P A Permana

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians
    P A Permana
    Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, Arizona, 85016, USA
    Biochem Biophys Res Commun 258:184-6. 1999
  2. ncbi Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes
    Y H Lee
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabetologia 48:1776-83. 2005
  3. ncbi Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians
    S Nair
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetologia 48:1784-8. 2005
  4. ncbi Identification of differentially expressed genes in skeletal muscle of non-diabetic insulin-resistant and insulin-sensitive Pima Indians by differential display PCR
    Y H Lee
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetologia 46:1567-75. 2003
  5. ncbi Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms
    X Yang
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:111-3. 2001
  6. ncbi 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle
    S Nair
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetologia 47:1088-95. 2004
  7. ncbi Mutations in the genes for hepatocyte nuclear factor (HNF)-1alpha, -4alpha, -1beta, and -3beta; the dimerization cofactor of HNF-1; and insulin promoter factor 1 are not common causes of early-onset type 2 diabetes in Pima Indians
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA
    Diabetes Care 23:302-4. 2000
  8. ncbi Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)
    J Vaughn
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, AZ 85016, USA
    Biochem Biophys Res Commun 274:302-9. 2000
  9. ncbi Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit
    P A Permana
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, 85016, USA
    Mol Genet Metab 70:151-8. 2000
  10. ncbi Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians
    P A Permana
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Genomics 41:110-4. 1997

Detail Information

Publications14

  1. ncbi Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians
    P A Permana
    Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, Arizona, 85016, USA
    Biochem Biophys Res Commun 258:184-6. 1999
    ..These results exclude any significant role of protein targeting to glycogen/PPP1R5 in insulin resistance in Pima Indians...
  2. ncbi Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes
    Y H Lee
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabetologia 48:1776-83. 2005
    ..CONCLUSIONS/INTERPRETATION: This study provides evidence supporting the active role of mature adipocytes in obesity-related inflammation. It also provides potential candidate genes for susceptibility to obesity...
  3. ncbi Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians
    S Nair
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetologia 48:1784-8. 2005
    ..The aim of this study was to elucidate the potential role of adipocyte precursor cells (preadipocytes/stromal vascular cells [SVC])...
  4. ncbi Identification of differentially expressed genes in skeletal muscle of non-diabetic insulin-resistant and insulin-sensitive Pima Indians by differential display PCR
    Y H Lee
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetologia 46:1567-75. 2003
    ..We carried out muscle gene expression profiling to identify differentially expressed genes associated with insulin resistance...
  5. ncbi Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms
    X Yang
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:111-3. 2001
    ..The expression levels of the major isoforms, calpain-10a and -10f, were positively correlated with the total calpain-10 mRNA levels, indicating a cumulative effect...
  6. ncbi 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle
    S Nair
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetologia 47:1088-95. 2004
    ..We have shown that adipose tissue 11beta-HSD1 mRNA levels were associated with adiposity and insulinaemia. Here we conducted further expression and genetic association studies in Pima Indians...
  7. ncbi Mutations in the genes for hepatocyte nuclear factor (HNF)-1alpha, -4alpha, -1beta, and -3beta; the dimerization cofactor of HNF-1; and insulin promoter factor 1 are not common causes of early-onset type 2 diabetes in Pima Indians
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA
    Diabetes Care 23:302-4. 2000
    ..The purpose of this study was to determine whether alterations in known MODY genes and two MODY candidate genes contribute to the development of early-onset type 2 diabetes in Pima Indians...
  8. ncbi Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)
    J Vaughn
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, AZ 85016, USA
    Biochem Biophys Res Commun 274:302-9. 2000
    ..The characterization of the KCNJ9 gene should facilitate further studies on the function of the KCNJ9 protein and allow evaluation of the potential role of the locus in Type II diabetes...
  9. ncbi Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit
    P A Permana
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, 85016, USA
    Mol Genet Metab 70:151-8. 2000
    ..This study does not support a role for Arg883 and Asp905 variants independent of the ARE2 allele in the impaired insulin-stimulated glycogen synthesis in the muscle of Pima Indians...
  10. ncbi Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians
    P A Permana
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Genomics 41:110-4. 1997
    ..The information on the genomic structure of PPP1R2 is important for exploring this gene as a potential candidate contributing to insulin resistance and NIDDM in other populations...
  11. ncbi mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action
    J Koska
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health DHHS, Phoenix, AZ, USA
    Int J Obes (Lond) 33:842-50. 2009
    ..To determine whether the mRNA concentrations of inflammation response genes in isolated adipocytes and in cultured preadipocytes are related to adipocyte size and in vivo insulin action in obese individuals...
  12. ncbi A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85016, USA
    J Clin Invest 106:R69-73. 2000
    ..A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons...
  13. ncbi Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians
    X Yang
    Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, , Sweden
    Diabetologia 45:1584-93. 2002
    ..Furthermore, differentially expressed genes in chromosomal regions with linkage to diabetes and insulin resistance serve as new diabetes susceptibility genes...
  14. ncbi What are subcutaneous adipocytes really good for?
    J Klein
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Exp Dermatol 16:45-70. 2007
    ....