-33. 2005
    ....
  55. pmc Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 161:805-16. 2003
    ..These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system...
  56. pmc Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2
    Jeffrey R Gingrich
    Brain and Behaviour Program, Hospital for Sick Children, Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Proc Natl Acad Sci U S A 101:6237-42. 2004
    ....