Karin E Peterson
Affiliation: National Institutes of Health
Christensen L, Woods T, Carmody A, Caughey B, Peterson K. Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia. J Neuroinflammation. 2014;11:70 pubmed publisher
..This increased neuroinflammatory response to PAMPs may explain why the developing brain is particularly sensitive to infection and why infection or stress during this time can lead to long-term damage in the CNS. ..
Woods T, Du M, Carmody A, Peterson K. Neuropeptide Y Negatively Influences Monocyte Recruitment to the Central Nervous System during Retrovirus Infection. J Virol. 2015;90:2783-93 pubmed publisher
..These studies provide a mechanism by which the nervous system, through the production of NPY, can suppress monocyte trafficking to the brain and reduce retrovirus-induced neurological disease. ..
Bauler T, Starr T, Nagy T, Sridhar S, Scott D, Winkler C, et al
. Salmonella Meningitis Associated with Monocyte Infiltration in Mice. Am J Pathol. 2017;187:187-199 pubmed publisher
..Thus, Nramp1 is not essential for Salmonella entry into the CNS or neuroinflammation, but may influence the mechanisms of CNS entry as well as the severity of meningitis. ..
Taylor K, Woods T, Winkler C, Carmody A, Peterson K. Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease. J Virol. 2014;88:11070-9 pubmed publisher
..Thus, this study demonstrates a reason for susceptibility to LACV infection in young animals and shows that early therapeutic treatment in young animals can prevent neurological disease. ..
Mukherjee P, Winkler C, Taylor K, Woods T, Nair V, Khan B, et al
. SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons. J Immunol. 2015;195:4913-21 pubmed publisher
..These studies identify a non-MyD88 pathway of TLR7/ TLR9 signaling in neurons and provide a mechanism for how innate immune responses in the CNS directly induce neuronal damage. ..
Winkler C, Myers L, Woods T, Messer R, Carmody A, McNally K, et al
. Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infection in Brain and Testes. J Immunol. 2017;198:3526-3535 pubmed publisher
Winkler C, Myers L, Woods T, Carmody A, Taylor K, Peterson K. Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice. J Neuroinflammation. 2017;14:62 pubmed publisher
Winkler C, Woods T, Robertson S, McNally K, Carmody A, Best S, et al
. Cutting Edge: CCR2 Is Not Required for Ly6Chi Monocyte Egress from the Bone Marrow but Is Necessary for Migration within the Brain in La Crosse Virus Encephalitis. J Immunol. 2018;200:471-476 pubmed publisher
..These studies demonstrate that the CCR2 requirement for iMO egress to the blood is not universal for all viruses. ..
Peterson K, Du M. Innate immunity in the pathogenesis of polytropic retrovirus infection in the central nervous system. Immunol Res. 2009;43:149-59 pubmed publisher