W R Perlman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
  2. ncbi request reprint Age-related differences in glucocorticoid receptor mRNA levels in the human brain
    William R Perlman
    MiNDS Unit, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neurobiol Aging 28:447-58. 2007
  3. ncbi request reprint Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortex
    W R Perlman
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neuroscience 134:81-95. 2005
  4. ncbi request reprint Estradiol alters transcription factor gene expression in primate prefrontal cortex
    J Wang
    Developmental Endocrinology Branch, National Institute of Child Health, Bethesda, Maryland, USA
    J Neurosci Res 76:306-14. 2004
  5. ncbi request reprint Cloning and expression of zebra finch (Taeniopygia guttata) steroidogenic factor 1: overlap with hypothalamic but not with telencephalic aromatase
    Robert J Agate
    Department of Physiological Science, Brain Research Institute, University of California Los Angeles, 621 Charles E Young Drive South, Los Angeles, CA 90095 1606
    Biol Reprod 66:1127-33. 2002
  6. ncbi request reprint Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, MD 20892 1385, USA
    Biol Psychiatry 58:812-24. 2005
  7. ncbi request reprint Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:844-52. 2004
  8. ncbi request reprint Expression of androgen receptor mRNA in zebra finch song system: developmental regulation by estrogen
    Yong Hwan Kim
    Department of Physiological Science and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 469:535-47. 2004
  9. ncbi request reprint Expression of estrogen receptor and aromatase mRNAs in embryonic and posthatch zebra finch brain
    William R Perlman
    Department of Physiological Science, Interdepartmental Program for Neuroscience and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurobiol 55:204-19. 2003
  10. ncbi request reprint Expression of androgen receptor mRNA in the late embryonic and early posthatch zebra finch brain
    William R Perlman
    Department of Physiological Science, Interdepartmental Program for Neuroscience and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, California 90095 1606, USA
    J Comp Neurol 455:513-30. 2003

Detail Information

Publications10

  1. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
    ..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing...
  2. ncbi request reprint Age-related differences in glucocorticoid receptor mRNA levels in the human brain
    William R Perlman
    MiNDS Unit, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neurobiol Aging 28:447-58. 2007
    ..Increased GR mRNA in prefrontal cortex during adolescence and adulthood suggests that human GR-mediated forebrain regulation of cognition and the neuroendocrine stress response may be more salient during late maturation and at maturity...
  3. ncbi request reprint Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortex
    W R Perlman
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neuroscience 134:81-95. 2005
    ....
  4. ncbi request reprint Estradiol alters transcription factor gene expression in primate prefrontal cortex
    J Wang
    Developmental Endocrinology Branch, National Institute of Child Health, Bethesda, Maryland, USA
    J Neurosci Res 76:306-14. 2004
    ..These data indicate that estrogen may have direct as well as indirect effects on neuronal gene expression in the primate prefrontal cortex...
  5. ncbi request reprint Cloning and expression of zebra finch (Taeniopygia guttata) steroidogenic factor 1: overlap with hypothalamic but not with telencephalic aromatase
    Robert J Agate
    Department of Physiological Science, Brain Research Institute, University of California Los Angeles, 621 Charles E Young Drive South, Los Angeles, CA 90095 1606
    Biol Reprod 66:1127-33. 2002
    ..These findings suggest that steroidogenesis in the zebra finch brain may be regulated by both SF1-dependent and SF1-independent mechanisms. No sex differences were detected in SF1 expression in brain...
  6. ncbi request reprint Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, MD 20892 1385, USA
    Biol Psychiatry 58:812-24. 2005
    ..We hypothesized that gender-specific alterations in DLPFC and hippocampus estrogen receptor alpha (ERalpha) mRNA levels may exist in MMI patients...
  7. ncbi request reprint Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:844-52. 2004
    ..We also hypothesized that estrogen receptor alpha (ERalpha) mRNA expression might be altered in the amygdala, on the basis of observed gender differences in mental illness...
  8. ncbi request reprint Expression of androgen receptor mRNA in zebra finch song system: developmental regulation by estrogen
    Yong Hwan Kim
    Department of Physiological Science and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 469:535-47. 2004
    ....
  9. ncbi request reprint Expression of estrogen receptor and aromatase mRNAs in embryonic and posthatch zebra finch brain
    William R Perlman
    Department of Physiological Science, Interdepartmental Program for Neuroscience and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurobiol 55:204-19. 2003
    ..The results fail to provide support for the hypothesis that sexual differentiation of the song system is mediated by sex differences in the expression of these mRNAs at these ages...
  10. ncbi request reprint Expression of androgen receptor mRNA in the late embryonic and early posthatch zebra finch brain
    William R Perlman
    Department of Physiological Science, Interdepartmental Program for Neuroscience and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, California 90095 1606, USA
    J Comp Neurol 455:513-30. 2003
    ..Our results suggested that androgens act early in neural development and therefore may contribute to the process of sexual differentiation...